Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Agnoli GC et al. | Volume-induced natriuresis in healthy women: renal metabolism of prostacyclin and thromboxane, and physiological role of prostanoids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237476 |
Yu J and Hu WS | [Effects of neferine on platelet aggregation in rabbits]. | 1997 | Yao Xue Xue Bao | pmid:11243209 |
Praticò D et al. | Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248083 |
Carvalho CR et al. | Antigen-induced bronchial hyperreactivity and bronchopulmonary inflammation in rats: effect of TNF receptor binding protein. | 2001 | Exp. Lung Res. | pmid:11258800 |
de la Riva IJ et al. | Effect of oral L-arginine administration for three weeks in two kidney-two clip hypertensive rats. | 2000 | Arch. Physiol. Biochem. | pmid:11262599 |
Oikawa K et al. | Elimination of Kupffer cells suppresses activation of nuclear factor kappa B and production of cytokines and eicosanoids in non-heart-beating donors. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267090 |
Uchiyama M et al. | Comparison between nonpulsatile and pulsatile machine perfusion preservation in liver transplantation from non-heart-beating donors. | 2001 Feb-Mar | Transplant. Proc. | pmid:11267136 |
Torras J et al. | Renal protective effect of liposomed superoxide dismutase in an experimental warm ischemia model. | 1994 | Transpl. Int. | pmid:11271283 |
Skovronsky DM et al. | Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C. | 2001 | J. Biol. Chem. | pmid:11278299 |
Komers R et al. | Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes. | 2001 | J. Clin. Invest. | pmid:11285308 |
Chen CY and Lin TH | Effects of nickel chloride on human platelets: enhancement of lipid peroxidation, inhibition of aggregation and interaction with ascorbic acid. | 2001 | J. Toxicol. Environ. Health Part A | pmid:11289317 |
Clayton HA et al. | A coculture model of intrahepatic islet transplantation: activation of Kupffer cells by islets and acinar tissue. | 2001 Jan-Feb | Cell Transplant | pmid:11294466 |
Lim JW et al. | Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells. | 2001 | Lab. Invest. | pmid:11310828 |
Guyton K et al. | Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation. | 2001 | J. Leukoc. Biol. | pmid:11310850 |
Turull A et al. | Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats. | 2001 | Inflammation | pmid:11321358 |
Rilantono LI et al. | Dietary antioxidative potential in arteries. | 2000 | Clin. Hemorheol. Microcirc. | pmid:11321428 |
Hu DH | [Effects of taurine enhancement of synthesis of TxA2 and PGI2 in cultured intra-pulmonary arteriolar smooth muscle cells under acute hypoxia]. | 1998 | Sheng Li Xue Bao | pmid:11324559 |
Kijima Y et al. | Transcardiac 8-iso-prostaglandin F(2 alpha)generation from acute myocardial infarction heart: insight into abrupt reperfusion and oxidant stress. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334551 |
Karamouzis M et al. | In situ microdialysis of intramuscular prostaglandin and thromboxane in contracting skeletal muscle in humans. | 2001 | Acta Physiol. Scand. | pmid:11350265 |
Cracowski JL et al. | Enhanced in vivo lipid peroxidation in scleroderma spectrum disorders. | 2001 | Arthritis Rheum. | pmid:11352247 |
Burch RM et al. | Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of imidazole. | 1979 | J. Pharmacol. Exp. Ther. | pmid:113526 |
Wang LL et al. | Effects of MN-9202 on platelet aggregation, 5-HT release, TXB2 synthesis, and calcium mobilization in rabbit platelets in vitro. | 2000 | Acta Pharmacol. Sin. | pmid:11360670 |
Zhang T et al. | [Clinical observation on preventing and treating coronary atherosclerotic heart disease with tongmai jiangzhi oral liquid]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11367649 |
Yu Y et al. | [Changes of prostaglandins in kidney tissue in gentamicin-induced acute renal tubular injury in rats]. | 1998 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:11367732 |
Franconi F et al. | Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro. | 2001 | Thromb. Res. | pmid:11369419 |
