Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Olson MT et al. | Effect of assay specificity on the association of urine 11-dehydro thromboxane B2 determination with cardiovascular risk. | 2012 | J. Thromb. Haemost. | pmid:23072449 |
Jarvis GE et al. | A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1). | 2012 | J. Thromb. Haemost. | pmid:22103309 |
Alizzi AM et al. | Reduction of post-surgical pericardial adhesions using a pig model. | 2012 | Heart Lung Circ | pmid:22078313 |
Hui C et al. | Changes in coagulation and hemodynamics during pregnancy: a prospective longitudinal study of 58 cases. | 2012 | Arch. Gynecol. Obstet. | pmid:22083312 |
Hu YY et al. | Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells. | 2012 | Immunol. Invest. | pmid:22087636 |
Shoeb M and Ramana KV | Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. | 2012 | Free Radic. Biol. Med. | pmid:22067901 |
Tong Z et al. | Influence of ShuJinHuoXue tablets on ischemia reperfusion injury of animals' skeletal muscle. | 2012 | Molecules | pmid:22801363 |
Sakai H et al. | Cardiopulmonary hemodynamic responses to the small injection of hemoglobin vesicles (artificial oxygen carriers) in miniature pigs. | 2012 | J Biomed Mater Res A | pmid:22615268 |
Santostefano MJ et al. | Off-target platelet activation in macaques unique to a therapeutic monoclonal antibody. | 2012 | Toxicol Pathol | pmid:22552394 |
Larsen SB et al. | Increased platelet aggregation and serum thromboxane levels in aspirin-treated patients with prior myocardial infarction. | 2012 | Thromb. Haemost. | pmid:22534977 |
Li C et al. | Reversal of the anti-platelet effects of aspirin and clopidogrel. | 2012 | J. Thromb. Haemost. | pmid:22268852 |
RodrÃguez-Vilarrupla A et al. | PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats. | 2012 | J. Hepatol. | pmid:22245887 |
Mullins KB et al. | Effects of carprofen, meloxicam and deracoxib on platelet function in dogs. | 2012 | Vet Anaesth Analg | pmid:22248445 |
Bednar F et al. | Evaluation of aspirin's effect on platelet function early after coronary artery bypass grafting. | 2012 | J. Cardiothorac. Vasc. Anesth. | pmid:22281116 |
Cathcart CJ et al. | Lack of inhibitory effect of acetylsalicylic acid and meloxicam on whole blood platelet aggregation in cats. | 2012 | J Vet Emerg Crit Care (San Antonio) | pmid:22316324 |
Mo J et al. | Expression of interleukin-18 in a rat model of deep vein thrombosis. | 2012 | J Cardiovasc Surg (Torino) | pmid:22318348 |
Hartanto MD et al. | Urinary 11-dehydro-thromboxane Bâ‚‚ and 2,3-dinor-6-keto-prostaglandin-Fâ‚α in healthy post-menopausal and pre-menopausal women receiving aspirin 100 mg. | 2012 | J. Thromb. Thrombolysis | pmid:22311294 |
Smith JP et al. | Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. | 2012 | Hypertension | pmid:22311905 |
Brivio I et al. | The pulmonary pharmacology of [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide] (2NTX-99), an anti-atherotrombotic compound with therapeutic potential in pathological conditions that target lung vasculature. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22342851 |
Lemkes BA et al. | The influence of aspirin dose and glycemic control on platelet inhibition in patients with type 2 diabetes mellitus. | 2012 | J. Thromb. Haemost. | pmid:22252020 |
Matsuzawa S et al. | Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury. | 2012 | Arzneimittelforschung | pmid:22945770 |
Macaluso M et al. | How biomarkers will change psychiatry. Part II: Biomarker selection and potential inflammatory markers of depression. | 2012 | J Psychiatr Pract | pmid:22805902 |
Shih CY and Chou TC | The antiplatelet activity of magnolol is mediated by PPAR-β/γ. | 2012 | Biochem. Pharmacol. | pmid:22750553 |
Rocca B et al. | The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes. | 2012 | J. Thromb. Haemost. | pmid:22471290 |
Lee JJ et al. | Morusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular disease. | 2012 | J. Atheroscler. Thromb. | pmid:22472211 |
