Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Celiac Disease D002446 16 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Intracranial Embolism and Thrombosis D002542 5 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Chediak-Higashi Syndrome D002609 4 associated lipids
Chest Pain D002637 4 associated lipids
Choline Deficiency D002796 16 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Bell JG et al. Dietary sunflower, linseed and fish oils affect phospholipid fatty acid composition, development of cardiac lesions, phospholipase activity and eicosanoid production in Atlantic salmon (Salmo salar). 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8248271
Tannirandorn Y et al. Production of urinary 11-keto-thromboxane B2 in normal and hypertensive pregnancies. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:2020732
Pham HC et al. Comparative effects on TXA2 biosynthesis of products extracted from Lippia multiflora Moldenke leaves. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3241820
Sinzinger H et al. Diminished platelet residence time on active human atherosclerotic lesions in-vivo--evidence for an optimal dose of aspirin? 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3241821
Myers SI et al. Long-term resuscitation of hemorrhage/reperfusion injury (H/R) stimulates renal PGE2 release. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8832762
Zhang T et al. Effects of the incubation of long-chain polyunsaturated fatty acids on platelet lipids and thromboxane release. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150370
Sinzinger H et al. PGE1-induced arterial thromboresistance is a vascular property as identified by cross-perfusion technique. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150379
Closa D et al. Prostanoids and free radicals in Cl4C-induced hepatotoxicity in rats: effect of astilbin. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150380
Koopmans PP et al. The urinary excretion of prostaglandins and thromboxane B2 in healthy volunteers: a study in males and females, and on the influence of seminal fluid contamination. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3413191
Fritsche KL and Cassity NA Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981628
Chavali SR et al. Increased production of TNF-alpha and decreased levels of dienoic eicosanoids, IL-6 and IL-10 in mice fed menhaden oil and juniper oil diets in response to an intraperitoneal lethal dose of LPS. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774171
Dahl-Puustinen ML et al. Effects of repeated oral doses of fenflumizole on platelet aggregation and thromboxane formation in man ex vivo. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3357910
Vijaya Kumar M et al. The anhydrous milk fat, ghee, lowers serum prostaglandins and secretion of leukotrienes by rat peritoneal macrophages. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574649
Vincent JE and Zijlstra FJ The effect of adrenalectomy on the aggregation of rat blood platelets and the endogenous formation of thromboxane B2 and 12-hydroxy-5,8,10,14-eicosatetraenoic acid. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3357912
Serebruany VL et al. Serial changes of the plasma prostanoids during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9051723
Devi MM and Das UN Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15380818
Vaughn DM et al. Elevation of thromboxane in pressure wounds. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2762367
Nimpf J et al. Postprandial hyperlipemia inhibits platelet aggregation without affecting prostanoid metabolism. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2762369
González E et al. Nitric oxide modulates placental prostanoid production from late pregnant non-insulin-dependent diabetic rat. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888203
Agnoli GC et al. Renal synthesis of prostacyclin and thromboxane in healthy women: differential effects of a short-term saline loading. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780876
Pancera P et al. Changes in peripheral hemodynamics and vasodilating prostaglandins after high-dose short-term ibuprofen in chronically treated hypertensive patients. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8860111