Loew D et al. | Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. | 2001 | Clin. Pharmacol. Ther. | pmid:11372004 |
Yoshinari D et al. | Effects of a dual inhibitor of tumor necrosis factor-alpha and interleukin-1 on lipopolysaccharide-induced lung injury in rats: involvement of the p38 mitogen-activated protein kinase pathway. | 2001 | Crit. Care Med. | pmid:11373433 |
Ogata K et al. | Attenuation of ischemia and reperfusion injury of canine livers by inhibition of type II phospholipase A2 with LY329722. | 2001 | Transplantation | pmid:11374398 |
Katoh M et al. | Inhibitory effects of TA-993 and its metabolite MB3 on platelet activation induced by collagen and U-46619 in human platelets. | 2001 | Biol. Pharm. Bull. | pmid:11379769 |
Miyake K et al. | Effects of olopatadine hydrochloride on the increase of histamine and peptide-leukotrienes concentrations in nasal lavage fluid following the antigen-antibody reaction in actively sensitized guinea pigs. | 2001 | Jpn. J. Pharmacol. | pmid:11388650 |
Cantaro S et al. | Urinary excretion of vasoactive substances in chronic renal failure. | 2001 | Clin. Nephrol. | pmid:11393385 |
Tuppo EE et al. | Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease. | 2001 | Brain Res. Bull. | pmid:11397549 |
Sontag W | Release of mediators by DMSO-differentiated HL-60 cells exposed to electric interferential current and the requirement of biochemical prestimulation. | 2001 | Int. J. Radiat. Biol. | pmid:11403712 |
Norio K et al. | Eicosanoids and delayed graft function in human renal transplantation. | 2001 | Transplant. Proc. | pmid:11406239 |
Karamouzis M et al. | The response of muscle interstitial prostaglandin E(2)(PGE(2)), prostacyclin I(2)(PGI(2)) and thromboxane A(2)(TXA(2)) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418021 |
Okita M et al. | Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418023 |
Feldman M et al. | Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay. | 2001 | J. Am. Coll. Cardiol. | pmid:11419884 |
Engström K et al. | Effect of low-dose aspirin in combination with stable fish oil on whole blood production of eicosanoids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11427037 |
Oketani K et al. | In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production. | 2001 | Eur. J. Pharmacol. | pmid:11430933 |
Minuz P et al. | NCX4016 (NO-aspirin) inhibits thromboxane biosynthesis and tissue factor expression and activity in human monocytes. | 2001 Jul-Aug | Med. Sci. Monit. | pmid:11433179 |
Gossmann J et al. | Pathophysiology of cyclosporine-induced nephrotoxicity in humans: a role for nitric oxide? | 2001 | Kidney Blood Press. Res. | pmid:11435743 |
Dubé JN et al. | Characterization of a partial prostaglandin endoperoxide H synthase-1 deficiency in a patient with a bleeding disorder. | 2001 | Br. J. Haematol. | pmid:11442478 |
Tran HS et al. | Prostacyclin is neither sufficient alone nor necessary to cause pulmonary dysfunction: results from infusions of prostacyclin and antiprostacyclin antibody in porcine septic shock. | 2001 | Crit. Care Med. | pmid:11445706 |
Coelho-Filho OR et al. | Pravastatin reduces myocardial lesions induced by acute inhibition of nitric oxide biosynthesis in normocholesterolemic rats. | 2001 | Int. J. Cardiol. | pmid:11461744 |
Wojakowski W and Gmiński J | Plasma levels of von willebrand factor, endothelin-1, prostacyclin and thromboxane in children from families with high risk of premature coronary artery disease. | 2001 | Scand. J. Clin. Lab. Invest. | pmid:11465346 |
Rosón MI et al. | Serotonin hypersensitivity in aorta of two kidney-two clip hypertensive rats: calcium contribution and prostanoids-nitric oxide interactions. | 2001 | Arch. Physiol. Biochem. | pmid:11471069 |
Catella-Lawson F et al. | Oral glycoprotein IIb/IIIa antagonism in patients with coronary artery disease. | 2001 | Am. J. Cardiol. | pmid:11472700 |
Zoja C et al. | Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis. | 2001 | Kidney Int. | pmid:11473648 |
Wu Y et al. | [Clinical study on improving effect of Buyang Huanwu decoction on plasma thromboxane B2, 6-keto-prostaglandin F1 alpha, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475715 |
