Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Simmons PM et al. | The release of leukotriene B4 during experimental inflammation. | 1983 | Biochem. Pharmacol. | pmid:6305369 |
Klosterhalfen B et al. | Time course of various inflammatory mediators during recurrent endotoxemia. | 1992 | Biochem. Pharmacol. | pmid:1599496 |
Stenson WF and Lobos E | Inhibition of platelet thromboxane synthetase by sulfasalazine. | 1983 | Biochem. Pharmacol. | pmid:6135423 |
Chang J et al. | Effects of thiazinamium chloride, promethazine and chlorpromazine on thromboxane B2 synthesis, phagocytosis and respiratory burst by rat alveolar macrophages. | 1983 | Biochem. Pharmacol. | pmid:6138040 |
Deckmyn H et al. | Manipulation of the local thromboxane and prostacyclin balance in vivo by the antithrombotic compounds dazoxiben, acetylsalicylic acid and nafazatrom. | 1983 | Biochem. Pharmacol. | pmid:6578796 |
Llopis J et al. | Eicosanoids released following inhibition of the endoplasmic reticulum Ca2+ pump stimulate Ca2+ efflux in the perfused rat liver. | 1993 | Biochem. Pharmacol. | pmid:8390834 |
Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
Patscheke H | Thromboxane synthase inhibition potentiates washed platelet activation by endogenous and exogenous arachidonic acid. | 1985 | Biochem. Pharmacol. | pmid:3922373 |
Segarnick DJ et al. | Precursor- and pool-dependent differential effects of ethanol on human platelet prostanoid synthesis. | 1985 | Biochem. Pharmacol. | pmid:3922375 |
Satoh K et al. | Effects of sulfonylurea agents on platelet arachidonic acid metabolism; study on platelet homogenates. | 1994 | Biochem. Pharmacol. | pmid:8093094 |
Vanderhoek JY et al. | Inhibitory potencies of fish oil hydroxy fatty acids on cellular lipoxygenases and platelet aggregation. | 1991 | Biochem. Pharmacol. | pmid:1831021 |
Cerletti C et al. | Requirement of ADP for arachidonic acid-induced platelet aggregation: studies with selective thromboxane-synthase inhibitors. | 1986 | Biochem. Pharmacol. | pmid:3083818 |
Bakhle YS and Grantham CJ | Selective effect of pulmonary oedema on prostaglandin E2 pharmacokinetics in rat lung. | 1985 | Biochem. Pharmacol. | pmid:3935117 |
Kanda N and Watanabe S | Suppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes. | 2006 | Biochem. Pharmacol. | pmid:16784723 |
Klosterhalfen B et al. | Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. | 1996 | Biochem. Pharmacol. | pmid:8937427 |
Chang WC et al. | Inhibition of thromboxane B2 and 6-ketoprostaglandin F1 alpha formation by anti-inflammatory drugs in carrageenin-induced granuloma. | 1978 | Biochem. Pharmacol. | pmid:619892 |
Yu SM et al. | Dicentrine, a novel antiplatelet agent inhibiting thromboxane formation and increasing the cyclic AMP level of rabbit platelets. | 1992 | Biochem. Pharmacol. | pmid:1310852 |
Spaethe SM et al. | Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors. | 1992 | Biochem. Pharmacol. | pmid:1310855 |
Tolman EL and Fuller BL | Inhibition of thromboxane synthesis in guinea pig lung and human platelets by clotrimazole and other imidazole antifungals. | 1983 | Biochem. Pharmacol. | pmid:6316985 |
Oishi K and Yamaguchi M | Regulatory effect of arachidonic acid on the calcium transport system in rat liver nuclei. | 1993 | Biochem. Pharmacol. | pmid:8385946 |
Medini L et al. | Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. | 1990 | Biochem. Pharmacol. | pmid:2105092 |
Faili A et al. | Reduction by arachidonic acid of prostaglandin I2-induced cyclic AMP formation. Involvement of prostaglandins E2 and F2 alpha. | 1993 | Biochem. Pharmacol. | pmid:8388209 |
Huang TF et al. | Halysin, an antiplatelet Arg-Gly-Asp-containing snake venom peptide, as fibrinogen receptor antagonist. | 1991 | Biochem. Pharmacol. | pmid:1888330 |
Salmon JA et al. | Benoxaprofen does not inhibit formation of leukotriene B4 in a model of acute inflammation. | 1984 | Biochem. Pharmacol. | pmid:6089840 |
