Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Fletcher MS et al. | Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice. | 1982 | Br J Surg | pmid:6751458 |
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Axelrod L and Levine L | Plasma prostaglandin levels in rats with diabetes mellitus and diabetic ketoacidosis. | 1982 | Diabetes | pmid:6816644 |
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Strano A et al. | Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. | 1982 | Thromb. Haemost. | pmid:6753232 |
Numano F et al. | Effects of thromboxane A2 injection on the rabbit coronary artery. II. The production of infarcts in cholesterol-fed animals. | 1982 | Exp. Mol. Pathol. | pmid:6956517 |
Flynn JT and Demling RH | Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. | 1982 | Adv Shock Res | pmid:6753534 |
Vlodavsky I et al. | Platelet interaction with the extracellular matrix produced by cultured endothelial cells: a model to study the thrombogenicity of isolated subendothelial basal lamina. | 1982 | Thromb. Res. | pmid:7179215 |
Grundfest CC et al. | Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism. | 1982 | Biochim. Biophys. Acta | pmid:6814492 |
Smith MC et al. | Prostacyclin substitution for heparin in long-term hemodialysis. | 1982 | Am. J. Med. | pmid:6753575 |
Deby-Dupont G et al. | Release of thromboxane B2 during adult respiratory distress syndrome and its inhibition by non steroidal anti-inflammatory substances in man. | 1982 | Arch Int Pharmacodyn Ther | pmid:7181589 |
Aharony D et al. | Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid. | 1982 | Biochim. Biophys. Acta | pmid:6814496 |
Ylikorkala O et al. | Prostacyclin and thromboxane in chronic uremia: effect of hemodialysis. | 1982 | Clin. Nephrol. | pmid:6754193 |
Shohami E et al. | [Thromboxane in rat brain following incomplete ischemia]. | 1982 | Harefuah | pmid:7182317 |
Ylikorkala O et al. | Production of prostacyclin and thromboxane during cesarean section. | 1982 | Obstet Gynecol | pmid:6755324 |
Utsunomiya T et al. | Modification of inflammatory response to aspiration with ibuprofen. | 1982 | Am. J. Physiol. | pmid:6756172 |
Hamasaki Y et al. | Hypoxia stimulates prostacyclin generation by dog lung in vitro. | 1982 | Prostaglandins Leukot Med | pmid:7051045 |
Tooke JE et al. | Aspirin, prostacyclin and post-occlusive reactive hyperaemia in man. | 1982 | Prostaglandins Leukot Med | pmid:6757966 |
Herman CA et al. | Prostaglandins of the one, two, and three series affect blood pressure in the american bullfrog, Rana catesbeiana. | 1982 | Gen. Comp. Endocrinol. | pmid:6761235 |
Davì G et al. | Thromboxane B2 formation and platelet sensitivity to prostacyclin in insulin-dependent and insulin-independent diabetics. | 1982 | Thromb. Res. | pmid:6761893 |
Goldsmith JC and Needleman SW | A comparative study of thromboxane and prostacyclin release from ex vivo and cultured bovine vascular endothelium. | 1982 | Prostaglandins | pmid:6815717 |
Mitrovic D et al. | The in vitro production of prostanoids by cultured bovine articular chondrocytes. | 1982 | Prostaglandins | pmid:6801735 |
Hornych A et al. | Radioimmunoassay measurement of thromboxane B2 in human plasma and urine. | 1982 | Prostaglandins Leukot Med | pmid:6954551 |
Mest HJ et al. | Influence of mental stress on plasma level of prostaglandins, thromboxane B2 and on circulating platelet aggregates in man. | 1982 | Prostaglandins Leukot Med | pmid:6955811 |
Karmali RA et al. | Macrophage production of prostaglandins: effects of fetal calf serum and diazepam. Use of an improved method for extracting 6-keto-PGF1 alpha. | 1982 | Prostaglandins Leukot Med | pmid:6955812 |
Mehta J et al. | Severe intracoronary thromboxane release preceding acute coronary artery occlusion. | 1982 | Prostaglandins Leukot Med | pmid:6955814 |
Numano F et al. | Changes in the plasma levels of thromboxane B2 and cyclic nucleotides in patients with Takayasu disease. | 1982 | Jpn. Circ. J. | pmid:6119373 |
