Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Xu ZC | [An experimental study on the mechanism of antiatherosclerotic effect of nifedipine]. | 1993 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:8243235 |
Wang ZH | [Correlation between serotonin and prostaglandins in peritoneal fluid collected from patients with pelvic congestion]. | 1993 | Zhonghua Fu Chan Ke Za Zhi | pmid:8243156 |
Huang YP and Ma TY | [Effect of 3,4-dihydroxyacetophenone treatment on intrauterine growth retardation]. | 1993 | Zhonghua Fu Chan Ke Za Zhi | pmid:8243155 |
Wassef NM and Alving CR | Complement-dependent phagocytosis of liposomes. | 1993 | Chem. Phys. Lipids | pmid:8242836 |
Walmrath D et al. | Endotoxin primes perfused rabbit lungs for enhanced vasoconstrictor response to staphylococcal alpha-toxin. | 1993 | Am. Rev. Respir. Dis. | pmid:8239151 |
DuBard MB et al. | Are pill counts valid measures of compliance in clinical obstetric trials? | 1993 | Am. J. Obstet. Gynecol. | pmid:8238182 |
Owen J et al. | The effect of low-dose aspirin on umbilical artery Doppler measurements. | 1993 | Am. J. Obstet. Gynecol. | pmid:8238148 |
Maher JE et al. | The effect of low-dose aspirin on fetal urine output and amniotic fluid volume. | 1993 | Am. J. Obstet. Gynecol. | pmid:8238144 |
Walsh SW et al. | Peroxide induces vasoconstriction in the human placenta by stimulating thromboxane. | 1993 | Am. J. Obstet. Gynecol. | pmid:8238110 |
Zhang P et al. | [Effects of methylflavonolamine on TXA2 and PGI2 plasma levels in rabbits with myocardial infarction]. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8237408 |
Kuhn DC et al. | Characterization of alveolar macrophage eicosanoid production in a non-human primate model of mineral dust exposure. | 1993 | Prostaglandins | pmid:8234829 |
Su YC and Wang DX | Effect of hypoxia on release of vasoactive substances from cultured pulmonary arterial and aortic endothelial cells. | 1993 | J. Tongji Med. Univ. | pmid:8230362 |
Futaki N et al. | Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation. | 1993 | J. Pharm. Pharmacol. | pmid:8229647 |
Valcamonico A et al. | Low dose aspirin in pregnancy: a clinical and biochemical study of effects on the newborn. | 1993 | J Perinat Med | pmid:8229615 |
Hidi R et al. | Increased synthesis and secretion of a 14-kDa phospholipase A2 by guinea pig alveolar macrophages. Dissociation from arachidonic acid liberation and modulation by dexamethasone. | 1993 | J. Immunol. | pmid:8228250 |
Montalescot G et al. | Imaging the ovine heparin-protamine interaction with 111In-protamine. | 1993 | J. Appl. Physiol. | pmid:8226502 |
Gao WX | [Detection of plasma thromboxane B2 and 6-keto-prostaglandin Fl alpha in patients with recurrent aphthous ulceration]. | 1993 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:8222959 |
Di GX et al. | Exercise therapy of non-insulin dependent diabetes mellitus. Effects of acute exercise loading. | 1993 | Chin. Med. J. | pmid:8222889 |
Adatia I et al. | Thromboxane A2 and prostacyclin biosynthesis in children and adolescents with pulmonary vascular disease. | 1993 | Circulation | pmid:8222105 |
Huang YS | [Myocardial damage and its mechanism in burn patients]. | 1993 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:8221314 |
Zhang BL and Sassard J | Eicosanoid-dependence of responses of pre- but not postglomerular vessels to noradrenaline in rat isolated kidneys. | 1993 | Br. J. Pharmacol. | pmid:8220883 |
Ko FN et al. | Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr. | 1993 | Biochem. Pharmacol. | pmid:8216367 |
Ko FN et al. | Daphnoretin, a new protein kinase C activator isolated from Wikstroemia indica C.A. Mey. | 1993 | Biochem. J. | pmid:8216237 |
Zeng GQ et al. | [Effects of 6-(alpha alpha-diphenylacetylpiperazinyl) phenyl-5-methyl-4,5-dihydro-3 (2H)-pyridazinone on rabbit platelet aggregation and TXB2, cAMP production]. | 1993 | Yao Xue Xue Bao | pmid:8213167 |
Weide I and Simmet T | Leukotriene formation by peripheral monocytes in contact-activated human blood. | 1993 | Thromb. Res. | pmid:8211886 |
Orr JA et al. | Transient ventilatory responses to endotoxin infusion in the cat are mediated by thromboxane A2. | 1993 | Respir Physiol | pmid:8210758 |
