Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Boutaud O and Oates JA | Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes. | 2010 | Methods Mol. Biol. | pmid:20645166 |
Kawaguchi T et al. | The human megakaryocytic cell line UT-7/TPO expresses functional platelet agonist signals mediated through GPVI and thromboxane receptor. | 2010 | Cell Biol. Int. | pmid:20522022 |
Parmar JH et al. | Significant prostacyclin/thromboxane level imbalance after lower limb arterial angioplasty: a possible platelet function alteration. | 2010 | J Vasc Interv Radiol | pmid:20800778 |
Kawabata K et al. | Inhibition of secretory phospholipase A2 activity attenuates acute cardiogenic pulmonary edema induced by isoproterenol infusion in mice after myocardial infarction. | 2010 | J. Cardiovasc. Pharmacol. | pmid:20625313 |
Fukushima H et al. | Mechanisms underlying early development of pulmonary vascular obstructive disease in Down syndrome: An imbalance in biosynthesis of thromboxane A2 and prostacyclin. | 2010 | Am. J. Med. Genet. A | pmid:20583254 |
Laguta PS et al. | [Aspirin resistance in patients with stable ischemic heart disease]. | 2010 | Kardiologiia | pmid:21526557 |
Ren R et al. | Protective effects of Danshensu on liver injury induced by omethoate in rats. | 2010 | Toxicol. Mech. Methods | pmid:20843270 |
Watanabe H et al. | [Thromboxane A2 (TXA2), thromboxane B2(TXB2)]. | 2010 | Nippon Rinsho | pmid:20963856 |
Huang HC et al. | Simvastatin effects on portal-systemic collaterals of portal hypertensive rats. | 2010 | J. Gastroenterol. Hepatol. | pmid:20659230 |
Ferrante E et al. | Determinants of thromboxane biosynthesis in rheumatoid arthritis: Role of RAGE and oxidant stress. | 2010 | Free Radic. Biol. Med. | pmid:20541603 |
Hepgül G et al. | Preventive effect of pentoxifylline on acute radiation damage via antioxidant and anti-inflammatory pathways. | 2010 | Dig. Dis. Sci. | pmid:19294507 |
Addad F et al. | Response variability to aspirin and one-year prediction of vascular events in patients with stable coronary artery disease. | 2010 | J. Thromb. Thrombolysis | pmid:19381450 |
De La Cruz JP et al. | Virgin olive oil administration improves the effect of aspirin on retinal vascular pattern in experimental diabetes mellitus. | 2010 | Br. J. Nutr. | pmid:20350343 |
Smock KJ and Rodgers GM | Laboratory evaluation of aspirin responsiveness. | 2010 | Am. J. Hematol. | pmid:20229592 |
Dołegowska B et al. | Dynamics of thromboxane level changes during early phase of allograft reperfusion. | 2009 Sep-Oct | Clin Transplant | pmid:19298388 |
Tantry US et al. | Aspirin resistance. | 2009 Sep-Oct | Prog Cardiovasc Dis | pmid:19732606 |
Thomson VS et al. | Aspirin resistance in Indian patients with coronary artery disease and cardiovascular events. | 2009 Oct-Dec | J Postgrad Med | pmid:20083870 |
Goodman L et al. | Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model. | 2009 Jan-Feb | J. Vet. Intern. Med. | pmid:19175721 |
Capodanno D and Angiolillo DJ | Platelet monitoring for PCI: which test is the one to choose? | 2009 | Hamostaseologie | pmid:19882078 |
Gao XR et al. | Efficacy of different doses of aspirin in decreasing blood levels of inflammatory markers in patients with cardiovascular metabolic syndrome. | 2009 | J. Pharm. Pharmacol. | pmid:19903376 |
Zuo Y et al. | Gross-total hematoma removal of hypertensive basal ganglia hemorrhages: a long-term follow-up. | 2009 | J. Neurol. Sci. | pmid:19801153 |
Frelinger AL et al. | Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization. | 2009 | Circulation | pmid:19996015 |
Kambara T et al. | Propofol suppresses prostaglandin E(2) production in human peripheral monocytes. | 2009 | Immunopharmacol Immunotoxicol | pmid:19951072 |
Guerrero MD et al. | Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression. | 2009 | Eur. J. Pharmacol. | pmid:19686718 |
