Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Snapper JR et al. | Effects of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia. | 1984 | J. Clin. Invest. | pmid:6501570 |
Giani E et al. | Sex differences in platelet thromboxane and arterial prostacyclin production in control and n-6 fatty acid supplemented rats. | 1984 | Prostaglandins | pmid:6441187 |
McCluskey ER et al. | In vivo inhibition of thromboxane synthetase in infarcted canine myocardium. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6539597 |
Chan PK and Gentry PA | Inhibition of bovine platelet function by T-2 toxin, HT-2 toxin, diacetoxyscirpenol and deoxynivalenol. | 1984 | Food Chem. Toxicol. | pmid:6540739 |
Moufarrij NA et al. | Thromboxane synthetase inhibition in acute focal cerebral ischemia in cats. | 1984 | J. Neurosurg. | pmid:6542131 |
Hock CE and Lefer AM | Beneficial effect of a thromboxane synthetase inhibitor in traumatic shock. | 1984 | Circ. Shock | pmid:6542462 |
Katz JM et al. | Inhibition of prostaglandin action and bone resorption by copper. | 1984 | Ann. Rheum. Dis. | pmid:6441529 |
Ito T et al. | Selective thromboxane synthetase inhibitor and ischemic heart disease. | 1984 | Biomed. Biochim. Acta | pmid:6542777 |
De Clerck F et al. | Platelet-vessel wall interactions in hemostasis: implication of 5-hydroxytryptamine. | 1984 | Agents Actions | pmid:6543415 |
Menys VC and Davies JA | Thromboxane-mediated activation of platelets and enhancement of platelet uptake onto collagen-coated glass or deendothelialized rabbit aorta. Comparative effects of a thromboxane antagonist (EPO45) and a thromboxane synthetase inhibitor (dazoxiben). | 1984 | Lab. Invest. | pmid:6546403 |
Pedersen AK et al. | Inhibition of thromboxane biosynthesis in serum: limitations of the measurement of immunoreactive 6-keto-PGF1 alpha. | 1984 | Thromb. Res. | pmid:6546456 |
Krishnamurthi S et al. | Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways. | 1984 | Biochem. Pharmacol. | pmid:6091666 |
Novo S et al. | Platelet activity in relation to smoke and exercise in patients with chronic obstructive lung disease: effects of platelet antiaggregating drugs. | 1984 | Adv. Exp. Med. Biol. | pmid:6546467 |
Ford WD et al. | Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations. | 1984 | Arch. Dis. Child. | pmid:6546658 |
Rosenblum WI and Hirsh PD | Some interrelationships between glucose levels thromboxane production and prostacyclin production in normal and diabetic mice. | 1984 | Prostaglandins | pmid:6546804 |
Le Breton GC et al. | 2-(6-carboxyhexyl)cyclopentanone hexylhydrazone: a potent inhibitor of the blood platelet cyclo-oxygenase. | 1984 | Prostaglandins | pmid:6427851 |
Saldeen P et al. | Thromboxane production in umbilical vein grafts. | 1984 | Thromb. Res. | pmid:6546814 |
Schwartz D et al. | Renal arachidonic acid metabolism and cellular changes in the rabbit renal vein constricted kidney: inflammation as a common process in renal injury models. | 1984 | Prostaglandins | pmid:6427853 |
Emau P et al. | Function of prostaglandins, thromboxane A2, and histamine in hypersensitivity reaction to experimental bluetongue disease in calves. | 1984 | Am. J. Vet. Res. | pmid:6093650 |
Bush LR et al. | Effects of the selective thromboxane synthetase inhibitor dazoxiben on variations in cyclic blood flow in stenosed canine coronary arteries. | 1984 | Circulation | pmid:6546902 |
Wilson TW et al. | Determination of 6-keto-prostaglandin F1 alpha and thromboxane B2 in urine by high-performance liquid chromatography and radioimmunoassay. | 1984 | J. Chromatogr. | pmid:6546935 |
Mitsuhashi N and Kato J | Bioconversion of arachidonic acid to prostaglandins and related compounds in human myometrium and uterine cervix. | 1984 | Endocrinol. Jpn. | pmid:6442700 |
Fantone JC et al. | Stimulus specificity of prostaglandin inhibition of rabbit polymorphonuclear leukocyte lysosomal enzyme release and superoxide anion production. | 1984 | Am. J. Pathol. | pmid:6324595 |
Benedetto C et al. | Production of prostacyclin, 6-keto-PGF1 alpha and thromboxane B2 by incubated samples of umbilical vessels: a comparison of methods for expressing the results on dry weight, wet weight, protein or DNA bases. | 1984 | Prostaglandins | pmid:6390522 |
