Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Halushka PV et al. | Insulin and arachidonic acid metabolism in diabetes mellitus. | 1985 | Metab. Clin. Exp. | pmid:3934501 |
Carmo LG et al. | Platelet desensitization induced by arachidonic acid is not due to cyclo-oxygenase inactivation and involves the endoperoxide receptor. | 1985 | Br. J. Pharmacol. | pmid:2994786 |
Segarnick DJ et al. | Precursor- and pool-dependent differential effects of ethanol on human platelet prostanoid synthesis. | 1985 | Biochem. Pharmacol. | pmid:3922375 |
Papanicolaou N et al. | Selective inhibition of renal thromboxane biosynthesis increased sodium excretion rate in normal and saline-loaded rats. | 1985 | Clin. Sci. | pmid:3880524 |
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De Caterina R et al. | Nitrates and endothelial prostacyclin production: studies in vitro. | 1985 | Circulation | pmid:3917245 |
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Kiyomiya K and Oh-ishi S | Involvement of arachidonic acid metabolites in acute inflammation: detection of 6-keto-PGF1 alpha, thromboxane B2 and PGD2 in rat pleurisy induced by phorbol myristate acetate. | 1985 | Jpn. J. Pharmacol. | pmid:3936958 |
Bottoms GD et al. | Endotoxin-induced eicosanoid production by equine vascular endothelial cells and neutrophils. | 1985 | Circ. Shock | pmid:3919961 |
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Yamaguchi M and Mori N | 6-Keto prostaglandin F1 alpha, thromboxane B2, and 13,14-dihydro-15-keto prostaglandin F concentrations of normotensive and preeclamptic patients during pregnancy, delivery, and the postpartum period. | 1985 | Am. J. Obstet. Gynecol. | pmid:3838119 |
Johnson A and Malik AB | Pulmonary transvascular fluid and protein exchange after thrombin-induced microembolism. Differential effects of cyclooxygenase inhibitors. | 1985 | Am. Rev. Respir. Dis. | pmid:3925828 |
Patrono C et al. | Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus. | 1985 | J. Clin. Invest. | pmid:3900132 |
O'Keefe EH et al. | Effects of a thromboxane synthetase inhibitor and a thromboxane antagonist on release and activity of thromboxane A2 and prostacyclin in vitro. | 1985 | Prostaglandins | pmid:3925501 |
Ouwendijk RJ et al. | Production of leukotrienes and prostaglandins by human ascites cells. | 1985 | Eur. J. Clin. Invest. | pmid:3007158 |
Aitokallio-Tallberg A et al. | Prostacyclin and thromboxane in breast cancer: relationship between steroid receptor status and medroxyprogesterone acetate. | 1985 | Br. J. Cancer | pmid:2986666 |
Schmitz JM et al. | Vascular prostaglandin and thromboxane production in a canine model of myocardial ischemia. | 1985 | Circ. Res. | pmid:3926340 |
Strano A et al. | [Formation of platelet thromboxane in a patient with type I glycogenosis]. | 1985 | Recenti Prog Med | pmid:3868788 |
Jensen W et al. | Hemodynamic measurements in a sheep model with a hollow fiber artificial kidney containing modified cellulose. | 1985 | Life Support Syst | pmid:3870598 |
Kopp KJ et al. | Template bleeding time and thromboxane generation in the horse: effects of three non-steroidal anti-inflammatory drugs. | 1985 | Equine Vet. J. | pmid:3878280 |
Conti P et al. | Enhanced thromboxane synthesis and vacuolization in human polymorphonuclear leucocytes induced by human lymphokine containing supernatants. | 1985 | Clin. Rheumatol. | pmid:3879473 |
Mahiout A et al. | Ex vivo model for pre-clinical evaluation of dialyzers containing new membranes. | 1985 | Life Support Syst | pmid:3879954 |
Wong C et al. | Effect of a body burn on the lung response to endotoxin. | 1985 | J Trauma | pmid:3880823 |
Khirabadi BS et al. | Urine immunoreactive thromboxane B2 in rat cardiac allograft rejection. | 1985 | Transplantation | pmid:3880966 |
Mehta J and Mehta P | Prostacyclin and thromboxane A2 production by human cardiac atrial tissues. | 1985 | Am. Heart J. | pmid:3880988 |
Friedrich T et al. | Follow-up of prostaglandin plasma levels after acute myocardial infarction. | 1985 | Am. Heart J. | pmid:3880994 |
Shephard EG et al. | Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin F1 alpha and beta-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. | 1985 | Br J Clin Pharmacol | pmid:2581599 |
Addonizio VP et al. | Iloprost (ZK36374), a stable analogue of prostacyclin, preserves platelets during simulated extracorporeal circulation. | 1985 | J. Thorac. Cardiovasc. Surg. | pmid:2582210 |
