Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Pfliegler G et al. | Platelet function studies in myeloproliferative disorders. | 1986 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2435631 |
Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
Chiricolo M et al. | Prostaglandin and thromboxane biosynthesis in resting and activated platelet-free monocytes from aged subjects. | 1986 | Gerontology | pmid:3086183 |
Tripp CS et al. | Monocyte migration explains the changes in macrophage arachidonate metabolism during the immune response. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3099288 |
Reilly IA et al. | Increased thromboxane biosynthesis in a human preparation of platelet activation: biochemical and functional consequences of selective inhibition of thromboxane synthase. | 1986 | Circulation | pmid:2938849 |
Perico N et al. | Effect of short-term cyclosporine administration in rats on renin-angiotensin and thromboxane A2: possible relevance to the reduction in glomerular filtration rate. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3531461 |
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Quilley CP and Rifkind AB | Prostaglandin release by the chick embryo heart is increased by 2,3,7,8-tetrachlorodibenzo-p-dioxin and by other cytochrome P-448 inducers. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3085671 |
Bartolini G et al. | Regulation of thromboxane A2 biosynthesis in platelet-free human monocytes and the possible role of polypeptide growth factor(s) in the induction of cyclooxygenase system. | 1986 | Biochim. Biophys. Acta | pmid:3085720 |
Czer GT et al. | Low-dose PGI2 prevents monocrotaline-induced thromboxane production and lung injury. | 1986 | J. Appl. Physiol. | pmid:3081477 |
Cross PE et al. | Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. | 1986 | J. Med. Chem. | pmid:3081722 |
Huijgens PC et al. | Aspirin does not inhibit human megakaryocyte thromboxane synthesis in vivo. | 1986 | Scand J Haematol | pmid:3081996 |
Fitzgerald DJ et al. | Platelet activation in unstable coronary disease. | 1986 | N. Engl. J. Med. | pmid:3531859 |
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Schenkein HA | LPS-stimulated release of prostaglandin E and thromboxane B2 from the U937 cell line. | 1986 | Cell. Immunol. | pmid:3100058 |
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Fuller RW et al. | Immunoglobulin E-dependent stimulation of human alveolar macrophages: significance in type 1 hypersensitivity. | 1986 | Clin. Exp. Immunol. | pmid:2947765 |
Strobl-Jäger E et al. | Platelet half-life in comparison to other in-vivo platelet function parameters such as thromboxane B2, beta-thromboglobulin and platelet factor 4 in patients with atherosclerotic lesions with and without hyperlipoproteinemia. | 1986 | VASA | pmid:2948337 |
Spence JD | The arthritic patient with hypertension: selection of an NSAID. | 1986 | Scand. J. Rheumatol. Suppl. | pmid:3541167 |
Foegh ML et al. | Eicosanoids, gamma-interferon and inflammatory cells in kidney transplant patients. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949550 |
Bito LZ | Prostaglandins and other eicosanoids: their ocular transport, pharmacokinetics, and therapeutic effects. | 1986 | Trans Ophthalmol Soc U K | pmid:3541303 |
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Davì G et al. | Enhanced platelet sensitivity to prostacyclin after isosorbide-5-mononitrate in patients with stable angina pectoris. | 1986 | Z Kardiol | pmid:3541421 |
Säynävälammi P | Effects of captopril on the urinary excretion of prostanoids and kallikrein in spontaneously hypertensive rats. | 1986 | Acta Pharmacol Toxicol (Copenh) | pmid:3541494 |
Morris DD et al. | Endotoxin-induced changes in plasma concentrations of thromboxane and prostacyclin in neonatal calves given antiserum to a mutant Escherichia coli (J-5). | 1986 | Am. J. Vet. Res. | pmid:3541703 |