Schafer W et al. | Urinary excretion of 6-keto-PGF1 alpha TxB2 and PGE2 in a rat animal model for preeclampsia-like syndrome. | 1993 | Prostaglandins | pmid:8210446 |
Myers SI and Hernandez R | Leukotriene C4 regulation of splanchnic blood flow during ischemia. | 1994 | Am. J. Surg. | pmid:8209929 |
Andersen PH | Portal infusion of low dosage endotoxin: a model simulating translocation of ruminal endotoxin in cattle. | 1994 | Acta Vet. Scand. | pmid:8209817 |
Dernell WS et al. | Thromboxane as a measure of cutaneous vascular damage following irradiation. | 1994 | Plast. Reconstr. Surg. | pmid:8208814 |
Kernacki KA and Berk RS | Characterization of the inflammatory response induced by corneal infection with Pseudomonas aeruginosa. | 1994 | J Ocul Pharmacol | pmid:8207331 |
MikhaÄlevskaia LL et al. | [Dynamics of binding of various prostanoids in mouse serum with spontaneous metastatic Lewis lung carcinoma; effect of exogenous prostaglandins on dissemination of the tumor]. | 1994 | Biull Eksp Biol Med | pmid:8204857 |
Blaise GA et al. | Platelet-induced vasomotion of isolated canine coronary artery in the presence of halothane or isoflurane. | 1994 | J. Cardiothorac. Vasc. Anesth. | pmid:8204810 |
Jean T and Bodinier MC | Mediators involved in inflammation: effects of Daflon 500 mg on their release. | 1994 | Angiology | pmid:8203787 |
Sasaki Y et al. | A case of familial central diabetes insipidus: the response of urinary prostaglandins to 1-deamino-8-D-arginine vasopressin. | 1994 | J. Urol. | pmid:8201652 |
Nordøy A et al. | Effects of dietary fat content, saturated fatty acids, and fish oil on eicosanoid production and hemostatic parameters in normal men. | 1994 | J. Lab. Clin. Med. | pmid:8201271 |
Satoh K et al. | Pyrazolopyridine derivative acts as a novel cyclooxygenase inhibitor: antiplatelet effect in aged patients with ischemic stroke. | 1994 | J Am Geriatr Soc | pmid:8201150 |
Messa GL et al. | Action of 2-acetoxy-trifluoromethylbenzoic acid (Triflusal) on platelet function after repeated oral administration in man: a pharmacological clinical study. | 1993 | Int J Clin Pharmacol Res | pmid:8200721 |
McKellar QA et al. | Pharmacodynamics of tolfenamic acid in dogs. Evaluation of dose response relationships. | 1994 | Eur. J. Pharmacol. | pmid:8200415 |
Takase B et al. | Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. | 1994 | Am. J. Cardiol. | pmid:8198031 |
Riendeau D et al. | Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. | 1994 | J. Biol. Chem. | pmid:8195210 |
Luo Y | [Improvement of prostacyclin-thromboxane A2 balance in patients with acute myocardial infarction by intermittent aspirin]. | 1993 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:8194434 |
Louden KA et al. | Neonatal platelet reactivity and serum thromboxane B2 production in whole blood: the effect of maternal low dose aspirin. | 1994 | Br J Obstet Gynaecol | pmid:8193093 |
Nanji AA et al. | Cimetidine prevents alcoholic hepatic injury in the intragastric feeding rat model. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8182552 |
Larsson PT et al. | Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin. | 1994 | Circulation | pmid:8181117 |
Schönberger JP et al. | Systemic blood activation during and after autotransfusion. | 1994 | Ann. Thorac. Surg. | pmid:8179396 |
Pearse DB and Wagner EM | Role of the bronchial circulation in ischemia-reperfusion lung injury. | 1994 | J. Appl. Physiol. | pmid:8175514 |
Constable AL et al. | Production of prostanoids by Lewis rat Schwann cells in vitro. | 1994 | Brain Res. | pmid:8173981 |
Salvati P et al. | A comparative evaluation of thromboxane receptor blockade, thromboxane synthase inhibition and both in animal models of arterial thrombosis. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8169831 |
Nabekura H et al. | Fallopian tube prostaglandin production with and without endometriosis. | 1994 Jan-Feb | Int J Fertil Menopausal Stud | pmid:8167682 |
Lages B and Weiss HJ | Evidence for a role of glycoprotein IIb-IIIa, distinct from its ability to support aggregation, in platelet activation by ionophores in the presence of extracellular divalent cations. | 1994 | Blood | pmid:8167340 |
