Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Thorngren M et al. Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid. 1983 Lancet pmid:6133107
Stenson WF and Lobos E Inhibition of platelet thromboxane synthetase by sulfasalazine. 1983 Biochem. Pharmacol. pmid:6135423
Chang J et al. Effects of thiazinamium chloride, promethazine and chlorpromazine on thromboxane B2 synthesis, phagocytosis and respiratory burst by rat alveolar macrophages. 1983 Biochem. Pharmacol. pmid:6138040
Düsing R et al. Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. 1983 Am. J. Physiol. pmid:6337507
Winter M et al. Synthesis of thromboxane B2 in uraemia and the effects of dialysis. 1983 Thromb. Res. pmid:6868024
Lismonde M et al. [The presence of 6-oxo-PGF1alpha and thromboxane B2 in peritoneal exudates released by iota-carrageenan in the rat]. 1983 Arch. Int. Physiol. Biochim. pmid:6198994
Wientroub S et al. Changes in tissue concentration of prostaglandins during endochondral bone differentiation. 1983 Biochem. Biophys. Res. Commun. pmid:6582850
Horellou MH et al. Familial and constitutional bleeding disorder due to platelet cyclo-oxygenase deficiency. 1983 Am. J. Hematol. pmid:6404162
Nerlich M et al. Effect of thermal injury on endotoxin-induced lung injury. 1983 Surgery pmid:6337423
Stratta P et al. Warning: platelet factor 4, beta-thromboglobulin and thromboxane in donor's plasma units. 1983 Thromb. Haemost. pmid:6189235
de Kergommeaux BD et al. Effects of ASA on thromboxane and prostacyclin synthesis by rabbit aorta and pulmonary artery. 1983 Prostaglandins Leukot Med pmid:6410417
Bromberg Y and Pick E Unsaturated fatty acids as second messengers of superoxide generation by macrophages. 1983 Cell. Immunol. pmid:6307532
Ahlquist DA et al. Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. 1983 Am. J. Physiol. pmid:6401937
Buchanan MR et al. The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects. 1983 Thromb. Res. pmid:6221436
Yamamoto S et al. Enzyme immunoassay of thromboxane B2 and 6-keto-prostaglandin F1 alpha as a substitute for radioimmunoassay. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221523
Weerasekera DA et al. Chemiluminescence immunoassay of thromboxane B2. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221524
Davi' G et al. Platelet activation after adrenergic stimulation in hypertensive patients: effects of acebutolol. 1983 Eur. Heart J. pmid:6352266
Ito T et al. Effects of a selective inhibitor of thromboxane synthetase (OKY-1581) in humans. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221531
FitzGerald GA et al. Aspirin inhibits endogenous prostacyclin and thromboxane biosynthesis in man. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221534
FitzGerald GA et al. Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. 1983 J. Clin. Invest. pmid:6355181
van der Giessen WJ et al. Acute effect of cigarette smoking on cardiac prostaglandin synthesis and platelet behavior in patients with coronary heart disease. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221546
Jouve R et al. [Plasma thromboxane B2 and capacity of the aorta to produce prostacyclin in arteriopathies of the lower extremities]. 1983 J Mal Vasc pmid:6355348
Bach MK et al. In vivo and in vitro actions of a new selective inhibitor of leukotriene C and D synthesis. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221551
Mehta J et al. Stimulation of vessel wall prostacyclin by selective thromboxane synthetase inhibitor OKY 1581. 1983 Prostaglandins Leukot Med pmid:6356153
Grose JH et al. Imbalanced prostacyclin and thromboxane A2 production in essential hypertension. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221555