Kosugi T et al. Glomerular thromboxane contributes to pressor response in deoxycorticosterone acetate-salt hypertension. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9578151
Lueddeckens G et al. Importance of secondary TXA2 release in mediating of endothelin-1 induced bronchoconstriction and vasopressin in the guinea-pig. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8469685
Pregnolato P et al. Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981629
Bordia A et al. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654398
Sinzinger H Comments on "Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications". 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12445490
Delemarre FM et al. Urinary prostaglandin excretion in pregnancy: the effect of dietary sodium restriction. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11049696
Nakamura H et al. Difference in urinary 11-dehydro TXB2 and LTE4 excretion in patients with rheumatoid arthritis. 2001 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:11993724
Bordet JC et al. Modulation of prostanoid formation by various polyunsaturated fatty acids during platelet-endothelial cell interactions. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2110676
Peredo HA and Enero MA Effect of endothelium removal on basal and muscarinic cholinergic stimulated rat mesenteric vascular bed prostanoid synthesis. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8321873
Jung YS et al. Antithrombotic effect of onion in streptozotocin-induced diabetic rat. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12054917
González ET et al. Prostanoid modulation of glucose transport in isolated diabetic rat uterus. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8804128
Wolfram RM et al. Effect of black tea on (iso-)prostaglandins and platelet aggregation in healthy volunteers. 2002 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:12144875
Fekkes D et al. Eicosanoid and amino acid metabolism in transient acute psychoses with psychedelic symptoms. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8804122
Feng J et al. Beneficial effects of iloprost cardioplegia in ischemic arrest in isolated working rat heart. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8804125
Oguogho A et al. Chloroquine minimizes sampling artefacts for radioimmunological determination of thromboxane B2 in plasma. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9175176
Reese EA et al. Gabapentin's minimal action on markers of rat brain arachidonic acid metabolism agrees with its inefficacy against bipolar disorder. 2012 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:22841517
Turi S et al. Laser aggregometer studies, ATP release and thromboxane B2 release and cAMP concentration of the platelets in nephrotic syndrome. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7938102
Goldberg RN et al. The role of leukotrienes in the late hemodynamic manifestations of group B streptococcal sepsis in piglets. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3054937
Gow JA et al. The effect of regular and enteric-coated aspirin on bleeding time, thromboxane, and prostacyclin. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8361987
Ramírez M et al. Effect of dietary nucleotides and orotate on the blood levels of prostacyclin (PGI2) and thromboxane (TXA2) in the weanling rat. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1881942
Takami M and Tsukada W Effects of DP-1904, a thromboxane synthetase inhibitor, on the antigen-induced airway hyperresponsiveness and infiltration of inflammatory cells in guinea-pigs. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:10102387
Lassila R and Laustiola KE Cigarette smoking and platelet-vessel wall interactions. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1502254
Uehara Y et al. Abnormal response of urinary eicosanoid system to norepinephrine infusion in patients with essential hypertension. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1502257
Rao GH et al. Effect of Amrinone, a cardiotonic drug, on hemodynamics and platelet function. 1981 Prostaglandins Med pmid:6784136
Gullner HG et al. Correction of increased prostacyclin synthesis in Bartter's syndrome by indomethacin treatment. 1980 Prostaglandins Med pmid:6994153
