Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Blache D | Enhanced arachidonic acid and calcium metabolism in cholesteryl sulfate-enriched rat platelets. | 1996 | J Lipid Mediat Cell Signal | pmid:8925194 |
Cirino G et al. | Indomethacin and thromboxane A2/prostaglandin H2 antagonist SQ29,548 impair in vitro contractions of aortic rings of ex vivo-treated lipopolysaccharide rats. | 1996 | J Lipid Mediat Cell Signal | pmid:8925198 |
Janssen PL et al. | Consumption of ginger (Zingiber officinale roscoe) does not affect ex vivo platelet thromboxane production in humans. | 1996 | Eur J Clin Nutr | pmid:8933126 |
Klosterhalfen B et al. | Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. | 1996 | Biochem. Pharmacol. | pmid:8937427 |
Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
Baenkler HW et al. | Eicosanoids from biopsy of normal and polypous nasal mucosa. | 1996 | Rhinology | pmid:8938887 |
Milani M et al. | Effects of two different HMG-CoA reductase inhibitors on thromboxane production in type IIA hypercholesterolemia. | 1996 | Biomed. Pharmacother. | pmid:8952866 |
Serebruany VL et al. | Hemostatic changes after early versus late intracoronary magnesium during acute myocardial infarction in swine. | 1996 | J. Cardiovasc. Pharmacol. | pmid:8961080 |
Gries A et al. | Lipoprotein(a) inhibits collagen-induced aggregation of thrombocytes. | 1996 | Arterioscler. Thromb. Vasc. Biol. | pmid:8963722 |
Reilly M et al. | Modulation of oxidant stress in vivo in chronic cigarette smokers. | 1996 | Circulation | pmid:8964113 |
Hirakata H et al. | Sevoflurane inhibits human platelet aggregation and thromboxane A2 formation, possibly by suppression of cyclooxygenase activity. | 1996 | Anesthesiology | pmid:8968193 |
Fukushima C et al. | Inhibitory effect of thromboxane A2 synthetase inhibitor, DP-1904, on antigen-induced contraction of human lung parenchyma. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8970439 |
Li KL et al. | The effect of ketoprofen creams on periodontal disease in rhesus monkeys. | 1996 | J. Periodont. Res. | pmid:8971650 |
Landoni MF and Lees P | Pharmacokinetics and pharmacodynamics of ketoprofen enantiomers in the horse. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8971676 |
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Nanji AA et al. | Thromboxane inhibitors attenuate pathological changes in alcoholic liver disease in the rat. | 1997 | Gastroenterology | pmid:8978360 |
Miyahara T et al. | Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep. | 1996 Nov-Dec | Exp. Lung Res. | pmid:8979046 |
Matsumoto K et al. | Role of thromboxane-A2 and cholinergic mechanisms in bronchoconstriction induced by cigarette smoke in guinea-pigs. | 1996 | Eur. Respir. J. | pmid:8980955 |
Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Dayal S et al. | Increased ratio of thromboxane B2 and 6-keto PGF1 alpha in patients of hepatic venous outflow obstruction. | 1996 | Eur. J. Haematol. | pmid:8982298 |
Santini G et al. | Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxide synthases. | 1996 | Eur. J. Pharmacol. | pmid:8982652 |
Nagao T et al. | Effect of DP-1904, a thromboxane A2 synthase inhibitor, on passive Heymann nephritis in rats. | 1996 | Eur. J. Pharmacol. | pmid:8982653 |
Isenring P et al. | Eicosanoid modulation of the norepinephrine effect on blood pressure and renal hemodynamics in humans. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8992495 |
Prié S et al. | Eosinophils and neutrophils modify arachidonic acid-induced relaxation of guinea-pig trachea. | 1996 | Eur. J. Pharmacol. | pmid:8997620 |
Belisario MA et al. | In vitro effect of avarone and avarol, a quinone/hydroquinone couple of marine origin, on platelet aggregation. | 1996 | Pharmacol. Toxicol. | pmid:9000256 |
Pacchiarini L et al. | In vitro effect of reduced glutathione on platelet function. | 1996 Nov-Dec | Haematologica | pmid:9009436 |
Yamamura S et al. | Prostaglandin levels of primary bone tumor tissues correlate with peritumoral edema demonstrated by magnetic resonance imaging. | 1997 | Cancer | pmid:9010098 |
Watanabe A et al. | Effect of TYB-2285 on lung anaphylaxis in actively sensitized rats. | 1997 | Gen. Pharmacol. | pmid:9013209 |
Lewis DA et al. | Production of endothelium-derived factors from sodded expanded polytetrafluoroethylene grafts. | 1997 | J. Vasc. Surg. | pmid:9013924 |
Leung S et al. | Isolation and purification of anticardiolipin antibody from plasma of a patient with antiphospholipid syndrome: induced generation of platelet thromboxane A2 synthesis. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014216 |
Liu CZ and Huang TF | Crovidisin, a collagen-binding protein isolated from snake venom of Crotalus viridis, prevents platelet-collagen interaction. | 1997 | Arch. Biochem. Biophys. | pmid:9016825 |
Sheu JR et al. | Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. | 1996 | Eur. J. Pharmacol. | pmid:9016940 |
Matsumoto H et al. | Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9020023 |
Ringdahl BE et al. | Effect of nicotine on arachidonic acid metabolites and epithelial parameters in rat oral mucosa. | 1997 | J. Oral Pathol. Med. | pmid:9021551 |
Liao CH et al. | Antiplatelet effect of demethyldiisoeugenol. | 1996 | Can. J. Physiol. Pharmacol. | pmid:9022830 |
Cheng JB et al. | The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023272 |
Cervar M et al. | Drug actions in preeclampsia: aspirin, but not magnesium chloride or dihydralazine, differentially inhibits cultured human trophoblast release of thromboxane and prostacyclin without affecting angiotensin II, endothelin-1, or leukotriene B4 secretion. | 1997 | Am. J. Obstet. Gynecol. | pmid:9024091 |
Israels SJ et al. | Deficient thromboxane synthesis and response in platelets from premature infants. | 1997 | Pediatr. Res. | pmid:9029642 |
Zingarelli B et al. | The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity. | 1997 | Br. J. Pharmacol. | pmid:9031736 |
Okazawa A et al. | 8-Epi-PGF2alpha induces airflow obstruction and airway plasma exudation in vivo. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9032175 |
Alavi N and Singh A | Events that stimulate release of thromboxane B2 in passive heymann nephritis. | 1997 | Proc. Soc. Exp. Biol. Med. | pmid:9034135 |
Keen HL et al. | Thromboxane is required for full expression of angiotensin hypertension in rats. | 1997 | Hypertension | pmid:9039120 |
Rodwell LT et al. | Effect of inhaled frusemide and oral indomethacin on the airway response to hypertonic saline challenge in asthmatic subjects. | 1997 | Thorax | pmid:9039247 |
Nanji AA et al. | Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. | 1997 | Gastroenterology | pmid:9041257 |
Kadir A et al. | Phenylbutazone pharmacokinetics and bioavailability in the dromedary camel (Camelus dromedarius). | 1997 | J. Vet. Pharmacol. Ther. | pmid:9049950 |
Serebruany VL et al. | Serial changes of the plasma prostanoids during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051723 |
Yeh SL et al. | Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition. | 1997 | Nutrition | pmid:9058445 |
Feng J et al. | Effects of tetramethylpyrazine on the release of PGI2 and TXA2 in the hypoxic isolated rat heart. | 1997 | Mol. Cell. Biochem. | pmid:9059992 |