Henriksen RA and Brotherton AF Evidence that activation of platelets and endothelium by thrombin involves distinct sites of interaction. Studies with the dysthrombin, Thrombin Quick I. 1983 J. Biol. Chem. pmid:6358210
Hornych A et al. Thromboxane B2 in borderline and essential hypertension. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221556
Kaliman J et al. [Venous prostacycline synthesis and plasma thromboxane B2 after low-dose aspirin]. 1983 Wien. Klin. Wochenschr. pmid:6359724
MacIntyre DE et al. Role of endogenous arachidonate metabolites in phospholipid-induced human platelet activation. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221557
Ylikorkala O et al. Prostacyclin and thromboxane in ovarian cancer: effect of cytostatics and prostaglandin synthesis inhibitors. 1983 Gynecol. Oncol. pmid:6360817
Tada M et al. [Biochemistry of coronary artery disease--prostaglandins]. 1983 Rinsho Byori pmid:6361336
Hardisty RM et al. A new congenital defect of platelet secretion: impaired responsiveness of the platelets to cytoplasmic free calcium. 1983 Br. J. Haematol. pmid:6830700
Jørgensen KA et al. The survival of pig to rabbit renal xenografts during inhibition of thromboxane synthesis. 1983 Thromb. Res. pmid:6364449
Mandrovnaia NV et al. [Age-related changes in prostacyclin and thromboxane B2 biosynthesis under normal conditions and in arterial hypertension]. 1983 Kardiologiia pmid:6366325
Randall MJ and Wilding RI Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01). 1983 Br J Clin Pharmacol pmid:6687429
Bruckner G et al. Dietary trilinoelaidate: effects on hematological parameters, serum eicosanoids and tissue fatty acid composition in rats. 1983 J. Nutr. pmid:6687476
Bessin P et al. Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs. 1983 Eur. J. Pharmacol. pmid:6687572
Ingerman-Wojenski CM et al. Early morphological changes in the endothelium of a peripheral artery of rabbits fed an atherogenic diet. 1983 Exp. Mol. Pathol. pmid:6687574
Hartung HP and Toyka KV Tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages. 1983 Immunol. Lett. pmid:6687720
D'Angelo A et al. Effect of des-amino-D-arginine vasopressin (DDAVP) on plasma levels of platelet and endothelial cell release products. 1983 Thromb. Haemost. pmid:6687766
Ku EC et al. Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models. 1983 Biochem. Biophys. Res. Commun. pmid:6687803
Anderegg K et al. Effects of a pyridine derivative thromboxane synthetase inhibitor and its inactive isomer in endotoxic shock in the rat. 1983 Br. J. Pharmacol. pmid:6687819
Todd MH et al. The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs. 1983 Thromb. Res. pmid:6687961
Halushka PV et al. Studies on the beneficial effects of aspirin in endotoxic shock. Relationship to inhibition of arachidonic acid metabolism. 1983 Am. J. Med. pmid:6687979
Tsukatani E Etiology of EPH-gestosis from the viewpoint of dynamics of vasoactive prostanoid, lipid peroxides and vitamin E. 1983 Nippon Sanka Fujinka Gakkai Zasshi pmid:6688085
Higgs GA et al. The source of thromboxane and prostaglandins in experimental inflammation. 1983 Br. J. Pharmacol. pmid:6652359
Anton RF et al. In vivo regional levels of PGE and thromboxane in mouse brain: effect of decapitation, focused microwave fixation, and indomethacin. 1983 Prostaglandins pmid:6658001
Mahoney D et al. Influence of dietary polyunsaturated fatty acids on renal & aortic prostaglandin synthesis in 1 kidney 1 clip Goldblatt hypertensive rats. 1983 Prostaglandins pmid:6658002
Martin JF et al. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. 1983 Thromb. Res. pmid:6658722
Cohen RA et al. 5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries. 1983 Am. J. Physiol. pmid:6660308
Cortellaro M et al. Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment. 1983 Thromb. Haemost. pmid:6665767
