Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Merola AJ et al. | Prostaglandin response in the exercise conditioned rat. | 1984 | Prostaglandins Leukot Med | pmid:6377328 |
Cuthbert AW et al. | Mediators of the secretory response to kinins. | 1984 | Br. J. Pharmacol. | pmid:6331559 |
Brown CG and Poyser NL | Studies on ovarian prostaglandin production in relation to ovulation in the rat. | 1984 | J. Reprod. Fertil. | pmid:6595406 |
Mitrovic D et al. | Anti-inflammatory drugs, prostanoid and proteoglycan production by cultured bovine articular chondrocytes. | 1984 | Prostaglandins | pmid:6595718 |
Watanabe J et al. | Effect of vitamin E on platelet aggregation in diabetes mellitus. | 1984 | Tohoku J. Exp. Med. | pmid:6474447 |
Prinz RA et al. | Platelet activation by human pancreatic fluid. | 1984 | J. Surg. Res. | pmid:6482425 |
Wilson L and Huang LS | Temporal response of uterine prostaglandins to estradiol treatment in the ovariectomized-pregnant rat. | 1984 | Prostaglandins | pmid:6484214 |
Walinsky P et al. | Thromboxane A2 in acute myocardial infarction. | 1984 | Am. Heart J. | pmid:6485997 |
Vicenzi E et al. | Human mononuclear phagocytes from different anatomical sites differ in their capacity to metabolize arachidonic acid. | 1984 | Clin. Exp. Immunol. | pmid:6432383 |
Schenkein HA and Rutherford RB | Effects of serum on C3b-stimulated release of prostaglandins and thromboxane B2 from human monocytes. | 1984 | Immunopharmacology | pmid:6511367 |
Fung WP et al. | Effect of ethanol on gastric secretion of thromboxane B2. | 1984 | Med. J. Malaysia | pmid:6513851 |
Ninnemann JL and Stockland AE | Participation of prostaglandin E in immunosuppression following thermal injury. | 1984 | J Trauma | pmid:6231383 |
Sekiya K and Okuda H | Inhibitory action of soluble elastin on thromboxane B2 formation in blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6320905 |
Olanoff LS et al. | Effects of oleic acid on pulmonary capillary leak and thromboxanes. | 1984 | J. Surg. Res. | pmid:6233456 |
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Riess H et al. | Effects of BM 13.177, a new antiplatelet drug in patients with atherosclerotic disease. | 1984 | Thromb. Res. | pmid:6237460 |
Nichols AB et al. | Effect of heparin bonding on catheter-induced fibrin formation and platelet activation. | 1984 | Circulation | pmid:6237807 |
Sicard GA et al. | Prostaglandin production and platelet reactivity of small-diameter grafts. | 1984 | J. Vasc. Surg. | pmid:6238179 |
Goodman MG and Weigle WO | Regulation of B-lymphocyte proliferative responses by arachidonate metabolites: effects on membrane-directed versus intracellular activators. | 1984 | J. Allergy Clin. Immunol. | pmid:6432883 |
Zammit M et al. | Aspirin therapy in small-caliber arterial prostheses: long-term experimental observations. | 1984 | J. Vasc. Surg. | pmid:6238183 |
Klaverkamp J and Völkl KP | Maintenance of platelet viability after platelet-labeling with fluorescein isothiocyanate. | 1984 | Haemostasis | pmid:6238881 |
De Lorgeril M et al. | [Platelet function and coronary disease: demonstration of a so-called unstable platelet syndrome]. | 1984 | Arch Mal Coeur Vaiss | pmid:6239599 |
Robson MC et al. | A new explanation for the progressive tissue loss in electrical injuries. | 1984 | Plast. Reconstr. Surg. | pmid:6422484 |
Messmore HL et al. | Molecular markers of platelet activation. | 1984 | Semin. Thromb. Hemost. | pmid:6240115 |
Lampugnani MG and de Gaetano G | Effects of metabolized and unmetabolized arachidonate on rat platelet shape change. | 1984 | Am. J. Physiol. | pmid:6433724 |
Triolo G et al. | Circulating immune complexes and platelet thromboxane synthesis in patients with insulin-dependent (type I) diabetes mellitus. | 1984 | Diabetes | pmid:6611280 |
Koike K et al. | Platelet secretion defect in patients with the attention deficit disorder and easy bruising. | 1984 | Blood | pmid:6692042 |
Vesterqvist O et al. | Development of a GC-MS method for quantitation of 2,3-dinor-TxB2 and determinations of the daily urinary excretion rates in healthy humans. | 1984 | Thromb. Res. | pmid:6695361 |
Davì G et al. | Platelet function changes in acute myocardial infarction. | 1984 | Adv. Exp. Med. Biol. | pmid:6695571 |
Mehta J et al. | Thromboxane release in coronary artery disease: spontaneous versus pacing-induced angina. | 1984 | Am. Heart J. | pmid:6695662 |
Klotz TA et al. | Urinary excretion of thromboxane B2 in patients with venous thromboembolic disease. | 1984 | Chest | pmid:6697787 |
