Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Snapper JR et al. | Role of endothelin in endotoxin-induced sustained pulmonary hypertension in sheep. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9445282 |
Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
Parra T et al. | Cyclosporine A nephrotoxicity: role of thromboxane and reactive oxygen species. | 1998 | J. Lab. Clin. Med. | pmid:9452128 |
Yanagisawa H et al. | Ureteral obstruction enhances eicosanoid production in cortical and medullary tubules of rat kidneys. | 1997 | Kidney Blood Press. Res. | pmid:9453451 |
Erez E et al. | Thromboxane production in human lung during cardiopulmonary bypass: beneficial effect of aspirin? | 1998 | Ann. Thorac. Surg. | pmid:9456103 |
Chiba Y et al. | Effects of depletion of leukocytes and platelets on cardiac dysfunction after cardiopulmonary bypass. | 1998 | Ann. Thorac. Surg. | pmid:9456104 |
Hanaoka M et al. | Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep. | 1998 Jan-Feb | Exp. Lung Res. | pmid:9457466 |
Robbins DL et al. | Effect of anticardiolipin/beta2-glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the antiphospholipid syndrome. | 1998 | J. Rheumatol. | pmid:9458202 |
Forastiero R et al. | Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. | 1998 | Thromb. Haemost. | pmid:9459320 |
Keen HL et al. | Maintenance of baseline angiotensin II potentiates insulin hypertension in rats. | 1998 | Hypertension | pmid:9461234 |
Liao CH et al. | Bakkenolide G, a natural PAF-receptor antagonist. | 1997 | J. Pharm. Pharmacol. | pmid:9466352 |
Kruse-Elliott KT et al. | Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. | 1998 | Shock | pmid:9466472 |
Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
Fujita M et al. | Effects of a specific cysteinyl leukotriene antagonist, pranlukast, on antigen-induced cysteinyl leukotriene-mediated rhinitis in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469640 |
Chang MC et al. | Antithrombotic effect of crotalin, a platelet membrane glycoprotein Ib antagonist from venom of Crotalus atrox. | 1998 | Blood | pmid:9473223 |
Yamanobe S et al. | Analysis of urinary 11-dehydrothromboxane B2 in patients with occluded retinal vein using GC/SIM. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482168 |
Nieuwenhuys CM and Hornstra G | The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. | 1998 | Biochim. Biophys. Acta | pmid:9487152 |
Provost P et al. | Platelets, neutrophils, and vasoconstriction after arterial injury by angioplasty in pigs: effects of MK-886, a leukotriene biosynthesis inhibitor. | 1998 | Br. J. Pharmacol. | pmid:9489613 |
Takeda H et al. | Time course study for airway inflammation and responsiveness by repeated provocation of aeroantigen in guinea pigs. | 1997 | Prostaglandins | pmid:9491210 |
Takakuwa K et al. | Immunosuppressive therapy for recurrent aborters with positive antiphospholipid antibodies and alteration of 6ketoPGF1 alpha/TXB2 ratio. | 1997 | J Perinat Med | pmid:9494925 |
Turner NC et al. | Elevated renal endothelin-I clearance and mRNA levels associated with albuminuria and nephropathy in non-insulin-dependent diabetes mellitus: studies in obese fa/fa Zucker rats. | 1997 | Clin. Sci. | pmid:9497794 |
Bagdasarian A et al. | IVIG adverse reactions: potential role of cytokines and vasoactive substances. | 1998 | Vox Sang. | pmid:9501404 |
Bernareggi M et al. | Bronchopulmonary effects of 8-epi-PGF2A in anaesthetised guinea pigs. | 1998 | Pharmacol. Res. | pmid:9503483 |
Dschietzig T et al. | Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction. | 1998 | Crit. Care Med. | pmid:9504580 |
