Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Pearl JM et al. | Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass. | 1999 | Ann. Thorac. Surg. | pmid:10543508 |
Tanaka H et al. | Leukotriene (LT)-receptor antagonist is more effective in asthmatic patients with a low baseline ratio of urinary LTE4 to 2,3-dinor-6-keto-prostaglandin (PG)F1alpha. | 1999 | Allergy | pmid:10380781 |
Chen G et al. | [The effect of the molecular triggers of hemostatic activity on thrombosis in early stage of electrical injuries]. | 1999 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:11501103 |
Chahine R et al. | The anti-thromboxane A2 synthetase activity of myocardial tissue and its variation during ischemia and reperfusion in isolated rabbit heart. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328329 |
Peredo HA and Filinger EJ | Effect of dipyridamole on prostanoid production in rat isolated atria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328333 |
Liguori A et al. | Loop diuretics enhance the secretion of prostacyclin in vitro, in healthy persons, and in patients with chronic heart failure. | 1999 | Eur. J. Clin. Pharmacol. | pmid:10335906 |
Davis KA et al. | Prostanoids: early mediators in the secondary injury that develops after unilateral pulmonary contusion. | 1999 | J Trauma | pmid:10338399 |
Gallery ED et al. | In vitro human decidual endothelial cell thromboxane secretion in preeclampsia is not abnormal. | 1999 | Hypertens Pregnancy | pmid:10586525 |
Pavord ID et al. | Induced sputum eicosanoid concentrations in asthma. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10588604 |
Kohda N et al. | Effect of cilostazol, a phosphodiesterase III inhibitor, on experimental thrombosis in the porcine carotid artery. | 1999 | Thromb. Res. | pmid:10593428 |
Morrow JD et al. | Increased formation of thromboxane in vivo in humans with mastocytosis. | 1999 | J. Invest. Dermatol. | pmid:10417625 |
Catella-Lawson F et al. | Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10215647 |
Holt S et al. | Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor. | 1999 | Kidney Int. | pmid:9893136 |
Mizugaki M et al. | Monitoring of the thromboxane A2/prostacyclin ratio in the urine of patients with retinal vascular occlusion through the low-dose-aspirin therapy using the gas chromatography/selected ion monitoring method. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10593167 |
Hishinuma T et al. | Urinary thromboxane A2/prostacyclin balance reflects the pathological state of a diabetic. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10593168 |
Hoch B and Bernhard M | Reduced prostacyclin to thromboxane A2 ratio is correlated with central apneas in preterm infants. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10593170 |
Langberg H et al. | Metabolism and inflammatory mediators in the peritendinous space measured by microdialysis during intermittent isometric exercise in humans. | 1999 | J. Physiol. (Lond.) | pmid:10066916 |
Gonchar M et al. | Kinetics of prostanoid synthesis by macrophages is regulated by arachidonic acid sources. | 1999 | Eur. J. Biochem. | pmid:10504410 |
Takahashi H et al. | Ureteral obstruction reverses glomerular proliferation in immune complex glomerulonephritis. | 1999 | J. Lab. Clin. Med. | pmid:10072261 |
Chou TC et al. | Antiplatelet effect of amlodipine: a possible mechanism through a nitric oxide-mediated process. | 1999 | Biochem. Pharmacol. | pmid:10535758 |
Feldman M and Cryer B | Aspirin absorption rates and platelet inhibition times with 325-mg buffered aspirin tablets (chewed or swallowed intact) and with buffered aspirin solution. | 1999 | Am. J. Cardiol. | pmid:10468077 |
Obata T et al. | Simultaneous assay of prostaglandins and thromboxane in the cerebrospinal fluid by gas chromatography-mass spectrometry-selected ion monitoring. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10491991 |