Salmon JA et al. | Benoxaprofen does not inhibit formation of leukotriene B4 in a model of acute inflammation. | 1984 | Biochem. Pharmacol. | pmid:6089840 |
Girotti MJ et al. | Effects of immunization on cardiopulmonary alterations of gram-negative endotoxemia. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6368499 |
Lefkowith JB et al. | Macrophage-dependent arachidonate metabolism in hydronephrosis. | 1984 | Kidney Int. | pmid:6434790 |
Hutton RA et al. | Assessment of platelet function in patients with Raynaud's syndrome. | 1984 | J. Clin. Pathol. | pmid:6229551 |
Stuart MJ et al. | Differences in thromboxane production between neonatal and adult platelets in response to arachidonic acid and epinephrine. | 1984 | Pediatr. Res. | pmid:6435080 |
Goldyne ME | Heterogeneity in leukocyte preparations: effects on defining eicosanoid metabolism by human lymphocytes and monocytes. | 1984 | J. Allergy Clin. Immunol. | pmid:6088610 |
Pickard JD et al. | Arterial eicosanoid production following chronic exposure to a periarterial haematoma. | 1984 | J. Neurol. Neurosurg. Psychiatr. | pmid:6589362 |
MacDermot J et al. | Synthesis of leukotriene B4, and prostanoids by human alveolar macrophages: analysis by gas chromatography/mass spectrometry. | 1984 | Prostaglandins | pmid:6326199 |
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Koskimies AI et al. | Peritoneal fluid 6-keto-prostaglandin F1 alpha, thromboxane B2 in endometriosis and unexplained infertility. | 1984 | Acta Obstet Gynecol Scand Suppl | pmid:6594012 |
Branski D et al. | Prostaglandins in small intestinal mucosa of children with celiac disease. | 1984 | J. Pediatr. Gastroenterol. Nutr. | pmid:6594493 |
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Brandt R et al. | Effect of propranolol, practolol and atenolol on human platelet thromboxane formation and plasma levels of prostaglandins 6-keto-F1 alpha and E2. | 1984 | Prostaglandins Leukot Med | pmid:6597450 |
Chiba S et al. | Sex and age-related differences in the urinary excretion of TXB2 in normal human subjects: a possible pathophysiological role of TXA2 in the aged kidney. | 1984 | Prostaglandins Leukot Med | pmid:6597456 |
Kerry R et al. | Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility. | 1984 | Biochem. Pharmacol. | pmid:6147145 |
Mahmud I et al. | Thromboxane synthesizing system in rat liver. | 1984 | Prostaglandins Leukot Med | pmid:6597457 |
Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
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Burch RM and Halushka PV | Alterations in extracellular calcium concentration differentially influence prostaglandin and thromboxane synthesis in epithelial cells from the toad urinary bladder. | 1984 | Arch. Biochem. Biophys. | pmid:6422855 |
Crutchley DJ | Effects of inhibitors of arachidonic acid metabolism on thromboplastin activity in human monocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422935 |
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Axelrod L and Cornelius P | Plasma prostaglandin levels and circulating fuel levels in rats with diabetic ketoacidosis: effects of cyclooxygenase inhibitors and of alpha and beta adrenergic blockade. | 1984 | Prostaglandins | pmid:6440213 |
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Codde JP et al. | Validation of the direct radioimmunoassay of prostanoids in serum and kidney. | 1984 | Prostaglandins Leukot Med | pmid:6587406 |
Shaala S et al. | Local effect of thromboxane B2 on the contractility of the human non pregnant uterus. | 1984 | Prostaglandins Leukot Med | pmid:6587408 |
Higgins AJ et al. | Influence of phenylbutazone on eicosanoid levels in equine acute inflammatory exudate. | 1984 | Cornell Vet | pmid:6587959 |
Meydani M et al. | Effects of dietary methionine, methylmercury, and atrazine on ex-vivo synthesis of prostaglandin E1 and thromboxane B2. | 1984 | Prostaglandins Leukot Med | pmid:6588393 |
Branski D et al. | Effect of cimetidine on human gastric and duodenal prostanoid synthesis. | 1984 | Scand. J. Gastroenterol. | pmid:6589742 |
Galli C et al. | Acute effects of ethanol, caffeine, or both on platelet aggregation, thromboxane formation, and plasma-free fatty acids in normal subjects. | 1984 | Drug Nutr Interact | pmid:6510241 |
Lelcuk S et al. | Inhibition of ischemia-induced thromboxane synthesis in man. | 1984 | J Trauma | pmid:6325720 |
Swart SS et al. | Functional significance of the platelet alpha2-adrenoceptor: studies in patients with myeloproliferative disorders. | 1984 | Thromb. Res. | pmid:6326344 |