Gresele P et al. | L-652,343, a novel dual cyclo/lipoxygenase inhibitor, inhibits LTB4-production by stimulated human polymorphonuclear cells but not by stimulated human whole blood. | 1987 | Biochem. Pharmacol. | pmid:2823826 |
De La Cruz JP et al. | Effects of S-adenosyl-L-methionine on platelet thromboxane and vascular prostacyclin. | 1997 | Biochem. Pharmacol. | pmid:9264331 |
Maynard PM et al. | Effect of glutathione depletion on tissue and plasma prostacyclin and thromboxane in rats. | 1992 | Biochem. Pharmacol. | pmid:1554377 |
de Gaetano G et al. | Low dose aspirin does not prevent fibrinolytic response to venous occlusion. | 1986 | Biochem. Pharmacol. | pmid:3755907 |
Bauer J et al. | Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. | 2011 | Biochem. Pharmacol. | pmid:20933508 |
Gairola CG and Tai HH | Cigarette smoke-induced alterations in the release of arachidonate metabolites by pulmonary alveolar macrophage from selenium-fed and selenium-deficient rats. | 1986 | Biochem. Pharmacol. | pmid:3015150 |
Lloret S and Moreno JJ | In vitro and in vivo effects of the anti-inflammatory peptides, antiflammins. | 1992 | Biochem. Pharmacol. | pmid:1417964 |
Chou TC et al. | Antiplatelet effect of amlodipine: a possible mechanism through a nitric oxide-mediated process. | 1999 | Biochem. Pharmacol. | pmid:10535758 |
Rajtar G et al. | Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors. | 1985 | Biochem. Pharmacol. | pmid:3918536 |
Williamson EM et al. | Studies on the mechanism of action of 12-deoxyphorbolphenylacetate, a potent platelet aggregating tigliane ester. | 1981 | Biochem. Pharmacol. | pmid:6794576 |
Lorenz RL et al. | Effects on prostanoid formation and pharmacokinetics of dazmegrel (UK-38,485), a novel thromboxane synthase inhibitor, in man. | 1986 | Biochem. Pharmacol. | pmid:3513767 |
Suntres ZE and Shek PN | Prophylaxis against lipopolysaccharide-induced lung injuries by liposome-entrapped dexamethasone in rats. | 2000 | Biochem. Pharmacol. | pmid:10704946 |
Matsuoka I et al. | Inhibitory effect of 8-bromo cyclic GMP on an extracellular Ca2+-dependent arachidonic acid liberation in collagen-stimulated rabbit platelets. | 1989 | Biochem. Pharmacol. | pmid:2544181 |
Palmer RM and Salmon JA | Comparison of the effects of some compounds on human neutrophil degranulation and leukotriene B4 and thromboxane B2 synthesis. | 1985 | Biochem. Pharmacol. | pmid:2986647 |
Alanko J et al. | Catechol estrogens as inhibitors of leukotriene synthesis. | 1998 | Biochem. Pharmacol. | pmid:9413936 |
Lynch TJ et al. | Carbon tetrachloride-induced eicosanoid synthesis and enzyme release from rat peritoneal leucocytes. | 1985 | Biochem. Pharmacol. | pmid:2986650 |
Rothberg KG and Hitchcock M | In vitro biosynthesis of cyclooxygenase metabolites in ovalbumin-sensitized and control lungs of guinea pigs. | 1982 | Biochem. Pharmacol. | pmid:6812589 |
Joseph S and MacDermot J | Stimulation of U937 human monocytic cells by thrombin results in inositol trisphosphate formation and the mobilisation of intracellular Ca2+ but not the synthesis of thromboxane B2. | 1991 | Biochem. Soc. Trans. | pmid:1889682 |
Bone EA et al. | The effects of strontium and calcium ions on 5-hydroxytryptamine secretion and thromboxane B2 biosynthesis in washed human platelets. | 1980 | Biochem. Soc. Trans. | pmid:7450206 |
Mitchell MD | Prostaglandins at parturition and in the neonatal infant. | 1980 | Biochem. Soc. Trans. | pmid:7450282 |
Taylor L et al. | Prostaglandin production by type II alveolar epithelial cells. | 1979 | Biochim. Biophys. Acta | pmid:435506 |
Shaw JO et al. | Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). | 1981 | Biochim. Biophys. Acta | pmid:7213765 |
Powell WS | Metabolism of prostaglandins, prostaglandin analogs and thromboxane B2 by lung and liver microsomes from pregnant rabbits. | 1979 | Biochim. Biophys. Acta | pmid:518891 |
Wahle KW and Peacock LI | Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet function. | 1996 | Biochim. Biophys. Acta | pmid:8652649 |
Teng CM et al. | Biphasic effect on platelet aggregation by phospholipase a purified from Vipera russellii snake venom. | 1984 | Biochim. Biophys. Acta | pmid:6426517 |