Rao GH et al. Modification of human platelet response to sodium arachidonate by membrane modulation. 1981 Prostaglandins Med pmid:6261286
Makheja AN et al. Effects of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis. 1979 Prostaglandins Med pmid:552092
Lefer AM et al. Protective effects of a novel thromboxane analog in lethal traumatic shock. 1979 Prostaglandins Med pmid:552102
Lewy RI et al. Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina. 1979 Prostaglandins Med pmid:575861
Ohuchi K et al. Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. 1979 Prostaglandins Med pmid:583576
Roy AC et al. Effect of intravenous infusion of OKY-1581 (sodium-(E)-3-[4-(3-pyridylmethyl)phenyl] -2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon. 1981 Prostaglandins Med pmid:7029585
Hwang DH Aggregation and inhibition of rat platelets, and the formation of endoperoxide metabolites. 1980 Prostaglandins Med pmid:7413850
Uyama O et al. Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease. 1981 Prostaglandins Med pmid:7302001
Matsumoto M et al. Platelet aggregation induced by arachidonic acid and thromboxane generation in patients with hypertension or cerebrovascular disease. 1981 Prostaglandins Med pmid:7323212
Gilani SH and Persaud TV Embryopathic effects of thromboxane B2 in the chick. 1981 Prostaglandins Med pmid:7267828
Ohuchi K et al. Prostaglandin production by minced carrageenin granuloma tissue of rats and its inhibition by dexamethasone and cycloheximide. 1980 Prostaglandins Med pmid:6893750
Oka M and Manku MS Spironolactone decreases the formation of prostaglandins and related substances from arachidonic acid in rat vascular rings and human platelets. 1980 Prostaglandins Med pmid:7394062
Karmali RA et al. Intrarenal growth of the Walker 256 tumour and renal vein concentrations of PGE2, PGF 2 alpha, and TXB2: effects of diazepam. 1980 Prostaglandins Med pmid:7394064
Ohnishi H et al. Effects of trapidil on thromboxane A2-induced aggregation of platelets, ischemic changes in heart and biosynthesis of thromboxane A2. 1981 Prostaglandins Med pmid:6894333
Rao GH et al. Influence of epinephrine on the aggregation response of aspirin-treated platelets. 1980 Prostaglandins Med pmid:7403340
Hamberg M et al. A method for measurement of platelet regeneration in man. 1978 Prostaglandins Med pmid:104315
Kinney EL and Demers LM Plasma 6 keto PGE1 alpha concentration in Raynaud's phenomenon. 1981 Prostaglandins Med pmid:6895673
Karmazyn M and Dhalla NS Thromboxane B2: a cardiodepressant of isolated rat hearts and inhibitor of sarcolemma Na+ - K+ stimulated ATPase activity. 1979 Prostaglandins Med pmid:233217
Ali M et al. Inhibition of human platelet cyclooxygenase by alpha-tocopherol. 1980 Prostaglandins Med pmid:6771778
Hausman N et al. Antenatal administration of celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, appears to improve placental perfusion in the pregnant rabbit. 2003 Prostaglandins Other Lipid Mediat. pmid:12611495
Suzuki N et al. Quantitative liquid chromatography-tandem mass spectrometric analysis of 11-dehydro TXB2 in urine. 2004 Prostaglandins Other Lipid Mediat. pmid:15165035
Leclerc P et al. Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation. 2013 Prostaglandins Other Lipid Mediat. pmid:24045148
Ozaki N et al. Differential regulation of prostacyclin and thromboxane by dexamethasone and celecoxib during oxidative stress in newborn rabbits. 2002 Prostaglandins Other Lipid Mediat. pmid:12428679
Ochi T and Goto T Anti-inflammatory activity of a novel selective cyclooxygenase-2 inhibitor, FR140423, on type II collagen-induced arthritis in Lewis rats. 2001 Prostaglandins Other Lipid Mediat. pmid:11785783
Harada Y et al. Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat. 1998 Prostaglandins Other Lipid Mediat. pmid:9653772
Mizugaki M et al. Monitoring of the thromboxane A2/prostacyclin ratio in the urine of patients with retinal vascular occlusion through the low-dose-aspirin therapy using the gas chromatography/selected ion monitoring method. 1999 Prostaglandins Other Lipid Mediat. pmid:10593167
Hishinuma T et al. Urinary thromboxane A2/prostacyclin balance reflects the pathological state of a diabetic. 1999 Prostaglandins Other Lipid Mediat. pmid:10593168
Hoch B and Bernhard M Reduced prostacyclin to thromboxane A2 ratio is correlated with central apneas in preterm infants. 1999 Prostaglandins Other Lipid Mediat. pmid:10593170
