Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ersöz G et al. | Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. | 2002 | Thromb. Res. | pmid:12676189 |
Svensson J and Samuelsson K | Inhibition of platelet function by low dose acetylsalicylic acid in patients with cerebrovascular disease. | 1983 | Thromb. Res. | pmid:20218005 |
Weide I and Simmet T | Leukotriene formation by peripheral monocytes in contact-activated human blood. | 1993 | Thromb. Res. | pmid:8211886 |
Takasaki W et al. | Superiority of plasma 11-dehydro-TXB2 to TXB2 as an index of in vivo TX formation in rabbits after dosing of CS-518, a TX synthase inhibitor. | 1993 | Thromb. Res. | pmid:8367836 |
Saldeen P et al. | Increased synthesis of thromboxane B2 and 6-keto-PGF1 alpha in hand veins from patients with deep venous thrombosis. | 1983 | Thromb. Res. | pmid:6658723 |
Boyd JA and Eling TE | Prostaglandin release and the interaction of platelets with the pulmonary vasculature of rat and guinea pig. | 1980 Jul 1-15 | Thromb. Res. | pmid:7003800 |
Martin JF et al. | Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique. | 1982 | Thromb. Res. | pmid:6814004 |
Mikashima H and Muramoto Y | Protective effect of Y-20811, a long-lasting thromboxane synthetase inhibitor, on endotoxin shock in rabbits. | 1990 | Thromb. Res. | pmid:2326771 |
Agren JJ et al. | Dose responses in platelet fatty acid composition, aggregation and prostanoid metabolism during moderate freshwater fish diet. | 1990 | Thromb. Res. | pmid:2326774 |
Pedersen AK et al. | Inhibition of thromboxane biosynthesis in serum: limitations of the measurement of immunoreactive 6-keto-PGF1 alpha. | 1984 | Thromb. Res. | pmid:6546456 |
Grauso F et al. | Effects of iloprost (ZK 36374), a prostacyclin derivative, on platelet function after ischaemic exercise in patients with stable angina pectoris. | 1987 | Thromb. Res. | pmid:2447664 |
Saldeen P et al. | Thromboxane production in umbilical vein grafts. | 1984 | Thromb. Res. | pmid:6546814 |
Udvardy M et al. | Plasma thromboxane and prostacyclin metabolite ratio in atherosclerosis and diabetes mellitus. | 1987 | Thromb. Res. | pmid:3116717 |
GarcÃa Frade LJ et al. | Diabetes mellitus as a hypercoagulable state: its relationship with fibrin fragments and vascular damage. | 1987 | Thromb. Res. | pmid:3118498 |
Davì G et al. | Thromboxane B2 formation and platelet sensitivity to prostacyclin in insulin-dependent and insulin-independent diabetics. | 1982 | Thromb. Res. | pmid:6761893 |
Ditter H et al. | Effects of prostacyclin during cardiopulmonary bypass in men on plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1 alpha and heparin. | 1983 | Thromb. Res. | pmid:6197766 |
Cerskus AL et al. | Thromboxane B2 and 6-keto-prostaglandin F1 alpha synthesis during infusion of collagen and arachidonic acid in rabbits: inhibition by aspirin and sulfinpyrazone. | 1980 | Thromb. Res. | pmid:7414555 |
Castaldi PA et al. | Evidence for a platelet membrane defect in the myeloproliferative syndromes. | 1982 | Thromb. Res. | pmid:6960545 |
Gachályi B et al. | In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man. | 1984 | Thromb. Res. | pmid:6474407 |
Fitzpatrick F et al. | Development of a gas chromatographic-mass spectrometric method using a stable isotope internal standard for quantitation of thromboxane B2. | 1984 | Thromb. Res. | pmid:6474413 |
Dalli E et al. | Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers. | 2011 | Thromb. Res. | pmid:21737127 |
Toivanen J et al. | Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphinpyrazone, acetylsalicylic acid and indomethacin by human tissues in vitro. | 1985 | Thromb. Res. | pmid:3920778 |
Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
Arruzazabala ML et al. | Effects of Policosanol on platelet aggregation in rats. | 1993 | Thromb. Res. | pmid:8475481 |
