Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yousefipour Z et al. | Ciglitazone, a peroxisome proliferator-activated receptor gamma inducer, ameliorates renal preglomerular production and activity of angiotensin II and thromboxane A2 in glycerol-induced acute renal failure. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17494862 |
Lee CR et al. | Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. | 2008 | Clin. Pharmacol. Ther. | pmid:17495879 |
Aïd S and Bosetti F | Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging. | 2007 | Brain Res. Bull. | pmid:17499644 |
Heizer ML et al. | 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. | 1991 | Stroke | pmid:1750047 |
Wang YP et al. | Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750461 |
Wang YP et al. | The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal blood. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750462 |
Myatt L et al. | Endothelin-1-induced vasoconstriction is not mediated by thromboxane release and action in the human fetal-placental circulation. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750466 |
Kang IS et al. | Dose-related action of gonadotropin-releasing hormone on basal prostanoid production from the human term placenta. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750474 |
Markham SM et al. | The effect of the menstrual cycle and of decompression stress on arachidonic acid-induced platelet aggregation and on intrinsic platelet thromboxane production in women compared with men. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750481 |
Bergman A et al. | The role of prostaglandins in detrusor instability. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750483 |
Allais G et al. | Naproxen sodium in short-term prophylaxis of pure menstrual migraine: pathophysiological and clinical considerations. | 2007 | Neurol. Sci. | pmid:17508177 |
Amrani DL et al. | Hemostatic evaluation of Sarns/3M-VAD implantation in calves. | 1991 Jul-Sep | ASAIO Trans | pmid:1751163 |
Wong PC et al. | Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits. | 2007 | J. Cardiovasc. Pharmacol. | pmid:17513951 |
Hohlfeld T et al. | Variable platelet response to aspirin in patients with ischemic stroke. | 2007 | Cerebrovasc. Dis. | pmid:17519543 |
Miyamoto K et al. | [Effects of differently composed liposomes on pulmonary arterial pressure in sheep--involvement of pulmonary intravascular macrophages]. | 1991 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:1753504 |
He B et al. | [Effect of salt-loading on prostacyclin and thromboxane metabolism in kidney]. | 1991 | Sheng Li Xue Bao | pmid:1754905 |
Crescente M et al. | Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings. | 2007 | Thromb. Haemost. | pmid:17549313 |
Undas A et al. | Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin. | 2007 | Thromb. Haemost. | pmid:17549314 |
Rostagno C et al. | In vitro effects of two novel calcium antagonists (nitrendipine and nisoldipine) on intraplatelet calcium redistribution, platelet aggregation and thromboxane A2 formation. Comparison with diltiazem, nifedipine and verapamil. | 1991 | Thromb. Res. | pmid:1754998 |
Chakroun T et al. | Screening for aspirin resistance in stable coronary artery patients by three different tests. | 2007 | Thromb. Res. | pmid:17553552 |
Pucsok JM et al. | Effect of exercise on levels of cyclo-oxygenase mediators in exhaled breath condensate in elite athletes. | 2007 | J Sports Med Phys Fitness | pmid:17557063 |
Hsiao G et al. | Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: in vitro and in vivo studies. | 2007 | Cardiovasc. Res. | pmid:17560560 |
Basselin M et al. | Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. | 2007 | Neurochem. Res. | pmid:17562170 |
Aras-Lopéz R et al. | Dexamethasone decreases contraction to electrical field stimulation in mesenteric arteries from spontaneously hypertensive rats through decreases in thromboxane A2 release. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17562850 |
Gurbel PA et al. | Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study. | 2007 | Circulation | pmid:17562955 |
