| MeSH term | MeSH ID | Detail |
|---|---|---|
| Intracranial Hemorrhage, Hypertensive | D020299 | 1 associated lipids |
| Cholecystitis, Acute | D041881 | 1 associated lipids |
| Atrial Premature Complexes | D018880 | 1 associated lipids |
| Bluetongue | D001819 | 1 associated lipids |
| Gastric Dilatation | D013271 | 1 associated lipids |
| Latex Hypersensitivity | D020315 | 1 associated lipids |
| Stomach Volvulus | D013277 | 1 associated lipids |
| Foot Rot | D005535 | 1 associated lipids |
| Frostbite | D005627 | 1 associated lipids |
| Strongyle Infections, Equine | D013319 | 1 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| ChavarrÃa ME et al. | Prostacyclin/thromboxane early changes in pregnancies that are complicated by preeclampsia. | 2003 | Am. J. Obstet. Gynecol. | pmid:12712098 |
| Wang YP et al. | Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750461 |
| Wang YP et al. | The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal blood. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750462 |
| Myatt L et al. | Endothelin-1-induced vasoconstriction is not mediated by thromboxane release and action in the human fetal-placental circulation. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750466 |
| Markham SM et al. | The effect of the menstrual cycle and of decompression stress on arachidonic acid-induced platelet aggregation and on intrinsic platelet thromboxane production in women compared with men. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750481 |
| Walsh SW | Preeclampsia: an imbalance in placental prostacyclin and thromboxane production. | 1985 | Am. J. Obstet. Gynecol. | pmid:3923838 |
| Hauth JC et al. | Low-dose aspirin therapy to prevent preeclampsia. | 1993 | Am. J. Obstet. Gynecol. | pmid:8475955 |
| Keith JC et al. | Beneficial effects of U-63,557A, a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension. | 1987 | Am. J. Obstet. Gynecol. | pmid:3605254 |
| Ylikorkala O et al. | Maternal prostacyclin, thromboxane, and placental blood flow. | 1983 | Am. J. Obstet. Gynecol. | pmid:6338724 |
| Ylikorkala O et al. | Amniotic fluid prostacyclin and thromboxane in normal, preeclamptic, and some other complicated pregnancies. | 1981 | Am. J. Obstet. Gynecol. | pmid:6895277 |
| Nelson DM et al. | Hypoxia limits differentiation and up-regulates expression and activity of prostaglandin H synthase 2 in cultured trophoblast from term human placenta. | 1999 | Am. J. Obstet. Gynecol. | pmid:10203658 |
| Glance DG et al. | Prostaglandin production and stimulation by angiotensin II in the isolated perfused human placental cotyledon. | 1985 | Am. J. Obstet. Gynecol. | pmid:3855602 |
| Bergman A et al. | The role of prostaglandins in detrusor instability. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750483 |
| Hauth JC et al. | Maternal serum thromboxane B2 reduction versus pregnancy outcome in a low-dose aspirin trial. | 1995 | Am. J. Obstet. Gynecol. | pmid:7645637 |
| Spitz B et al. | Low-dose aspirin. I. Effect on angiotensin II pressor responses and blood prostaglandin concentrations in pregnant women sensitive to angiotensin II. | 1988 | Am. J. Obstet. Gynecol. | pmid:3189434 |
| Miller KW and Keith JC | Erythrocyte morphologic features and serum chemistry studies in ovine pregnancy-induced hypertension treated with thromboxane synthetase inhibitors. | 1988 | Am. J. Obstet. Gynecol. | pmid:3189458 |
| Jouppila P et al. | Ritodrine infusion during late pregnancy: effects on fetal and placental blood flow, prostacyclin, and thromboxane. | 1985 | Am. J. Obstet. Gynecol. | pmid:3885740 |
| Sørensen JD et al. | Effects of fish oil supplementation in the third trimester of pregnancy on prostacyclin and thromboxane production. | 1993 | Am. J. Obstet. Gynecol. | pmid:8456902 |
| Aune B et al. | Hormone replacement therapy reduces the reactivity of monocytes and platelets in whole blood--a beneficial effect on atherogenesis and thrombus formation? | 1995 | Am. J. Obstet. Gynecol. | pmid:8610768 |