Hussein Z et al. | Characterization of the pharmacokinetics and pharmacodynamics of a new oral thromboxane A2-receptor antagonist AA-2414 in normal subjects: population analysis. | 1994 | Clin. Pharmacol. Ther. | pmid:8162671 |
Piccirillo G et al. | High plasma concentrations of cortisol and thromboxane B2 in patients with depression. | 1994 | Am. J. Med. Sci. | pmid:8160715 |
Ganry O et al. | Effect of sodium bicarbonate and sodium chloride on arterial blood pressure, plasma renin activity and urinary prostaglandins in healthy volunteers. | 1993 | J Hypertens Suppl | pmid:8158345 |
Cirino G et al. | Human recombinant phospholipase A2 inhibits platelet aggregation in vitro and in vivo in rat and guinea pig. | 1994 | Eur. J. Pharmacol. | pmid:8157055 |
Yang SX et al. | [Comparison of lipoperoxidative damage in plasma and platelet with the ratio of thromboxane A2 and prostaglandin I2 in blood stasis syndrome with coronary heart disease]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8155941 |
de Waart DR et al. | Studies on the urinary excretion of thromboxane B2 in Zellweger patients and control subjects: evidence for a major role for peroxisomes in the beta-oxidative chain-shortening of thromboxane B2. | 1994 | Biochim. Biophys. Acta | pmid:8155738 |
Markewitz A et al. | Reduction of cyclosporine-induced nephrotoxicity by cilastatin following clinical heart transplantation. | 1994 | Transplantation | pmid:8154033 |
Katoh K et al. | Direct evidence for erythropoietin-induced release of endothelin from peripheral vascular tissue. | 1994 | Life Sci. | pmid:8152333 |
Deng X et al. | [Changes in TXB2/6-keto-PGF1 alpha ratio and their relation to blood lipids of Type A behavioral patterns]. | 1993 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:8150445 |
Adcock JJ et al. | The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator release. | 1978 | Prostaglandins | pmid:81495 |
Liu FM and Xu SC | Effect of captopril cardioplegia on renin-angiotensin system, prostaglandins, free radicals and electrolytes in the isolated hypothermic ischemic and reperfusion rabbit hearts. | 1993 | Chin. Med. J. | pmid:8143507 |
Best LC et al. | Dipyridamole and platelet function. | 1978 | Lancet | pmid:81402 |
Kitabayashi K et al. | Increased graft survival by utilization of 15-deoxyspergualin in a canine pancreatic allotransplantation model. | 1994 | Eur Surg Res | pmid:8137847 |
Watanabe J et al. | Effects of cilostazol, a phosphodiesterase inhibitor, on urinary excretion of albumin and prostaglandins in non-insulin-dependent diabetic patients. | 1993 Oct-Nov | Diabetes Res. Clin. Pract. | pmid:8137717 |
Wei J et al. | [Clinical and experimental study on effects of ji shen mixture for infantile acute glomerulonephritis]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8136648 |
Xu X et al. | [Relation between traditional Chinese medicinal syndrome differentiation and blood platelet function in 310 cases of blood stasis]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8136643 |
Uematsu T et al. | Pharmacokinetic and pharmacodynamic profiles of CS-518, a selective, long-lasting thromboxane synthase inhibitor, after single and multiple oral administration to healthy volunteers. | 1994 | J Clin Pharmacol | pmid:8132850 |
Engineer DM et al. | Modulation of slow-reacting substance of anaphylaxis and histamine release by prostacyclin and thromboxanes [proceedings]. | 1978 | J. Physiol. (Lond.) | pmid:81301 |
Fauler J et al. | Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. | 1994 | Arthritis Rheum. | pmid:8129769 |
Kurita A et al. | The effects of orally administered atenolol on the coronary hemodynamics and prostaglandin metabolism in angina pectoris patients. | 1994 | Angiology | pmid:8129203 |
Oda H et al. | Alcohol and coronary spasm. | 1994 | Angiology | pmid:8129199 |
Smith WJ et al. | Prevention of complement-induced pulmonary hypertension and improvement of right ventricular function by selective thromboxane receptor antagonism. | 1994 | J. Thorac. Cardiovasc. Surg. | pmid:8127109 |
Rose ML et al. | Effect of endotoxin on tirilazad mesylate (U74006F) pharmacokinetic parameters in neonatal calves. | 1993 | J. Vet. Pharmacol. Ther. | pmid:8126760 |
Kambara K et al. | Effects of acetylsalicylic acid on pulmonary vascular tone and membrane permeability in blood-perfused dog lung. | 1993 | J. Appl. Physiol. | pmid:8125875 |