Tu CT et al. | Antifibrotic activity of rofecoxib in vivo is associated with reduced portal hypertension in rats with carbon tetrachloride-induced liver injury. | 2007 | J. Gastroenterol. Hepatol. | pmid:17565644 |
Atzori L et al. | Thiol modification in H2O2- and thromboxane-induced vaso- and bronchoconstriction in rat perfused lung. | 1991 | J. Appl. Physiol. | pmid:1757354 |
Fujioka K et al. | Thromboxane synthase inhibition and cardiopulmonary function during endotoxemia in sheep. | 1991 | J. Appl. Physiol. | pmid:1757360 |
Graff J et al. | Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. | 2007 | Clin Ther | pmid:17577465 |
González-Correa JA et al. | Gender differences in the effect of aspirin on retinal ischemia, prostanoid synthesis and nitric oxide production in experimental type 1-like diabetes. | 2007 Aug-Sep | Vascul. Pharmacol. | pmid:17581795 |
Greenstein A et al. | The role of oxygen free radicals and prostaglandins in reperfusion injury to warm ischemic kidneys. | 1991 | Urol. Res. | pmid:1759334 |
Abbas NA et al. | Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats. | 1991 | Biomed. Biochim. Acta | pmid:1759973 |
Jiang J et al. | Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat. | 2007 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:17612651 |
Otani Y et al. | Effects of the COX-2 inhibitor FK3311 on ischemia - reperfusion injury in the rat lung. | 2007 May-Jun | J Invest Surg | pmid:17613692 |
FitzGerald GA et al. | Presystemic acetylation of platelets by aspirin: reduction in rate of drug delivery to improve biochemical selectivity for thromboxane A2. | 1991 | J. Pharmacol. Exp. Ther. | pmid:1762060 |
Schulman G et al. | Complement activation retards resolution of acute ischemic renal failure in the rat. | 1991 | Kidney Int. | pmid:1762308 |
Basselin M et al. | Chronic carbamazepine administration reduces N-methyl-D-aspartate receptor-initiated signaling via arachidonic acid in rat brain. | 2007 | Biol. Psychiatry | pmid:17628508 |
Mike I et al. | The differences in 12-hydroxyeicosatetraenoic acid and thromboxane B2 release from guinea pig platelets. | 1991 | Prostaglandins | pmid:1763200 |
Nádasy GL et al. | Role of endothelium, oxygen and ionic milieu in the prostacyclin and thromboxane production of rat aortic tissue slices. | 1991 | Acta Physiol Hung | pmid:1763652 |
Chang MC et al. | Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilization. | 2007 | Br. J. Pharmacol. | pmid:17641677 |
González-Correa JA et al. | Differences in the influence of the interaction between acetylsalicylic acid and salicylic acid on platelet function in whole blood and isolated platelets: influence of neutrophils. | 2007 | Pharmacol. Res. | pmid:17644353 |
Gendron ME and Thorin E | A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17644574 |
Gonzalez-Revalderia J et al. | Usefulness of thromboxane B2 in diagnosis of renal transplant rejection. | 1991 | Clin. Chem. | pmid:1764806 |
Kim YJ and Chung HY | Antioxidative and anti-inflammatory actions of docosahexaenoic acid and eicosapentaenoic acid in renal epithelial cells and macrophages. | 2007 | J Med Food | pmid:17651056 |
Weber AA et al. | Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers. | 2007 | Platelets | pmid:17654308 |
Bray PF et al. | Heritability of platelet function in families with premature coronary artery disease. | 2007 | J. Thromb. Haemost. | pmid:17663734 |
Pritze S et al. | Effect of platelet-activating factor on porcine pulmonary blood vessels in vitro. | 1991 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:1766475 |
Li XM et al. | [Physiological effects of cold and cool Chinese herbal medicine of channel tropism of stomach on rats with stomach-heat syndrome]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17672345 |
Shizukuda Y et al. | Effect of prednisolone on myocardial infarct healing: characteristics and comparison with indomethacin. | 1991 | Can J Cardiol | pmid:1768984 |
Xing X and Li H | Isolated liver perfusion for regional chemotherapy in rats. | 2007 | HBPD INT | pmid:17690035 |
Nocun M et al. | French maritime pine bark extract Pycnogenol reduces thromboxane generation in blood from diabetic male rats. | 2008 | Biomed. Pharmacother. | pmid:17698319 |