Gust R et al. | Role of cyclooxygenase-2 in oleic acid-induced acute lung injury. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10508803 |
Thakur V et al. | Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs. | 1999 | Am. J. Hypertens. | pmid:10509552 |
Véricel E et al. | The influence of low intake of n-3 fatty acids on platelets in elderly people. | 1999 | Atherosclerosis | pmid:10525140 |
Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
Hayashi N et al. | Effects of intravenous omega-3 and omega-6 fat emulsion on cytokine production and delayed type hypersensitivity in burned rats receiving total parenteral nutrition. | 1998 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:9829609 |
Guimarães PC et al. | Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension. | 1998 May-Jun | Sao Paulo Med J | pmid:9876450 |
RogovyÄ IuE | [Beta 2-microglobulin as a criterion of dysfunction in the regulation of proximal tubular activity in mercuric chloride-induced nephropathy]. | 1998 May-Jun | Urol Nefrol (Mosk) | pmid:9644989 |
DeVries A et al. | Ketoconazole in the prevention of acute respiratory distress syndrome. | 1998 May-Jun | Pharmacotherapy | pmid:9620108 |
Sheu JR et al. | Inhibitory mechanisms of naloxone on human platelets. | 1998 Jul-Aug | Clin. Exp. Pharmacol. Physiol. | pmid:9673433 |
Carvalho C et al. | Inhibition of airway hyperreactivity, edema, and lung cell infiltration by compound U-83836E in sensitized guinea pigs. | 1998 Jul-Aug | Can. J. Physiol. Pharmacol. | pmid:10030451 |
Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
Hanaoka M et al. | Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep. | 1998 Jan-Feb | Exp. Lung Res. | pmid:9457466 |
Schuligoi R et al. | Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells. | 1998 | Inflamm. Res. | pmid:9657255 |
Kruse-Elliott KT et al. | Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. | 1998 | Shock | pmid:9466472 |
Mayser P et al. | Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial. | 1998 | J. Am. Acad. Dermatol. | pmid:9555791 |
Shen ZQ et al. | Effects of copper-aspirin complex on platelet aggregation and thrombosis in rabbits and mice. | 1998 | J. Pharm. Pharmacol. | pmid:9877314 |
Huang YS et al. | Serial experimental and clinical studies on the pathogenesis of multiple organ dysfunction syndrome (MODS) in severe burns. | 1998 | Burns | pmid:9915670 |
Murphy NP et al. | Functional relevance of the expression of ligand-induced binding sites in the response to platelet GP IIb/IIIa antagonists in vivo. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9694954 |
Simon LS et al. | Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. | 1998 | Arthritis Rheum. | pmid:9751091 |
Thomson M et al. | Prostanoid synthesis in whole blood cells from fish of the Arabian Gulf. | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9787758 |
Smith CJ et al. | Pharmacological analysis of cyclooxygenase-1 in inflammation. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9789085 |
Sheu JR et al. | Mechanisms involved in the antiplatelet activity of Escherichia coli lipopolysaccharide in human platelets. | 1998 | Br. J. Haematol. | pmid:9792285 |
Ozyazgan I et al. | Eicosanoids and inflammatory cells in frostbitten tissue: prostacyclin, thromboxane, polymorphonuclear leukocytes, and mast cells. | 1998 | Plast. Reconstr. Surg. | pmid:9623831 |
Obase Y et al. | Effects of cysteinyl-leukotriene receptor antagonist, thromboxane A2 receptor antagonist, and thromboxane A2 synthetase inhibitor on antigen-induced bronchoconstriction in patients with asthma. | 1998 | Chest | pmid:9792572 |
Stephenson AH et al. | 5,6-Epoxyeicosatrienoic acid reduces increases in pulmonary vascular resistance in the dog. | 1998 | Am. J. Physiol. | pmid:9688901 |
Wu Y et al. | [Clinical study on improving effect of Buyang Huanwu decoction on plasma thromboxane B2, 6-keto-prostaglandin F1 alpha, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475715 |