Reis F et al. | The peripheral serotonergic system and platelet aggregation in cyclosporin A-induced hypertensive rats. | 1999 | Thromb. Res. | pmid:10605951 |
Patrono C et al. | Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects. | 1980 Feb 1-15 | Thromb. Res. | pmid:7368167 |
Lin CH et al. | HA-29: an inhibitor of thromboxane A2 formation with antagonism of thromboxane A2/prostaglandin endoperoxide receptor in rabbit platelets. | 1992 | Thromb. Res. | pmid:1412184 |
Tindall H et al. | Thrombin generation precedes platelet activation in native blood taken from the hand during multiple blood sampling following cold challenge. | 1987 | Thromb. Res. | pmid:3617016 |
Mannucci L et al. | Indobufen is a potent inhibitor of whole blood aggregation in patients with a high atherosclerotic risk. | 1987 | Thromb. Res. | pmid:3445229 |
Chakroun T et al. | Screening for aspirin resistance in stable coronary artery patients by three different tests. | 2007 | Thromb. Res. | pmid:17553552 |
Simmet T and Luck W | Clotting of whole human blood induces cysteinyl-leukotriene formation. | 1989 | Thromb. Res. | pmid:2549655 |
Chetty N and Bradlow BA | The effects of a vegetarian diet on platelet function and fatty acids. | 1983 | Thromb. Res. | pmid:6612688 |
Best LC et al. | Mode of action of dipyridamole on human platelets. | 1979 | Thromb. Res. | pmid:229583 |
Franconi F et al. | Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro. | 2001 | Thromb. Res. | pmid:11369419 |
Petroni A et al. | Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. | 1995 | Thromb. Res. | pmid:7482432 |
De La Cruz JP et al. | Antithrombotic potential of olive oil administration in rabbits with elevated cholesterol. | 2000 | Thromb. Res. | pmid:11113274 |
Barnhart MI et al. | DDAVP: does the drug have a direct effect on the vessel wall? | 1983 | Thromb. Res. | pmid:6415852 |
Maderna P et al. | Differential effects of oral administrations to human volunteers of acetylsalicylic acid, sodium salicylate and indomethacin on 12-hydroxyeicosatetraenoic acid formation by stimulated platelets. | 1988 | Thromb. Res. | pmid:3194896 |
Saldeen P and Saldeen T | 6-keto-prostaglandin F1 alpha/thromboxane B2 ratio in vascular and lung tissue. | 1983 | Thromb. Res. | pmid:6688484 |
Teng CM et al. | Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. | 1990 | Thromb. Res. | pmid:2169076 |
Platelet function during long-term treatment with ketanserin of claudicating patients with peripheral atherosclerosis. A multi-center, double-blind, placebo-controlled trial. The PACK Trial Group. | 1989 | Thromb. Res. | pmid:2528841 | |
Yue TL et al. | Pharmacological profile of G619, a new platelet aggregation inhibitor. | 1992 | Thromb. Res. | pmid:1412200 |
Russell NH et al. | Platelet adenine nucleotides and arachidonic acid metabolism in the myeloproliferative disorders. | 1981 | Thromb. Res. | pmid:6794179 |
Lagarde M et al. | Increase of platelet thromboxane A2 formation and of its plasmatic half-life in diabetes mellitus. | 1980 | Thromb. Res. | pmid:7466751 |
Togna GI et al. | Cisplatin triggers platelet activation. | 2000 | Thromb. Res. | pmid:10973681 |
Saloheimo P et al. | Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage. | 2005 | Thromb. Res. | pmid:15733969 |
Grimm LJ et al. | Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. | 1981 | Thromb. Res. | pmid:6801806 |
Hashizume T et al. | Vinblastine inhibits platelet aggregation by a microtubule-independent mechanism, probably by its perturbing action on the plasma membrane. | 1988 | Thromb. Res. | pmid:3135636 |
Teng CM et al. | Antiplatelet actions of some coumarin compounds isolated from plant sources. | 1992 | Thromb. Res. | pmid:1523611 |
Schmid P et al. | Passive smoking and platelet thromboxane. | 1996 | Thromb. Res. | pmid:8907294 |
Preston FE et al. | Low-dose aspirin inhibits platelet and venous cyclo-oxygenase in man. | 1982 | Thromb. Res. | pmid:6815823 |
Pinto S et al. | No signs of increased thrombin generation in menopause. | 1990 | Thromb. Res. | pmid:2201101 |