| Hauth J et al. | Maternal serum thromboxane B2 concentrations do not predict improved outcomes in high-risk pregnancies in a low-dose aspirin trial. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medical Units. | 1998 | Am. J. Obstet. Gynecol. | pmid:9822499 |
| Kurki T et al. | Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin. | 1992 | Am. J. Obstet. Gynecol. | pmid:1733190 |
| Johnson RD et al. | Aspirin induces increased expression of both prostaglandin H synthase-1 and prostaglandin H synthase-2 in cultured human placental trophoblast. | 1997 | Am. J. Obstet. Gynecol. | pmid:9240586 |
| Kang IS et al. | Dose-related action of gonadotropin-releasing hormone on basal prostanoid production from the human term placenta. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750474 |
| Benigni A et al. | Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated? | 1985 | Am. J. Nephrol. | pmid:2996352 |
| Abdelwhab S and Elshinnawy S | Pulmonary hypertension in chronic renal failure patients. | 2008 | Am. J. Nephrol. | pmid:18635926 |
| Yang D et al. | Effects of short- and long-term hypercholesterolemia on contrast-induced acute kidney injury. | 2012 | Am. J. Nephrol. | pmid:22189165 |
| Shibasaki T et al. | Mizoribine reduces urinary protein excretion in rats given puromycin aminonucleoside. | 1996 | Am. J. Nephrol. | pmid:8919236 |
| Patrono C and Salvati P | Thromboxane biosynthesis and pharmacologic modulation in progressive glomerulosclerosis. | 1989 | Am. J. Nephrol. | pmid:2646922 |
| Deray G et al. | Effects of ciclosporin on plasma renin activity, catecholamines and prostaglandins in patients with idiopathic uveitis. | 1988 | Am. J. Nephrol. | pmid:3055993 |
| Piccirillo G et al. | High plasma concentrations of cortisol and thromboxane B2 in patients with depression. | 1994 | Am. J. Med. Sci. | pmid:8160715 |
| Oates JC et al. | Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis. | 2011 | Am. J. Med. Sci. | pmid:20924284 |
| Li JX et al. | Delayed thromboxane or tumor necrosis factor-alpha, but not leukotriene inhibition, attenuates prolonged pulmonary hypertension in endotoxemia. | 1995 | Am. J. Med. Sci. | pmid:7668305 |
| Shook LA et al. | Dimethylthiourea reverses sepsis-induced pulmonary hypertension in piglets. | 1990 | Am. J. Med. Sci. | pmid:2115294 |
| White RP et al. | Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus. | 1990 | Am. J. Med. Sci. | pmid:2321665 |
| Fukushima H et al. | Mechanisms underlying early development of pulmonary vascular obstructive disease in Down syndrome: An imbalance in biosynthesis of thromboxane A2 and prostacyclin. | 2010 | Am. J. Med. Genet. A | pmid:20583254 |
| Preston FE | Aspirin, prostaglandins, and peripheral gangrene. | 1983 | Am. J. Med. | pmid:6859070 |
| Van Solingen RM et al. | Comparison of the effects of ketoprofen on platelet function in the presence and absence of aspirin. | 2001 | Am. J. Med. | pmid:11566459 |
| Smith MC et al. | Prostacyclin substitution for heparin in long-term hemodialysis. | 1982 | Am. J. Med. | pmid:6753575 |
| Ehrlich HP | Promotion of vascular patency in dermal burns with ibuprofen. | 1984 | Am. J. Med. | pmid:6547810 |
| Barbui T et al. | Aspirin and risk of bleeding in patients with thrombocythemia. | 1987 | Am. J. Med. | pmid:3497579 |
| Magner P | Effects of sulindac on renal prostaglandins and glomerular filtration rate. | 1991 | Am. J. Med. | pmid:1867250 |
| Payno A et al. | Prostanoid production in post-gastrectomy gastritis. Influence of sucralfate. | 1989 | Am. J. Med. | pmid:2735331 |
| Shepherd HA et al. | Effect of sucralfate and cimetidine on rheumatoid patients with active gastroduodenal lesions who are taking nonsteroidal anti-inflammatory drugs. A pilot study. | 1989 | Am. J. Med. | pmid:2735335 |
| Patrono C and Pierucci A | Renal effects of nonsteroidal anti-inflammatory drugs in chronic glomerular disease. | 1986 | Am. J. Med. | pmid:3092667 |
| Halushka PV et al. | Studies on the beneficial effects of aspirin in endotoxic shock. Relationship to inhibition of arachidonic acid metabolism. | 1983 | Am. J. Med. | pmid:6687979 |