Lang J et al. | [Comparative study on effect of Panax notoginseng and ticlid in treating early diabetic nephropathy]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475719 |
Lin S et al. | [Clinical study on active factors of vascular endothelial cells in acute cerebral infarction patients and therapeutical effect of activating blood stasis]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477811 |
Huang R et al. | [Effects in tetramethylpyrazine on TXA2 and PGI2 by cardio-pulmonary bypass in congenital heart diseases with pulmonary hypertension patients]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477904 |
Xu J et al. | [Study on relativity between oxygen free radical and thromboxane B2, 6-keto-PGF1 alpha during ligustrazine treatment of intrauterine growth retardation]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477921 |
Yang VW et al. | Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis. | 1998 | Cancer Res. | pmid:9563494 |
Xing X et al. | [Preserving remnant liver function after major hepatic vein occlusion]. | 1998 | Zhonghua Wai Ke Za Zhi | pmid:11825430 |
Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
Giardiello FM et al. | Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. | 1998 | Dig. Dis. Sci. | pmid:9512123 |
Liao CH et al. | Effect of PP1D-1, a synthetic antiplatelet compound, on rabbit platelets. | 1998 | Jpn. J. Pharmacol. | pmid:9541276 |
LaNoue JL et al. | Alveolar macrophage response to remote organ injury. | 1998 | Shock | pmid:9565254 |
Darien BJ et al. | Low molecular weight heparin prevents the pulmonary hemodynamic and pathomorphologic effects of endotoxin in a porcine acute lung injury model. | 1998 | Shock | pmid:9565256 |
Muscará MN et al. | Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat. | 1998 | Life Sci. | pmid:9566780 |
Davì G et al. | Increased thromboxane metabolites excretion in liver cirrhosis. | 1998 | Thromb. Haemost. | pmid:9569186 |
Chen J et al. | [Study on the relationship between the bond absorption of chronic periapical periodontitis and PGE2 and TXB2]. | 1998 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:11774418 |
Kimura H et al. | Compensatory excretion of prostacyclin and thromboxane metabolites in obstructive sleep apnea syndrome. | 1998 | Intern. Med. | pmid:9550591 |
Dschietzig T et al. | Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction. | 1998 | Crit. Care Med. | pmid:9504580 |
Hu DH | [Effects of taurine enhancement of synthesis of TxA2 and PGI2 in cultured intra-pulmonary arteriolar smooth muscle cells under acute hypoxia]. | 1998 | Sheng Li Xue Bao | pmid:11324559 |
Ooi BS et al. | Stimulation of endothelial cell production of vasoconstrictive substances by hypertensive sera. | 1998 | Am. J. Hypertens. | pmid:9524055 |
Cignarella A et al. | Platelet activation supports the development of venous thrombosis in hyperlipidemic rats. | 1998 | Blood Coagul. Fibrinolysis | pmid:9607118 |
van der Weiden RM et al. | Which prostanoid metabolites should be determined for the study of reproductive processes? | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610843 |
Beitz A | Influence of diet-modified lipoprotein fractions from rabbits on eicosanoid production and on proliferation of rabbit skin fibroblasts. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610847 |
Agnoli GC et al. | Effects of experimental salt depletion on urinary prostanoid excretions in normal women. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610848 |
Stamler A et al. | Low-dose dopexamine's effect on lung and gut function after CPB in a sheep model. | 1998 | J. Surg. Res. | pmid:9587356 |
Franconi F et al. | Further insights into the anti-aggregating activity of NMDA in human platelets. | 1998 | Br. J. Pharmacol. | pmid:9630340 |
Whiteford M et al. | Effect of liposome-encapsulated hemoglobin on the development of endotoxin-induced shock in the rat. | 1998 | Shock | pmid:9645495 |
Mainwaring RD et al. | Complement activation and cytokine generation after modified Fontan procedure. | 1998 | Ann. Thorac. Surg. | pmid:9647087 |
