Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Schuette AH et al. | Effect of lung thromboxane generation on regional blood flow during sheep bypass. | 1982 | Am. J. Physiol. | pmid:7065206 |
Mäkilä UM et al. | Regulation of prostacyclin and thromboxane production by human umbilical vessels: the effect of estradiol and progesterone in a superfusion model. | 1982 | Prostaglandins Leukot Med | pmid:7043492 |
Han P et al. | Inhibition of platelet function of antiarrhythmic drugs, verapamil and disopyramide. | 1982 | Thromb. Haemost. | pmid:7101234 |
Krausz MM et al. | Adverse effects of prostacyclin used to perfuse isolated lung lobes. | 1982 | Am. J. Physiol. | pmid:7044149 |
Hirsh PD et al. | Influence of blood sampling site and technique on thromboxane concentrations in patients with ischemic heart disease. | 1982 | Am. Heart J. | pmid:7102506 |
Siess W et al. | Plasma catecholamines, platelet aggregation and associated thromboxane formation after physical exercise, smoking or norepinephrine infusion. | 1982 | Circulation | pmid:7044612 |
Chierchia S et al. | Failure of thromboxane A2 blockade to prevent attacks of vasospastic angina. | 1982 | Circulation | pmid:7116586 |
Sasagawa S et al. | Effects of thromboxane A2 injection on the rabbit coronary artery. I. Physiologic effects in healthy animals. | 1982 | Exp. Mol. Pathol. | pmid:7117494 |
Socini A et al. | Effects of the coumarin derivative AD6 on platelet aggregation, platelet vessel wall interactions and 6 keto PGF1 alpha production in perfused aortas, in experimentally hypercholesterolaemic rabbits. | 1982 | Pharmacol Res Commun | pmid:7048340 |
Fantone JC et al. | Inhibition of vascular permeability changes in rats by captopril. | 1982 | J. Clin. Invest. | pmid:6282931 |
Ylikorkala O and Viinikka L | Effect of amnioscopy on concentrations of prostaglandin F2 alpha, prostacyclin and thromboxane in maternal plasma. | 1982 | Gynecol. Obstet. Invest. | pmid:6954125 |
Simpson RM et al. | Generation of thromboxane A2 and aorta-contracting activity from platelets stimulated with modified C-reactive protein. | 1982 | Immunology | pmid:7118160 |
Leach CM and Thorburn GD | A comparative study of collagen induced thromboxane release from platelets of different species: implications for human atherosclerosis models. | 1982 | Prostaglandins | pmid:7122912 |
Bottoms GD et al. | Thromboxane, prostaglandin I2 (epoprostenol), and the hemodynamic changes in equine endotoxin shock. | 1982 | Am. J. Vet. Res. | pmid:7049018 |
Poubelle P et al. | [Mononucleated phagocytes from rheumatoid synovial fluid. Synthesis of prostanoids and first pharmacological applications]. | 1982 | Rev Rhum Mal Osteoartic | pmid:7123126 |
Homma T and Malik KU | Effect of prostaglandins on pancreatic circulation in anesthetized dogs. | 1982 | J. Pharmacol. Exp. Ther. | pmid:7050343 |
Bradlow BA and Chetty N | Dosage frequency for suppression of platelet function by low dose aspirin therapy. | 1982 | Thromb. Res. | pmid:7123514 |
Buchanan MR et al. | Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase. | 1982 | Thromb. Res. | pmid:7071811 |
Tremoli E et al. | Metformin reduces platelet hypersensitivity in hypercholesterolemic rabbits. | 1982 | Atherosclerosis | pmid:7073794 |
Tanabe M et al. | Coronary circulatory failure and thromboxane A2 release during coronary occlusion and reperfusion in anaesthetised dogs. | 1982 | Cardiovasc. Res. | pmid:7074670 |
Dorsch W et al. | Mediator studies in skin blister fluid from patients with dual skin reactions after intradermal allergen injection. | 1982 | J. Allergy Clin. Immunol. | pmid:6181112 |
Fletcher MS et al. | Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice. | 1982 | Br J Surg | pmid:6751458 |