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Naesh O et al. | Platelet function in surgical stress. | 1985 | Thromb. Haemost. | pmid:2935969 |
Takahata K et al. | [Effect of PSK on prostaglandin metabolism (I)]. | 1985 | Gan To Kagaku Ryoho | pmid:3888117 |
Miyazaki H et al. | Microdetermination of prostaglandins and thromboxane B2 by gas chromatography/high-resolution selected-ion monitoring. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936139 |
Hutchison AA et al. | Effect of endotoxemia on hypoxic pulmonary vasoconstriction in unanesthetized sheep. | 1985 | J. Appl. Physiol. | pmid:3888946 |
Kobayashi N et al. | Effect of changes in prostaglandin synthesis by platelets and vessel wall on the formation of arterial thrombosis in rabbits. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936159 |
Ogawa K et al. | Effects of orally administered glandular kallikrein on urinary kallikrein and prostaglandin excretion, plasma immunoreactive prostanoids and platelet aggregation in essential hypertension. | 1985 | Klin. Wochenschr. | pmid:3889484 |
Nishikawa K et al. | (E)-7-Phenyl-7-(3-pyridyl)-6-heptenoic acid (CV-4151): a potent, specific thromboxane A2 synthetase inhibitor. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936160 |
Vapaatalo H | Prostaglandins and coronary circulation. | 1985 | Acta Med. Scand. Suppl. | pmid:3890471 |
Takagi S and Den K | Prostacyclin and thromboxane A2 in preeclamptic umbilical circulation. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936183 |
Ylikorkala O and Mäkilä UM | Prostacyclin and thromboxane in gynecology and obstetrics. | 1985 | Am. J. Obstet. Gynecol. | pmid:3890549 |
McGowan HM et al. | The effect of dietary alteration of prostaglandin synthesis on blood pressure and the reversal of hypertension in the one-kidney, one-clip rat. | 1985 | Prostaglandins | pmid:3859891 |
Granström E et al. | Monitoring thromboxane production in vivo: metabolic and analytical aspects. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936194 |
FitzGerald GA et al. | Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936207 |
Greer IA et al. | Immunoreactive prostacyclin and thromboxane metabolites in normal pregnancy and the puerperium. | 1985 | Br J Obstet Gynaecol | pmid:3890936 |
Kuzuya T et al. | Determination of plasma thromboxane B2 by radioimmunoassay: methodological problems and accuracy. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936210 |
Slotman GJ et al. | Thromboxane and prostacyclin in clinical acute respiratory failure. | 1985 | J. Surg. Res. | pmid:3892164 |
Hsu CY et al. | Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury. | 1985 | Neurology | pmid:3892363 |
Morita I et al. | Effect of dietary protein level on platelet aggregation in rat. | 1985 | Prostaglandins Leukot Med | pmid:3892545 |
de Lorgeril M et al. | Acute influence of cigarette smoke in platelets, catecholamines and neurophysins in the normal conditions of daily life. | 1985 | Eur. Heart J. | pmid:2937635 |
Lelcuk S et al. | Prostacyclin and thromboxane A2 moderate postischemic renal failure. | 1985 | Surgery | pmid:3895535 |
von Schacky C et al. | Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. | 1985 | J. Clin. Invest. | pmid:2997286 |
Codde JP and Beilin LJ | Dietary fish oil prevents dexamethasone induced hypertension in the rat. | 1985 | Clin. Sci. | pmid:3905217 |
Amado JA et al. | Influence of acetylsalicylic acid on bleeding time and serum thromboxane B2 in diabetes mellitus type I. | 1985 | Diabete Metab | pmid:4007228 |
De Servi S et al. | [Myocardial ischemia during exertion. Correlations between blood levels of thromboxane B2 and changes in coronary flow and resistance]. | 1985 | G Ital Cardiol | pmid:4007353 |
McGinley S et al. | The effect of inhibiting brain thromboxane biosynthesis on pentylenetetrazole-induced seizure threshold. | 1985 | J. Neurosci. Res. | pmid:4009745 |
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Kelton JG et al. | A platelet function defect in preeclampsia. | 1985 | Obstet Gynecol | pmid:3966011 |
Mundie TG et al. | Byssinosis: Release of prostaglandins, thromboxane, and 5-hydroxytryptamine in bronchopulmonary lavage fluid after inhalation of cotton dust extracts. | 1985 | Am. J. Pathol. | pmid:3966532 |
Higashihara M et al. | A monoclonal anti-human platelet antibody: a new platelet aggregating substance. | 1985 | Blood | pmid:3967086 |