Tsai WJ et al. | Characterization of the antiplatelet effects of (2S)-5-methoxy-6-methylflavan-7-ol from Draconis Resina. | 1998 | Eur. J. Pharmacol. | pmid:9617759 |
Kalgutkar AS et al. | Aspirin-like molecules that covalently inactivate cyclooxygenase-2. | 1998 | Science | pmid:9596581 |
Bernareggi M et al. | Bronchopulmonary effects of 8-epi-PGF2A in anaesthetised guinea pigs. | 1998 | Pharmacol. Res. | pmid:9503483 |
Cadroy Y et al. | Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. | 1998 | J. Immunol. | pmid:9637532 |
Li G et al. | Ischemic preconditioning enhances donor lung preservation in canine lung transplantation. | 1998 | Chin. Med. J. | pmid:11189228 |
Guo Q et al. | [Influence of moderate hypothermia on the contents of 6-KETO-PGF1 alpha and TXB2 in brain tissues after cardiac arrest and resuscitation in dogs]. | 1998 | Hunan Yi Ke Da Xue Xue Bao | pmid:11189396 |
Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
Herrera JA et al. | Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. | 1998 | Obstet Gynecol | pmid:9540946 |
Gust R et al. | Synergistic hemodynamic effects of low-dose endotoxin and acute lung injury. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620928 |
de la Cruz JP et al. | Effect of WEB 2086-BS, an antagonist of platelet-activating factor receptors, on retinal vascularity in diabetic rats. | 1998 | Eur. J. Pharmacol. | pmid:9845270 |
Aoki T et al. | Difference of (Ca2+)i movements in platelets stimulated by thrombin and TRAP: the involvement of alpha(IIb)beta3-mediated TXA2 synthesis. | 1998 | Thromb. Haemost. | pmid:9657446 |
Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
Bode-Böger SM et al. | Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo. | 1998 | Cardiovasc. Res. | pmid:9659460 |
Menè P et al. | Eicosanoid synthesis in peripheral blood monocytes: a marker of disease activity in lupus nephritis. | 1998 | Am. J. Kidney Dis. | pmid:9820447 |
Adler S and Bollu R | Glomerular endothelial cell injury mediated by shiga-like toxin-1. | 1998 | Kidney Blood Press. Res. | pmid:9661132 |
Geertsen PF et al. | Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2. | 1998 | Clin. Sci. | pmid:9662488 |
Hauth J et al. | Maternal serum thromboxane B2 concentrations do not predict improved outcomes in high-risk pregnancies in a low-dose aspirin trial. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medical Units. | 1998 | Am. J. Obstet. Gynecol. | pmid:9822499 |
Chen MF et al. | Vitamin E supplementation attenuates myointimal proliferation of the abdominal aorta after balloon injury in diet-induced hypercholesterolemic rabbits. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9777654 |
Kalgutkar AS et al. | Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. | 1998 | J. Med. Chem. | pmid:9822550 |
Schmeck J et al. | Endothelin-1 and thromboxane A2 increase pulmonary vascular resistance in granulocyte-mediated lung injury. | 1998 | Crit. Care Med. | pmid:9824081 |
Stadelmann WK et al. | Aprotinin in ischemia-reperfusion injury: flap survival and neutrophil response in a rat skin flap model. | 1998 | Microsurgery | pmid:9846997 |
Nieuwenhuys CM and Hornstra G | The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. | 1998 | Biochim. Biophys. Acta | pmid:9487152 |
Inoue H et al. | Changes in endothelin-1, 6-keto-PG-F1 alpha, and TX-B2 in random pattern flaps. | 1998 | J. Cardiovasc. Pharmacol. | pmid:9595517 |
Fuse S et al. | Plasma thromboxane B2 concentration in patients with ventricular septal defect and pulmonary hypertension. | 1998 | Jpn. Circ. J. | pmid:9583446 |
Heller DA et al. | Mortality and biomarkers of aging in heterogeneous stock (HS) mice. | 1998 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:9597046 |
Jiang XW et al. | Effects of low-dose Beraprost sodium, a stable prostaglandin I2 analogue, on reperfusion injury to rabbit lungs. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9817723 |