| Hakim RM and Schafer AI | Hemodialysis-associated platelet activation and thrombocytopenia. | 1985 | Am. J. Med. | pmid:3885730 |
| Maruyama T et al. | Thromboxane-dependent portopulmonary hypertension. | 2005 | Am. J. Med. | pmid:15639216 |
| Di Minno G et al. | Platelet dysfunction in uremia. Multifaceted defect partially corrected by dialysis. | 1985 | Am. J. Med. | pmid:3933340 |
| Hirsh PD et al. | Prostaglandins and ischemic heart disease. | 1981 | Am. J. Med. | pmid:7032286 |
| Macconi D et al. | Defective platelet aggregation in response to platelet-activating factor in uremia associated with low platelet thromboxane A2 generation. | 1992 | Am. J. Kidney Dis. | pmid:1562019 |
| Ingram AJ et al. | Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model. | 1995 | Am. J. Kidney Dis. | pmid:7847360 |
| Barcelli UO et al. | High linoleic acid diets ameliorate diabetic nephropathy in rats. | 1990 | Am. J. Kidney Dis. | pmid:2399916 |
| Gaspari F et al. | Influence of antacid administrations on aspirin absorption in patients with chronic renal failure on maintenance hemodialysis. | 1988 | Am. J. Kidney Dis. | pmid:3354570 |
| Francos GC et al. | Dialysis-induced hypoxemia: membrane dependent and membrane independent causes. | 1985 | Am. J. Kidney Dis. | pmid:3919574 |
| Clive DM et al. | Potassium homeostasis with indomethacin therapy in normal subjects. | 1992 | Am. J. Kidney Dis. | pmid:1739077 |
| Noris M et al. | Renal prostacyclin biosynthesis is reduced in children with hemolytic-uremic syndrome in the context of systemic platelet activation. | 1992 | Am. J. Kidney Dis. | pmid:1496967 |
| Sreedhara R et al. | Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIb-IIIa receptors. | 1996 | Am. J. Kidney Dis. | pmid:8604704 |
| Menè P et al. | Eicosanoid synthesis in peripheral blood monocytes: a marker of disease activity in lupus nephritis. | 1998 | Am. J. Kidney Dis. | pmid:9820447 |
| Cumming AD et al. | Vasoactive hormones in the renal response to systemic sepsis. | 1988 | Am. J. Kidney Dis. | pmid:3276170 |
| Viganò G et al. | Recombinant human erythropoietin to correct uremic bleeding. | 1991 | Am. J. Kidney Dis. | pmid:2063854 |
| Fitscha P et al. | Effects of isradipine on platelet function in hypertension at rest and during exercise. | 1991 | Am. J. Hypertens. | pmid:1827015 |
| Ooi BS et al. | Stimulation of endothelial cell production of vasoconstrictive substances by hypertensive sera. | 1998 | Am. J. Hypertens. | pmid:9524055 |
| Suzuki A et al. | Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats. | 2007 | Am. J. Hypertens. | pmid:17485012 |
| Nawarskas JJ et al. | Effect of aspirin on blood pressure in hypertensive patients taking enalapril or losartan. | 1999 | Am. J. Hypertens. | pmid:10480471 |
| Awad AS et al. | Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats. | 2005 | Am. J. Hypertens. | pmid:15831366 |
| Thakur V et al. | Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs. | 1999 | Am. J. Hypertens. | pmid:10509552 |
| Ganafa AA et al. | Amlodipine attenuates oxidative stress-induced hypertension. | 2004 | Am. J. Hypertens. | pmid:15363814 |
| Singh D et al. | Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets. | 1981 | Am. J. Hematol. | pmid:6274189 |
| Zaitsu M et al. | Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. | 2003 | Am. J. Hematol. | pmid:12555215 |
| Wu X et al. | Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma. | 2003 | Am. J. Hematol. | pmid:12949886 |
| Stuart MJ | Effect of endotoxin on arachidonic acid release and thromboxane B2 production by human platelets. | 1981 | Am. J. Hematol. | pmid:7030066 |
| Gross S and Worthington-White DA | The effects of PGF2 alpha, PGI2, and TxB2 on human CFU-C in healthy and leukemic patients. | 1984 | Am. J. Hematol. | pmid:6372442 |
| Meyers KM et al. | Evaluation of the platelet storage pool deficiency in the feline counterpart of the Chediak-Higashi syndrome. | 1981 | Am. J. Hematol. | pmid:7315839 |