Randall MJ et al. | UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity. | 1981 Jul 1-15 | Thromb. Res. | pmid:6795753 |
Armstrong RA et al. | No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study. | 2000 | Thromb. Res. | pmid:11108899 |
Weber AA et al. | 40 mg of aspirin are not sufficient to inhibit platelet function under conditions of limited compliance. | 2000 | Thromb. Res. | pmid:10709913 |
Wu TM et al. | Inhibitory effect of hexapeptide (RGRHGD) on platelet aggregation. | 2000 | Thromb. Res. | pmid:10674405 |
Leoncini G et al. | In retinal vein occlusion platelet response to thrombin is increased. | 2009 | Thromb. Res. | pmid:19660790 |
Perneby C et al. | Optimization of an enzyme immunoassay for 11-dehydro-thromboxane B(2) in urine: comparison with GC-MS. | 1999 | Thromb. Res. | pmid:10632465 |
Driss F et al. | Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid. | 1984 | Thromb. Res. | pmid:6098051 |
Carter AJ and Jones EW | The effect of the degree of diabetic control on thromboxane synthesis in clotted whole blood. | 1986 | Thromb. Res. | pmid:3515613 |
Mogensen F et al. | Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. | 1985 | Thromb. Res. | pmid:4038824 |
Neiman J et al. | Platelet uptake of serotonin (5-HT) during ethanol withdrawal in male alcoholics. | 1987 | Thromb. Res. | pmid:2820078 |
De la Cruz JP et al. | Effect of erythrocytes and prostacyclin production in the effect of fructose and sorbitol on platelet activation in human whole blood in vitro. | 1997 | Thromb. Res. | pmid:9219331 |
Weigel G et al. | Regulation of eicosanoid release in human umbilical endothelial cells. | 1991 | Thromb. Res. | pmid:1656543 |
Ko FN et al. | Antiplatelet effects of protopine isolated from Corydalis tubers. | 1989 | Thromb. Res. | pmid:2559491 |
Ito T et al. | Role of activated platelets in endotoxin-induced DIC in rats. | 1990 | Thromb. Res. | pmid:2080492 |
Lukaszyk A et al. | Blood platelet function in canine acute pancreatitis with reference to treatment with Nafamostat mesilate (FUT-175). | 1992 | Thromb. Res. | pmid:1579898 |
Wallis RB | Mechanisms of action of sulphinpyrazone. | 1983 | Thromb. Res. Suppl. | pmid:6415857 |
Perkett EA et al. | Lymphocyte and granulocyte migration across the endothelial layer of bovine pulmonary artery intimal explants towards lymphocyte conditioned medium. | 1986 | Tissue Cell | pmid:3810636 |
Nakazawa I et al. | Some features of the metastatic cancer cells in prostaglandin production. | 1989 | Tohoku J. Exp. Med. | pmid:2510366 |
Watanabe J et al. | Effect of vitamin E on platelet aggregation in diabetes mellitus. | 1984 | Tohoku J. Exp. Med. | pmid:6474447 |
Watanabe J et al. | Effect of prostaglandin synthetase inhibitors on platelet aggregation and thromboxane production in diabetes mellitus. | 1984 | Tohoku J. Exp. Med. | pmid:6515648 |
Nakazawa I et al. | Some features in prostaglandin synthesis of the cancer cells which metastasized into liver from intestinal cancer lesions. | 1993 | Tohoku J. Exp. Med. | pmid:8266326 |
Tomita Y et al. | Leukotrienes and thromboxane B2 stimulate normal human melanocytes in vitro: possible inducers of postinflammatory pigmentation. | 1988 | Tohoku J. Exp. Med. | pmid:3252558 |
Santostefano MJ et al. | Off-target platelet activation in macaques unique to a therapeutic monoclonal antibody. | 2012 | Toxicol Pathol | pmid:22552394 |
McKinnon KP et al. | In vitro ozone exposure increases release of arachidonic acid products from a human bronchial epithelial cell line. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8442000 |
Carpenter LJ and Roth RA | Involvement of thromboxane in injury to isolated rat lungs perfused with phorbol myristate acetate in the presence and absence of neutrophils. | 1987 | Toxicol. Appl. Pharmacol. | pmid:3672516 |