Heinonen PK and Metsä-Ketelä T | Prostaglandin and thromboxane production in ovarian cancer tissue. | 1984 | Gynecol. Obstet. Invest. | pmid:6396175 |
Chen LS et al. | Plasma concentrations of 6-keto-prostaglandin F1 alpha, thromboxane B2 and platelet aggregation in patients with essential hypertension. | 1984 | Jpn Heart J | pmid:6549401 |
Ishihara Y et al. | [Cigarette smoking and lung metabolism--effect of cigarette smoking on blood levels of 6-keto PGF1 alpha, thromboxane B2 and lipoperoxide in healthy volunteers]. | 1984 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:6549510 |
Watanabe J et al. | Effect of vitamin E on platelet aggregation in diabetes mellitus. | 1984 | Thromb. Haemost. | pmid:6495252 |
Stahl RA et al. | Glomerular prostaglandin formation in two-kidney, one-clip hypertensive rats. | 1984 | Am. J. Physiol. | pmid:6507633 |
Kääpä P et al. | Thromboxane B2 production by fetal and neonatal platelets: effect of idiopathic respiratory distress syndrome and birth asphyxia. | 1984 | Pediatr. Res. | pmid:6472947 |
Gachályi B et al. | In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man. | 1984 | Thromb. Res. | pmid:6474407 |
Brown CG and Poyser NL | Studies on ovarian prostaglandin production in relation to ovulation in the rat. | 1984 | J. Reprod. Fertil. | pmid:6595406 |
Fitzpatrick F et al. | Development of a gas chromatographic-mass spectrometric method using a stable isotope internal standard for quantitation of thromboxane B2. | 1984 | Thromb. Res. | pmid:6474413 |
Mitrovic D et al. | Anti-inflammatory drugs, prostanoid and proteoglycan production by cultured bovine articular chondrocytes. | 1984 | Prostaglandins | pmid:6595718 |
Watanabe J et al. | Effect of vitamin E on platelet aggregation in diabetes mellitus. | 1984 | Tohoku J. Exp. Med. | pmid:6474447 |
Prinz RA et al. | Platelet activation by human pancreatic fluid. | 1984 | J. Surg. Res. | pmid:6482425 |
Wilson L and Huang LS | Temporal response of uterine prostaglandins to estradiol treatment in the ovariectomized-pregnant rat. | 1984 | Prostaglandins | pmid:6484214 |
Walinsky P et al. | Thromboxane A2 in acute myocardial infarction. | 1984 | Am. Heart J. | pmid:6485997 |
D'Angelo A et al. | Increased production of platelet thromboxane B2 in non-insulin-dependent diabetes. Relationship to vascular complications. | 1984 | Eur. J. Clin. Invest. | pmid:6428908 |
Ninnemann JL and Stockland AE | Participation of prostaglandin E in immunosuppression following thermal injury. | 1984 | J Trauma | pmid:6231383 |
DiSesa VJ et al. | Disadvantages of prostacyclin infusion during cardiopulmonary bypass: a double-blind study of 50 patients having coronary revascularization. | 1984 | Ann. Thorac. Surg. | pmid:6388516 |
Takeda H et al. | [Changes of platelet aggregation, serum thromboxane and prostacyclin in lung cancer and pulmonary metastatic patients following operation]. | 1984 | Kyobu Geka | pmid:6389949 |
Olanoff LS et al. | Effects of oleic acid on pulmonary capillary leak and thromboxanes. | 1984 | J. Surg. Res. | pmid:6233456 |
Jackson EK et al. | Attenuation of noradrenergic neurotransmission by the thromboxane synthetase inhibitor, UK 38,485. | 1984 | Life Sci. | pmid:6330486 |
Hartung HP et al. | Release of prostaglandin E and thromboxane from macrophages by stimulation with factor H. | 1984 | Clin. Exp. Immunol. | pmid:6234114 |
Uotila P et al. | Prostanoids and hemodynamics in man before and during cardiopulmonary bypass. | 1984 | Prostaglandins | pmid:6335260 |
Kawai C | New horizons in cardiology. | 1984 | Int. J. Cardiol. | pmid:6334040 |
Hänsch GM et al. | Macrophages release arachidonic acid, prostaglandin E2, and thromboxane in response to late complement components. | 1984 | J. Immunol. | pmid:6432907 |
Robson MC et al. | A new explanation for the progressive tissue loss in electrical injuries. | 1984 | Plast. Reconstr. Surg. | pmid:6422484 |
Huang HC | Release of slow reacting substance from the guinea-pig lung by phospholipases A2 of Vipera russelli snake venom. | 1984 | Toxicon | pmid:6206608 |