Shaw JO and Lyons RM | Requirement for different Ca2+ pools in the activation of rabbit platelets II. Phospholipase activity. | 1982 | Biochim. Biophys. Acta | pmid:6800410 |
Dejana E et al. | Bleeding time in rats: a comparison of different experimental conditions. | 1982 | Thromb. Haemost. | pmid:6753230 |
Axelrod L and Levine L | Plasma prostaglandin levels in rats with diabetes mellitus and diabetic ketoacidosis. | 1982 | Diabetes | pmid:6816644 |
DiMinno G et al. | Stored human platelets retain full aggregation potential in response to pairs of aggregating agents. | 1982 | Blood | pmid:6800418 |
Strano A et al. | Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. | 1982 | Thromb. Haemost. | pmid:6753232 |
Flynn JT and Demling RH | Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. | 1982 | Adv Shock Res | pmid:6753534 |
Grundfest CC et al. | Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism. | 1982 | Biochim. Biophys. Acta | pmid:6814492 |
Smith MC et al. | Prostacyclin substitution for heparin in long-term hemodialysis. | 1982 | Am. J. Med. | pmid:6753575 |
Zipser RD and Martin K | Urinary excretion of arterial blood prostaglandins and thromboxanes in man. | 1982 | Am. J. Physiol. | pmid:6950668 |
Aharony D et al. | Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid. | 1982 | Biochim. Biophys. Acta | pmid:6814496 |
Ylikorkala O et al. | Prostacyclin and thromboxane in chronic uremia: effect of hemodialysis. | 1982 | Clin. Nephrol. | pmid:6754193 |
Ylikorkala O et al. | Production of prostacyclin and thromboxane during cesarean section. | 1982 | Obstet Gynecol | pmid:6755324 |
Utsunomiya T et al. | Modification of inflammatory response to aspiration with ibuprofen. | 1982 | Am. J. Physiol. | pmid:6756172 |
Hamasaki Y et al. | Hypoxia stimulates prostacyclin generation by dog lung in vitro. | 1982 | Prostaglandins Leukot Med | pmid:7051045 |
Tooke JE et al. | Aspirin, prostacyclin and post-occlusive reactive hyperaemia in man. | 1982 | Prostaglandins Leukot Med | pmid:6757966 |
Herman CA et al. | Prostaglandins of the one, two, and three series affect blood pressure in the american bullfrog, Rana catesbeiana. | 1982 | Gen. Comp. Endocrinol. | pmid:6761235 |
Panganamala RV and Cornwell DG | The effects of vitamin E on arachidonic acid metabolism. | 1982 | Ann. N. Y. Acad. Sci. | pmid:6816121 |
Mitrovic D et al. | The in vitro production of prostanoids by cultured bovine articular chondrocytes. | 1982 | Prostaglandins | pmid:6801735 |
Hornych A et al. | Radioimmunoassay measurement of thromboxane B2 in human plasma and urine. | 1982 | Prostaglandins Leukot Med | pmid:6954551 |
Mest HJ et al. | Influence of mental stress on plasma level of prostaglandins, thromboxane B2 and on circulating platelet aggregates in man. | 1982 | Prostaglandins Leukot Med | pmid:6955811 |
Watanabe T et al. | Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. | 1982 | J. Biol. Chem. | pmid:6816798 |
Graham RM et al. | Effects of short-term beta blockade on blood pressure, plasma thromboxane B2, and plasma and urinary prostaglandins E2 and F2 alpha in normal subjects. | 1982 | Clin. Pharmacol. Ther. | pmid:6120775 |
Reines HD et al. | Plasma thromboxane concentrations are raised in patients dying with septic shock. | 1982 | Lancet | pmid:6123885 |
White JG and Rao GH | Effects of a microtubule stabilizing agent on the response of platelets to vincristine. | 1982 | Blood | pmid:6124288 |
Chong BH et al. | Heparin-induced thrombocytopenia: association of thrombotic complications with heparin-dependent IgG antibody that induces thromboxane synthesis in platelet aggregation. | 1982 | Lancet | pmid:6128550 |
