Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yokoyama Y et al. | Up-regulated thromboxane production in the rat liver with biliary obstruction does not contribute to promote hepatic injury. | 2008 | Shock | pmid:17885643 |
Meen O et al. | No case of COX-1-related aspirin resistance found in 289 patients with symptoms of stable CHD remitted for coronary angiography. | 2008 | Scand. J. Clin. Lab. Invest. | pmid:17934975 |
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Yan Q et al. | Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18579648 |
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Menzies D et al. | Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma. | 2008 | J. Allergy Clin. Immunol. | pmid:18313127 |
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Selg E et al. | Effects of selective and non-selective COX inhibitors on antigen-induced release of prostanoid mediators and bronchoconstriction in the isolated perfused and ventilated guinea pig lung. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18294831 |
Basselin M et al. | Chronic carbamazepine administration attenuates dopamine D2-like receptor-initiated signaling via arachidonic acid in rat brain. | 2008 | Neurochem. Res. | pmid:18302021 |
Signore C et al. | Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking > or =48 g of alcohol per day. | 2008 | Alcohol. Clin. Exp. Res. | pmid:18715278 |
Roethig HJ et al. | A 12-month, randomized, controlled study to evaluate exposure and cardiovascular risk factors in adult smokers switching from conventional cigarettes to a second-generation electrically heated cigarette smoking system. | 2008 | J Clin Pharmacol | pmid:18319361 |
Al-Salam Z et al. | The effect of dobutamine on platelet aggregatory function in newborn piglets with hypoxia and reoxygenation. | 2008 | Shock | pmid:18323735 |
Park JW et al. | 15,16-dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization. | 2008 | Arch. Pharm. Res. | pmid:18277607 |
Schwartz JI et al. | Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 versus COX-1 in healthy subjects. | 2008 | J Clin Pharmacol | pmid:18434566 |
Cui J et al. | Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441194 |
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Hinz B et al. | Impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers. | 2008 | Int J Clin Pharmacol Ther | pmid:18397691 |
Bruce EC et al. | Platelet thromboxane A2 secretion in patients with major depression responsive to electroconvulsive therapy. | 2008 | Psychosom Med | pmid:18378867 |
Wooten JG et al. | Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs. | 2008 | Am. J. Vet. Res. | pmid:18380576 |
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Banting A et al. | Efficacy of oral and parenteral ketoprofen in lactating cows with endotoxin-induced acute mastitis. | 2008 | Vet. Rec. | pmid:18953074 |
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Otani Y et al. | Effects of the COX-2 inhibitor FK3311 on ischemia - reperfusion injury in the rat lung. | 2007 May-Jun | J Invest Surg | pmid:17613692 |
Jiang J et al. | Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat. | 2007 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:17612651 |
Csanyi G et al. | Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats. | 2007 Jul-Aug | Pharmacol Rep | pmid:17901574 |
Komers R et al. | Cyclo-oxygenase-2 inhibition attenuates the progression of nephropathy in uninephrectomized diabetic rats. | 2007 Jan-Feb | Clin. Exp. Pharmacol. Physiol. | pmid:17201733 |
González-Correa JA et al. | Gender differences in the effect of aspirin on retinal ischemia, prostanoid synthesis and nitric oxide production in experimental type 1-like diabetes. | 2007 Aug-Sep | Vascul. Pharmacol. | pmid:17581795 |
Wong PC et al. | Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits. | 2007 | J. Cardiovasc. Pharmacol. | pmid:17513951 |
Hsiao G et al. | Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: in vitro and in vivo studies. | 2007 | Cardiovasc. Res. | pmid:17560560 |
Basselin M et al. | Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. | 2007 | Neurochem. Res. | pmid:17562170 |
Marvin CC et al. | Synthesis of thromboxane B2 via ketalization/ring-closing metathesis. | 2007 | Org. Lett. | pmid:18047355 |