Dietrich-Muszalska A and Olas B | Isoprostenes as indicators of oxidative stress in schizophrenia. | 2009 | World J. Biol. Psychiatry | pmid:19673085 |
Lowe FJ et al. | Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers. | 2009 | Clin. Chem. Lab. Med. | pmid:19676143 |
Stanke-Labesque F et al. | Increased urinary leukotriene E4 excretion in obstructive sleep apnea: effects of obesity and hypoxia. | 2009 | J. Allergy Clin. Immunol. | pmid:19596146 |
Huntjens DR et al. | Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors. | 2009 | Eur J Pain | pmid:18774319 |
Correa JA et al. | Virgin olive oil polyphenol hydroxytyrosol acetate inhibits in vitro platelet aggregation in human whole blood: comparison with hydroxytyrosol and acetylsalicylic acid. | 2009 | Br. J. Nutr. | pmid:18775097 |
Hynninen VV et al. | Oral voriconazole and miconazole oral gel produce comparable effects on the pharmacokinetics and pharmacodynamics of etoricoxib. | 2009 | Eur. J. Clin. Pharmacol. | pmid:18777173 |
Muir AR et al. | Assessment of aspirin resistance varies on a temporal basis in patients with ischaemic heart disease. | 2009 | Heart | pmid:18697805 |
Foudi N et al. | Selective cyclooxygenase-2 inhibition directly increases human vascular reactivity to norepinephrine during acute inflammation. | 2009 | Cardiovasc. Res. | pmid:18952694 |
Rogers LK et al. | Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen. | 2009 | Pediatr. Res. | pmid:18703992 |
Fernández-Arche A et al. | Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators. | 2009 | J. Nutr. Biochem. | pmid:18555679 |
Zeng HH et al. | [Effect of safflower injection on pulmonary hypertension in rat during chronic hypoxia and hypercapnia]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21186611 |
Santilli F et al. | Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin "resistance". | 2009 | J. Am. Coll. Cardiol. | pmid:19232899 |
Lev EI | Aspirin resistance transient laboratory finding or important clinical entity? | 2009 | J. Am. Coll. Cardiol. | pmid:19232900 |
Sobotková A et al. | Antioxidants change platelet responses to various stimulating events. | 2009 | Free Radic. Biol. Med. | pmid:19766712 |
Shen H et al. | Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study). | 2009 | Am. J. Cardiol. | pmid:19660620 |
Leoncini G et al. | In retinal vein occlusion platelet response to thrombin is increased. | 2009 | Thromb. Res. | pmid:19660790 |
Canales A et al. | Platelet aggregation, eicosanoid production and thrombogenic ratio in individuals at high cardiovascular risk consuming meat enriched in walnut paste. A crossover, placebo-controlled study. | 2009 | Br. J. Nutr. | pmid:19068151 |
Duda MK et al. | Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction. | 2009 | Cardiovasc. Res. | pmid:19015135 |
Hynninen VV et al. | Voriconazole increases while itraconazole decreases plasma meloxicam concentrations. | 2009 | Antimicrob. Agents Chemother. | pmid:19015346 |
Kerola M et al. | Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19152549 |
Lauring B et al. | Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects. | 2009 | J Clin Pharmacol | pmid:19833861 |
O'Donnell ME et al. | The effects of cilostazol on exercise-induced ischaemia-reperfusion injury in patients with peripheral arterial disease. | 2009 | Eur J Vasc Endovasc Surg | pmid:19112032 |
Bailey SR et al. | Plasma concentrations of endotoxin and platelet activation in the developmental stage of oligofructose-induced laminitis. | 2009 | Vet. Immunol. Immunopathol. | pmid:19091426 |
Dołegowska B et al. | Platelets arachidonic acid metabolism in patients with essential hypertension. | 2009 | Platelets | pmid:19440924 |
Ahmad M et al. | Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. | 2009 | Brain Res. | pmid:19446533 |
Li L et al. | The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor. | 2009 | Eur. J. Pharmacol. | pmid:19243697 |