Chacho KJ et al. | Peritoneal fluid in patients with and without endometriosis: prostanoids and macrophages and their effect on the spermatozoa penetration assay. | 1986 | Am. J. Obstet. Gynecol. | pmid:2940869 |
Simonson MS and Dunn MJ | Leukotriene C4 and D4 contract rat glomerular mesangial cells. | 1986 | Kidney Int. | pmid:3465969 |
Endean ED et al. | Effect of thromboxane synthetase inhibition on canine autogenous vein grafts. | 1986 | J. Surg. Res. | pmid:3702387 |
Croft KD et al. | Dietary fish oils reduce plasma levels of platelet activating factor precursor (lyso-PAF) in rats. | 1986 | Life Sci. | pmid:3702610 |
Handley DA et al. | Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. | 1986 | Immunopharmacology | pmid:3733419 |
Houston DS et al. | Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides. | 1986 | J. Clin. Invest. | pmid:3734103 |
Simpson PJ et al. | Reduction in the incidence of thrombosis by the thromboxane synthetase inhibitor CGS 13080 in a canine model of coronary artery injury. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3735129 |
Arai M | [Plasma thromboxane B2 levels in various liver diseases]. | 1986 | Nihon Shokakibyo Gakkai Zasshi | pmid:3735742 |
Catapano AL et al. | Bile lipids, platelet aggregability and pro-ApoAI processing in 2 cases of Tangier disease. | 1986 | Monogr Atheroscler | pmid:3736556 |
Semrad SD et al. | Hypertension in bulls and steers anesthetized with guaifenesin-thiobarbiturate-halothane combination. | 1986 | Am. J. Vet. Res. | pmid:3740628 |
Ono N et al. | Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug (4). Mode of action on anti-inflammatory activity. | 1986 | Jpn. J. Pharmacol. | pmid:3102823 |
Bucchi F et al. | Salicylate may prevent the inhibitory effect of indomethacin on serum thromboxane formation in man. | 1986 | Prostaglandins Leukot Med | pmid:3456617 |
Laffi G et al. | Effects of sulindac and ibuprofen in patients with cirrhosis and ascites. An explanation for the renal-sparing effect of sulindac. | 1986 | Gastroenterology | pmid:3079594 |
Ishihara Y et al. | Effect of thromboxane synthetase inhibitors (OKY-046, OKY-1580) on experimentally induced air embolism in anesthetized dogs. | 1986 | Prostaglandins Leukot Med | pmid:3457388 |
Schenkein HA | Prostaglandin E and thromboxane B2 release by PMA-induced U937 cells in response to C3b. | 1986 | J. Leukoc. Biol. | pmid:3457882 |
Hawkey CJ | Synthesis of prostaglandin E2, thromboxane B2 and prostaglandin catabolism in gastritis and gastric ulcer. | 1986 | Gut | pmid:3468053 |
Schaub RG and Yamashita A | Leukocyte mediated vein injury and thrombosis is reduced by a lipoxygenase inhibitor. | 1986 | Exp. Mol. Pathol. | pmid:3025012 |
Ahmed T et al. | Endotoxin-induced changes in pulmonary hemodynamics and respiratory mechanics. Role of lipoxygenase and cyclooxygenase products. | 1986 | Am. Rev. Respir. Dis. | pmid:3098146 |
Tremoli E et al. | In vitro effects of aspirin and non steroidal anti-inflammatory drugs on the formation of 12-hydroxyeicosatetraenoic acid by platelets. | 1986 | Prostaglandins Leukot Med | pmid:3094026 |
Mischler EH et al. | Correction of linoleic acid deficiency in cystic fibrosis. | 1986 | Pediatr. Res. | pmid:3456148 |
Mikhailidis DP et al. | Platelet function defects in chronic alcoholism. | 1986 | Br Med J (Clin Res Ed) | pmid:3094624 |
Bottoms GD et al. | Release of eicosanoids from white blood cells, platelets, smooth muscle cells, and endothelial cells in response to endotoxin and A23187. | 1986 | Circ. Shock | pmid:3094976 |
Shohami E and Gross J | Effects of hypoxia and anoxia on the ex vivo release of prostaglandins from mouse cortical slices. | 1986 | J. Neurochem. | pmid:3464697 |