Di Minno G et al. | Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides. | 1982 | Thromb. Res. | pmid:6803385 |
Suehiro A et al. | The role of platelet hyperfunction in thrombus formation in hyperlipidemia. | 1982 | Thromb. Res. | pmid:6803387 |
Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
Goldyne ME and Stobo JD | Human monocytes synthesize eicosanoids from T lymphocyte-derived arachidonic acid. | 1982 | Prostaglandins | pmid:6819603 |
Mehta P et al. | Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production. | 1982 | Prostaglandins | pmid:6820165 |
Nolan RD et al. | The pericardium as a source of prostacyclin in the dog, ox and rat. | 1982 | Prostaglandins | pmid:6820168 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). | 1982 | Thromb. Res. | pmid:6897751 |
De Caterina R et al. | [Effect of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. | 1982 | Cardiologia | pmid:6927441 |
Davì G et al. | [Effects of flurbiprofen on platelet function in patients with ischemic cardiomyopathy]. | 1982 | Cardiologia | pmid:6927457 |
Whinnery MA et al. | Thromboxane B2 and prostaglandin E2 in the rat kidney with unilateral ureteral obstruction. | 1982 | Am. J. Physiol. | pmid:6950670 |
McNamara DB et al. | Prostaglandin endoperoxide metabolism by microsomes of whole kidneys from normal, congenital unilateral hydronephrotic and unilateral ureteral obstructed rats. | 1982 | Prostaglandins | pmid:6962465 |
Hornych A et al. | [Urinary thromboxane B2 in hypertensive patients]. | 1982 | Arch Mal Coeur Vaiss | pmid:6810812 |
Worthington RE and Nakeff A | Aspirin inhibits rat megakaryocyte thromboxane synthesis. | 1982 | Prostaglandins | pmid:6812167 |
Havill AM et al. | alpha-Naphthylthiourea produces dose-dependent lung vascular injury in sheep. | 1982 | Am. J. Physiol. | pmid:6812437 |
Lecompte T et al. | Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6809005 |
Preston FE et al. | Low-dose aspirin inhibits platelet and venous cyclo-oxygenase in man. | 1982 | Thromb. Res. | pmid:6815823 |
Burch RM and Halushka PV | Vasopressin stimulates prostaglandin and thromboxane synthesis in toad bladder epithelial cells. | 1982 | Am. J. Physiol. | pmid:6816073 |
Patrignani P et al. | Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. | 1982 | J. Clin. Invest. | pmid:7045161 |
Bakhle YS and Zakrzewski JT | Effects of the oestrous cycle on the metabolism of arachidonic acid in rat isolated lung. | 1982 | J. Physiol. (Lond.) | pmid:6809935 |
Neri Serheri GG et al. | Platelet aggregation and thromboxane A2 production after adrenergic stimulation in young healthy humans. | 1982 | Haemostasis | pmid:6279476 |
Watkins WD et al. | Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: effect of an imidazole derivative. | 1982 | Prostaglandins | pmid:7048422 |
Dore-Duffy P | Differential effect of prostaglandins and other products of arachidonic acid metabolism on measles virus replication in Vero cells. | 1982 | Prostaglandins Leukot Med | pmid:6281810 |
Miller OV et al. | Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. | 1982 | Biochim. Biophys. Acta | pmid:6285985 |
Hüttemeier PC et al. | Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep. | 1982 | Circ. Res. | pmid:7042108 |
Kunkel SL et al. | Production of cyclooxygenase products and superoxide anion by macrophages in response to chemotactic factors. | 1982 | Prostaglandins | pmid:6300969 |
Panossian A et al. | On the mechanism of biosynthesis of leukotrienes and related compounds. | 1982 | FEBS Lett. | pmid:6297982 |
Pawlowski NA et al. | Uptake and metabolism of monohydroxy-eicosatetraenoic acids by macrophages. | 1982 | J. Exp. Med. | pmid:6951919 |
Nugent WC et al. | Prostaglandin response to intravenous nitroglycerin. | 1982 | J. Surg. Res. | pmid:6810023 |