Lang J et al. | [Comparative study on effect of Panax notoginseng and ticlid in treating early diabetic nephropathy]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475719 |
Lin S et al. | [Clinical study on active factors of vascular endothelial cells in acute cerebral infarction patients and therapeutical effect of activating blood stasis]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477811 |
Huang R et al. | [Effects in tetramethylpyrazine on TXA2 and PGI2 by cardio-pulmonary bypass in congenital heart diseases with pulmonary hypertension patients]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477904 |
Xu J et al. | [Study on relativity between oxygen free radical and thromboxane B2, 6-keto-PGF1 alpha during ligustrazine treatment of intrauterine growth retardation]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477921 |
Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
Rebrov BA | [Role of thromboxane A2 (B2) in the pathogenesis of stress proteinuria in healthy persons]. | 2001 Mar-Apr | Urologiia | pmid:11490711 |
Valeri CR et al. | Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss. | 2001 | Transfusion | pmid:11493727 |
Khan HH et al. | Plasma CPU-86017 concentrations regarding suppression of ouabain-induced cardiac arrhythmias and decrease of heart rate in guinea pigs. | 2000 | Acta Pharmacol. Sin. | pmid:11501061 |
Chen G et al. | [The effect of the molecular triggers of hemostatic activity on thrombosis in early stage of electrical injuries]. | 1999 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:11501103 |
Wang W et al. | Effects of magnesium lithospermate B on aggregation and 5-HT release in rabbit washed platelets. | 2000 | Acta Pharmacol. Sin. | pmid:11501172 |
Ploner F et al. | Effects of combined selective iNOS inhibition and peroxynitrite blockade during endotoxemia in pigs. | 2001 | Shock | pmid:11508865 |
Diebolt M et al. | Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression. | 2001 | Hypertension | pmid:11509469 |
Tomida T et al. | Altered expression of prostacyclin synthase in a subset of the thick ascending limb cells and mesangial cells in 5/6-nephrectomized rats. | 2001 | Hypertens. Res. | pmid:11510754 |
Bölke E et al. | Changes of gut barrier function during anesthesia and cardiac surgery. | 2001 | Angiology | pmid:11515987 |
Takeyoshi I et al. | The effect of a selective cyclooxygenase-2 inhibitor in extended liver resection with ischemia in dogs. | 2001 | J. Surg. Res. | pmid:11516201 |
Muramatsu H et al. | [Correlation between the clinical effects of Seratrodast and the level of 11-dehydrothromboxane B2 in urine/sputum in bronchial asthma patients]. | 2001 | Arerugi | pmid:11517517 |
Dowd NP et al. | Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo. | 2001 | J. Clin. Invest. | pmid:11518732 |
Calzada C et al. | 12(S)-Hydroperoxy-eicosatetraenoic acid increases arachidonic acid availability in collagen-primed platelets. | 2001 | J. Lipid Res. | pmid:11518767 |
Fritsma GA et al. | Monitoring the antiplatelet action of aspirin. | 2001 | JAAPA | pmid:11523339 |
Patrono C et al. | Inhibition of platelet cyclooxygenase by aspirin-like drugs: methods for in vitro and ex vivo assessment. | 1979 | Agents Actions Suppl. | pmid:115255 |
Davì G et al. | Oxidative stress and platelet activation in homozygous homocystinuria. | 2001 | Circulation | pmid:11535567 |
Li F et al. | [Effects of frostbite on some factors of blood coagulation system in rats under hypoxia]. | 1996 | Space Med Med Eng (Beijing) | pmid:11539914 |
Alcaraz A et al. | Experimental kidney transplantation in pigs from non-heart-beating donors: evaluation of vasoactive substances and renal artery flow. | 2001 | Transplant. Proc. | pmid:11543815 |
Beck-Speier I et al. | Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages. | 2001 | Environ. Health Perspect. | pmid:11544173 |
Giese A et al. | Thromboxane synthase regulates the migratory phenotype of human glioma cells. | 1999 | Neuro-oncology | pmid:11550298 |