Foegh ML et al. | Aspirin inhibition of thromboxane release in thrombosis and renal transplant rejection. | 1982 | Lancet | pmid:6119441 |
Graham RM et al. | Effects of short-term beta blockade on blood pressure, plasma thromboxane B2, and plasma and urinary prostaglandins E2 and F2 alpha in normal subjects. | 1982 | Clin. Pharmacol. Ther. | pmid:6120775 |
Krishnamurthi S et al. | Effect of pyridoxal 5'-phosphate (PALP) on human platelet aggregation, dense granule release and thromboxane B2 generation--role of Schiff base formation. | 1982 | Thromb. Haemost. | pmid:6891107 |
Reines HD et al. | Plasma thromboxane concentrations are raised in patients dying with septic shock. | 1982 | Lancet | pmid:6123885 |
Hall ER et al. | The reduction of platelet thrombi on damaged vessel wall by a thromboxane synthetase inhibitor in rabbits. | 1982 | Thromb. Res. | pmid:6891109 |
White JG and Rao GH | Effects of a microtubule stabilizing agent on the response of platelets to vincristine. | 1982 | Blood | pmid:6124288 |
Davì G et al. | [Effects of flurbiprofen on the platelet function in patients with ischemic cardiopathy]. | 1982 | Cardiologia | pmid:6892383 |
De Caterina R et al. | [Effects of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. | 1982 | Cardiologia | pmid:6892461 |
Ody C et al. | 6-Ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and thromboxane B2 production by endothelial cells, smooth muscle cells and fibroblasts cultured from piglet aorta. | 1982 | Biochim. Biophys. Acta | pmid:6214281 |
Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
Goldyne ME and Stobo JD | Human monocytes synthesize eicosanoids from T lymphocyte-derived arachidonic acid. | 1982 | Prostaglandins | pmid:6819603 |
Rock JA et al. | Cul-de-sac fluid in women with endometriosis: fluid volume and prostanoid concentration during the proliferative phase of the cycle--days 8 to 12. | 1982 | Fertil. Steril. | pmid:6953017 |
de Boer AC et al. | Platelet release and thromboxane synthesis in symptomatic coronary artery disease. | 1982 | Circulation | pmid:6212161 |
Mari D et al. | Coagulation and platelet activation after retinal vein occlusions. | 1982 | Haemostasis | pmid:6215293 |
de Clerck F et al. | Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist. | 1982 | Agents Actions | pmid:6215842 |
Mehta J and Mehta P | Effects of propranolol therapy on platelet release and prostaglandin generation in patients with coronary heart disease. | 1982 | Circulation | pmid:6216027 |
Uderman HD et al. | Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone. | 1982 | Prostaglandins | pmid:6897296 |
Katsumata M et al. | Diphenylhydantoin: an alternative ligand of a glucocorticoid receptor affecting prostaglandin generation in A/J mice. | 1982 | Science | pmid:6897299 |
Mehta P et al. | Thromboxane and prostacyclin generation by intact human vessels in response to balloon catheter trauma. | 1982 | Prostaglandins Leukot Med | pmid:6217465 |
Koyama I et al. | [Production of 6-keto-prostaglandin F1 alpha and thromboxane B2 in mouse peritoneal macrophages during preparation of the cells]. | 1982 | Yakugaku Zasshi | pmid:6897423 |
Wilson L et al. | Alterations in reproductive tissue prostaglandins E and F, 6-keto-prostaglandin F1 alpha and thromboxane B2 with gestational age in the rat. | 1982 | Biol. Reprod. | pmid:6897617 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). | 1982 | Thromb. Res. | pmid:6897751 |
De Caterina R et al. | [Effect of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. | 1982 | Cardiologia | pmid:6927441 |
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Whinnery MA et al. | Thromboxane B2 and prostaglandin E2 in the rat kidney with unilateral ureteral obstruction. | 1982 | Am. J. Physiol. | pmid:6950670 |
Hwang DH and Donovan J | In vitro and in vivo effects of vitamin E on arachidonic acid metabolism in rat platelets. | 1982 | J. Nutr. | pmid:6806455 |
