Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Abortion, Habitual D000026 5 associated lipids
Acidosis D000138 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Agranulocytosis D000380 7 associated lipids
Airway Obstruction D000402 13 associated lipids
Albuminuria D000419 18 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Anaphylaxis D000707 35 associated lipids
Anemia D000740 21 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Authors Title Published Journal PubMed Link
Yin K et al. Study of mechanisms of glucocorticoid hypertension in rats: endothelial related changes and their amelioration by dietary fish oils. 1992 Br. J. Pharmacol. pmid:1393269
Zhang JY and Luo LL [Intrauterine device-induced menorrhagia and endometrial content of prostacyclins]. 1992 Zhonghua Fu Chan Ke Za Zhi pmid:1395902
Wang M [Studies on plasma beta-thromboglobulin, thromboxane A2, prostaglandin I2 concentration and platelet count in liver diseases]. 1992 Zhonghua Nei Ke Za Zhi pmid:1395919
Mei XW et al. [The interaction of some active and immunological factors in blood in the development of chronic cor pulmonale]. 1992 Zhonghua Nei Ke Za Zhi pmid:1395928
Watson ED et al. Arachidonate metabolites in bronchoalveolar lavage fluid from horses with and without COPD. 1992 Equine Vet. J. pmid:1396512
Pretolani M et al. Inhibition by azelastine of the effects of platelet-activating factor in lungs from actively sensitised guinea-pigs. 1992 Eur. J. Pharmacol. pmid:1397002
Goldman G et al. Reactive oxygen species and elastase mediate lung permeability after acid aspiration. 1992 J. Appl. Physiol. pmid:1399982
Koizumi T et al. Effects of thromboxane synthase inhibition on tumor necrosis factor-induced lung injury in sheep. 1992 J. Appl. Physiol. pmid:1399989
Coffee KA et al. Endotoxin tolerance is associated with altered GTP-binding protein function. 1992 J. Appl. Physiol. pmid:1400011
Weber C et al. Gas chromatographic-mass spectrometric determination of 11-dehydrothromboxane B2 in human urine. 1992 J. Chromatogr. pmid:1400727
Abramson MM et al. Flurbiprofen effect on gingival crevicular fluid prostaglandin and thromboxane levels in humans. 1992 J. Periodont. Res. pmid:1403584
Altavilla D et al. Protective effects of endotoxin tolerance in tumor bearing rats. 1992 Pharmacol. Res. pmid:1409293
Ferretti A et al. GC/MS/MS quantification of 11-dehydrothromboxane B2 in human urine. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1409763
Stier CT et al. Enhanced thromboxane formation by blood but not whole platelets from spontaneously hypertensive rats. 1992 Prostaglandins pmid:1410518
Rabinovici R et al. Hemodynamic, hematologic and eicosanoid mediated mechanisms in 7.5 percent sodium chloride treatment of uncontrolled hemorrhagic shock. 1992 Surg Gynecol Obstet pmid:1411892
Husted SE et al. Intravenous acetylsalicylic acid--dose-related effects on platelet function and fibrinolysis in healthy males. 1992 Thromb. Haemost. pmid:1412171
Lin CH et al. HA-29: an inhibitor of thromboxane A2 formation with antagonism of thromboxane A2/prostaglandin endoperoxide receptor in rabbit platelets. 1992 Thromb. Res. pmid:1412184
Yue TL et al. Pharmacological profile of G619, a new platelet aggregation inhibitor. 1992 Thromb. Res. pmid:1412200
Tohgi H et al. Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin. 1992 Stroke pmid:1412574
Santillan-Doherty P et al. Urinary thromboxane B2 excretion during acute rejection in cyclosporine-treated experimental lung allotransplantation. 1992 Transplant. Proc. pmid:1412957
Atzori L et al. Vasoconstriction and bronchoconstriction induced by 2,5-di-(tert-butyl)1,4-benzohydroquinone, an endoplasmic reticular Ca2+-ATPase inhibitor, in isolated and perfused rat lung. 1992 Agents Actions pmid:1414686
Diss EM et al. Study of thromboxane and prostacyclin metabolism in an in vitro model of first-trimester human trophoblast. 1992 Am. J. Obstet. Gynecol. pmid:1415390
Wang Y et al. Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia. 1992 Am. J. Obstet. Gynecol. pmid:1415430
