Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Hyperlipidemias D006949 73 associated lipids
Bronchitis D001991 6 associated lipids
Pneumonia D011014 10 associated lipids
Shock, Septic D012772 11 associated lipids
Intracranial Embolism and Thrombosis D002542 5 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Radiation Injuries, Experimental D011833 11 associated lipids
Death, Sudden D003645 12 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hypertension, Renal D006977 9 associated lipids
Tachycardia D013610 7 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Neutropenia D009503 15 associated lipids
Meningioma D008579 11 associated lipids
Lung Diseases, Obstructive D008173 10 associated lipids
Retinal Diseases D012164 4 associated lipids
Arthritis, Juvenile D001171 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Clark KE et al. Effect of bisenoic prostaglandins and arachidonic acid on the uterine vasculature of pregnant sheep. 1982 Am. J. Obstet. Gynecol. pmid:7065014
Schuette AH et al. Effect of lung thromboxane generation on regional blood flow during sheep bypass. 1982 Am. J. Physiol. pmid:7065206
Mäkilä UM et al. Regulation of prostacyclin and thromboxane production by human umbilical vessels: the effect of estradiol and progesterone in a superfusion model. 1982 Prostaglandins Leukot Med pmid:7043492
Han P et al. Inhibition of platelet function of antiarrhythmic drugs, verapamil and disopyramide. 1982 Thromb. Haemost. pmid:7101234
Krausz MM et al. Adverse effects of prostacyclin used to perfuse isolated lung lobes. 1982 Am. J. Physiol. pmid:7044149
Hirsh PD et al. Influence of blood sampling site and technique on thromboxane concentrations in patients with ischemic heart disease. 1982 Am. Heart J. pmid:7102506
Chierchia S et al. Failure of thromboxane A2 blockade to prevent attacks of vasospastic angina. 1982 Circulation pmid:7116586
Sasagawa S et al. Effects of thromboxane A2 injection on the rabbit coronary artery. I. Physiologic effects in healthy animals. 1982 Exp. Mol. Pathol. pmid:7117494
Fantone JC et al. Inhibition of vascular permeability changes in rats by captopril. 1982 J. Clin. Invest. pmid:6282931
Ylikorkala O and Viinikka L Effect of amnioscopy on concentrations of prostaglandin F2 alpha, prostacyclin and thromboxane in maternal plasma. 1982 Gynecol. Obstet. Invest. pmid:6954125
Simpson RM et al. Generation of thromboxane A2 and aorta-contracting activity from platelets stimulated with modified C-reactive protein. 1982 Immunology pmid:7118160
Peterson MB et al. Thromboxane mediates acute pulmonary hypertension in sheep extracorporeal perfusion. 1982 Am. J. Physiol. pmid:7051860
Fitzpatrick FA A radioimmunoassay for thromboxane B2. 1982 Meth. Enzymol. pmid:7132759
Maas RL et al. Quantitative assay of urinary 2,3-dinor thromboxane B2 by GC-MS. 1982 Meth. Enzymol. pmid:7132771
Pace-Asciak CR and Edwards NS Preparation of 2,3,4,5-tetranor-thromboxane B2, the major urinary catabolite of thromboxane B2 in the rat. 1982 Meth. Enzymol. pmid:7132772
Martin JF et al. Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique. 1982 Thromb. Res. pmid:6814004
Dorsch W et al. Mediator studies in skin blister fluid from patients with dual skin reactions after intradermal allergen injection. 1982 J. Allergy Clin. Immunol. pmid:6181112
Hadding U et al. Peritoneal macrophages release prostaglandin E and thromboxane B2 in response to C3b. 1982 Adv. Exp. Med. Biol. pmid:7158499
Fletcher MS et al. Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice. 1982 Br J Surg pmid:6751458
Shaw JO and Lyons RM Requirement for different Ca2+ pools in the activation of rabbit platelets II. Phospholipase activity. 1982 Biochim. Biophys. Acta pmid:6800410
Dejana E et al. Bleeding time in rats: a comparison of different experimental conditions. 1982 Thromb. Haemost. pmid:6753230