Kimura Y et al. | Effects of stilbenes on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3922423 |
Bellan JA et al. | Concentration-activity profile of the modulation of cyclooxygenase product formation by reduced glutathione in microsomal fractions from the goat lung. | 1990 | Biochim. Biophys. Acta | pmid:2114178 |
Fischer S et al. | Formation of prostacyclin and thromboxane in man as measured by the main urinary metabolites. | 1986 | Biochim. Biophys. Acta | pmid:3754157 |
Shaw JO and Lyons RM | Requirement for different Ca2+ pools in the activation of rabbit platelets II. Phospholipase activity. | 1982 | Biochim. Biophys. Acta | pmid:6800410 |
Bartolini G et al. | Regulation of thromboxane A2 biosynthesis in platelet-free human monocytes and the possible role of polypeptide growth factor(s) in the induction of cyclooxygenase system. | 1986 | Biochim. Biophys. Acta | pmid:3085720 |
Grundfest CC et al. | Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism. | 1982 | Biochim. Biophys. Acta | pmid:6814492 |
Aharony D et al. | Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid. | 1982 | Biochim. Biophys. Acta | pmid:6814496 |
Croft KD et al. | Dietary modification of fatty acid and prostaglandin synthesis in the rat. Effect of variations in the level of dietary fat. | 1984 | Biochim. Biophys. Acta | pmid:6548159 |
Blackwell GJ et al. | Prostacyclin prolongs viability of washed human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6291622 |
Cathcart MC et al. | Thromboxane synthase expression and correlation with VEGF and angiogenesis in non-small cell lung cancer. | 2014 | Biochim. Biophys. Acta | pmid:24480048 |
Geisel J et al. | Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation. | 1991 | Biochim. Biophys. Acta | pmid:1909897 |
Du JT et al. | Sex differences in arachidonate cyclo-oxygenase products in elicited rat peritoneal macrophages. | 1984 | Biochim. Biophys. Acta | pmid:6428458 |
Cook-Johnson RJ et al. | Endothelial cell COX-2 expression and activity in hypoxia. | 2006 | Biochim. Biophys. Acta | pmid:17046322 |
Busshardt E et al. | Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. | 1989 | Biochim. Biophys. Acta | pmid:2563228 |
Honda A et al. | Appearance of the arachidonic acid metabolic pathway in human promyelocytic leukemia (HL-60) cells during monocytic differentiation: enhancement of thromboxane synthesis by 1 alpha,25-dihydroxyvitamin D-3. | 1986 | Biochim. Biophys. Acta | pmid:3089289 |
Sekiya K and Okuda H | Inhibitory action of soluble elastin on thromboxane B2 formation in blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6320905 |
Heemskerk JW et al. | Influence of dietary fatty acids on membrane fluidity and activation of rat platelets. | 1989 | Biochim. Biophys. Acta | pmid:2752022 |
Ciabattoni G et al. | Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. | 1989 | Biochim. Biophys. Acta | pmid:2752040 |
Patrignani P et al. | Fractional conversion of thromboxane A2 and B2 to urinary 2,3-dinor-thromboxane B2 and 11-dehydrothromboxane B2 in the cynomolgus monkey. | 1989 | Biochim. Biophys. Acta | pmid:2752041 |
Malemud CJ et al. | Prostaglandin biosynthesis by lapine articular chondrocytes in culture. | 1981 | Biochim. Biophys. Acta | pmid:6894251 |
Roberts LJ et al. | Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. | 1979 | Biochim. Biophys. Acta | pmid:389290 |
Fitzpatrick FA and Gorman RR | A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. | 1978 | Biochim. Biophys. Acta | pmid:629996 |
Bishai I and Coceani F | Transformations of prostaglandin H2 in the cat brain. | 1981 | Biochim. Biophys. Acta | pmid:6894549 |
Orlandi M et al. | Thromboxane A2 synthase activity in platelet free human monocytes. | 1994 | Biochim. Biophys. Acta | pmid:7811713 |
Truitt A et al. | Antiplatelet effects of conjugated linoleic acid isomers. | 1999 | Biochim. Biophys. Acta | pmid:10320806 |
Huang TF et al. | Characterization of a potent platelet aggregation inhibitor from Agkistrodon rhodostoma snake venom. | 1987 | Biochim. Biophys. Acta | pmid:3620499 |