Martin SE et al. Neuropeptide Y and coronary vasoconstriction: role of thromboxane A2. 1992 Am. J. Physiol. pmid:1415751
Matsumoto M et al. Lung traction causes an increase in plasma prostacyclin concentration and decrease in mean arterial blood pressure. 1992 Anesth. Analg. pmid:1416133
Mistakopulo NF et al. [The effect of indomethacin and leukinferon on the level of blood plasma thromboxane B2, platelet aggregation and the immune system of patients with endometrial cancer in the perioperative period]. 1992 Mar-Apr Anesteziol Reanimatol pmid:1416192
Gershwin LJ and Giri SN Effects of allergen challenge on plasma concentrations of prostaglandins, thromboxane B2, and histamine in calves infected with bovine respiratory syncytial virus. 1992 Am. J. Vet. Res. pmid:1416375
Miller RF et al. Effect of sulfidopeptide leukotriene receptor antagonists on endotoxin-induced pulmonary dysfunction in awake sheep. 1992 Am. Rev. Respir. Dis. pmid:1416431
Lloret S and Moreno JJ In vitro and in vivo effects of the anti-inflammatory peptides, antiflammins. 1992 Biochem. Pharmacol. pmid:1417964
Beitz J et al. Influence of HDL on the formation of 6-keto-PGF1 alpha and TXB2 in vitro: the importance of the source of HDL. 1992 Eicosanoids pmid:1419081
Surya II et al. Enhancement of platelet functions by low density lipoproteins. 1992 Biochim. Biophys. Acta pmid:1420343
RÃ¥ngemark C et al. Tobacco use and urinary excretion of thromboxane A2 and prostacyclin metabolites in women stratified by age. 1992 Circulation pmid:1423963
Hui SC et al. Arachidonic acid metabolism in nicotine-treated rats and nicotine-incubated rabbit aortic smooth muscle cells. 1992 Clin. Exp. Pharmacol. Physiol. pmid:1424297
Hoshino H et al. Mechanism and prevention of chronic colonic inflammation with trinitrobenzene sulfonic acid in rats. 1992 Clin. Exp. Pharmacol. Physiol. pmid:1424301
Cagossi M et al. Effects of various prostaglandin synthesis inhibitors on the tone of the lower oesophageal sphincter in man. 1992 Eur. J. Clin. Pharmacol. pmid:1425897
Evangelista V et al. Inhibition by heparin of platelet activation induced by neutrophil-derived cathepsin G. 1992 Eur. J. Pharmacol. pmid:1425930
Chen MF et al. Effects of dietary supplementation with fish oil on prostanoid metabolism during acute coronary occlusion with or without reperfusion in diet-induced hypercholesterolemic rabbits. 1992 Int. J. Cardiol. pmid:1428263
Brenner T et al. Glucocorticoid regulation of eicosanoid production by glial cells under basal and stimulated conditions. 1992 J. Neuroimmunol. pmid:1430157
Kunievsky B and Yavin E Platelet-activating factor stimulates arachidonic acid release and enhances thromboxane B2 production in intact fetal rat brain ex vivo. 1992 J. Pharmacol. Exp. Ther. pmid:1432689
Soma LR et al. Plasma concentrations of flunixin in the horse: its relationship to thromboxane B2 production. 1992 J. Vet. Pharmacol. Ther. pmid:1433493
Hattori T et al. Studies on the antinephritic effect of plant components (4): Reduction of protein excretion by berberine and coptisine in rats with original-type anti-GBM nephritis. 1992 Jpn. J. Pharmacol. pmid:1434112
Wagner B et al. Studies on the effect of two angiotensin-converting enzyme inhibitors, captopril and cilazapril, on platelet and vascular prostaglandin metabolism in vivo. 1992 Naunyn Schmiedebergs Arch. Pharmacol. pmid:1436129
Nadasy GL et al. Pharmacological modulation of prostacyclin and thromboxane production of rat and cat venous tissue slices. 1992 Prostaglandins pmid:1438884
Weide I et al. Effects of cyclooxygenase inhibitors on ex vivo cysteinyl-leukotriene production by whole human blood allowed to clot spontaneously. Comparison to stimulated blood. 1992 Thromb. Res. pmid:1440511
Sirén AL et al. Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats. 1992 Stroke pmid:1440713
Halt PS et al. Alcohol exacerbates behavioral and neurochemical effects of rat spinal cord trauma. 1992 Arch. Neurol. pmid:1444885
Kawada T et al. Pretreatment with catalase or dimethyl sulfoxide protects alloxan-induced acute lung edema in dogs. 1992 J. Appl. Physiol. pmid:1447076