De Caterina R et al. Antiplatelet effects of isosorbide dinitrate in man. 1983 Z Kardiol pmid:6666233
Smith EF et al. RCS from human platelets: is it only thromboxane? 1983 Eur. J. Pharmacol. pmid:6667711
Sakanishi N et al. [Effect of reduced glutathione on endotoxin shock]. 1983 Masui pmid:6668649
Moonen P et al. An improved method for separation of thromboxane B2 by reversed phase liquid chromatography. 1983 Prostaglandins pmid:6669711
Gethmann U et al. Effect of catecholestrogens on prostaglandin release by rat pituitaries superfused in vitro. 1983 Arch. Gynecol. pmid:6320749
Fukumoto S and Tanaka K Protective effects of thromboxane A2 synthetase inhibitors on endotoxin shock. 1983 Prostaglandins Leukot Med pmid:6576388
Kinney EL et al. Mechanism of action of amrinone: role of thromboxane synthetase inhibition. 1983 Prostaglandins Leukot Med pmid:6576389
Hawkey CJ et al. Imbalance of prostacyclin and thromboxane synthesis in Crohn's disease. 1983 Gut pmid:6578172
Zijlstra FJ et al. Separation of the two components of the contractile activity of leukotriene C4 on the guinea pig lung parenchymal strip. 1983 Prostaglandins Leukot Med pmid:6578519
Roy L et al. Increased plasma concentrations of prostacyclin metabolite 6-keto-PGF1 alpha in essential hypertension. Influence of therapy with labetalol. 1983 Am. J. Cardiol. pmid:6823861
Reuben SR et al. Effects of dazoxiben on exercise performance in chronic stable angina. 1983 Br J Clin Pharmacol pmid:6402000
Mahoney DP et al. Radioimmunoassay of prostaglandins and thromboxane B2 in extracted and unextracted urine and serum using an iodinated ligand. 1983 Prostaglandins Leukot Med pmid:6579570
Güllner HG et al. Renal thromboxane excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Effect of vasopressin treatment. 1983 Prostaglandins Leukot Med pmid:6580653
Sakanishi N et al. Thromboxane A2 and hemodynamic-biochemical parameters in canine endotoxin shock. 1983 Bull. Tokyo Med. Dent. Univ. pmid:6580966
Orlandi M et al. Normal plasma thromboxane B2 (TXB2) and 6-keto-PGF1 alpha levels in childhood diabetes. 1983 Prostaglandins Leukot Med pmid:6583712
Männistö J and Uotila P Cigarette smoke ventilation decreases thromboxane B2 metabolism in isolated rat lungs. 1983 Prostaglandins Leukot Med pmid:6583713
Sharon P et al. Prostanoid synthesis by cultured gastric and duodenal mucosa: Possible role in the pathogenesis of duodenal ulcer. 1983 Scand. J. Gastroenterol. pmid:6584967
Rao GH et al. Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin. 1983 Jul-Aug Arteriosclerosis pmid:6411052
Konieczkowski M et al. Glomerular synthesis of prostaglandins and thromboxane in spontaneously hypertensive rats. 1983 Jul-Aug Hypertension pmid:6407990
Stuart MJ The effect of irradiation on platelet arachidonic acid metabolism. 1983 Mar-Apr Transfusion pmid:6404019
Newman WH et al. Increased myocardial release of prostacyclin in dogs with heart failure. 1983 Mar-Apr J. Cardiovasc. Pharmacol. pmid:6188889
Coker SJ and Parratt JR Nifedipine reduces arrhythmias but does not alter prostanoid release during coronary artery occlusion and reperfusion in anaesthetised greyhounds. 1983 May-Jun J. Cardiovasc. Pharmacol. pmid:6191139
Peskar BM Effects of carbenoxolone on the gastric mucosal prostaglandin and thromboxane system. 1983 Sep-Oct Acta Gastroenterol. Belg. pmid:6324520
Burke SE et al. Protection of ischemic cat myocardium by CGS-13080, a selective potent thromboxane A2 synthesis inhibitor. 1983 Sep-Oct J. Cardiovasc. Pharmacol. pmid:6195474
Menys VC and Davies JA Thromboxane-mediated activation of platelets and enhancement of platelet uptake onto collagen-coated glass or deendothelialized rabbit aorta. Comparative effects of a thromboxane antagonist (EPO45) and a thromboxane synthetase inhibitor (dazoxiben). 1984 Lab. Invest. pmid:6546403
