Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Patel K and Bakhle YS | Thromboxane B2 (TxB2) metabolism in rat isolated lung and its inhibition by drugs. | 1983 | Prostaglandins Leukot Med | pmid:6573689 |
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Zijlstra FJ et al. | Separation of the two components of the contractile activity of leukotriene C4 on the guinea pig lung parenchymal strip. | 1983 | Prostaglandins Leukot Med | pmid:6578519 |
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Svensson J | Structure and quantitative determination of the major urinary metabolite of thromboxane B2 in the guinea pig. | 1979 | Prostaglandins | pmid:472333 |
Leach CM and Thorburn GD | A comparative study of collagen induced thromboxane release from platelets of different species: implications for human atherosclerosis models. | 1982 | Prostaglandins | pmid:7122912 |
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Ritter JM et al. | Predominance of locally-produced prostaglandin E2 over prostacyclin in skin incisions in man. | 1987 | Prostaglandins | pmid:3329746 |
Brown EM and Swartz SL | Production of prostaglandins by dispersed cells and fragments from bovine parathyroid glands. | 1985 | Prostaglandins | pmid:3883430 |
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Dembélé-Duchesne MJ et al. | Some new prospects in the mechanism of control of arachidonate metabolism in human placenta and amnion. | 1981 | Prostaglandins | pmid:6801732 |
Mitrovic D et al. | The in vitro production of prostanoids by cultured bovine articular chondrocytes. | 1982 | Prostaglandins | pmid:6801735 |
Keith JC et al. | Ridogrel improves maternal/fetal homeostasis in an ovine model of pregnancy-induced hypertension. | 1994 | Prostaglandins | pmid:8016393 |
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Yoshimoto T et al. | Selective inhibition of prostaglandin endoperoxide thromboxane isomerase by 1-carboxyalkylimidazoles. | 1978 | Prostaglandins | pmid:725083 |
Schneidkraut MJ and Carlson RW | Cecal ligation and puncture is associated with pulmonary injury in the rat: role of cyclooxygenase pathway products. | 1993 | Prostaglandins | pmid:8493358 |
Anderson MW et al. | Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase. | 1978 | Prostaglandins | pmid:725086 |
Flynn JT et al. | Zymosan-activated plasma-mediated thromboxane production by the perfused rabbit liver and isolated hepatocytes: involvement of calcium. | 1990 | Prostaglandins | pmid:2281142 |
Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
Goldyne ME and Stobo JD | Human monocytes synthesize eicosanoids from T lymphocyte-derived arachidonic acid. | 1982 | Prostaglandins | pmid:6819603 |
Morel DR et al. | Dose-dependent effects of a pyridoquinazoline thromboxane synthetase inhibitor on arachidonic acid metabolites and hemodynamics during E. coli endotoxemia in anesthetized sheep. | 1987 | Prostaglandins | pmid:3118413 |
O'Keefe EH et al. | Effects of a thromboxane synthetase inhibitor and a thromboxane antagonist on release and activity of thromboxane A2 and prostacyclin in vitro. | 1985 | Prostaglandins | pmid:3925501 |
Huttemeier PC et al. | Microdialysis measurements of PGD2, TXB2 and 6-KETO-PGF1 alpha in rat CA1 hippocampus during transient cerebral ischemia. | 1993 | Prostaglandins | pmid:8430228 |
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MacDermot J et al. | Synthesis of leukotriene B4, and prostanoids by human alveolar macrophages: analysis by gas chromatography/mass spectrometry. | 1984 | Prostaglandins | pmid:6326199 |
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McNamara DB et al. | Prostaglandin endoperoxide metabolism by microsomes of whole kidneys from normal, congenital unilateral hydronephrotic and unilateral ureteral obstructed rats. | 1982 | Prostaglandins | pmid:6962465 |
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Hsu P et al. | Effects of ischemia/reperfusion on brain tissue prostanoids and leukotrienes in newborn pigs. | 1991 | Prostaglandins | pmid:1666191 |
Madden MC et al. | Effect of hypoxia on prostacyclin production in cultured pulmonary artery endothelium. | 1986 | Prostaglandins | pmid:3094092 |
Worthington RE and Nakeff A | Aspirin inhibits rat megakaryocyte thromboxane synthesis. | 1982 | Prostaglandins | pmid:6812167 |
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Nigam S et al. | The concentrations of 6-keto-PGF1 alpha and TXB2 in plasma samples from patients with benign and malignant tumours of the breast. | 1985 | Prostaglandins | pmid:3839084 |
Petroni A et al. | Differential effects of various vasoactive drugs on basal and stimulated levels of TXB2 and 6-keto-PGF1 alpha in rat brain. | 1985 | Prostaglandins | pmid:3839085 |
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Ritter JM et al. | Low dose aspirin treatment in late pregnancy differentially inhibits cyclo-oxygenase in maternal platelets. | 1987 | Prostaglandins | pmid:3124218 |
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Kuhn DC et al. | Eicosanoid production and transfer in the placenta of the diabetic pregnancy. | 1990 | Prostaglandins | pmid:2120739 |
Maghni K et al. | Release of prostaglandins and thromboxanes by guinea pig isolated type II pneumocytes. | 1990 | Prostaglandins | pmid:2120740 |
Henriksson P et al. | Thromboxane synthase inhibition: "endoperoxide shunt phenomenon" does not occur in healthy humans in vivo. | 1990 | Prostaglandins | pmid:2106716 |
Freed MS et al. | Essential fatty acid deficiency inhibits early but not late leukocyte infiltration in rabbit myocardial infarcts. | 1989 | Prostaglandins | pmid:2546188 |
Kuhn DC et al. | Characterization of alveolar macrophage eicosanoid production in a non-human primate model of mineral dust exposure. | 1993 | Prostaglandins | pmid:8234829 |