Udvardy M et al. Altered primary haemostasis in Conn's syndrome. 1992 Thromb. Res. pmid:1448795
Rasmanis G et al. Evidence of increased platelet activation after thrombolysis in patients with acute myocardial infarction. 1992 Br Heart J pmid:1449919
Szebeni J et al. Complement activation during hemorrhagic shock and resuscitation in swine. 2003 Shock pmid:14501949
Kiberd BA The functional and structural changes of the glomerulus throughout the course of murine lupus nephritis. 1992 J. Am. Soc. Nephrol. pmid:1450369
Fujii S et al. L-arginine reverses p47phox and gp91phox expression induced by high salt in Dahl rats. 2003 Hypertension pmid:14504257
Vani G et al. Histone H1 modulates immune status in experimental breast cancer. 2003 Chemotherapy pmid:14504437
Tanaka Y et al. Effects of exercise on platelet and aortic functions in aged rats. 2003 Acta Physiol. Scand. pmid:14510779
Rossoni G et al. Nitric oxide-releasing aspirin inhibits vasoconstriction in perfused tail artery of normotensive and spontaneously hypertensive rats. 2003 Eur. J. Pharmacol. pmid:14512099
Beck-Speier I et al. Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. 2003 Prostaglandins Other Lipid Mediat. pmid:14518563
Takase B et al. Effect of diltiazem on silent ischemic episodes, plasma bradykinin and prostaglandin metabolism. 1992 Int. J. Cardiol. pmid:1452374
Peng W et al. Effects of sustained ligustrazine on hemorrheology in patients with chronic pulmonary heart disease. 1992 J. Tongji Med. Univ. pmid:1453503
Rota S et al. Methylprednisolone dosage effects on peripheral lymphocyte subpopulations and eicosanoid synthesis. 1992 Kidney Int. pmid:1453591
Li JS et al. [Change in intestinal free radical and prostaglandin metabolism in the aged rats with pneumococcus pneumonia]. 2003 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:14552688
Dotevall A et al. Cigarette smoking increases thromboxane A2 formation without affecting platelet survival in young healthy females. 1992 Thromb. Haemost. pmid:1455405
Kivioja A et al. Platelet activation during acute phase after multiple trauma. 1992 Ann Chir Gynaecol pmid:1456710
Pearl JM et al. Leukocyte-depleted reperfusion of transplanted human hearts: a randomized, double-blind clinical trial. 1992 Nov-Dec J. Heart Lung Transplant. pmid:1457432
Wolfram RM et al. Narghile (water pipe) smoking influences platelet function and (iso-)eicosanoids. 2003 Life Sci. pmid:14575812
Nagano H et al. Effects of a human urinary kininogenase (SK-827) on cerebral microcirculation after glass bead-induced cerebral embolism in rabbits. 1992 Sep-Oct In Vivo pmid:1457742
Chouinard ML et al. Pharmacokinetics and biochemical efficacy of pirmagrel, a thromboxane synthase inhibitor, in renal allograft recipients. 1992 Clin. Pharmacol. Ther. pmid:1458769
Resnick DK et al. Regional and temporal changes in prostaglandin E2 and thromboxane B2 concentrations after spinal cord injury. 2001 Nov-Dec Spine J pmid:14588301
Resnick DK et al. Selective cyclooxygenase 2 inhibition lowers spinal cord prostaglandin concentrations after injury. 2001 Nov-Dec Spine J pmid:14588302
Kankuri E et al. Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro. 2003 Thromb. Res. pmid:14592552
Zhang C et al. Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. 2003 J. Hypertens. pmid:14597858
Wang ZF et al. The role of inflammatory mediators in severe acute pancreatitis and regulation of glucocorticoids. 2003 HBPD INT pmid:14599960
De León EJ et al. A new chloroquinolinyl chalcone derivative as inhibitor of inflammatory and immune response in mice and rats. 2003 J. Pharm. Pharmacol. pmid:14604476
Tanaka S et al. High dose of inhaled fluticasone reduces high levels of urinary leukotriene E4 in the early morning in mild and moderate nocturnal asthma. 2003 Chest pmid:14605047
Dong WG et al. Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats. 2003 World J. Gastroenterol. pmid:14606091
von Aulock S et al. Granulocyte colony-stimulating factor (filgrastim) treatment primes for increased ex vivo inducible prostanoid release. 2004 J. Pharmacol. Exp. Ther. pmid:14610236