Addonizio VP et al. Inhibition of human platelet function by verapamil. 1982 Thromb. Res. pmid:7164035
Axelrod L and Levine L Plasma prostaglandin levels in rats with diabetes mellitus and diabetic ketoacidosis. 1982 Diabetes pmid:6816644
DiMinno G et al. Stored human platelets retain full aggregation potential in response to pairs of aggregating agents. 1982 Blood pmid:6800418
Strano A et al. Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. 1982 Thromb. Haemost. pmid:6753232
Vargaftig BB et al. Adrenaline and PAF-acether synergize to trigger cyclooxygenase-independent activation of plasma-free human platelets. 1982 Thromb. Res. pmid:7164036
Numano F et al. Effects of thromboxane A2 injection on the rabbit coronary artery. II. The production of infarcts in cholesterol-fed animals. 1982 Exp. Mol. Pathol. pmid:6956517
Flynn JT and Demling RH Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. 1982 Adv Shock Res pmid:6753534
Vlodavsky I et al. Platelet interaction with the extracellular matrix produced by cultured endothelial cells: a model to study the thrombogenicity of isolated subendothelial basal lamina. 1982 Thromb. Res. pmid:7179215
Grundfest CC et al. Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism. 1982 Biochim. Biophys. Acta pmid:6814492
Smith MC et al. Prostacyclin substitution for heparin in long-term hemodialysis. 1982 Am. J. Med. pmid:6753575
Deby-Dupont G et al. Release of thromboxane B2 during adult respiratory distress syndrome and its inhibition by non steroidal anti-inflammatory substances in man. 1982 Arch Int Pharmacodyn Ther pmid:7181589
Zipser RD and Martin K Urinary excretion of arterial blood prostaglandins and thromboxanes in man. 1982 Am. J. Physiol. pmid:6950668
Aharony D et al. Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid. 1982 Biochim. Biophys. Acta pmid:6814496
Shohami E et al. [Thromboxane in rat brain following incomplete ischemia]. 1982 Harefuah pmid:7182317
Hamasaki Y et al. Hypoxia stimulates prostacyclin generation by dog lung in vitro. 1982 Prostaglandins Leukot Med pmid:7051045
Goldsmith JC and Needleman SW A comparative study of thromboxane and prostacyclin release from ex vivo and cultured bovine vascular endothelium. 1982 Prostaglandins pmid:6815717
Blackwell GJ et al. Prostacyclin prolongs viability of washed human platelets. 1982 Biochim. Biophys. Acta pmid:6291622
Panganamala RV and Cornwell DG The effects of vitamin E on arachidonic acid metabolism. 1982 Ann. N. Y. Acad. Sci. pmid:6816121
Karmali RA et al. Prostaglandin regulation of murine mammary tumor virus production: a basis for some of the glucocorticoid and prolactin actions on mammary tumor cell cultures. 1982 Prostaglandins Leukot Med pmid:6296884
Mitrovic D et al. The in vitro production of prostanoids by cultured bovine articular chondrocytes. 1982 Prostaglandins pmid:6801735
Watanabe T et al. Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. 1982 J. Biol. Chem. pmid:6816798
Jaweed MM et al. Changes in thromboxane B2 and 6-keto-PGF1 alpha after direct electrical stimulation of the denervated rat gastrocnemius1,2. 1982 Prostaglandins Leukot Med pmid:6956927
Taube C et al. Enhanced thromboxane production in the aorta of spontaneously hypertensive rats in vitro. 1982 Prostaglandins Leukot Med pmid:6960370
Castaldi PA et al. Evidence for a platelet membrane defect in the myeloproliferative syndromes. 1982 Thromb. Res. pmid:6960545
Rachmilewitz D et al. Prostanoid synthesis by cultured peripheral blood mononuclear cells in inflammatory diseases of the bowel. 1982 Gastroenterology pmid:6949849
Krishnamurthi S et al. Effect of pyridoxal 5'-phosphate (PALP) on human platelet aggregation, dense granule release and thromboxane B2 generation--role of Schiff base formation. 1982 Thromb. Haemost. pmid:6891107