Bruegel M et al. | Sepsis-associated changes of the arachidonic acid metabolism and their diagnostic potential in septic patients. | 2012 | Crit. Care Med. | pmid:22511130 |
Totani L et al. | Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse. | 2012 | Thromb. Haemost. | pmid:22436970 |
Ajamieh H et al. | Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation. | 2012 | J. Gastroenterol. Hepatol. | pmid:22432744 |
Shatoor AS et al. | Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats. | 2012 | Thromb. Res. | pmid:22261477 |
Brentnall C et al. | Potency and selectivity of carprofen enantiomers for inhibition of bovine cyclooxygenase in whole blood assays. | 2012 | Res. Vet. Sci. | pmid:22703724 |
Peters SM et al. | In vivo characterization of inflammatory biomarkers in swine and the impact of flunixin meglumine administration. | 2012 | Vet. Immunol. Immunopathol. | pmid:22648045 |
Zhou MT et al. | Continuous regional arterial infusion with fluorouracil and octreotide attenuates severe acute pancreatitis in a canine model. | 2012 | PLoS ONE | pmid:22655040 |
Saadawi S et al. | Inhibitory effects of acetylmelodorinol, chrysin and polycarpol from Mitrella kentii on prostaglandin Eâ‚‚ and Thromboxane Bâ‚‚ production and platelet activating factor receptor binding. | 2012 | Molecules | pmid:22538486 |
Sadilkova L et al. | The purification step is not crucial in EIA measurements of thromboxane B2 and 11-dehydrothromboxane B2 in human plasma. | 2012 | Clin. Lab. | pmid:22372363 |
Salama MM et al. | Resistance to low-dose aspirin therapy among patients with acute coronary syndrome in relation to associated risk factors. | 2012 | J Clin Pharm Ther | pmid:23121257 |
Yokoyama H et al. | Theoretical investigation of aspirin dosage regimen to exhibit optimal antiplatelet effects and decrease risk of upper gastrointestinal lesions. | 2012 | Biol. Pharm. Bull. | pmid:23047244 |
Liou JT et al. | Levobupivacaine differentially suppresses platelet aggregation by modulating calcium release in a dose-dependent manner. | 2012 | Acta Anaesthesiol Taiwan | pmid:23026170 |
Thomason J et al. | Platelet cyclooxygenase expression in normal dogs. | 2011 Sep-Oct | J. Vet. Intern. Med. | pmid:21985141 |
Alcott CJ et al. | Clinical and immunomodulating effects of ketamine in horses with experimental endotoxemia. | 2011 Jul-Aug | J. Vet. Intern. Med. | pmid:21745244 |
Chakroun T et al. | The cyclooxygenase-1 C50T polymorphism is not associated with aspirin responsiveness status in stable coronary artery disease in Tunisian patients. | 2011 Jul-Aug | Genet Test Mol Biomarkers | pmid:21434767 |
Saihkay HN et al. | Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits. | 2011 Jan-Feb | J Pharmacol Toxicol Methods | pmid:20646985 |
Brainard BM et al. | Effects of clopidogrel and aspirin on platelet aggregation, thromboxane production, and serotonin secretion in horses. | 2011 Jan-Feb | J. Vet. Intern. Med. | pmid:21143302 |
Lukasik M et al. | Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients. | 2011 | Thromb. Res. | pmid:21788065 |
Shen L et al. | In vivo oxidation, platelet activation and simultaneous occurrence of natural immunity in atherosclerosis-prone mice. | 2011 | Isr. Med. Assoc. J. | pmid:21845968 |
Mattiello T et al. | Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting. | 2011 | J. Am. Coll. Cardiol. | pmid:21816313 |
Ramadan E et al. | Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats. | 2011 | Neuropharmacology | pmid:21839100 |
Puccetti L et al. | Effects of atorvastatin and rosuvastatin on thromboxane-dependent platelet activation and oxidative stress in hypercholesterolemia. | 2011 | Atherosclerosis | pmid:21056418 |
Basselin M et al. | Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites. | 2011 | Neurochem. Res. | pmid:20981485 |
Dimitrievska S et al. | Low thrombogenicity coating of nonwoven PET fiber structures for vascular grafts. | 2011 | Macromol Biosci | pmid:21259437 |
Basselin M et al. | Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. | 2011 | J. Cereb. Blood Flow Metab. | pmid:20664612 |