Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Fitzpatrick FA | A radioimmunoassay for thromboxane B2. | 1982 | Meth. Enzymol. | pmid:7132759 |
Maas RL et al. | Quantitative assay of urinary 2,3-dinor thromboxane B2 by GC-MS. | 1982 | Meth. Enzymol. | pmid:7132771 |
Pace-Asciak CR and Edwards NS | Preparation of 2,3,4,5-tetranor-thromboxane B2, the major urinary catabolite of thromboxane B2 in the rat. | 1982 | Meth. Enzymol. | pmid:7132772 |
Martin JF et al. | Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique. | 1982 | Thromb. Res. | pmid:6814004 |
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Blackwell GJ et al. | Prostacyclin prolongs viability of washed human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6291622 |
Karmali RA et al. | Prostaglandin regulation of murine mammary tumor virus production: a basis for some of the glucocorticoid and prolactin actions on mammary tumor cell cultures. | 1982 | Prostaglandins Leukot Med | pmid:6296884 |
Jaweed MM et al. | Changes in thromboxane B2 and 6-keto-PGF1 alpha after direct electrical stimulation of the denervated rat gastrocnemius1,2. | 1982 | Prostaglandins Leukot Med | pmid:6956927 |
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Rachmilewitz D et al. | Prostanoid synthesis by cultured peripheral blood mononuclear cells in inflammatory diseases of the bowel. | 1982 | Gastroenterology | pmid:6949849 |
Capitanio A et al. | Detection of circulating released platelets after renal transplantation. | 1982 | Transplantation | pmid:6461116 |
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Rock JA et al. | Cul-de-sac fluid in women with endometriosis: fluid volume and prostanoid concentration during the proliferative phase of the cycle--days 8 to 12. | 1982 | Fertil. Steril. | pmid:6953017 |
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Chen LS et al. | Changes of plasma 6-keto-PGF1 alpha and thromboxane B2 levels and platelet aggregation after tourniquet ischemia on the upper limb in normal subjects and patients with ischemic heart disease. | 1982 | Jpn. Circ. J. | pmid:6896534 |
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Koyama I et al. | Release of 6-keto-prostaglandin F1 alpha and thromboxane B2 from mouse peritoneal macrophages during their adhesion and spreading on a glass surface. | 1982 | Prostaglandins | pmid:6896924 |
Meydani SN and Dupont J | Effect of zinc deficiency on prostaglandin synthesis in different organs of the rat. | 1982 | J. Nutr. | pmid:7045297 |
Srivastava KC and Awasthi KK | A comparative study on the effect of cis (oleic, linoleic) and trans (elaidic, linoelaidic) fatty acids on the in vitro prostaglandin biosynthesis in human blood platelets from (1-14C) arachidonic acid. | 1982 | Prostaglandins Leukot Med | pmid:6818563 |
Kelley VE et al. | Effect of ibuprofen, a fatty acid cyclooxygenase inhibitor, on murine lupus. | 1982 | Clin. Immunol. Immunopathol. | pmid:6819912 |
Cerletti C et al. | Non-steroidal anti-inflammatory drugs react with two sites on platelet cyclo-oxygenase. Evidence from "in vivo" drug interaction studies in rats. | 1982 | Biochim. Biophys. Acta | pmid:6799004 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane formation by platelets and vascular prostacyclin production from BB rats. An animal model for type I diabetes. | 1982 | Prostaglandins | pmid:6812171 |
Bodzenta A et al. | Platelet malondialdehyde and plasma thromboxane B2 formation in patients with obliterative arteriosclerosis of the lower limbs. | 1982 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:6188668 |
Harada Y et al. | Changes in the levels of prostaglandins and thromboxane and their roles in the accumulation of exudate in rat carrageenin-induced pleurisy--a profile analysis using gas chromatography-mass spectrometry. | 1982 | Prostaglandins | pmid:6889754 |