John H et al. Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid. 1998 Prostaglandins Other Lipid Mediat. pmid:9785378
Lynch CM et al. The role of thromboxane A(2) in the pathogenesis of intrauterine growth restriction associated with maternal smoking in pregnancy. 2011 Prostaglandins Other Lipid Mediat. pmid:21723954
Beck-Speier I et al. Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. 2003 Prostaglandins Other Lipid Mediat. pmid:14518563
Hasan J et al. Early postnatal ibuprofen and indomethacin effects in suckling and weanling rat kidneys. 2008 Prostaglandins Other Lipid Mediat. pmid:18096423
Moussa O et al. Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring. 2011 Prostaglandins Other Lipid Mediat. pmid:21983220
Nishimaki S and Seki K An imbalance between prostacyclin and thromboxane in relation to cerebral blood flow in neonates with maternal preeclampsia. 1999 Prostaglandins Other Lipid Mediat. pmid:10482286
Brivio I et al. The pulmonary pharmacology of [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide] (2NTX-99), an anti-atherotrombotic compound with therapeutic potential in pathological conditions that target lung vasculature. 2012 Prostaglandins Other Lipid Mediat. pmid:22342851
Cherdon C et al. BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase. 2011 Prostaglandins Other Lipid Mediat. pmid:21397034
Buluç M et al. Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats. 2002 Prostaglandins Other Lipid Mediat. pmid:12428691
Yao X et al. Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach. Prostaglandins Other Lipid Mediat. pmid:25841349
Suzuki N et al. Difference in urinary LTE4 and 11-dehydro-TXB2 excretion in asthmatic patients. 2000 Prostaglandins Other Lipid Mediat. pmid:11060902
Chen MF et al. Vitamin E supplementation attenuates myointimal proliferation of the abdominal aorta after balloon injury in diet-induced hypercholesterolemic rabbits. 1998 Prostaglandins Other Lipid Mediat. pmid:9777654
Daza L et al. Captopril effect on prostaglandin E2, thromboxane B2 and proteinuria in lupus nephritis patients. 2005 Prostaglandins Other Lipid Mediat. pmid:16303616
Dawood MY and Khan-Dawood FS Differential suppression of menstrual fluid prostaglandin F2a, prostaglandin E2, 6-keto prostaglandin F1a and thromboxane B2 by suprofen in women with primary dysmenorrhea. 2007 Prostaglandins Other Lipid Mediat. pmid:17259081
Giedrojć J et al. [Investigation of prostaglandins in supernatant of cultured monocytes]. 2000 Prz. Lek. pmid:10907365
Zielonka TM et al. [Concentration of thromboxane B2 in bronchoalveolar lavage fluid in selected interstitial pulmonary diseases]. 1995 Prz. Lek. pmid:7568987
Giedrojć J et al. [Interaction of platelets with monocytes with regard to arachidonic acid metabolites]. 2000 Prz. Lek. pmid:11199865
Bruce EC et al. Platelet thromboxane A2 secretion in patients with major depression responsive to electroconvulsive therapy. 2008 Psychosom Med pmid:18378867
Shemesh E et al. Symptoms of posttraumatic stress disorder in patients who have had a myocardial infarction. 2006 May-Jun Psychosomatics pmid:16684940
Aritzi S et al. Hostile personality characteristics and prostaglandins in essential hypertension. 1989 Psychother Psychosom pmid:2486875
Berti F et al. Protective activity of inhaled frusemide against immunological respiratory changes and mediator release in guinea-pigs. 1992 Pulm Pharmacol pmid:1377065
Pelé JP et al. Secretion of thromboxane B2 and prostaglandin E2 by guinea-pig lung cells isolated by centrifugal elutriation and by macrophages obtained by bronchoalveolar lavage. 1989 Pulm Pharmacol pmid:2485200
Rossoni G et al. Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs. 2007 Pulm Pharmacol Ther pmid:16533614
Lessa A et al. The effect of pentoxifylline on the pulmonary response to high tidal volume ventilation in rats. 2008 Pulm Pharmacol Ther pmid:17251044
Dreesen RG and Becker GJ Effects of streptokinase in thrombolytic therapy: a radiology research project. 1987 Jan-Feb Radiol Technol pmid:3823412
Ishibashi M et al. Identification of 11-dehydro-2,3-dinorthromboxane B3 in human urine based on the mass spectral properties of 11-dehydrothromboxane B3 and related compounds. 1995 Rapid Commun. Mass Spectrom. pmid:8829476