Ekblad U | The effect of oxytocin and betamimetic stimulation on prostaglandin release in perfused human fetal placenta. | 1986 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:3469120 |
Loo MH et al. | Effect of thromboxane inhibition on renal blood flow in dogs with complete unilateral ureteral obstruction. | 1986 | J. Urol. | pmid:3464764 |
Jakubowski JA et al. | Low-dose enteric-coated aspirin: a practical approach to continuous-release low-dose aspirin and presystemic acetylation of human platelet cyclooxygenase. | 1986 | J. Lab. Clin. Med. | pmid:3097223 |
Kutti J et al. | Evaluation of platelet reactivity in diabetes mellitus. | 1986 | Acta Med Scand | pmid:2938425 |
Gong LS et al. | [Plasma thromboxane B2 and 6-keto-prostaglandin F1-alpha concentrations in patients with essential and renovascular hypertension]. | 1986 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:3755674 |
de Gaetano G et al. | Low dose aspirin does not prevent fibrinolytic response to venous occlusion. | 1986 | Biochem. Pharmacol. | pmid:3755907 |
Craig-Schmidt MC et al. | The essential fatty acid deficient chicken as a model for cystic fibrosis. | 1986 | Am. J. Clin. Nutr. | pmid:3466523 |
Zucker ML et al. | Platelet function in hypercholesterolemics before and after hypolipidemic drug therapy. | 1986 | Haemostasis | pmid:2939008 |
Smallbone BW et al. | Effects of verapamil on thromboxane synthesis and pulmonary hypertension in sheep. | 1986 | Clin Invest Med | pmid:3757320 |
Mueller HS et al. | Platelet hyperactivity in acute myocardial infarction in man--effects of prostacyclin. | 1986 | Herz | pmid:2939012 |
Siegl AM and Moroff G | Effect of forskolin on the maintenance of platelet properties during storage. | 1986 | J. Lab. Clin. Med. | pmid:3760676 |
Legrand YJ et al. | Activation of platelets by microfibrils and collagen. A comparative study. | 1986 | Lab. Invest. | pmid:2939291 |
Komatsu H et al. | Beneficial effect of OKY-046, a selective thromboxane A2 synthetase inhibitor, on experimental cerebral vasospasm. | 1986 | Jpn. J. Pharmacol. | pmid:3761754 |
Fiore S et al. | Endotoxin-induced TxB2 release by polymorphonuclears and macrophages. | 1986 | Boll. Soc. Ital. Biol. Sper. | pmid:3098261 |
Burhop KE et al. | Platelet-activating factor increases lung vascular permeability to protein. | 1986 | J. Appl. Physiol. | pmid:3804927 |
Fuller RW and MacDermot J | Stimulation of IgE sensitized human alveolar macrophages by anti-IgE is unaffected by sodium cromoglycate. | 1986 | Clin. Allergy | pmid:3098449 |
Lokesh BR et al. | Peritoneal macrophages from mice fed dietary (n-3) polyunsaturated fatty acids secrete low levels of prostaglandins. | 1986 | J. Nutr. | pmid:3806247 |
Kirschenbaum MA and Chaudhari A | Effect of experimental diabetes on glomerular filtration rate and glomerular prostanoid production in the rat. | 1986 | Miner Electrolyte Metab | pmid:3807832 |
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Szczeklik A et al. | Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. | 1986 | Thromb. Haemost. | pmid:3563961 |
Michael LH et al. | Myocardial ischemia: platelet and thromboxane concentrations in cardiac lymph and the effects of ibuprofen and prostacyclin. | 1986 | Circ. Res. | pmid:3524894 |
Gairola CG and Tai HH | Cigarette smoke-induced alterations in the release of arachidonate metabolites by pulmonary alveolar macrophage from selenium-fed and selenium-deficient rats. | 1986 | Biochem. Pharmacol. | pmid:3015150 |
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Greer IA et al. | Endothelial stimulation by DDAVP in von Willebrand's disease and haemophilia. | 1986 | Haemostasis | pmid:3084364 |
Hatmi M et al. | Modulation by cyclic AMP of arachidonic acid-induced platelet desensitization. | 1986 | Eur. J. Pharmacol. | pmid:3028837 |
Cerletti C et al. | Comparison of the effects of oral and intravenous aspirin administration on platelet and peripheral vascular cyclo-oxygenase activity: studies in rats and in man. | 1986 | Agents Actions Suppl. | pmid:3101444 |