Sha JP et al. | [Effect of the recombinant staphylokinase on pancreatic ischemia in severe acute pancreatitis of rats]. | 2007 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:17708840 |
Silvanto M et al. | Effect of 3 g of intravenous paracetamol on post-operative analgesia, platelet function and liver enzymes in patients undergoing tonsillectomy under local anaesthesia. | 2007 | Acta Anaesthesiol Scand | pmid:17711562 |
Spurney RF et al. | Physiologic role for enhanced renal thromboxane production in murine lupus nephritis. | 1991 | Prostaglandins | pmid:1771236 |
Morello A et al. | A chemiluminescent immunoassay for urinary thromboxane B2. | 1991 | Prostaglandins | pmid:1771240 |
Doube A et al. | Effect of misoprostol on concentrations of prostaglandins in synovial fluid. | 1991 | Ann. Rheum. Dis. | pmid:1772296 |
Park MK et al. | Antiplatelet and antithrombotic activity of indole-3-carbinol in vitro and in vivo. | 2008 | Phytother Res | pmid:17724769 |
Weber C et al. | Production of thromboxane and prostaglandins in human blood in the presence of thromboxane synthase inhibitors: a comparison of RIA and GC/MS determinations. | 1991 | Blood Coagul. Fibrinolysis | pmid:1773000 |
Huang HF and Wang M | [Effects of gossypol and GnRHa on the prostaglandins contents of endometriotic cell and in situ]. | 1991 | Zhong Xi Yi Jie He Za Zhi | pmid:1773465 |
Xi ZQ | [Clinical application and prospect of bulbus Allii for relieving asthma]. | 1991 | Zhong Xi Yi Jie He Za Zhi | pmid:1773477 |
Agren JJ et al. | Fish diet and physical fitness in relation to membrane and serum lipids, prostanoid metabolism and platelet aggregation in female students. | 1991 | Eur J Appl Physiol Occup Physiol | pmid:1773818 |
Neulen J et al. | Arachidonic acid metabolism and prostaglandin production by primate preimplantation blastocysts. | 1991 | Prostaglandins | pmid:1775634 |
Tzeng SH et al. | Inhibition of platelet aggregation by some flavonoids. | 1991 | Thromb. Res. | pmid:1776142 |
Louden KA et al. | Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre-eclampsia. | 1991 | Br J Obstet Gynaecol | pmid:1777456 |
Pittet JF and Morel DR | Imbalance between plasma levels of thromboxane B2 and 6-keto-prostaglandin F1 alpha during subacute endotoxin-induced hyperdynamic sepsis or multiple organ failure syndrome in sheep. | 1991 | Circ. Shock | pmid:1777948 |
Enzan K et al. | Pulmonary hemodynamic reaction to foreign blood in goats and rabbits. | 1991 | J. Appl. Physiol. | pmid:1778918 |
Hidaka T et al. | Arachidonate metabolism in bovine gallbladder mucosa. | 1991 | Kurume Med J | pmid:1779599 |
Wang YL et al. | Effect of ubiquinone on ischemic arrhythmia in conscious rats. | 1991 | Zhongguo Yao Li Xue Bao | pmid:1781279 |
Zhang YL et al. | [Protective action of sophoridine on acute myocardial infarction in anesthetized dogs]. | 1991 | Zhongguo Yao Li Xue Bao | pmid:1781291 |
Jiang YY et al. | [Effects of econazole and clotrimazole on TXB2 and PGE2 production in calcimycin-stimulated neutrophils and arachidonic acid-stimulated platelets]. | 1991 | Zhongguo Yao Li Xue Bao | pmid:1781294 |
Anfossi G et al. | Calcium-channel blocking agents verapamil and diltiazem are inhibitors of vasopressin-induced human platelet activation. | 1991 | Clin. Exp. Pharmacol. Physiol. | pmid:1782723 |
DiChiara J et al. | The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study. | 2007 | Diabetes | pmid:17848625 |
Kalaitzis C et al. | Role of eicosanoids of the contralateral kidney in maintenance of two-kidney, one-clip renovascular hypertension in rats. | 2007 | Scand. J. Urol. Nephrol. | pmid:17853043 |
Mitsuhashi T et al. | [Alteration of leukotriene C4 levels in experimental spinal cord injury]. | 1991 | Nippon Seikeigeka Gakkai Zasshi | pmid:1787345 |
Eizayaga FX et al. | Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. | 2007 | World J. Gastroenterol. | pmid:17876871 |
Sergienko AA | [The content of stable forms of prostacyclin I2 and thromboxane A2 in the blood plasma in diabetic angiopathies]. | 1991 Jul-Aug | Probl Endokrinol (Mosk) | pmid:1788186 |
Yokoyama Y et al. | Up-regulated thromboxane production in the rat liver with biliary obstruction does not contribute to promote hepatic injury. | 2008 | Shock | pmid:17885643 |