Capitanio A et al. Detection of circulating released platelets after renal transplantation. 1982 Transplantation pmid:6461116
Hall ER et al. The reduction of platelet thrombi on damaged vessel wall by a thromboxane synthetase inhibitor in rabbits. 1982 Thromb. Res. pmid:6891109
Davì G et al. [Effects of flurbiprofen on the platelet function in patients with ischemic cardiopathy]. 1982 Cardiologia pmid:6892383
De Caterina R et al. [Effects of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. 1982 Cardiologia pmid:6892461
Di Minno G et al. Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides. 1982 Thromb. Res. pmid:6803385
Suehiro A et al. The role of platelet hyperfunction in thrombus formation in hyperlipidemia. 1982 Thromb. Res. pmid:6803387
Needleman SW et al. Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. 1982 Prostaglandins pmid:6819602
Goldyne ME and Stobo JD Human monocytes synthesize eicosanoids from T lymphocyte-derived arachidonic acid. 1982 Prostaglandins pmid:6819603
de Boer AC et al. Platelet release and thromboxane synthesis in symptomatic coronary artery disease. 1982 Circulation pmid:6212161
Mari D et al. Coagulation and platelet activation after retinal vein occlusions. 1982 Haemostasis pmid:6215293
Casey LC et al. Prevention of endotoxin-induced pulmonary hypertension in primates by the use of a selective thromboxane synthetase inhibitor, OKY 1581. 1982 J. Pharmacol. Exp. Ther. pmid:6896528
de Clerck F et al. Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist. 1982 Agents Actions pmid:6215842
Chen LS et al. Changes of plasma 6-keto-PGF1 alpha and thromboxane B2 levels and platelet aggregation after tourniquet ischemia on the upper limb in normal subjects and patients with ischemic heart disease. 1982 Jpn. Circ. J. pmid:6896534
Mehta P et al. Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production. 1982 Prostaglandins pmid:6820165
Mehta J and Mehta P Effects of propranolol therapy on platelet release and prostaglandin generation in patients with coronary heart disease. 1982 Circulation pmid:6216027
Evans CA et al. Gestational changes in prostanoid concentrations in intrauterine tissues and fetal fluids from pregnant sheep, and the relation to prostanoid output in vitro. 1982 Biol. Reprod. pmid:6896829
Nolan RD et al. The pericardium as a source of prostacyclin in the dog, ox and rat. 1982 Prostaglandins pmid:6820168
Koyama I et al. Release of 6-keto-prostaglandin F1 alpha and thromboxane B2 from mouse peritoneal macrophages during their adhesion and spreading on a glass surface. 1982 Prostaglandins pmid:6896924
Uderman HD et al. Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone. 1982 Prostaglandins pmid:6897296
Katsumata M et al. Diphenylhydantoin: an alternative ligand of a glucocorticoid receptor affecting prostaglandin generation in A/J mice. 1982 Science pmid:6897299
Mehta P et al. Thromboxane and prostacyclin generation by intact human vessels in response to balloon catheter trauma. 1982 Prostaglandins Leukot Med pmid:6217465
Koyama I et al. [Production of 6-keto-prostaglandin F1 alpha and thromboxane B2 in mouse peritoneal macrophages during preparation of the cells]. 1982 Yakugaku Zasshi pmid:6897423
Wilson L et al. Alterations in reproductive tissue prostaglandins E and F, 6-keto-prostaglandin F1 alpha and thromboxane B2 with gestational age in the rat. 1982 Biol. Reprod. pmid:6897617
Randall MJ and Wilding RI Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). 1982 Thromb. Res. pmid:6897751
De Caterina R et al. [Effect of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. 1982 Cardiologia pmid:6927441
Davì G et al. [Effects of flurbiprofen on platelet function in patients with ischemic cardiomyopathy]. 1982 Cardiologia pmid:6927457
McNamara DB et al. Prostaglandin endoperoxide metabolism by microsomes of whole kidneys from normal, congenital unilateral hydronephrotic and unilateral ureteral obstructed rats. 1982 Prostaglandins pmid:6962465
