Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
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Mayer AM et al. | Cyanobacterial Microcystis aeruginosa lipopolysaccharide elicits release of superoxide anion, thromboxane Bâ‚‚, cytokines, chemokines, and matrix metalloproteinase-9 by rat microglia. | 2011 | Toxicol. Sci. | pmid:21362633 |
Frost-Pineda K et al. | Biomarkers of potential harm among adult smokers and nonsmokers in the total exposure study. | 2011 | Nicotine Tob. Res. | pmid:21330277 |
Li CH et al. | [Effect of electroacupuncture at different acupoints on plasma TXB2 and 6-keto-PGF(1alpha), contents in dysmenorrhea rats]. | 2011 | Zhen Ci Yan Jiu | pmid:22073886 |
Angiolillo DJ et al. | Impact of a fixed-dose combination of naproxen and esomeprazole magnesium on serum thromboxane B2 inhibition by low-dose aspirin over 5 days in healthy adults: a phase I, randomized, double-blind, placebo-controlled, noninferiority trial. | 2011 | Clin Ther | pmid:22078153 |
Sambu N et al. | Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study. | 2011 | Heart | pmid:21795297 |
Spectre G et al. | Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. | 2011 | Thromb. Haemost. | pmid:21800009 |
Hoh CM et al. | Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs. | 2011 | Am. J. Vet. Res. | pmid:21801060 |
Dalli E et al. | Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers. | 2011 | Thromb. Res. | pmid:21737127 |
Yan LG et al. | Injectable caltrop fruit saponin protects against ischemia-reperfusion injury in rat brain. | 2011 | Am. J. Chin. Med. | pmid:21476209 |
Liu JQ et al. | Effects of tanshinone IIA, a major component of Salvia miltiorrhiza, on platelet aggregation in healthy newborn piglets. | 2011 | J Ethnopharmacol | pmid:21453766 |
Halawani SH et al. | Aspirin failure in patients presenting with acute cerebrovascular ischaemia. | 2011 | Thromb. Haemost. | pmid:21544317 |
Gonçalves LH et al. | Urinary 11-dehydro thromboxane B₂ levels in type 2 diabetic patients before and during aspirin intake. | 2011 | Clin. Chim. Acta | pmid:21510926 |
Bauer J et al. | Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. | 2011 | Biochem. Pharmacol. | pmid:20933508 |
Oates JC et al. | Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis. | 2011 | Am. J. Med. Sci. | pmid:20924284 |
Furugen A et al. | Quantification of intracellular and extracellular prostanoids stimulated by A23187 by liquid chromatography/electrospray ionization tandem mass spectrometry. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21963481 |
Grove EL et al. | Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease. | 2011 | J. Thromb. Haemost. | pmid:20955349 |
Kleinedler JJ et al. | A dietary approach to increase in-stent stenosis and face validity of a rat model for arterial angioplasty and stenting. | 2011 | Atherosclerosis | pmid:21982412 |
Moussa O et al. | Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21983220 |
Trostchansky A et al. | Nitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2. | 2011 | J. Biol. Chem. | pmid:21266582 |
Trefiletti G et al. | 1-Phenyl-6,7-dihydroxy-isochroman suppresses lipopolysaccharide-induced pro-inflammatory mediator production in human monocytes. | 2011 | Br. J. Nutr. | pmid:21269535 |
Gremmel T et al. | Comparison of methods to evaluate aspirin-mediated platelet inhibition after percutaneous intervention with stent implantation. | 2011 | Platelets | pmid:21231857 |
Chandrasekaran CV et al. | Dual inhibitory effect of Glycyrrhiza glabra (GutGardâ„¢) on COX and LOX products. | 2011 | Phytomedicine | pmid:20864324 |
Kleinbongard P et al. | Acute vasomotor paralysis and potential downstream effects of paclitaxel from stents implanted for saphenous vein aorto-coronary bypass stenosis. | 2011 | Basic Res. Cardiol. | pmid:21472462 |
Ceprnja M et al. | Oxidative stress markers in patients with post-traumatic stress disorder. | 2011 | Coll Antropol | pmid:22397253 |
Lordkipanidzé M et al. | Heterogeneity in platelet cyclooxygenase inhibition by aspirin in coronary artery disease. | 2011 | Int. J. Cardiol. | pmid:20207433 |