Pedersen AK et al. Inhibition of thromboxane biosynthesis in serum: limitations of the measurement of immunoreactive 6-keto-PGF1 alpha. 1984 Thromb. Res. pmid:6546456
Novo S et al. Platelet activity in relation to smoke and exercise in patients with chronic obstructive lung disease: effects of platelet antiaggregating drugs. 1984 Adv. Exp. Med. Biol. pmid:6546467
Romero SD et al. Measurement of prostaglandins in the cerebrospinal fluid in cat, dog, and man. 1984 J. Neurochem. pmid:6593432
Gachályi B et al. In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man. 1984 Thromb. Res. pmid:6474407
Fitzpatrick F et al. Development of a gas chromatographic-mass spectrometric method using a stable isotope internal standard for quantitation of thromboxane B2. 1984 Thromb. Res. pmid:6474413
Watanabe J et al. Effect of vitamin E on platelet aggregation in diabetes mellitus. 1984 Tohoku J. Exp. Med. pmid:6474447
Brown C et al. Effects of age and steroid treatment on prostaglandin production by the rat uterus in relation to implantation. 1984 J. Reprod. Fertil. pmid:6583409
Del Maschio A et al. Inhibition of human platelet cyclo-oxygenase activity by sulfinpyrazone and three of its metabolites. 1984 Eur. J. Pharmacol. pmid:6432556
De Caterina R et al. Inhibition of platelet function by injectable isosorbide dinitrate. 1984 Am. J. Cardiol. pmid:6428211
Triolo G et al. Circulating immune complexes and platelet thromboxane synthesis in patients with insulin-dependent (type I) diabetes mellitus. 1984 Diabetes pmid:6611280
Alster P and Wennmalm A Effect of nicotine on the formation of prostacyclin-like activity and thromboxane in rabbit aorta and platelets. 1984 Br. J. Pharmacol. pmid:6367870
Girotti MJ et al. Effects of immunization on cardiopulmonary alterations of gram-negative endotoxemia. 1984 J Appl Physiol Respir Environ Exerc Physiol pmid:6368499
Zipser RD et al. Therapeutic trial of thromboxane synthesis inhibition in the hepatorenal syndrome. 1984 Gastroenterology pmid:6593268
Koskimies AI et al. Peritoneal fluid 6-keto-prostaglandin F1 alpha, thromboxane B2 in endometriosis and unexplained infertility. 1984 Acta Obstet Gynecol Scand Suppl pmid:6594012
Branski D et al. Prostaglandins in small intestinal mucosa of children with celiac disease. 1984 J. Pediatr. Gastroenterol. Nutr. pmid:6594493
Woodcock BE et al. The platelet defect in acute myeloid leukaemia. 1984 J. Clin. Pathol. pmid:6595273
Stimler NP Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors. 1984 Biochem. Biophys. Res. Commun. pmid:6440564
Mallarkey G and Smith GM In vivo platelet aggregation in the rat: dependence on extracellular divalent cation and inhibition by nonsteroidal anti-inflammatory drugs. 1984 Br. J. Pharmacol. pmid:6423018
Henke DC et al. Analysis of leukotrienes, prostaglandins, and other oxygenated metabolites of arachidonic acid by high-performance liquid chromatography. 1984 Anal. Biochem. pmid:6091494
Dahl ML and Uotila P Thromboxane formation during blood clotting is decreased by verapamil. 1984 Prostaglandins Leukot Med pmid:6585842
Hall ER et al. The reduction of potential TXB2 levels when serum is preincubated at room temperature. 1984 Prostaglandins Leukot Med pmid:6585846
Codde JP et al. Validation of the direct radioimmunoassay of prostanoids in serum and kidney. 1984 Prostaglandins Leukot Med pmid:6587406
Shaala S et al. Local effect of thromboxane B2 on the contractility of the human non pregnant uterus. 1984 Prostaglandins Leukot Med pmid:6587408
Turk J et al. Arachidonic acid metabolism in isolated pancreatic islets. I. Identification and quantitation of lipoxygenase and cyclooxygenase products. 1984 Biochim. Biophys. Acta pmid:6329307