| Horellou MH et al. | Familial and constitutional bleeding disorder due to platelet cyclo-oxygenase deficiency. | 1983 | Am. J. Hematol. | pmid:6404162 |
| Carvalho AC et al. | Platelet function in acute respiratory failure. | 1987 | Am. J. Hematol. | pmid:2956879 |
| Ryo R et al. | Deficiency of P62, a putative collagen receptor, in platelets from a patient with defective collagen-induced platelet aggregation. | 1992 | Am. J. Hematol. | pmid:1311144 |
| Jones CM et al. | Arachidonic acid metabolites produced by platelet-depleted human blood monocytes: a possible role in thrombogenesis. | 1989 | Am. J. Hematol. | pmid:2741910 |
| Antonucci R et al. | Enhancement of sickle erythrocyte adherence to endothelium by autologous platelets. | 1990 | Am. J. Hematol. | pmid:2109530 |
| Del Principe D et al. | Vitamin E consumption by human blood platelets activated by latex particles. | 1986 | Am. J. Hematol. | pmid:3953557 |
| Mezzano D et al. | Evidence that platelet buoyant density, but not size, correlates with platelet age in man. | 1981 | Am. J. Hematol. | pmid:7270546 |
| Suarez CR et al. | Neonatal and maternal platelets: activation at time of birth. | 1988 | Am. J. Hematol. | pmid:2972197 |
| Smock KJ and Rodgers GM | Laboratory evaluation of aspirin responsiveness. | 2010 | Am. J. Hematol. | pmid:20229592 |
| Hyman PE et al. | Enhanced urinary immunoreactive thromboxane in neonatal necrotizing enterocolitis. A diagnostic indicator of thrombotic activity. | 1987 | Am. J. Dis. Child. | pmid:2953236 |
| Hammerman C et al. | Hypoxic vs septic pulmonary hypertension. Selective role of thromboxane mediation. | 1988 | Am. J. Dis. Child. | pmid:3278589 |
| Gonzalez-Crussi F et al. | Prostaglandins in histiocytosis-X. PG synthesis by histiocytosis-X cells. | 1981 | Am. J. Clin. Pathol. | pmid:6970520 |
| Wander RC and Patton BD | Comparison of three species of fish consumed as part of a Western diet: effects on platelet fatty acids and function, hemostasis, and production of thromboxane. | 1991 | Am. J. Clin. Nutr. | pmid:1858697 |
| Stampfer MJ et al. | Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels. | 1988 | Am. J. Clin. Nutr. | pmid:3128100 |
| Salonen JT et al. | Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status. | 1991 | Am. J. Clin. Nutr. | pmid:1826987 |
| Wan Y et al. | Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. | 2001 | Am. J. Clin. Nutr. | pmid:11684527 |
| Prakash C et al. | Decreased systemic thromboxane A2 biosynthesis in normal human subjects fed a salmon-rich diet. | 1994 | Am. J. Clin. Nutr. | pmid:8074067 |
| Hayes KC et al. | Taurine modulates platelet aggregation in cats and humans. | 1989 | Am. J. Clin. Nutr. | pmid:2729158 |
| Delgado-Lista J et al. | Chronic dietary fat intake modifies the postprandial response of hemostatic markers to a single fatty test meal. | 2008 | Am. J. Clin. Nutr. | pmid:18258620 |
| Craig-Schmidt MC et al. | The essential fatty acid deficient chicken as a model for cystic fibrosis. | 1986 | Am. J. Clin. Nutr. | pmid:3466523 |
| Blair IA et al. | Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. | 1993 | Am. J. Clin. Nutr. | pmid:8424383 |
| Kwon JS et al. | Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. | 1991 | Am. J. Clin. Nutr. | pmid:1677525 |
| Qureshi AA et al. | Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). | 1991 | Am. J. Clin. Nutr. | pmid:2012010 |
| Qureshi AA et al. | Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, thromboxane B2, and platelet factor 4 in pigs with inherited hyperlipidemias. | 1991 | Am. J. Clin. Nutr. | pmid:2012015 |
| Blair IA et al. | Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects. | 1994 | Am. J. Clin. Nutr. | pmid:7977150 |
| McDonald BE et al. | Comparison of the effect of canola oil and sunflower oil on plasma lipids and lipoproteins and on in vivo thromboxane A2 and prostacyclin production in healthy young men. | 1989 | Am. J. Clin. Nutr. | pmid:2596428 |
| Freese R and Mutanen M | Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9280178 |