Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
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Okamatsu S et al. | Effect of calcium channel blockers on arachidonate-induced sudden death in rabbits. | 1981 | Proc. Soc. Exp. Biol. Med. | pmid:6261265 |
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Ylikorkala O et al. | Increased prostacyclin and thromboxane production in man during cardiopulmonary bypass. | 1981 | J. Thorac. Cardiovasc. Surg. | pmid:7019583 |
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Parks WM et al. | Comparative effect of ibuprofen on endothelial and platelet prostaglandin synthesis. | 1981 | J. Pharmacol. Exp. Ther. | pmid:7026767 |
Roy AC et al. | Effect of intravenous infusion of OKY-1581 (sodium-(E)-3-[4-(3-pyridylmethyl)phenyl] -2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon. | 1981 | Prostaglandins Med | pmid:7029585 |
Roselló J et al. | Quantitative profiling of the metabolic cascade of arachidonic acid by capillary gas chromatography mass spectrometry. | 1981 | Biomed. Mass Spectrom. | pmid:7236862 |
Cook JA et al. | Sensitization of essential fatty acid-deficient rats to endotoxin by arachidonate pretreatment: role of thromboxane A2. | 1981 | Circ. Shock | pmid:7237685 |
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Mahoney DA et al. | Urinary thromboxane B2 on allograft rejection. | 1981 | Lancet | pmid:6118500 |
Allen JB et al. | Irradiation decreases vascular prostacyclin formation with no concomitant effect on platelet thromboxane production. | 1981 | Lancet | pmid:6118629 |
Stenson WF et al. | Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. | 1981 | Prostaglandins | pmid:6803301 |
Kelly KL and Laychock SG | Prostaglandin synthesis and metabolism in isolated pancreatic islets of the rat. | 1981 | Prostaglandins | pmid:6803305 |
Smith MC and Dunn MJ | Impaired platelet thromboxane production in renal failure. | 1981 | Nephron | pmid:7329487 |
Lagarde M et al. | Inhibition of thrombin-induced platelet arachidonic acid release by 15-hydroperoxy-arachidonic acid. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7259783 |
Livio M et al. | Differential effects of itanoxone--a new hypolipidemic and hypouricemic drug--on platelet and vascular prostaglandin generation in rats. | 1981 | Atherosclerosis | pmid:7259827 |
Sterin-Borda L et al. | Stimulating effect of thromboxane B2 on isolated rat atria. | 1981 | Experientia | pmid:7262286 |
Roberts LJ et al. | Metabolism of thromboxane B2 in man. Identification of twenty urinary metabolites. | 1981 | J. Biol. Chem. | pmid:7263660 |
Zijlstra FJ and Vincent JE | Contractile characteristics of the rat stomach strip and the rabbit aorta and mesenteric artery. | 1981 | J Pharmacol Methods | pmid:7265989 |
Gilani SH and Persaud TV | Embryopathic effects of thromboxane B2 in the chick. | 1981 | Prostaglandins Med | pmid:7267828 |
Anderson CB et al. | Thromboxane-B2 and renovascular resistance during hypothermic pulsatile perfusion. | 1981 | Transplant. Proc. | pmid:7268892 |
Hirsh PD et al. | Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. | 1981 | N. Engl. J. Med. | pmid:6894016 |
Allan G and Levi R | Thromboxane and prostacyclin release during cardiac immediate hypersensitivity reactions in vitro. | 1981 | J. Pharmacol. Exp. Ther. | pmid:6894166 |
Malemud CJ et al. | Prostaglandin biosynthesis by lapine articular chondrocytes in culture. | 1981 | Biochim. Biophys. Acta | pmid:6894251 |
Ohnishi H et al. | Effects of trapidil on thromboxane A2-induced aggregation of platelets, ischemic changes in heart and biosynthesis of thromboxane A2. | 1981 | Prostaglandins Med | pmid:6894333 |
Coker SJ et al. | Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias. | 1981 | Nature | pmid:6894485 |
Bishai I and Coceani F | Transformations of prostaglandin H2 in the cat brain. | 1981 | Biochim. Biophys. Acta | pmid:6894549 |
Sobel M et al. | Circulating platelet products in unstable angina pectoris. | 1981 | Circulation | pmid:6450001 |
Drake TS et al. | Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F1 alpha in endometriosis. | 1981 | Am. J. Obstet. Gynecol. | pmid:6894667 |
Seitz M et al. | The influence of synovial fluid from patients with rheumatoid arthritis on the proliferation of peripheral blood lymphocytes and the prostanoid release from monocytes. | 1981 | Agents Actions | pmid:7340450 |
Prancan A et al. | Platelet thromboxane production during endotoxin shock. | 1981 | Agents Actions | pmid:7340458 |
She HS et al. | Metabolism of prostaglandin endoperoxide by microsomes from cat lung. | 1981 | Prostaglandins | pmid:6894797 |
Agradi E et al. | In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. | 1981 | Prostaglandins | pmid:6794104 |
Russell NH et al. | Platelet adenine nucleotides and arachidonic acid metabolism in the myeloproliferative disorders. | 1981 | Thromb. Res. | pmid:6794179 |
Mezzano D et al. | Evidence that platelet buoyant density, but not size, correlates with platelet age in man. | 1981 | Am. J. Hematol. | pmid:7270546 |
Shaw JO | Effects of extracellular Ca2+ and the intracellular Ca2+ antagonist 8-(n,n-diethylamino)octyl-3,4,5-trimethoxybenzoate on rabbit platelet conversion of arachidonic acid into thromboxane. | 1981 | Prostaglandins | pmid:6789402 |
Ingerman-Wojenski C et al. | Prostacyclin production in rabbit arteries in situ: inhibition by arachidonic acid-induced endothelial cell damage or by low-dose aspirin. | 1981 | Prostaglandins | pmid:6789404 |