Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Buchanan MR and Hirsh J | Effect of aspirin and salicylate on platelet-vessel wall interactions in rabbits. | 1984 Jul-Aug | Arteriosclerosis | pmid:6380468 |
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Egg D | Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis. | 1984 Mar-Apr | Z Rheumatol | pmid:6730731 |
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Laustiola K et al. | Exercise-induced increase in plasma arachidonic acid and thromboxane B2 in healthy men: effect of beta-adrenergic blockade. | 1984 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6202971 |
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Ahlsten G et al. | Aggregation of and thromboxane B2 synthesis in platelets from newborn infants of smoking and non-smoking mothers. | 1985 | Prostaglandins Leukot Med | pmid:3863152 |
Rosenkranz B and Frölich JC | Plasma concentrations and anti-platelet effects after low dose acetylsalicylic acid. | 1985 | Prostaglandins Leukot Med | pmid:3864170 |
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Yajima M et al. | Plasma thromboxane B2, 6-keto PGF1 alpha and cyclic nucleotides levels as related to treadmill exercise test in patients with ischemic heart disease. | 1985 | Jpn. Circ. J. | pmid:2982050 |
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Kobayashi H et al. | Effects of 6-keto-prostaglandin E1 on ascitic hepatoma-130 in vivo comparison with chemotherapeutic agents. | 1985 | Prostaglandins | pmid:3920729 |
Powell AM et al. | Menstrual-PGF2 alpha, PGE2 and TXA2 in normal and dysmenorrheic women and their temporal relationship to dysmenorrhea. | 1985 | Prostaglandins | pmid:3856904 |
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VanRollins M et al. | Metabolism of 7,10,13,16-docosatetraenoic acid to dihomo-thromboxane, 14-hydroxy-7,10,12-nonadecatrienoic acid and hydroxy fatty acids by human platelets. | 1985 | Biochim. Biophys. Acta | pmid:3918572 |
Gee MH et al. | Eicosanoids, leukocytes and lung injury. | 1985 | Prog. Clin. Biol. Res. | pmid:3934681 |
Zavagli G et al. | Platelet aggregation and evaluation of the ratio thromboxane B2/6-keto-prostaglandin F1 alpha in the plasma of patients on long term cimetidine treatment. | 1985 | Prostaglandins Leukot Med | pmid:2997804 |
Shono F et al. | A solid-phase enzyme immunoassay of thromboxane B2. | 1985 | J. Biochem. | pmid:3935648 |
Sinzinger H | Double blind study of the influence of co-dergocrine on platelet parameters in healthy volunteers. | 1985 | Eur. J. Clin. Pharmacol. | pmid:2998802 |
Greer IA et al. | Platelet activation in allergic asthma. | 1985 | Thromb. Haemost. | pmid:2931855 |
Safai-Kutti S et al. | Impaired in vivo platelet reactivity in infantile autism. | 1985 | Acta Paediatr Scand | pmid:2931944 |
Mikhailidis DP et al. | Heparin-induced platelet aggregation in anorexia nervosa and in severe peripheral vascular disease. | 1985 | Eur. J. Clin. Invest. | pmid:3938401 |
Meese CO et al. | Measurement of thromboxane B2 in human urine by isotope dilution and negative ion chemical ionization mass spectrometry. | 1985 | Biomed. Mass Spectrom. | pmid:2932184 |
Boss AH et al. | Effect of incremental doses of aspirin on bleeding time, platelet aggregation and thromboxane production in patients with cerebrovascular disease. | 1985 | Eur. J. Clin. Invest. | pmid:3938412 |
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Schambelan M et al. | Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus. | 1985 | J. Clin. Invest. | pmid:3156147 |
Velardo B and Lagarde M | Differential effect of external calcium on the oxygenated metabolism of endogenous and exogenous arachidonic acid in platelets. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927915 |
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Weisman SM et al. | Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3862805 |
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Galli C et al. | Modification of brain vascular eicosanoids after pharmacological treatment and ischemia in the rat: drugs and brain vascular eicosanoids. | 1985 | Cephalalgia | pmid:3839438 |
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Jackson EK | Effects of thromboxane synthase inhibition on vascular responsiveness in the in vivo rat mesentery. | 1985 | J. Clin. Invest. | pmid:4077980 |
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De Caterina R et al. | Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction. | 1985 | Thromb. Haemost. | pmid:4082090 |
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Semrad SD et al. | Flunixin meglumine given in small doses: pharmacokinetics and prostaglandin inhibition in healthy horses. | 1985 | Am. J. Vet. Res. | pmid:4083579 |
Ding YA et al. | Potentiation of adrenaline-induced platelet aggregation by angiotensin II. | 1985 | Thromb. Haemost. | pmid:4089801 |
Lawson JA et al. | Measurement of urinary 2,3-dinor-thromboxane B2 and thromboxane B2 using bonded-phase phenylboronic acid columns and capillary gas chromatography--negative-ion chemical ionization mass spectrometry. | 1985 | Anal. Biochem. | pmid:4091270 |
Salmon JA et al. | Evaluation of inhibitors of eicosanoid synthesis in leukocytes: possible pitfall of using the calcium ionophore A23187 to stimulate 5' lipoxygenase. | 1985 | Prostaglandins | pmid:2988019 |
Hutchison AA et al. | Plasma 6-keto prostaglandin F1 alpha and thromboxane B2 in sick preterm neonates. | 1985 | Prostaglandins Leukot Med | pmid:3859877 |