Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Raz A and Aharony D | Prostaglandin biosynthesis in platelets: demonstration and role of prostaglandin H2 leads to E2 isomerase. | 1978 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:705027 |
Chang WC et al. | Inhibition of thromboxane B2 and 6-ketoprostaglandin F1 alpha formation by anti-inflammatory drugs in carrageenin-induced granuloma. | 1978 | Biochem. Pharmacol. | pmid:619892 |
Goetzl EJ and Gorman RR | Chemotactic and chemokinetic stimulation of human eosinophil and neutrophil polymorphonuclear leukocytes by 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). | 1978 | J. Immunol. | pmid:621391 |
Lagarde M et al. | Impairment of platelet thromboxane A2 generation and of the platelet release reaction in two patients with congenital deficiency of platelet cyclo-oxygenase. | 1978 | Br. J. Haematol. | pmid:205238 |
Crawford A et al. | Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity. | 1978 | Biochem. Biophys. Res. Commun. | pmid:212039 |
Boura AL and Murphy RD | Thromboxane B2 inhibits prostaglandin E2 inactivation by the rat isolated perfused lung. | 1978 Jul-Aug | Clin. Exp. Pharmacol. Physiol. | pmid:699382 |
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Friedman LS et al. | Cardiovascular and pulmonary effects of thromboxane B2 in the dog. | 1979 | Circ. Res. | pmid:428069 |
Ciabattoni G et al. | Characterization of furosemide-induced activation of the renal prostaglandin system. | 1979 | Eur. J. Pharmacol. | pmid:393525 |
Svensson J | Structure and quantitative determination of the major urinary metabolite of thromboxane B2 in the guinea pig. | 1979 | Prostaglandins | pmid:472333 |
Langs DA et al. | Thromboxane molecules do not adopt the prostaglandin hairpin conformation. | 1979 | Nature | pmid:481594 |
Jonsson CE et al. | Prostaglandins and thromboxanes in burn injury in man. | 1979 | Scand J Plast Reconstr Surg | pmid:451477 |
Bailey JM et al. | Anti-inflammatory drugs in experimental atherosclerosis. Part 4. Inhibition of atherosclerosis in vivo and thromboxane synthesis and platelet aggregation in vitro. | 1979 | Atherosclerosis | pmid:454516 |
Taylor L et al. | Prostaglandin production by type II alveolar epithelial cells. | 1979 | Biochim. Biophys. Acta | pmid:435506 |
Folkert VW and Schlondorff D | Prostaglandin synthesis in isolated glomeruli. | 1979 | Prostaglandins | pmid:441427 |
Parker CW et al. | Formation of thromboxane B2 and hydroxyarachidonic acids in purified human lymphocytes in the presence and absence of PHA. | 1979 | J. Immunol. | pmid:448099 |
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de Deckere EA et al. | Influence of type of dietary fat on the prostaglandin release from isolated rabbit and rat hearts and from rat aortas. | 1979 | Prostaglandins | pmid:504696 |
Russell NH et al. | Thrombocytopathy in preleukaemia: association with a defect of thromboxane A2 activity. | 1979 | Br. J. Haematol. | pmid:570847 |
Anhut H et al. | Prostaglandin D2 is the prevailing prostaglandin in the acute inflammatory exudate of urate arthritis in the chicken. | 1979 | Br. J. Pharmacol. | pmid:570865 |
Lewy RI et al. | Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina. | 1979 | Prostaglandins Med | pmid:575861 |
Ohuchi K et al. | Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. | 1979 | Prostaglandins Med | pmid:583576 |
Daniel EE et al. | Prostaglandins and myogenic control of tension in lower esophageal sphincter in vitro. | 1979 | Prostaglandins | pmid:379920 |