Podjarny E et al. | Effect of angiotensin II on prostanoid synthesis in isolated rat glomeruli. | 1986 | Clin. Sci. | pmid:3457671 |
Laffi G et al. | Altered renal and platelet arachidonic acid metabolism in cirrhosis. | 1986 | Gastroenterology | pmid:3079716 |
Cifone MG et al. | Stimulatory effect of hr tumor necrosis factor on TxB2 release by polymorphonuclears and macrophages. | 1986 | Agents Actions | pmid:3825754 |
Carr DP et al. | Comparison of the systemic inhibition of thromboxane synthesis, anti-inflammatory activity and gastro-intestinal toxicity of non-steroidal anti-inflammatory drugs in the rat. | 1986 | Agents Actions | pmid:3825757 |
Ogletree ML et al. | Influence of steroidal and nonsteroidal anti-inflammatory agents on the accumulation of arachidonic acid metabolites in plasma and lung lymph after endotoxemia in awake sheep. Measurements of prostacyclin and thromboxane metabolites and 12-HETE. | 1986 | Am. Rev. Respir. Dis. | pmid:3079978 |
Bloom A et al. | Evidence against a platelet cyclooxygenase defect in uraemic subjects on chronic haemodialysis. | 1986 | Br. J. Haematol. | pmid:3080018 |
Singer P et al. | Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension. | 1986 | Atherosclerosis | pmid:3026412 |
Lorenz RL et al. | Effects on prostanoid formation and pharmacokinetics of dazmegrel (UK-38,485), a novel thromboxane synthase inhibitor, in man. | 1986 | Biochem. Pharmacol. | pmid:3513767 |
Guarner C et al. | Renal prostaglandins in cirrhosis of the liver. | 1986 | Clin. Sci. | pmid:3516533 |
Peskar BM et al. | Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa. | 1986 | Prostaglandins | pmid:3515429 |
Carter AJ and Jones EW | The effect of the degree of diabetic control on thromboxane synthesis in clotted whole blood. | 1986 | Thromb. Res. | pmid:3515613 |
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Burghuber OC et al. | Hydrogen peroxide induced pulmonary vasoconstriction in isolated rat lungs is attenuated by U60,257, a leucotriene synthesis blocker. | 1986 | Wien. Klin. Wochenschr. | pmid:3518246 |
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Seeger W et al. | Pulmonary microvascular injury induced by Pseudomonas aeruginosa cytotoxin in isolated rabbit lungs. | 1986 | Infect. Immun. | pmid:3519462 |
Westlund P et al. | Circulating and urinary thromboxane B2 metabolites in the rabbit: 11-dehydro-thromboxane B2 as parameter of thromboxane production. | 1986 | Prostaglandins | pmid:3520685 |
Slotman GJ et al. | Interaction of prostaglandins, activated complement, and granulocytes in clinical sepsis and hypotension. | 1986 | Surgery | pmid:3520916 |
Bales CW et al. | The effect of zinc deficiency and food restriction on prostaglandin E2 and thromboxane B2 in saliva and plasma of rats. | 1986 | Prostaglandins | pmid:3460117 |
Pohanka E and Sinzinger H | Effect of a single pentoxifylline administration on platelet sensitivity, plasma factor activity, plasma-6-oxo-PGF1 alpha and thromboxane B2 in healthy volunteers. | 1986 | Prostaglandins Leukot Med | pmid:3523540 |
Masi I et al. | Effects of CDP-choline on platelet aggregation and the antiaggregatory activity of arterial wall in the rat. | 1986 | Pharmacol Res Commun | pmid:3523545 |
Kobinia GS et al. | Influence of coronary artery obstruction on cardiac prostaglandin metabolism during experimental cardioplegic arrest. | 1986 | Thorac Cardiovasc Surg | pmid:2424127 |
Shinonaga M et al. | [Sequential measurements of TxB2 and 6-keto PGF1 alpha in cerebrospinal fluid and serum in patients with subarachnoid hemorrhage]. | 1986 | Neurol. Med. Chir. (Tokyo) | pmid:2429203 |
Winn R et al. | Lung permeability and hemodynamics during endotoxemia: effect of aprotinin. | 1986 | J. Surg. Res. | pmid:2431222 |