Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kranzhofer R and Ruef J | Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism. | 2006 | Platelets | pmid:16702043 |
Chen GG et al. | Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma. | 2006 | Cancer Lett. | pmid:15876485 |
Zhou Y et al. | Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice. | 2006 | Circ. Res. | pmid:16645140 |
Karkabounas S et al. | Anticarcinogenic and antiplatelet effects of carvacrol. | 2006 | Exp. Oncol. | pmid:16837902 |
Wilder-Smith CH et al. | Dose-effect comparisons of the CINOD AZD3582 and naproxen on upper gastrointestinal tract mucosal injury in healthy subjects. | 2006 | Scand. J. Gastroenterol. | pmid:16497612 |
Brenneis C et al. | Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. | 2006 | FASEB J. | pmid:16816110 |
Baltzer WI et al. | Measurement of urinary 11-dehydro-thromboxane B2 excretion in dogs with gastric dilatation-volvulus. | 2006 | Am. J. Vet. Res. | pmid:16426215 |
Chiu HF et al. | Mechanisms involved in the antiplatelet effect of C-phycocyanin. | 2006 | Br. J. Nutr. | pmid:16469164 |
Rossoni G et al. | Nitric oxide and prostacyclin pathways: an integrated mechanism that limits myocardial infarction progression in anaesthetized rats. | 2006 | Pharmacol. Res. | pmid:16488624 |
Lepäntalo A et al. | Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. | 2006 | Thromb. Haemost. | pmid:16493486 |
Kurosawa S et al. | Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy. | 2006 | J Clin Anesth | pmid:16517327 |
Flipo RM | [Are the NSAIDs able to compromising the cardio-preventive efficacy of aspirin?]. | 2006 | Presse Med | pmid:17078596 |
Dołegowska B et al. | Metabolism of eicosanoids and their action on renal function during ischaemia and reperfusion: the effect of alprostadil. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17011760 |
Ong TZ et al. | Nonsteroidal anti-inflammatory drug use is a significant cause of peptic ulcer disease in a tertiary hospital in Singapore: a prospective study. | 2006 | J. Clin. Gastroenterol. | pmid:17016134 |
Morchón R et al. | High levels of serum thromboxane B2 are generated during human pulmonary dirofilariosis. | 2006 | Clin. Vaccine Immunol. | pmid:17028222 |
Ibrahim S et al. | Transfer of very low density lipoprotein-associated phospholipids to activated human platelets. | 2006 | J. Lipid Res. | pmid:16293890 |
Cook-Johnson RJ et al. | Endothelial cell COX-2 expression and activity in hypoxia. | 2006 | Biochim. Biophys. Acta | pmid:17046322 |
Faraday N et al. | Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population. | 2006 | Am. J. Cardiol. | pmid:16950183 |
Zhao Y et al. | Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis. | 2006 | Ann. Allergy Asthma Immunol. | pmid:16802773 |
Lee KS et al. | Antiplatelet activity of [5-(2-methoxy-5-chlorophenyl)furan-2-ylcarbonyl]guanidine (KR-32570), a novel sodium/hydrogen exchanger-1 and its mechanism of action. | 2006 | Arch. Pharm. Res. | pmid:16756082 |
Peck OM et al. | The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide. | 2006 | Shock | pmid:16783195 |
Frelinger AL et al. | Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance. | 2006 | Circulation | pmid:16785341 |
Cox D et al. | Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers. | 2006 | Stroke | pmid:16794200 |
Munsterhjelm E et al. | Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers. | 2006 | Br J Anaesth | pmid:16698862 |
Nakamura K et al. | Effects of atorvastatin and aspirin combined therapy on inflammatory responses in patients undergoing coronary artery bypass grafting. | 2006 | Cytokine | pmid:17300951 |
Vranic II et al. | Adenosine cardioprotection study in clinical setting of paroxysmal supraventricular tachycardia. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16682179 |
Huntjens DR et al. | Correlation between in vitro and in vivo concentration-effect relationships of naproxen in rats and healthy volunteers. | 2006 | Br. J. Pharmacol. | pmid:16682968 |
Park HS et al. | Dietary trans-10, cis-12 and cis-9,trans-11 conjugated linoleic acids induce apoptosis in the colonic mucosa of rats treated with 1,2-dimethylhydrazine. | 2006 | J Med Food | pmid:16579724 |
Ohmori T et al. | Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: involvement of other signaling pathway(s) in cardiovascular events of aspirin-treated patients. | 2006 | J. Thromb. Haemost. | pmid:16706971 |
Perneby C et al. | Dose- and time-dependent antiplatelet effects of aspirin. | 2006 | Thromb. Haemost. | pmid:16601836 |
Zhang JY et al. | [Study on therapeutic effects of series of muskone on myocardial infarction canines]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17225541 |
Basili S et al. | Insulin resistance as a determinant of platelet activation in obese women. | 2006 | J. Am. Coll. Cardiol. | pmid:17174194 |
Hrushka NH et al. | [Effect of thromboxane B2 on morphological features of apoptosis in cultured rat hepatocytes exposed to hepatotropic substances]. | 2006 | Fiziol Zh | pmid:17176837 |
Niemi TT et al. | The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm. | 2006 | Blood Coagul. Fibrinolysis | pmid:16607076 |
Chiang N and Serhan CN | New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications. | 2006 | Compr Ther | pmid:17435267 |
Stergioulas AT and Filippou DK | Effects of physical conditioning on lipids and arachidonic acid metabolites in untrained boys: a longitudinal study. | 2006 | Appl Physiol Nutr Metab | pmid:16900233 |
Fujimoto Y et al. | Monochloramine potently inhibits arachidonic acid metabolism in rat platelets. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16615995 |
Xu S et al. | The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. | 2006 | Diabetes | pmid:16380483 |
Sánchez M et al. | Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. | 2006 | J. Hypertens. | pmid:16331104 |
Chiang N et al. | Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16293793 |
Wolfram RM et al. | Salivary isoprostanes indicate increased oxidation injury in periodontitis with additional tobacco abuse. | 2006 | Biofactors | pmid:17264390 |
González-Correa JA et al. | Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human blood. | 2005 May-Jun | Platelets | pmid:16011961 |
Myers SI et al. | Bile duct ligation induced acute inflammation up-regulates cyclooxygenase-2 content and PGE2 release in guinea pig gallbladder smooth muscle cell cultures. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850713 |
Nakamura K et al. | Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer. | 2005 | Nutrition | pmid:15925286 |
Blume C et al. | Different effect of cyclosporine A and mycophenolate mofetil on passive Heymann nephritis in the rat. | 2005 | Nephron Exp. Nephrol. | pmid:15855806 |
Wu CC et al. | 2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets. | 2005 | Eur. J. Pharmacol. | pmid:16313903 |
Zhu S et al. | [Influence of Minkeqing oral liquid on IL-6, IL-8, ET-1, TX-B2 in blood and to observe bronchoalveolar lavage fluid of the rat with inhalating ovalbumin]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16161448 |
Corazzi T et al. | Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). | 2005 | J. Pharmacol. Exp. Ther. | pmid:16144976 |
Cao D et al. | Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils. | 2005 | Life Sci. | pmid:16214179 |
Yao X et al. | [The changes of some vasoactive substances after operation in patients with obstructive sleep apnea-hypopnea syndrome]. | 2005 | Lin Chuang Er Bi Yan Hou Ke Za Zhi | pmid:16398051 |