BroulÃk PD et al. | Impact of antihypertensive therapy on the skeleton: effects of enalapril and AT1 receptor antagonist losartan in female rats. | 2001 | Physiol Res | pmid:11551140 |
Kaaja R et al. | Increased thromboxane production in women with a history of venous thromboembolic event: effect of heparins. | 2001 | Br. J. Haematol. | pmid:11552994 |
Oketani K et al. | Effect of E3040, an inhibitor of 5-lipoxygenase and thromboxane synthase, on rat bowel damage induced by lipopolysaccharide. | 2001 | Eur. J. Pharmacol. | pmid:11557269 |
Blann AD et al. | Changes in endothelial, leucocyte and platelet markers following contrast medium injection during angiography in patients with peripheral artery disease. | 2001 | Br J Radiol | pmid:11560828 |
Martinuzzo ME et al. | Increased lipid peroxidation correlates with platelet activation but not with markers of endothelial cell and blood coagulation activation in patients with antiphospholipid antibodies. | 2001 | Br. J. Haematol. | pmid:11564073 |
Van Solingen RM et al. | Comparison of the effects of ketoprofen on platelet function in the presence and absence of aspirin. | 2001 | Am. J. Med. | pmid:11566459 |
Jilma-Stohlawetz P et al. | Impaired platelet function among platelet donors. | 2001 | Thromb. Haemost. | pmid:11583322 |
Llinás MT et al. | Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine. | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11592955 |
Duan M et al. | Factors involved in the neuronal death during postischemic reperfusion: experimental study in rabbits. | 1999 | Chin. Med. J. | pmid:11593584 |
Lu G et al. | [Effect of xueling on relating substances of renal hypertension in rats]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11601304 |
Cyrus T et al. | Lipid peroxidation and platelet activation in murine atherosclerosis. | 2001 | Circulation | pmid:11602498 |
Sunose Y et al. | Effect of a cyclooxygenase-2 inhibitor, FK3311, in a canine lung transplantation model. | 2001 | Ann. Thorac. Surg. | pmid:11603431 |
Minuz P et al. | NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes. | 2001 | Br. J. Pharmacol. | pmid:11606332 |
Haastrup A et al. | Lipids stimulate the production of 6-keto-prostaglandin f(1alpha) in human dorsal hand veins. | 2001 | Hypertension | pmid:11641299 |
Galipeau D et al. | Chronic thromboxane synthase inhibition prevents fructose-induced hypertension. | 2001 | Hypertension | pmid:11641301 |
Tubaro E et al. | Anti-inflammatory and antiplatelet effects of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. | 2001 | Arzneimittelforschung | pmid:11642006 |
Wong PY and Cheung WY | Calmodulin stimulates human platelet phospholipase A2. | 1979 | Biochem. Biophys. Res. Commun. | pmid:116656 |
Okuma M and Uchino H | Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders. | 1979 | Blood | pmid:116695 |
Watanabe T et al. | Enhanced platelet sensitivity to prostacyclin in patients in an active stage of Takayasu arteritis. | 2001 | Thromb. Res. | pmid:11672751 |
Ziegler BK et al. | Incomplete thromboxane inhibition with 100 mg of intravenous acetylsalicylic acid in patients with acute ST elevation myocardial infarction: a placebo-controlled pilot trial. | 2001 | Thromb. Res. | pmid:11672759 |
Nüsing RM et al. | Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide. | 2001 | Clin. Pharmacol. Ther. | pmid:11673754 |
Gloor B et al. | Hydrocortisone treatment of early SIRS in acute experimental pancreatitis. | 2001 | Dig. Dis. Sci. | pmid:11680590 |
McConnell JP et al. | Urinary 11-dehydro-thromboxane B(2) and coagulation activation markers measured within 24 h of human acute ischemic stroke. | 2001 | Neurosci. Lett. | pmid:11684346 |
Wan Y et al. | Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. | 2001 | Am. J. Clin. Nutr. | pmid:11684527 |
Wang ZY et al. | Comparative study of platelet activation markers in diabetes mellitus patients complicated by cerebrovascular disease. | 2001 | Blood Coagul. Fibrinolysis | pmid:11685040 |
Wang WJ and Huang TF | A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist. | 2001 | Thromb. Haemost. | pmid:11686327 |