Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tsuruta LR et al. | Characterization of 11-dehydro-thromboxane B2 recombinant antibody obtained by phage display technology. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12628223 |
Tzanakakis GN et al. | The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis. | 2002 | Int J Gastrointest Cancer | pmid:12630766 |
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Yregård L et al. | Influence of local anaesthetics on inflammatory activity postburn. | 2003 | Burns | pmid:12781610 |
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Machin KL et al. | Pharmacodynamics of flunixin and ketoprofen in mallard ducks (Anas platyrhynchos). | 2001 | J. Zoo Wildl. Med. | pmid:12790425 |
Devillier P et al. | Activation of an epithelial neurokinin NK-1 receptor induces relaxation of rat trachea through release of prostaglandin E2. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1279160 |
Mentz P et al. | Interactions of prostanoids with the platelet activating factors. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1279731 |
Meune C et al. | Aspirin alters arterial function in patients with chronic heart failure treated with ACE inhibitors: a dose-mediated deleterious effect. | 2003 | Eur. J. Heart Fail. | pmid:12798824 |
von Aulock S et al. | Determination of the eicosanoid response to inflammatory stimuli in whole blood and its pharmacological modulation ex vivo. | 2003 | J. Immunol. Methods | pmid:12799039 |
Mohan CR et al. | Does iloprost mediate thromboxane activity and polymorphonuclear leukocyte sequestration in ischemic skeletal muscle? | 1992 Sep-Oct | J Cardiovasc Surg (Torino) | pmid:1280271 |
De La Cruz JP et al. | Differences in the effects of extended-release aspirin and plain-formulated aspirin on prostanoids and nitric oxide in healthy volunteers. | 2003 | Fundam Clin Pharmacol | pmid:12803576 |
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Davì G et al. | Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration. | 2003 | Circulation | pmid:12810609 |
Guyton K et al. | Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. | 2003 | Shock | pmid:12813370 |
Brunelleschi S et al. | Enhanced responsiveness of ovalbumin-sensitized guinea-pig alveolar macrophages to tachykinins. | 1992 | Br. J. Pharmacol. | pmid:1281723 |
Sartin JL et al. | Estradiol plus progesterone treatment modulates select elements of the proinflammatory cytokine cascade in steers: attenuated nitric oxide and thromboxane B2 production in endotoxemia. | 2003 | J. Anim. Sci. | pmid:12817503 |
Patrignani P et al. | Release of contracting autacoids by aortae of normal and atherosclerotic rabbits. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282972 |
Bode-Böger SM et al. | Endothelin release and shift in prostaglandin balance are involved in the modulation of vascular tone by recombinant erythropoietin. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282978 |
Montuschi P et al. | Exhaled leukotrienes and prostaglandins in COPD. | 2003 | Thorax | pmid:12832671 |
Reid G et al. | The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12835412 |
Li S et al. | [The experimental investigation on the preventive effects of API0134 against the re-occlusion of coronary arteries after therapeutic thrombolysis in dogs]. | 1999 | J. Tongji Med. Univ. | pmid:12840851 |
Ziser A et al. | Propofol does not induce pulmonary dysfunction in stressed endotoxic pigs receiving Intralipid. | 2003 | Crit. Care Med. | pmid:12847400 |
Castellani S et al. | Thromboxane inhibition improves renal perfusion and excretory function in severe congestive heart failure. | 2003 | J. Am. Coll. Cardiol. | pmid:12849673 |