Schilling MK et al. | Role of thromboxane and leukotriene B4 in patients with acute respiratory distress syndrome after oesophagectomy. | 1998 | Br J Anaesth | pmid:9505775 |
Giardiello FM et al. | Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. | 1998 | Dig. Dis. Sci. | pmid:9512123 |
Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
Rho MC et al. | Two distinct effects of 12S-hydroxyeicosatetraenoic acid on platelet aggregation by zooxanthellatoxin-A and ionomycin. | 1998 | Jpn. J. Pharmacol. | pmid:9517414 |
Giustina A et al. | Long-term treatment with the dual antithromboxane agent picotamide decreases microalbuminuria in normotensive type 2 diabetic patients. | 1998 | Diabetes | pmid:9519749 |
Bode-Böger SM et al. | Differential inhibition of human platelet aggregation and thromboxane A2 formation by L-arginine in vivo and in vitro. | 1998 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9521487 |
Ooi BS et al. | Stimulation of endothelial cell production of vasoconstrictive substances by hypertensive sera. | 1998 | Am. J. Hypertens. | pmid:9524055 |
Bons-Sicard C et al. | Localization and quantification of TXB2 in human healthy and inflammatory gingival mucosa. | 1998 | J. Periodont. Res. | pmid:9524318 |
Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
Fukushima C et al. | Effect of synthetase inhibitors and receptor antagonists in antigen-induced contraction of human lung parenchyma. | 1998 | Ann. Allergy Asthma Immunol. | pmid:9532973 |
Zhao Y et al. | Urinary thromboxane B2 in cardiac transplant patients as a screening method of rejection. | 1997 | Prostaglandins | pmid:9533183 |
Herrera JA et al. | Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. | 1998 | Obstet Gynecol | pmid:9540946 |
Liao CH et al. | Effect of PP1D-1, a synthetic antiplatelet compound, on rabbit platelets. | 1998 | Jpn. J. Pharmacol. | pmid:9541276 |
Suchkova V | Prostanoid and anti-thrombin III levels in premature infants. | 1997 | Adv. Exp. Med. Biol. | pmid:9547655 |
Kimura H et al. | Compensatory excretion of prostacyclin and thromboxane metabolites in obstructive sleep apnea syndrome. | 1998 | Intern. Med. | pmid:9550591 |
Mayser P et al. | Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial. | 1998 | J. Am. Acad. Dermatol. | pmid:9555791 |
Naran NH and Chetty N | The in vitro effect of ridogrel on platelet function in normocholesterolaemic and familial hypercholesterolaemic type IIa subjects. | 1997 | Thromb. Res. | pmid:9556227 |
van den Dorpel MA et al. | Forearm vasorelaxation in hypertensive renal transplant patients: the impact of withdrawal of cyclosporine. | 1998 | J. Hypertens. | pmid:9557926 |
Vormann J et al. | Pathobiochemical effects of graded magnesium deficiency in rats. | 1998 | Z Ernahrungswiss | pmid:9558736 |
Agostoni C et al. | Plasma arachidonic acid and serum thromboxane B2 concentrations in phenylketonuric children are correlated with dietary compliance. | 1998 | Z Ernahrungswiss | pmid:9558743 |
Yoshida T et al. | Improvement of renal function with selective thromboxane A2 synthetase inhibitor, DP-1904 in lupus nephritis. | 1997 | Adv. Exp. Med. Biol. | pmid:9561116 |
Müller M | In vivo measurement of interstitial TxB2-concentrations in skeletal muscle during ischemia and reperfusion. | 1997 | Adv. Exp. Med. Biol. | pmid:9561122 |
Arbogast E et al. | Intrauterine eicosanoid production in uncomplicated and hypertensive pregnancies: alterations of placental 12-hydroxyeicosatetraenoic acid. | 1997 | Adv. Exp. Med. Biol. | pmid:9561182 |
Yang VW et al. | Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis. | 1998 | Cancer Res. | pmid:9563494 |
LaNoue JL et al. | Alveolar macrophage response to remote organ injury. | 1998 | Shock | pmid:9565254 |