Scherhag R et al. | Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. | 1982 | Prostaglandins | pmid:6285420 |
Malemud CJ et al. | Correlation of the biosynthesis of prostaglandin and cyclic AMP in monolayer cultures of rabbit articular chondrocytes. | 1982 | Biochim. Biophys. Acta | pmid:6280776 |
Schafer AI et al. | Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6812645 |
Ylikorkala O et al. | The effect of oral contraceptives on antiaggregatory prostacyclin and proaggregatory thromboxane A2 in humans. | 1982 | Am. J. Obstet. Gynecol. | pmid:7036746 |
Kelton JG et al. | Sex-related differences in the efficacy of acetylsalicylic acid (ASA) : the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. | 1981 Oct 1-15 | Thromb. Res. | pmid:7330835 |
Randall MJ et al. | UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity. | 1981 Jul 1-15 | Thromb. Res. | pmid:6795753 |
Tsuboi T et al. | Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. | 1981 Jan 1-15 | Thromb. Res. | pmid:7233394 |
Bockman RS | Prostaglandin production by human blood monocytes and mouse peritoneal macrophages: synthesis dependent on in vitro culture conditions. | 1981 | Prostaglandins | pmid:6782622 |
Rittenhouse-Simmons S | Differential activation of platelet phospholipases by thrombin and ionophore A23187. | 1981 | J. Biol. Chem. | pmid:6783655 |
Shaw JO et al. | Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). | 1981 | Biochim. Biophys. Acta | pmid:7213765 |
Kass MA et al. | Prostaglandin and thromboxane synthesis by microsomes of inflamed rabbit ciliary body--iris. | 1981 | Invest. Ophthalmol. Vis. Sci. | pmid:7216665 |
Sakio H et al. | [Release of thromboxane A2 during hemorrhagic shock (author's transl)]. | 1981 | Masui | pmid:7218508 |
Kawaguchi H et al. | Thromboxane B2 biosynthesis and phospholipids hydrolysis in platelets from hypercholesterolemic rabbits. | 1981 | Lipids | pmid:7219079 |
Sirois P et al. | Comparative effects of leukotriene B4, prostaglandins I2 and E2, 6-keto-PGF1 alpha thromboxane B2 and histamine on selected smooth muscle preparations. | 1981 | J. Pharm. Pharmacol. | pmid:6115037 |
Coker SJ et al. | Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs. | 1981 | Br. J. Pharmacol. | pmid:7284679 |
Rifkin BR and Tai HH | Elevated thromboxane B2 levels in periodontal disease. | 1981 | J. Periodont. Res. | pmid:6453981 |
Morrison AR and Benabe JE | Prostaglandins in vascular tone in experimental obstructive nephropathy. | 1981 | Kidney Int. | pmid:6894950 |
Bombardieri S et al. | The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs. | 1981 | Br. J. Pharmacol. | pmid:6895043 |
Harms BA et al. | Prostaglandin release and altered microvascular integrity after burn injury. | 1981 | J. Surg. Res. | pmid:6895238 |
Ylikorkala O et al. | Amniotic fluid prostacyclin and thromboxane in normal, preeclamptic, and some other complicated pregnancies. | 1981 | Am. J. Obstet. Gynecol. | pmid:6895277 |
Ishihara Y et al. | [Effect of hypoxemia and pulmonary thromboembolism on plasma levels of 6-keto PGF 1 alpha, TxB, histamine and serotonin in anesthetized dogs (author's transl)]. | 1981 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:6895531 |
Defreyn G et al. | Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. | 1981 | Br. J. Haematol. | pmid:6268139 |
Agradi E et al. | In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. | 1981 | Prostaglandins | pmid:6794104 |
Beck N and Shaw JO | Thromboxane B2 and prostaglandin E2 in the K+-depleted rat kidney. | 1981 | Am. J. Physiol. | pmid:7468800 |
Laviolette M et al. | Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers. | 1981 | Am. Rev. Respir. Dis. | pmid:6794395 |