de Waart DR et al. | Studies on the urinary excretion of thromboxane B2 in Zellweger patients and control subjects: evidence for a major role for peroxisomes in the beta-oxidative chain-shortening of thromboxane B2. | 1994 | Biochim. Biophys. Acta | pmid:8155738 |
Sato T et al. | Inhibition of platelet aggregation by unsaturated fatty acids through interference with a thromboxane-mediated process. | 1987 | Biochim. Biophys. Acta | pmid:3663714 |
Gorman RR et al. | Independence of the cyclic AMP-lowering activity of thromboxane A2 from the platelet release reaction. | 1979 | Biochim. Biophys. Acta | pmid:216409 |
Fitzpatrick FA and Gorman RR | Regulatory role of cyclic adenosine 3',5'-monophosphate on the platelet cyclooxygenase and platelet function. | 1979 | Biochim. Biophys. Acta | pmid:216415 |
Fuse I and Tai HH | Does protein kinase C activation mediate thrombin-induced arachidonate release in human platelets? | 1988 | Biochim. Biophys. Acta | pmid:3140902 |
Murphy CT et al. | Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid. | 1991 | Biochim. Biophys. Acta | pmid:1661165 |
Surya II et al. | Enhancement of platelet functions by low density lipoproteins. | 1992 | Biochim. Biophys. Acta | pmid:1420343 |
Huang TF et al. | Antiplatelet protease, kistomin, selectively cleaves human platelet glycoprotein Ib. | 1993 | Biochim. Biophys. Acta | pmid:8251530 |
Robinson C and Hoult JR | Thromboxane A2 analogues inhibit the metabolism of thromboxane B2 in perfused guinea-pig lung. | 1983 | Biochim. Biophys. Acta | pmid:6652102 |
Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
Ko FN et al. | Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans. | 1990 | Biochim. Biophys. Acta | pmid:2162213 |
Tsunomori M et al. | 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. | 1996 | Biochim. Biophys. Acta | pmid:8679681 |
Ko FN et al. | Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. | 1995 | Biochim. Biophys. Acta | pmid:7548232 |
Mobley A et al. | Selective inhibition of 5-lipoxygenase pathway in rat pulmonary alveolar macrophages by cigarette smoking. | 1987 | Biochim. Biophys. Acta | pmid:3030439 |
Simon MF et al. | Selective inhibition of human platelet phospholipase A2 by buffering cytoplasmic calcium with the fluorescent indicator quin 2. Evidence for different calcium sensitivities of phospholipases A2 and C. | 1986 | Biochim. Biophys. Acta | pmid:3080024 |
Miller OV et al. | Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. | 1982 | Biochim. Biophys. Acta | pmid:6285985 |
Ko FN et al. | CIS-19, a novel platelet activating factor receptor antagonist: in vitro and in vivo studies. | 1993 | Biochim. Biophys. Acta | pmid:8380343 |
Hayashi Y et al. | Enzyme immunoassay of thromboxane B2. | 1983 | Biochim. Biophys. Acta | pmid:6407530 |
Chiabrando C et al. | Metabolism of thromboxane B2 in the isolated perfused rat kidney: mass spectrometric identification of urinary products. | 1989 | Biochim. Biophys. Acta | pmid:2597664 |
Nieuwenhuys CM and Hornstra G | The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. | 1998 | Biochim. Biophys. Acta | pmid:9487152 |
Lorenz RL et al. | A critical evaluation of urinary immunoreactive thromboxane: feasibility of its determination as a potential vascular risk indicator. | 1989 | Biochim. Biophys. Acta | pmid:2597697 |
Elliott GR et al. | Changes in resident rat peritoneal macrophage eicosanoid release, induced by altering the buffer K+/Na+ ratio, are Ca2+ dependent. | 1985 | Biochim. Biophys. Acta | pmid:3933563 |
Turk J et al. | Arachidonic acid metabolism in isolated pancreatic islets. I. Identification and quantitation of lipoxygenase and cyclooxygenase products. | 1984 | Biochim. Biophys. Acta | pmid:6329307 |
Robinson C et al. | Thromboxane B2 uptake and metabolism in isolated perfused lung. Identification and comparison with prostaglandin F2 alpha. | 1982 | Biochim. Biophys. Acta | pmid:6751406 |
Schafer AI et al. | Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6812645 |