Yokoyama Y et al. Role of thromboxane in producing portal hypertension following trauma-hemorrhage. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:14613921
Grekas D et al. Acute cyclosporin A renal dysfunction in dogs reversed by calcium antagonists and antiplatelet agents. 1992 Ren Fail pmid:1462000
Ohsaki S et al. Effect of prostaglandin E1 on graft function of kidneys from living related donors. 1992 Transpl. Int. pmid:14621746
Schütz A et al. Allogeneic heart transplantation following xenogeneic bridging. 1992 Transpl. Int. pmid:14621808
Yamada K et al. New morphological changes induced by FK506 in a short period in the rat kidney and the effect of superoxide dismutase and OKY-046 on THEM: the relationship of FK506 nephrotoxicity to lipid peroxidation and change in production of thromboxane A2 in the kidney. 1992 Transpl. Int. pmid:14621878
Mennander A et al. Chronic rejection of rat aortic allografts: effect of inhibition of the thromboxane cascade. 1992 Transpl. Int. pmid:14621882
Lyck F et al. [Thrombocyte aggregation and serum thromboxane B2 in patients with unstable angina pectoris treated with diltiazem or verapamil]. 1992 Ugeskr. Laeg. pmid:1462402
Tsipas G and Morphake P Beneficial effects of a diet rich in a mixture of n - 6/n - 3 essential fatty acids and of their metabolites on cyclosporine - nephrotoxicity. 2003 J. Nutr. Biochem. pmid:14629893
Moriguchi A et al. Antithrombotic effects of FK419, a novel nonpeptide platelet GPIIb/IIIa antagonist, in a guinea pig photochemically induced middle cerebral artery thrombosis model: comparison with ozagrel and argatroban. 2004 J. Pharmacol. Exp. Ther. pmid:14634048
Yi H et al. [Protective effect of selective cyclooxygenase-2 inhibitor on alcohol-induced liver injury in rats]. 2003 Zhonghua Gan Zang Bing Za Zhi pmid:14636441
Terres W et al. Prevalence and mechanism of streptokinase-induced platelet stimulation. Effect of acetylsalicylic acid. 1992 Eur. Heart J. pmid:1464340
De Keijzer MH and Provoost AP Effect of protein intake and unilateral nephrectomy on renal function and eicosanoid excretion in rats. 1992 Miner Electrolyte Metab pmid:1465043
Eder K et al. Conjugated linoleic acids lower the release of eicosanoids and nitric oxide from human aortic endothelial cells. 2003 J. Nutr. pmid:14652352
Minuz P et al. Determinants of platelet activation in human essential hypertension. 2004 Hypertension pmid:14656953
Petric R et al. Amelioration of experimental cyclosporine nephrotoxicity by calcium channel inhibition. 1992 Transplantation pmid:1465778
Eldar M et al. Bradykinin level in the great cardiac vein during balloon angioplasty of the left anterior descending coronary artery. 1992 Am. J. Cardiol. pmid:1466338
Xia Z et al. Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin-1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease. 2003 J. Thorac. Cardiovasc. Surg. pmid:14666012
Böhm E et al. 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. 2004 J. Biol. Chem. pmid:14668348
Arrebola MM et al. In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesis. 2004 J. Cardiovasc. Pharmacol. pmid:14668571
Freitas CF et al. Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs. 2004 J. Cardiovasc. Pharmacol. pmid:14668575
Sánchez-Muniz FJ et al. Platelet aggregation, thromboxane production and thrombogenic ratio in postmenopausal women consuming high oleic acid-sunflower oil or palmolein. 2003 Eur J Nutr pmid:14673602
Lin YL and Wang CT Activation of human platelets by the rabbit anticardiolipin antibodies. 1992 Blood pmid:1467520
Sheu JR et al. Inhibitory mechanisms of metallothionein on platelet aggregation in in vitro and platelet plug formation in in vivo experiments. 2003 Exp. Biol. Med. (Maywood) pmid:14681547
de La Puerta Vázquez R et al. Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. 2004 Metab. Clin. Exp. pmid:14681843
Gutiérrez Díaz JA et al. Interaction of platelets with subendothelium in rats treated with PCA-4230, a new antithrombotic agent. Effect of PCA-4230 on experimental thrombosis. 1992 Haemostasis pmid:1468723