Nawroth PP et al. | Thromboxane production by perturbed bovine aortic endothelial cells in culture. | 1985 | Blut | pmid:3967102 |
Martin JL et al. | Effect of high dose aspirin on coronary hemodynamics during pacing-induced myocardial ischemia. | 1985 | J. Am. Coll. Cardiol. | pmid:3968305 |
Wilcox CS et al. | Intrarenal prostaglandin release: effects of arachidonic acid and hyperchloremia. | 1985 | Kidney Int. | pmid:3930824 |
Westenfelder C et al. | Renal function in calves with total artificial hearts. | 1985 | Trans Am Soc Artif Intern Organs | pmid:3837477 |
Morris HG et al. | Effects of salsalate (nonacetylated salicylate) and aspirin on serum prostaglandins in humans. | 1985 | Ther Drug Monit | pmid:3866409 |
Wilson L and Huang LS | Contributions of the fetoplacental unit to augmented uterine prostaglandin levels periparturition in the rat. | 1985 | Biol. Reprod. | pmid:3840391 |
Levine RF et al. | Megakaryocyte interaction with subendothelial extracellular matrix is associated with adhesion, platelet-like shape change, and thromboxane A2 production. | 1985 | Blood | pmid:4027379 |
Templeton CB et al. | Effects of repeated endotoxin injections on prostanoids, hemodynamics, endothelial cells, and survival in ponies. | 1985 | Circ. Shock | pmid:3840414 |
Roberts DG et al. | Sulindac is not renal sparing in man. | 1985 | Clin. Pharmacol. Ther. | pmid:4028619 |
Fink MP et al. | Plasma levels of 6-keto PGF1 alpha but not TxB2 increase in rats with peritonitis due to cecal ligation. | 1985 | Circ. Shock | pmid:3840415 |
Codde JP et al. | Study of diet and drug interactions on prostanoid metabolism. | 1985 | Prostaglandins | pmid:4034991 |
Wise WC et al. | Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock. | 1985 | Circ. Shock | pmid:3840416 |
Brace LD and Fareed J | An objective assessment of the interaction of heparin and its fractions with human platelets. | 1985 | Semin. Thromb. Hemost. | pmid:4035366 |
Demling RH et al. | Role of subcutaneous tissue endotoxin in the production of prostanoid-induced lung injury: comparison with intravenous endotoxin response. | 1985 | Circ. Shock | pmid:3840417 |
Lorenz RR and Vanhoutte PM | Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels. | 1985 | Am. J. Physiol. | pmid:4037113 |
Takeda H et al. | [Early changes of vasoactive prostanoids in patients with mitral valve replacement]. | 1985 | Nihon Kyobu Geka Gakkai Zasshi | pmid:3840511 |
Remuzzi G et al. | Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. | 1985 | J. Clin. Invest. | pmid:4038407 |
Vinge E et al. | Single intravenous and oral doses of fenflumizole: pharmacokinetics and effects on prostanoid formation. | 1985 | Acta Pharmacol Toxicol (Copenh) | pmid:3840639 |
Mogensen F et al. | Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. | 1985 | Thromb. Res. | pmid:4038824 |
Bennett A et al. | Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo. | 1985 | Br. J. Pharmacol. | pmid:3840708 |
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Lorenzana RM et al. | Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1 alpha, thromboxane B2, and acid-base parameters. | 1985 | Fundam Appl Toxicol | pmid:3840756 |
Elliott GR et al. | Arachidonic acid, an in vivo inhibitor of carrageenin induced granulomas in the rat. | 1985 | Eur. J. Pharmacol. | pmid:2988985 |
Palmer RM and Salmon JA | Comparison of the effects of some compounds on human neutrophil degranulation and leukotriene B4 and thromboxane B2 synthesis. | 1985 | Biochem. Pharmacol. | pmid:2986647 |
Lynch TJ et al. | Carbon tetrachloride-induced eicosanoid synthesis and enzyme release from rat peritoneal leucocytes. | 1985 | Biochem. Pharmacol. | pmid:2986650 |
Armstrong RA et al. | Effect of the thromboxane receptor antagonist EP 092 on endotoxin shock in the sheep. | 1985 | Prostaglandins | pmid:2989977 |
Gay SW and Kosher RA | Prostaglandin synthesis during the course of limb cartilage differentiation in vitro. | 1985 | J Embryol Exp Morphol | pmid:3867724 |
Elliott GR et al. | Changes in resident rat peritoneal macrophage eicosanoid release, induced by altering the buffer K+/Na+ ratio, are Ca2+ dependent. | 1985 | Biochim. Biophys. Acta | pmid:3933563 |
Carter AJ and Hanley SP | The effect of platelet number and haematocrit on whole blood thromboxane synthesis. | 1985 | Thromb. Haemost. | pmid:4024033 |
Kawaguchi A et al. | Increase in urinary thromboxane B2 in rats caused by cyclosporine. | 1985 | Transplantation | pmid:4024243 |