Heistein LC et al. | Aspirin resistance in children with heart disease at risk for thromboembolism: prevalence and possible mechanisms. | 2008 | Pediatr Cardiol | pmid:17896127 |
Sekine S et al. | Lowering systolic blood pressure and increases in vasodilator levels in SHR with oral alpha-linolenic acid administration. | 2007 | J Oleo Sci | pmid:17898500 |
Csanyi G et al. | Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats. | 2007 Jul-Aug | Pharmacol Rep | pmid:17901574 |
Schonwetter DJ et al. | The interactive effects of Type A behavior and hostility on bleeding time thromboxane and prostacyclin formation. | 1991 | J Psychosom Res | pmid:1791578 |
Ansari HR et al. | Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17921329 |
Schwartz JI et al. | Effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs on urinary sodium excretion, blood pressure, and other renal function indicators in elderly subjects consuming a controlled sodium diet. | 2007 | J Clin Pharmacol | pmid:17925592 |
Holma R et al. | Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats. | 2007 | J. Physiol. Pharmacol. | pmid:17928642 |
Meen O et al. | No case of COX-1-related aspirin resistance found in 289 patients with symptoms of stable CHD remitted for coronary angiography. | 2008 | Scand. J. Clin. Lab. Invest. | pmid:17934975 |
Zhao S et al. | Predominant basal directional release of thromboxane, but not prostacyclin, by placental trophoblasts from normal and preeclamptic pregnancies. | 2008 | Placenta | pmid:17936899 |
Vacas MI et al. | Inhibition of human platelet aggregation and thromboxane B2 production by melatonin. Correlation with plasma melatonin levels. | 1991 Oct-Nov | J. Pineal Res. | pmid:1795222 |
Shushliapin OI et al. | [Pharmacological correction by roxicam of the prostacyclin-thromboxane system in acute myocardial infarction complicated by heart failure]. | 1991 | Kardiologiia | pmid:1795470 |
Fouke JM et al. | Effects of ozone on lung mechanics and cyclooxygenase metabolites in dogs. | 1991 | Prostaglandins | pmid:1796149 |
D'Orléans-Juste P et al. | Different pharmacological profiles of big-endothelin-3 and big-endothelin-1 in vivo and in vitro. | 1991 | Br. J. Pharmacol. | pmid:1797310 |
Suzuki S et al. | Changes of plasma thromboxane level in subarachnoid haemorrhage. A study with 11-dehydro-TXB2 as measuring index. | 1991 | Acta Neurochir (Wien) | pmid:1799160 |
Cheuk BL and Cheng SW | Can local secretion of prostaglandin E2, thromboxane B2, and interleukin-6 play a role in ruptured abdominal aortic aneurysm? | 2008 | World J Surg | pmid:17992560 |
Sun LQ et al. | [Relationship between syndrome differentiation of traditional Chinese medicine and vascular endothelial function in patients with diabetic arterial occlusion of lower extremities]. | 2007 | Zhong Xi Yi Jie He Xue Bao | pmid:17997934 |
Joseph S and MacDermot J | Thrombin signalling in U937 human monocytic cells is coupled to inositol phosphate formation but not to thromboxane B2 synthesis nor to inhibition of adenylate cyclase: distinct differences in thrombin signalling between U937 cells and platelets. | 1991 | Eur. J. Pharmacol. | pmid:1800126 |
Kawamura M et al. | Enhancement of endogenous prostaglandin I2 (prostacyclin) generation in vivo by a phenolic anti-inflammatory agent in the rabbit. | 1991 | Jpn. J. Pharmacol. | pmid:1800794 |
Fernandes AJ et al. | Mechanisms of thrombocytopenia in the acute phase of antigen-induced arthritis in rabbits. | 1991 | Prostaglandins | pmid:1801060 |
Peskar BM et al. | Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo. | 1991 | Prostaglandins | pmid:1801061 |
Torres-Duarte A and Amezcua JL | Thromboxane and prostacyclin generation by human umbilical veins after thrombin. | 1991 | Prostaglandins | pmid:1801064 |
Brezitskaia ON and Sedov KR | [Status of the thrombocytic-vascular component of the hemostasis system in the population of the Far North]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801462 |
Watanabe M et al. | Effect of endothelin-3 (ET-3) on renal function in rat perfused kidney. | 1991 | Endocrinol. Jpn. | pmid:1802684 |