Saihkay HN et al. | Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits. | 2011 Jan-Feb | J Pharmacol Toxicol Methods | pmid:20646985 |
Brainard BM et al. | Effects of clopidogrel and aspirin on platelet aggregation, thromboxane production, and serotonin secretion in horses. | 2011 Jan-Feb | J. Vet. Intern. Med. | pmid:21143302 |
Alcott CJ et al. | Clinical and immunomodulating effects of ketamine in horses with experimental endotoxemia. | 2011 Jul-Aug | J. Vet. Intern. Med. | pmid:21745244 |
Chakroun T et al. | The cyclooxygenase-1 C50T polymorphism is not associated with aspirin responsiveness status in stable coronary artery disease in Tunisian patients. | 2011 Jul-Aug | Genet Test Mol Biomarkers | pmid:21434767 |
Thomason J et al. | Platelet cyclooxygenase expression in normal dogs. | 2011 Sep-Oct | J. Vet. Intern. Med. | pmid:21985141 |
Chen CY et al. | Functional analysis of human thromboxane synthase polymorphic variants. | 2012 | Pharmacogenet. Genomics | pmid:22735388 |
Wen SH et al. | Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation. | 2012 | Shock | pmid:22777122 |
Vazzana N et al. | Endogenous secretory RAGE in obese women: association with platelet activation and oxidative stress. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22761461 |
Pelligand L et al. | Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation. | 2012 | J. Vet. Pharmacol. Ther. | pmid:21767277 |
Wenzel F et al. | Determination of thromboxane formation, soluble CD40L release and thrombopoietin clearance in apheresis platelet concentrates. | 2012 | Platelets | pmid:21806498 |
Zhou CB et al. | Decrease in inflammatory response does not prevent placental dysfunction after fetal cardiac bypass in goats. | 2012 | J. Thorac. Cardiovasc. Surg. | pmid:21821267 |
Tong Z et al. | Influence of ShuJinHuoXue tablets on ischemia reperfusion injury of animals' skeletal muscle. | 2012 | Molecules | pmid:22801363 |
Cesari M et al. | Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study. | 2012 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:22389462 |
Dragani A et al. | Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism. | 2012 | Thromb. Haemost. | pmid:22782530 |
Saito Y et al. | Disruption of group IVA cytosolic phospholipase A(2) attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-α-mediated pathway. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22427514 |
Su CL et al. | Inducible cyclooxygenase expression mediating hypoxia/reoxygenation-induced pulmonary vasoconstriction is attenuated by a cyclooxygenase inhibitor in rats. | 2012 | Transplant. Proc. | pmid:22564588 |
Skarke C et al. | Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. | 2012 | Clin. Pharmacol. Ther. | pmid:22278334 |
Lemkes BA et al. | The influence of aspirin dose and glycemic control on platelet inhibition in patients with type 2 diabetes mellitus. | 2012 | J. Thromb. Haemost. | pmid:22252020 |
Matsuzawa S et al. | Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury. | 2012 | Arzneimittelforschung | pmid:22945770 |
Chen C et al. | [Effects of extracts of Radix Scrophulariae on blood pressure in spontaneously hypertensive rats and the underlying mechanisms]. | 2012 | Zhong Xi Yi Jie He Xue Bao | pmid:22979933 |
Etulain J et al. | Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets. | 2012 | Thromb. Haemost. | pmid:22159527 |
Mayer AM et al. | Marine sponge Hymeniacidon sp. amphilectane metabolites potently inhibit rat brain microglia thromboxane B2 generation. | 2012 | Bioorg. Med. Chem. | pmid:22153874 |
Ju HK et al. | Metabolomic investigation of the anti-platelet aggregation activity of ginsenoside Rkâ‚ reveals attenuated 12-HETE production. | 2012 | J. Proteome Res. | pmid:22873173 |
Matsuura E et al. | On aspirin treatment but not baseline thromboxane B2 levels predict adverse outcomes in patients with acute coronary syndromes. | 2012 | J. Thromb. Haemost. | pmid:22784188 |
Chandrasekaran CV et al. | In vitro comparative evaluation of non-leaves and leaves extracts of Andrographis paniculata on modulation of inflammatory mediators. | 2012 | Antiinflamm Antiallergy Agents Med Chem | pmid:22882083 |