Brunner D et al. | Thromboxane, prostacyclin, beta-thromboglobin, and diabetes mellitus. | 1984 | Clin Ther | pmid:6206948 |
Gragnoli G et al. | [Effects of ticlopidine on the plasma levels of beta-thromboglobulin and thromboxane B2 in types 1 and 2 diabetics]. | 1984 | Minerva Med. | pmid:6207465 |
Rachmilewitz D and Karmeli F | Effect of nufenoxole on human colonic prostanoid synthesis, Na-K-ATPase and adenylate cyclase activities. | 1984 | Eur. J. Pharmacol. | pmid:6152213 |
Lampugnani MG and de Gaetano G | Effects of metabolized and unmetabolized arachidonate on rat platelet shape change. | 1984 | Am. J. Physiol. | pmid:6433724 |
Stock JL and Coderre JA | Calcitonin enhances production of prostaglandins by stimulated human monocytes. | 1984 | Prostaglandins | pmid:6087420 |
Triolo G et al. | Circulating immune complexes and platelet thromboxane synthesis in patients with insulin-dependent (type I) diabetes mellitus. | 1984 | Diabetes | pmid:6611280 |
Yui Y et al. | Intravenous infusion of a selective inhibitor of thromboxane A2 synthetase in man: influence on thromboxane B2 and 6-keto-prostaglandin F1 alpha levels and platelet aggregation. | 1984 | Circulation | pmid:6434196 |
Lee EC et al. | Functional responses of tumor cells to phorbol esters: role for prostaglandins. | 1984 | Oncology | pmid:6587276 |
Coker SJ and Parratt JR | The effects of nafazatrom on arrhythmias and prostanoid release during coronary artery occlusion and reperfusion in anaesthetized greyhounds. | 1984 | J. Mol. Cell. Cardiol. | pmid:6366241 |
Salmon JA et al. | Benoxaprofen does not inhibit formation of leukotriene B4 in a model of acute inflammation. | 1984 | Biochem. Pharmacol. | pmid:6089840 |
Alster P and Wennmalm A | Effect of nicotine on the formation of prostacyclin-like activity and thromboxane in rabbit aorta and platelets. | 1984 | Br. J. Pharmacol. | pmid:6367870 |
Girotti MJ et al. | Effects of immunization on cardiopulmonary alterations of gram-negative endotoxemia. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6368499 |
Dembinska-Kieć A et al. | Formation of leukotriene C4-like material by rat brain tissue. | 1984 | Eur. J. Pharmacol. | pmid:6426980 |
Stuart MJ et al. | Differences in thromboxane production between neonatal and adult platelets in response to arachidonic acid and epinephrine. | 1984 | Pediatr. Res. | pmid:6435080 |
Stuart MJ et al. | Effects of hyperoxia and hypoxia on vascular prostacyclin formation in vitro. | 1984 | Pediatrics | pmid:6435087 |
Pan IQ et al. | Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives. | 1984 | Br. J. Haematol. | pmid:6089860 |
Serhan CN et al. | Formation of leukotrienes and hydroxy acids by human neutrophils and platelets exposed to monosodium urate. | 1984 | Prostaglandins | pmid:6328582 |
Shohami E and Sidi A | Accumulation of prostacyclin in rat brain during haemorrhagic hypotension--possible role of PGI2 in autoregulation. | 1984 | J. Cereb. Blood Flow Metab. | pmid:6363432 |
Miyazaki H et al. | Microdetermination of prostaglandins and thromboxane B2 by capillary gas chromatography and negative ion chemical ionization mass spectrometry. | 1984 | J. Chromatogr. | pmid:6736155 |
Kelton JG et al. | A study of the bioavailability and platelet inhibitory effects of a new enteric-coated acetylsalicylic acid preparation. | 1984 | Thromb. Res. | pmid:6740573 |
Schultze G et al. | Effect of cyclosporine on the generation of prostanoids by cultured peripheral lymphocytes. | 1984 | Transplant. Proc. | pmid:6592863 |
Zipser RD et al. | Therapeutic trial of thromboxane synthesis inhibition in the hepatorenal syndrome. | 1984 | Gastroenterology | pmid:6593268 |
Koskimies AI et al. | Peritoneal fluid 6-keto-prostaglandin F1 alpha, thromboxane B2 in endometriosis and unexplained infertility. | 1984 | Acta Obstet Gynecol Scand Suppl | pmid:6594012 |
Branski D et al. | Prostaglandins in small intestinal mucosa of children with celiac disease. | 1984 | J. Pediatr. Gastroenterol. Nutr. | pmid:6594493 |
Woodcock BE et al. | The platelet defect in acute myeloid leukaemia. | 1984 | J. Clin. Pathol. | pmid:6595273 |