Yoshimoto T and Yamamoto S | Partial purification and assay of thromboxane A synthase from bovine platelets. | 1982 | Meth. Enzymol. | pmid:6890138 |
Miller JL et al. | Arachidonic acid metabolism in guinea pig megakaryocytes. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6812584 |
Rothberg KG and Hitchcock M | In vitro biosynthesis of cyclooxygenase metabolites in ovalbumin-sensitized and control lungs of guinea pigs. | 1982 | Biochem. Pharmacol. | pmid:6812589 |
Robinson C et al. | Thromboxane B2 uptake and metabolism in isolated perfused lung. Identification and comparison with prostaglandin F2 alpha. | 1982 | Biochim. Biophys. Acta | pmid:6751406 |
Uyama O et al. | Plasma concentrations of 6-keto-prostaglandin F1 alpha in patients with hypertension, cerebrovascular disease or Takayasu's arteritis. | 1982 Jan 1-15 | Thromb. Res. | pmid:6121391 |
Sakai K et al. | Roles of endogenous prostacyclin and thromboxane A2 in the ischemic canine heart. | 1982 Jan-Feb | J. Cardiovasc. Pharmacol. | pmid:6176788 |
Giannessi D et al. | Methodological assessment and applications of a radioimmunoassay for thromboxane (TxB2) to measurement of TxB2 release by platelets. | 1982 Jan-Mar | J. Nucl. Med. Allied Sci. | pmid:7108634 |
Shohami E et al. | The effect of incomplete cerebral ischemia on prostaglandin levels in rat brain. | 1982 Jul-Aug | Stroke | pmid:6896589 |
Mest HJ et al. | [Effect of stress on blood level of prostaglandins in students during exams]. | 1982 May-Jun | Farmakol Toksikol | pmid:7095121 |
Simmons PM et al. | The release of leukotriene B4 during experimental inflammation. | 1983 | Biochem. Pharmacol. | pmid:6305369 |
Mäkilä UM et al. | Relation between umbilical prostacyclin production and blood-flow in the fetus. | 1983 | Lancet | pmid:6132081 |
Thorngren M et al. | Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid. | 1983 | Lancet | pmid:6133107 |
Martin JL et al. | Effect of atrial pacing on intracoronary thromboxane production in coronary artery disease. | 1983 | J. Am. Coll. Cardiol. | pmid:6833660 |
Ferraris VA and Swanson E | Aspirin usage and perioperative blood loss in patients undergoing unexpected operations. | 1983 | Surg Gynecol Obstet | pmid:6836459 |
Margotat A et al. | A rapid and simple assay for the study of thromboxane B2 synthesis by intact human platelets. | 1983 | J Pharmacol Methods | pmid:6843139 |
Johnsen SA et al. | Conversion of arachidonic acid in human maternal and neonatal mononuclear leukocytes. | 1983 | Immunol. Lett. | pmid:6411611 |
Rotmensch HH et al. | Plasma platelet products and exercise-induced myocardial ischemia. | 1983 | J. Lab. Clin. Med. | pmid:6854135 |
Hamelin SS and Chan AC | Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate. | 1983 | Lipids | pmid:6855486 |
De Clerck F et al. | Platelet activation by endogenous 5-hydroxytryptamine and histamine released by mast cell degranulation with compound 48/80 in the rat. | 1983 | Agents Actions | pmid:6858790 |
Preston FE | Aspirin, prostaglandins, and peripheral gangrene. | 1983 | Am. J. Med. | pmid:6859070 |
Menys VC and Davies JA | Inhibitory effects of ZK 36374, a stable prostacyclin analogue, on adhesion of rabbit platelets to damaged aorta and serotonin release by adherent platelets. | 1983 | Clin. Sci. | pmid:6190604 |
Hartung HP and Toyka KV | Activation of macrophages by substance P: induction of oxidative burst and thromboxane release. | 1983 | Eur. J. Pharmacol. | pmid:6191998 |
Tanganelli I et al. | [Thromboxane, beta-thromboglobulin and the degree of blood sugar control in type 1 diabetes mellitus]. | 1983 | Boll. Soc. Ital. Biol. Sper. | pmid:6194801 |