Russell FA and Deykin D | The use of high pressure liquid chromatography (HPLC) for the separation of radiolabeled arachidonic acid and its metabolities produced by thrombin-treated human platelets. I. The validation of the technique. | 1979 | Prostaglandins | pmid:523671 |
Roberts LJ et al. | Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. | 1979 | Biochim. Biophys. Acta | pmid:389290 |
Dutilh CE et al. | Study of the two pathways for arachidonate oxygenation in blood platelets. | 1979 | Lipids | pmid:34075 |
Robak J and Kasperczyk H | [Prostaglandin synthetase components (author's transl)]. | 1979 | Postepy Biochem. | pmid:120943 |
Tremoli E et al. | Platelet thromboxanes and serum-cholesterol. | 1979 | Lancet | pmid:84115 |
Makheia AN et al. | Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic. | 1979 | Lancet | pmid:86023 |
Lewy RI et al. | Intravenous heparin initiates in-vivo synthesis and release of thromboxane in angina pectoris. | 1979 | Lancet | pmid:87990 |
Güllner HG et al. | Prostacyclin overproduction in Bartter's syndrome. | 1979 | Lancet | pmid:90861 |
Davis TM et al. | Prostacyclin and thromboxane metabolites in diabetes. | 1979 | Lancet | pmid:90875 |
Best L et al. | Effect of glucose on platelet thromboxane biosynthesis. | 1979 | Lancet | pmid:90876 |
Jarabak J and Fried J | Comparison of substrate specificities of the human placental NAD- and NADP-linked 15-hydroxyprostaglandin dehydrogenases. | 1979 | Prostaglandins | pmid:42948 |
Miura Y and Fukui N | Prostaglandins as possible triggers for liver regeneration after partial hepatectomy. A review. | 1979 | Cell Mol Biol Incl Cyto Enzymol | pmid:44483 |
Ford-Hutchinson AW et al. | The aggregation of rat neutrophils by arachidonic acid: a possible bioassay for lipoxygenase activity. | 1979 | J. Pharm. Pharmacol. | pmid:43380 |
Dembińska-Kièć A et al. | Prostacyclin-dependent differences in TXA2 formation by platelets from normal and atherosclerotic rabbits. | 1979 | Atherosclerosis | pmid:224890 |
Fitzpatrick FA and Gorman RR | Regulatory role of cyclic adenosine 3',5'-monophosphate on the platelet cyclooxygenase and platelet function. | 1979 | Biochim. Biophys. Acta | pmid:216415 |
Best LC et al. | Mode of action of dipyridamole on human platelets. | 1979 | Thromb. Res. | pmid:229583 |
Marcus AJ | The role of prostaglandins in platelet function. | 1979 | Prog Hematol | pmid:230534 |
Spagnuolo C et al. | PGF2 alpha, thromboxane B2 and HETE levels in gerbil brain cortex after ligation of common carotid arteries and decapitation. | 1979 | Prostaglandins | pmid:230539 |
Jonsson CE et al. | Efflux of cyclic AMP, prostaglandin E2 and F2 alpha and thromboxane B2 in leg lymph of rabbits after scalding injury. | 1979 | Acta Physiol. Scand. | pmid:232367 |
Karmazyn M and Dhalla NS | Thromboxane B2: a cardiodepressant of isolated rat hearts and inhibitor of sarcolemma Na+ - K+ stimulated ATPase activity. | 1979 | Prostaglandins Med | pmid:233217 |
Hassid A et al. | Prostaglandin synthesis in isolated rat kidney glomeruli. | 1979 | Proc. Natl. Acad. Sci. U.S.A. | pmid:286300 |
Le Breton GC et al. | 13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor. | 1979 | Proc. Natl. Acad. Sci. U.S.A. | pmid:291066 |
Chignard M et al. | Arachidonate-mediated bronchoconstriction and platelet activation are inhibited by microgram doses of compound L8027 which are not selective for thromboxane synthetase. | 1979 | Agents Actions Suppl. | pmid:291306 |
Peskar BA and Holland A | Plasma levels of immunoreactive 15-keto-13,14-dihydro-thromboxane B2 in guinea pigs during anaphylaxis and after histamine injection. | 1979 | Agents Actions Suppl. | pmid:294148 |