Ogushi F et al. | [In vitro release of arachidonate metabolites by human alveolar macrophages]. | 1984 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:6595434 |
Bommer J et al. | Plastic filing from dialysis tubing induces prostanoid release from macrophages. | 1984 | Kidney Int. | pmid:6595463 |
Brandt R et al. | Effect of propranolol, practolol and atenolol on human platelet thromboxane formation and plasma levels of prostaglandins 6-keto-F1 alpha and E2. | 1984 | Prostaglandins Leukot Med | pmid:6597450 |
Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
Morrison AR and Crowley JR | Identification of an unusual cyclooxygenase metabolite of arachidonic acid in rabbit renal medulla. | 1984 | Arch. Biochem. Biophys. | pmid:6437329 |
Holgate ST et al. | Anaphylactic- and calcium-dependent generation of prostaglandin D2 (PGD2), thromboxane B2, and other cyclooxygenase products of arachidonic acid by dispersed human lung cells and relationship to histamine release. | 1984 | J. Immunol. | pmid:6206153 |
Takeda H et al. | [Alternations in coagulation and fibrinolysis associated with extracorporeal circulation--the role of vasoactive prostanoids]. | 1984 | Rinsho Kyobu Geka | pmid:6395300 |
Tada M et al. | Reduction of prostacyclin synthesis as a possible cause of transient flow reduction in a partially constricted canine coronary artery. | 1984 | J. Mol. Cell. Cardiol. | pmid:6398370 |
Ylikorkala O | Prostanoids in gynaecology. | 1984 | Ann. Clin. Res. | pmid:6398666 |
Vapaatalo H et al. | Prostanoids in blood pressure regulation and their role in the blood pressure lowering effects induced by changes in dietary fats. | 1984 | Ann. Clin. Res. | pmid:6398981 |
Wang JP et al. | XC 386: a new antiplatelet agent. | 1984 | Thromb. Res. | pmid:6438827 |
Axelrod L and Cornelius P | Plasma prostaglandin levels and circulating fuel levels in rats with diabetic ketoacidosis: effects of cyclooxygenase inhibitors and of alpha and beta adrenergic blockade. | 1984 | Prostaglandins | pmid:6440213 |
Zimmermann I et al. | [Influence of vagus nerve, histamine, prostaglandin and catecholamine on airway obstruction]. | 1984 | Respiration | pmid:6473921 |
Chan CC et al. | Inhibition of prostanoid-mediated platelet aggregation in vivo and in vitro by 3-hydroxymethyl-dibenzo(b,f)thiepin 5,5-dioxide (L-640,035). | 1984 | J. Pharmacol. Exp. Ther. | pmid:6423813 |
Dahl ML and Uotila P | Salicylate does not interfere with aspirin in human blood in vivo. | 1984 | Prostaglandins Leukot Med | pmid:6585840 |
Dahl ML and Uotila P | Thromboxane formation during blood clotting is decreased by verapamil. | 1984 | Prostaglandins Leukot Med | pmid:6585842 |
Higgins AJ and Lees P | Arachidonic acid metabolites in carrageenin-induced equine inflammatory exudate. | 1984 | J. Vet. Pharmacol. Ther. | pmid:6423835 |
Hall ER et al. | The reduction of potential TXB2 levels when serum is preincubated at room temperature. | 1984 | Prostaglandins Leukot Med | pmid:6585846 |
Codde JP et al. | Validation of the direct radioimmunoassay of prostanoids in serum and kidney. | 1984 | Prostaglandins Leukot Med | pmid:6587406 |
Shaala S et al. | Local effect of thromboxane B2 on the contractility of the human non pregnant uterus. | 1984 | Prostaglandins Leukot Med | pmid:6587408 |
Higgins AJ et al. | Influence of phenylbutazone on eicosanoid levels in equine acute inflammatory exudate. | 1984 | Cornell Vet | pmid:6587959 |
Meydani M et al. | Effects of dietary methionine, methylmercury, and atrazine on ex-vivo synthesis of prostaglandin E1 and thromboxane B2. | 1984 | Prostaglandins Leukot Med | pmid:6588393 |
Branski D et al. | Effect of cimetidine on human gastric and duodenal prostanoid synthesis. | 1984 | Scand. J. Gastroenterol. | pmid:6589742 |
Oglesby TD and Gorman RR | The inhibition of arachidonic acid metabolism in human platelets by RHC 80267, a diacylglycerol lipase inhibitor. | 1984 | Biochim. Biophys. Acta | pmid:6424715 |
Grignani G et al. | Activation of platelet prostaglandin biosynthesis pathway during neoplastic cell-induced platelet aggregation. | 1984 | Thromb. Res. | pmid:6729776 |