Capodicasa G et al. | Platelet thromboxane formation and BTG levels after intensive charcoal HP in uremics or regular hemodialytic treatment (RHT). | 1983 | Int J Artif Organs | pmid:6195116 |
Ditter H et al. | Effects of prostacyclin during cardiopulmonary bypass in men on plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1 alpha and heparin. | 1983 | Thromb. Res. | pmid:6197766 |
Roth DM et al. | Protective actions of ibuprofen in arachidonate-induced sudden death. | 1983 | Pharmacology | pmid:6413987 |
Salmon JA et al. | Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovial lining in nonproliferative organ culture. | 1983 | Ann. Rheum. Dis. | pmid:6402992 |
Di Minno G et al. | Exposure of platelet fibrinogen-binding sites by collagen, arachidonic acid, and ADP: inhibition by a monoclonal antibody to the glycoprotein IIb-IIIa complex. | 1983 | Blood | pmid:6216929 |
Newman JH et al. | Effects of 100% oxygen on lung vascular function in awake sheep. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6345493 |
Eldor A et al. | Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells. | 1983 | Thromb. Haemost. | pmid:6346571 |
Sheng WY et al. | Kinetic comparison and regulation of the cascade of microsomal enzymes involved in renal arachidonate and endoperoxide metabolism. | 1983 | J. Biol. Chem. | pmid:6401732 |
Menys VC and Davies JA | Selective inhibition of thromboxane synthetase with dazoxiben - basis of its inhibitory effect on platelet adhesion. | 1983 | Thromb. Haemost. | pmid:6346575 |
Reeves WC et al. | The release of thromboxane A2 and prostacyclin following experimental acute pulmonary embolism. | 1983 | Prostaglandins Leukot Med | pmid:6348800 |
Aznavoorian SA et al. | Prostacyclin inhibits 5-hydroxytryptamine release but stimulates thromboxane synthesis during cardiopulmonary bypass. | 1983 | Prostaglandins | pmid:6348886 |
Kaar ML et al. | Prostacyclin and thromboxane in diabetic children. | 1983 | Prostaglandins Leukot Med | pmid:6351104 |
Parry MJ | Effects of thromboxane synthetase inhibition on arachidonate metabolism and platelet behaviour. | 1983 | Br J Clin Pharmacol | pmid:6401997 |
Fischer S et al. | The influence of selective thromboxane synthetase inhibition with a novel imidazole derivative, UK-38,485, on prostanoid formation in man. | 1983 | Circulation | pmid:6352080 |
Davi' G et al. | Platelet activation after adrenergic stimulation in hypertensive patients: effects of acebutolol. | 1983 | Eur. Heart J. | pmid:6352266 |
Jakubowski JA et al. | Arachidonic acid metabolism by platelets of differing size. | 1983 | Br. J. Haematol. | pmid:6402003 |
Kiff PS et al. | Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing. | 1983 | Br J Clin Pharmacol | pmid:6681708 |
Hutton I et al. | Effects of dazoxiben on transcardiac thromboxane levels and haemodynamics in coronary heart disease. | 1983 | Br J Clin Pharmacol | pmid:6681709 |
Zijlstra FJ et al. | Thrombotic thrombocytopenic purpura and plasma thromboxane B2 levels. | 1983 | Thromb. Res. | pmid:6684333 |
Lianos EA et al. | Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics. | 1983 | J. Clin. Invest. | pmid:6685136 |
Wynalda MA et al. | Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A), a new, selective thromboxane synthase inhibitor: intravenous and oral pharmacokinetics in dogs and correlations with ex situ thromboxane B2 production. | 1983 | Prostaglandins | pmid:6685888 |
McDonald JW et al. | Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep. | 1983 | Circ. Res. | pmid:6687354 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01). | 1983 | Br J Clin Pharmacol | pmid:6687429 |