Lecompte T et al. Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets. 1982 Biochem. Biophys. Res. Commun. pmid:6809005
Patrignani P et al. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. 1982 J. Clin. Invest. pmid:7045161
Bakhle YS and Zakrzewski JT Effects of the oestrous cycle on the metabolism of arachidonic acid in rat isolated lung. 1982 J. Physiol. (Lond.) pmid:6809935
Watkins WD et al. Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: effect of an imidazole derivative. 1982 Prostaglandins pmid:7048422
Hüttemeier PC et al. Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep. 1982 Circ. Res. pmid:7042108
Jackson CA et al. Relationship between platelet aggregation, thromboxane synthesis and albumin concentration in nephrotic syndrome. 1982 Br. J. Haematol. pmid:6810912
Cerletti C et al. Non-steroidal anti-inflammatory drugs react with two sites on platelet cyclo-oxygenase. Evidence from "in vivo" drug interaction studies in rats. 1982 Biochim. Biophys. Acta pmid:6799004
Kunkel SL et al. Production of cyclooxygenase products and superoxide anion by macrophages in response to chemotactic factors. 1982 Prostaglandins pmid:6300969
Levy-Toledano S et al. Human platelet activation in the absence of aggregation: a calcium-dependent phenomenon independent of thromboxane formation. 1982 Blood pmid:6803854
Rettkowski W et al. Studies of the influence of nitroglycerin on the synthesis of prostaglandins and thromboxane A2 and on platelet aggregation. 1982 Arzneimittelforschung pmid:6805480
Panossian A et al. On the mechanism of biosynthesis of leukotrienes and related compounds. 1982 FEBS Lett. pmid:6297982
Michelassi F et al. Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. 1982 Science pmid:6808665
Bodzenta A et al. Platelet malondialdehyde and plasma thromboxane B2 formation in patients with obliterative arteriosclerosis of the lower limbs. 1982 Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. pmid:6188668
Pawlowski NA et al. Uptake and metabolism of monohydroxy-eicosatetraenoic acids by macrophages. 1982 J. Exp. Med. pmid:6951919
Nugent WC et al. Prostaglandin response to intravenous nitroglycerin. 1982 J. Surg. Res. pmid:6810023
Harada Y et al. Changes in the levels of prostaglandins and thromboxane and their roles in the accumulation of exudate in rat carrageenin-induced pleurisy--a profile analysis using gas chromatography-mass spectrometry. 1982 Prostaglandins pmid:6889754
Yoshimoto T and Yamamoto S Partial purification and assay of thromboxane A synthase from bovine platelets. 1982 Meth. Enzymol. pmid:6890138
Tai HH Assay of thromboxane A synthase inhibitors. 1982 Meth. Enzymol. pmid:6890139
Scherhag R et al. Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. 1982 Prostaglandins pmid:6285420
Watkins WD et al. Thromboxane and prostacyclin changes during cardiopulmonary bypass with and without pulsatile flow. 1982 J. Thorac. Cardiovasc. Surg. pmid:6980332
Malemud CJ et al. Correlation of the biosynthesis of prostaglandin and cyclic AMP in monolayer cultures of rabbit articular chondrocytes. 1982 Biochim. Biophys. Acta pmid:6280776
Robinson C et al. Thromboxane B2 uptake and metabolism in isolated perfused lung. Identification and comparison with prostaglandin F2 alpha. 1982 Biochim. Biophys. Acta pmid:6751406
Schafer AI et al. Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets. 1982 Biochim. Biophys. Acta pmid:6812645
Xiu RJ et al. Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock. 1982 JAMA pmid:7057538
Kelton JG et al. Sex related differences in platelet function: the effect of aspirin. 1982 Blood pmid:7059670
Ylikorkala O et al. The effect of oral contraceptives on antiaggregatory prostacyclin and proaggregatory thromboxane A2 in humans. 1982 Am. J. Obstet. Gynecol. pmid:7036746