Barefield ES et al. | Thromboxane and pulmonary morphometry in the development of the pulmonary hypertensive response to group B streptococcus. | 1994 | Crit. Care Med. | pmid:8125003 |
Rabinovici R et al. | Lyophilized liposome encapsulated hemoglobin: evaluation of hemodynamic, biochemical, and hematologic responses. | 1994 | Crit. Care Med. | pmid:8124999 |
Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
Voss R et al. | In vitro and ex vivo effects of aspirin in patients on a low-dose aspirin therapy. | 1993 | Thromb. Res. | pmid:8122187 |
Elsasser TH et al. | Recombinant bovine somatotropin blunts plasma tumor necrosis factor-alpha, cortisol, and thromboxane-B2 responses to endotoxin in vivo. | 1994 | Endocrinology | pmid:8119146 |
Okano S et al. | Effect of dibutyryl cyclic AMP on hemodynamics and chemical mediators in dogs with experimentally-induced endotoxic shock. | 1993 | J. Vet. Med. Sci. | pmid:8117795 |
Gianello P et al. | Measurement of the vasoconstrictive substances endothelin, angiotensin II, and thromboxane B2 in cold storage solution can reveal previous renal ischemic insults. | 1994 | Transpl. Int. | pmid:8117396 |
Gerros TC et al. | Effect of dose and method of administration of endotoxin on cell mediator release in neonatal calves. | 1993 | Am. J. Vet. Res. | pmid:8116949 |
Semrad SD et al. | Pharmacokinetics of and serum thromboxane suppression by flunixin meglumine in healthy foals during the first month of life. | 1993 | Am. J. Vet. Res. | pmid:8116942 |
Martinuzzo ME et al. | Antiphospholipid antibodies enhance thrombin-induced platelet activation and thromboxane formation. | 1993 | Thromb. Haemost. | pmid:8115993 |
Axelrod L et al. | Effects of a small quantity of omega-3 fatty acids on cardiovascular risk factors in NIDDM. A randomized, prospective, double-blind, controlled study. | 1994 | Diabetes Care | pmid:8112187 |
Chen CR et al. | Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8111595 |
Hu WL and Ma YJ | [Effect of glycerol-induced acute renal failure in rabbit with Ligusticum wallichii on thromboxane B2, 6-keto-prostaglandin F1 alpha/thromboxane B2]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8111216 |
Gu MJ and Liu ZM | [Prevention of toxicity of cyclosporine A on rat pancreatic islet beta-cells by Ligustrazine]. | 1993 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8111213 |
Tokiwa K et al. | Pulmonary hypertension as a fatal complication of extrahepatic portal hypertension. | 1993 | Eur J Pediatr Surg | pmid:8110723 |
Lam JY et al. | Platelet aggregation, coronary artery disease progression and future coronary events. | 1994 | Am. J. Cardiol. | pmid:8109546 |
Heasman PA et al. | Changes in crevicular fluid levels of interleukin-1 beta, leukotriene B4, prostaglandin E2, thromboxane B2 and tumour necrosis factor alpha in experimental gingivitis in humans. | 1993 | J. Periodont. Res. | pmid:8101565 |
Mattsson E et al. | Prostanoid release immediately after balloon angioplasty in three models of atherosclerosis in rabbits. | 1993 | Eur J Surg | pmid:8095801 |
Hanai T et al. | Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues. | 1993 | J. Surg. Res. | pmid:8094103 |
Satoh K et al. | Effects of sulfonylurea agents on platelet arachidonic acid metabolism; study on platelet homogenates. | 1994 | Biochem. Pharmacol. | pmid:8093094 |
Magness RR et al. | Angiotensin II metabolic clearance rate and pressor responses in nonpregnant and pregnant women. | 1994 | Am. J. Obstet. Gynecol. | pmid:8092213 |
Kubatiev A et al. | Complement activation and neutrophil aggregation changes during haemodialysis. | 1993 | Int J Clin Pharmacol Res | pmid:8088929 |
Babushkina GV et al. | [Metabolism of several blood prostaglandins in patients with angina pectoris during helium-neon laser therapy]. | 1993 | Kardiologiia | pmid:8084118 |
Knight KR et al. | Infusions of a novel calcitonin gene-related peptide (CGRP) derivative at the time of reperfusion to salvage ischaemic rabbit skin flaps. | 1993 | Int J Tissue React | pmid:8077087 |
Prakash C et al. | Decreased systemic thromboxane A2 biosynthesis in normal human subjects fed a salmon-rich diet. | 1994 | Am. J. Clin. Nutr. | pmid:8074067 |