Sahota T et al. | Model-based analysis of thromboxane Bâ‚‚ and prostaglandin Eâ‚‚ as biomarkers in the safety evaluation of naproxen. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24667227 |
Eisenmann CJ and Miller RK | The effect of selenium compounds (selenite, selenate, ebselen) on the production of thromboxane and prostacyclin by the human term placenta in vitro. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7482536 |
Fujimoto Y et al. | Effects of endocrine disruptors on arachidonic acid metabolism in rabbit platelets. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12781627 |
Ganey PE and Roth RA | 5-Hydroxytryptamine and thromboxane in platelets from rats treated with monocrotaline pyrrole. | 1987 | Toxicol. Appl. Pharmacol. | pmid:3564035 |
Miller PD et al. | Effect of ozone exposure on lung functions and plasma prostaglandin and thromboxane concentrations in guinea pigs. | 1987 | Toxicol. Appl. Pharmacol. | pmid:3470978 |
Yarom R et al. | The effect of T-2 toxin on human platelets. | 1984 | Toxicol. Appl. Pharmacol. | pmid:6710522 |
Leung LK and Glauert HP | Reduction of the concentrations of prostaglandins E2 and F2alpha, and thromboxane B2 in cultured rat hepatocytes treated with the peroxisome proliferator ciprofibrate. | 1996 | Toxicol. Lett. | pmid:8644126 |
Ferrari D et al. | Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation. | 2016 | Toxicol. Lett. | pmid:27793764 |
Ren R et al. | Protective effects of Danshensu on liver injury induced by omethoate in rats. | 2010 | Toxicol. Mech. Methods | pmid:20843270 |
Mayer AM et al. | Cyanobacterial Microcystis aeruginosa lipopolysaccharide elicits release of superoxide anion, thromboxane Bâ‚‚, cytokines, chemokines, and matrix metalloproteinase-9 by rat microglia. | 2011 | Toxicol. Sci. | pmid:21362633 |
Mayer AM et al. | Classical and Alternative Activation of Cyanobacterium Oscillatoria sp. Lipopolysaccharide-Treated Rat Microglia in vitro. | 2016 | Toxicol. Sci. | pmid:26609141 |
Chan CP et al. | Inhibition of cyclooxygenase activity, platelet aggregation and thromboxane B2 production by two environmental toxicants: m- and o-cresol. | 2005 | Toxicology | pmid:15664436 |
Song YM et al. | Effects of scorpion venom bioactive polypolypeptides on platelet aggregation and thrombosis and plasma 6-keto-PG F1alpha and TXB2 in rabbits and rats. | 2005 | Toxicon | pmid:15975616 |
Huang HC | Release of slow reacting substance from the guinea-pig lung by phospholipases A2 of Vipera russelli snake venom. | 1984 | Toxicon | pmid:6206608 |
Al-Hassan JM et al. | Vasoconstrictor components in the Arabian Gulf catfish (Arius thalassinus, Ruppell) proteinaceous skin secretion. | 1986 | Toxicon | pmid:3824400 |
Zapol WM et al. | Plasma thromboxane and prostacyclin metabolites in sheep partial cardiopulmonary bypass. | 1980 | Trans Am Soc Artif Intern Organs | pmid:7018060 |
Westenfelder C et al. | Renal function in calves with total artificial hearts. | 1985 | Trans Am Soc Artif Intern Organs | pmid:3837477 |
Wonders TR et al. | Reduced plasma thromboxane elevation during partial cardiopulmonary bypass in thrombocytopenic sheep. | 1981 | Trans Am Soc Artif Intern Organs | pmid:7331082 |
Bito LZ | Prostaglandins and other eicosanoids: their ocular transport, pharmacokinetics, and therapeutic effects. | 1986 | Trans Ophthalmol Soc U K | pmid:3541303 |
Güllner HG et al. | Correction of increased prostacyclin production in Bartter's syndrome by indomethacin. | 1980 | Trans. Assoc. Am. Physicians | pmid:7018063 |
Di Minno G et al. | In vivo platelet activation in homozygous cystathionine beta-synthase deficiency: a probucol-sensitive phenomenon. | 1992 | Trans. Assoc. Am. Physicians | pmid:1308991 |
Tobian L et al. | Prostaglandin alterations in barely hypertensive Dahl S rats. | 1985 | Trans. Assoc. Am. Physicians | pmid:3842205 |
Böck M et al. | Storage of single-donor platelet concentrates: metabolic and functional changes. | 1993 | Transfusion | pmid:8480351 |