Hornych A et al. | [Urinary thromboxane B2 in hypertensive patients]. | 1982 | Arch Mal Coeur Vaiss | pmid:6810812 |
Worthington RE and Nakeff A | Aspirin inhibits rat megakaryocyte thromboxane synthesis. | 1982 | Prostaglandins | pmid:6812167 |
Havill AM et al. | alpha-Naphthylthiourea produces dose-dependent lung vascular injury in sheep. | 1982 | Am. J. Physiol. | pmid:6812437 |
Preston FE et al. | Low-dose aspirin inhibits platelet and venous cyclo-oxygenase in man. | 1982 | Thromb. Res. | pmid:6815823 |
Burch RM and Halushka PV | Vasopressin stimulates prostaglandin and thromboxane synthesis in toad bladder epithelial cells. | 1982 | Am. J. Physiol. | pmid:6816073 |
Bakhle YS and Zakrzewski JT | Effects of the oestrous cycle on the metabolism of arachidonic acid in rat isolated lung. | 1982 | J. Physiol. (Lond.) | pmid:6809935 |
Steel LK and Catravas GN | Radiation-induced changes in production of prostaglandins F2 alpha, E, and thromboxane B2 in guinea pig parenchymal lung tissues. | 1982 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:6818175 |
Meydani SN and Dupont J | Effect of zinc deficiency on prostaglandin synthesis in different organs of the rat. | 1982 | J. Nutr. | pmid:7045297 |
Neri Serheri GG et al. | Platelet aggregation and thromboxane A2 production after adrenergic stimulation in young healthy humans. | 1982 | Haemostasis | pmid:6279476 |
Dore-Duffy P | Differential effect of prostaglandins and other products of arachidonic acid metabolism on measles virus replication in Vero cells. | 1982 | Prostaglandins Leukot Med | pmid:6281810 |
Miller OV et al. | Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. | 1982 | Biochim. Biophys. Acta | pmid:6285985 |
Jackson CA et al. | Relationship between platelet aggregation, thromboxane synthesis and albumin concentration in nephrotic syndrome. | 1982 | Br. J. Haematol. | pmid:6810912 |
Levy-Toledano S et al. | Human platelet activation in the absence of aggregation: a calcium-dependent phenomenon independent of thromboxane formation. | 1982 | Blood | pmid:6803854 |
Rettkowski W et al. | Studies of the influence of nitroglycerin on the synthesis of prostaglandins and thromboxane A2 and on platelet aggregation. | 1982 | Arzneimittelforschung | pmid:6805480 |
Michelassi F et al. | Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. | 1982 | Science | pmid:6808665 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane formation by platelets and vascular prostacyclin production from BB rats. An animal model for type I diabetes. | 1982 | Prostaglandins | pmid:6812171 |
Nugent WC et al. | Prostaglandin response to intravenous nitroglycerin. | 1982 | J. Surg. Res. | pmid:6810023 |
Miller JL et al. | Arachidonic acid metabolism in guinea pig megakaryocytes. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6812584 |
Tai HH | Assay of thromboxane A synthase inhibitors. | 1982 | Meth. Enzymol. | pmid:6890139 |
Rothberg KG and Hitchcock M | In vitro biosynthesis of cyclooxygenase metabolites in ovalbumin-sensitized and control lungs of guinea pigs. | 1982 | Biochem. Pharmacol. | pmid:6812589 |
Watkins WD et al. | Thromboxane and prostacyclin changes during cardiopulmonary bypass with and without pulsatile flow. | 1982 | J. Thorac. Cardiovasc. Surg. | pmid:6980332 |
Robinson C et al. | Thromboxane B2 uptake and metabolism in isolated perfused lung. Identification and comparison with prostaglandin F2 alpha. | 1982 | Biochim. Biophys. Acta | pmid:6751406 |
Schafer AI et al. | Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6812645 |
Xiu RJ et al. | Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock. | 1982 | JAMA | pmid:7057538 |
Kelton JG et al. | Sex related differences in platelet function: the effect of aspirin. | 1982 | Blood | pmid:7059670 |
Ylikorkala O et al. | The effect of oral contraceptives on antiaggregatory prostacyclin and proaggregatory thromboxane A2 in humans. | 1982 | Am. J. Obstet. Gynecol. | pmid:7036746 |