Gordon PR et al. | Platelet arachidonate metabolism and platelet function in zinc-deficient rats. | 1983 | J. Nutr. | pmid:6403678 |
Okegawa T et al. | Endotoxin induces chronic prostaglandin and thromboxane synthesis from ureter-obstructed kidneys: role of inflammatory cells. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6403696 |
Hidaka T et al. | Thromboxane formation from arachidonic acid and prostaglandin H2 in rabbit spleen. | 1983 | J. Biochem. | pmid:6404897 |
Gerozissis K and Dray F | In-vitro prostanoid production by the rat vas deferens. | 1983 | J. Reprod. Fertil. | pmid:6572721 |
Zijlstra FJ and Vincent JE | Comparison of the determination of thromboxane A2 by bioassay on the rabbit mesenteric artery and in the form of TxB2 by radioimmunoassay. | 1983 | J Pharmacol Methods | pmid:6632924 |
Wilson L | Effects of estradiol and progesterone on uterine prostaglandin levels in the pregnant rat. | 1983 | Prostaglandins | pmid:6635211 |
Sanders TA and Hochland MC | A comparison of the influence on plasma lipids and platelet function of supplements of omega 3 and omega 6 polyunsaturated fatty acids. | 1983 | Br. J. Nutr. | pmid:6639916 |
Mehta JL | Prostaglandins: regulatory role in cardiovascular system and implications in ischemic heart disease. | 1983 | Int. J. Cardiol. | pmid:6642760 |
Mathieson MA et al. | Ischemia of the limb stimulates thromboxane production and myocardial depression. | 1983 | Surg Gynecol Obstet | pmid:6648769 |
Barrett PA and Butler KD | Shortening of platelet survival by induced hypercholesterolaemia in rabbits and its prolongation by anagrelide. | 1983 | Thromb. Haemost. | pmid:6648889 |
Robinson C and Hoult JR | Thromboxane A2 analogues inhibit the metabolism of thromboxane B2 in perfused guinea-pig lung. | 1983 | Biochim. Biophys. Acta | pmid:6652102 |
Socini A et al. | Fish oil administration as a supplement to a corn oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat. | 1983 | Prostaglandins | pmid:6310702 |
Gethmann U et al. | Effect of catecholestrogens on prostaglandin release by rat pituitaries superfused in vitro. | 1983 | Arch. Gynecol. | pmid:6320749 |
Hornych A et al. | Thromboxane B2 in borderline and essential hypertensive patients. | 1983 | Prostaglandins Leukot Med | pmid:6573683 |
Flynn JT et al. | Effects of anesthesia and surgery on prostanoid concentrations in plasma and pulmonary lymph. | 1983 | Prostaglandins Leukot Med | pmid:6573688 |
Patel K and Bakhle YS | Thromboxane B2 (TxB2) metabolism in rat isolated lung and its inhibition by drugs. | 1983 | Prostaglandins Leukot Med | pmid:6573689 |
Davì G et al. | Plasmatic TXB2 and 6-keto-PGF1 alpha levels during charcoal hemoperfusion in chronic renal failure patients. | 1983 | Prostaglandins Leukot Med | pmid:6573692 |
Lieb J et al. | Elevated levels of prostaglandin E2 and thromboxane B2 in depression. | 1983 | Prostaglandins Leukot Med | pmid:6574523 |
Okahara T et al. | Zonal heterogeneity of prostaglandin and thromboxane release in the dog kidney. | 1983 | Prostaglandins | pmid:6575405 |
Coceani F et al. | Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat. | 1983 | Am. J. Physiol. | pmid:6574712 |
Viinikka L et al. | Effect of prolonged treatment with acetylsalicylic acid and dipyridamole on platelet thromboxane A2 production in atherosclerotic subjects. | 1983 | Prostaglandins Leukot Med | pmid:6576385 |
Fukumoto S and Tanaka K | Protective effects of thromboxane A2 synthetase inhibitors on endotoxin shock. | 1983 | Prostaglandins Leukot Med | pmid:6576388 |
Butler RR et al. | Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6339712 |
Asbóth G et al. | Conversion of arachidonic acid to prostanoids in the avian uterus. | 1983 | Biochim. Biophys. Acta | pmid:6402032 |