Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Giani E et al. | Sex differences in platelet thromboxane and arterial prostacyclin production in control and n-6 fatty acid supplemented rats. | 1984 | Prostaglandins | pmid:6441187 |
Kopolovic R et al. | Effects of ibuprofen on a porcine model of acute respiratory failure. | 1984 | J. Surg. Res. | pmid:6708494 |
Teng CM et al. | Biphasic effect on platelet aggregation by phospholipase a purified from Vipera russellii snake venom. | 1984 | Biochim. Biophys. Acta | pmid:6426517 |
Schenkein HA and Rutherford B | C3-mediated release of prostaglandin from human monocytes. Behaviour in short-term culture. | 1984 | Immunology | pmid:6690398 |
Hsueh W et al. | Identification of C3b as the major serum protein that stimulates prostaglandin and thromboxane synthesis by macrophages. | 1984 | Prostaglandins | pmid:6240667 |
Pedersen AK et al. | Inhibition of thromboxane biosynthesis in serum: limitations of the measurement of immunoreactive 6-keto-PGF1 alpha. | 1984 | Thromb. Res. | pmid:6546456 |
Krishnamurthi S et al. | Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways. | 1984 | Biochem. Pharmacol. | pmid:6091666 |
Novo S et al. | Platelet activity in relation to smoke and exercise in patients with chronic obstructive lung disease: effects of platelet antiaggregating drugs. | 1984 | Adv. Exp. Med. Biol. | pmid:6546467 |
Ford WD et al. | Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations. | 1984 | Arch. Dis. Child. | pmid:6546658 |
Rosenblum WI and Hirsh PD | Some interrelationships between glucose levels thromboxane production and prostacyclin production in normal and diabetic mice. | 1984 | Prostaglandins | pmid:6546804 |
Saldeen P et al. | Thromboxane production in umbilical vein grafts. | 1984 | Thromb. Res. | pmid:6546814 |
Schwartz D et al. | Renal arachidonic acid metabolism and cellular changes in the rabbit renal vein constricted kidney: inflammation as a common process in renal injury models. | 1984 | Prostaglandins | pmid:6427853 |
Emau P et al. | Function of prostaglandins, thromboxane A2, and histamine in hypersensitivity reaction to experimental bluetongue disease in calves. | 1984 | Am. J. Vet. Res. | pmid:6093650 |
Bush LR et al. | Effects of the selective thromboxane synthetase inhibitor dazoxiben on variations in cyclic blood flow in stenosed canine coronary arteries. | 1984 | Circulation | pmid:6546902 |
Nagashima Y et al. | [The effects of hog pancreatic kallikrein on the plasma kinins-prostaglandins and renin-angiotensin-aldosterone systems]. | 1984 | Nihon Naibunpi Gakkai Zasshi | pmid:6097484 |
Wilson TW et al. | Determination of 6-keto-prostaglandin F1 alpha and thromboxane B2 in urine by high-performance liquid chromatography and radioimmunoassay. | 1984 | J. Chromatogr. | pmid:6546935 |
Ylikorkala O et al. | Maternal thromboxane, prostacyclin, and umbilical blood flow in humans. | 1984 | Obstet Gynecol | pmid:6546976 |
Hamasaki Y et al. | Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. | 1984 | Am. Rev. Respir. Dis. | pmid:6547031 |
Gallenkämper W et al. | Cardioprotective actions of pentoxifylline in an animal model of acute myocardial ischaemia. | 1984 | Br. J. Pharmacol. | pmid:6547067 |
Coker SJ and Parratt JR | The effects of timolol on arrhythmias and prostanoid release during canine myocardial ischaemia and reperfusion. | 1984 | Br. J. Pharmacol. | pmid:6547068 |
Cepa SR et al. | Positive-negative, chemical-ionization, direct exposure mass spectrometry of underivatized prostaglandins. | 1984 | Prostaglandins | pmid:6547237 |
Brown CG and Poyser NL | Studies on the control of prostaglandin production by the hypothalamus in relation to LH release in the rat. | 1984 | J. Endocrinol. | pmid:6593408 |
Romero SD et al. | Measurement of prostaglandins in the cerebrospinal fluid in cat, dog, and man. | 1984 | J. Neurochem. | pmid:6593432 |
Fantone JC et al. | Stimulus specificity of prostaglandin inhibition of rabbit polymorphonuclear leukocyte lysosomal enzyme release and superoxide anion production. | 1984 | Am. J. Pathol. | pmid:6324595 |
Benedetto C et al. | Production of prostacyclin, 6-keto-PGF1 alpha and thromboxane B2 by incubated samples of umbilical vessels: a comparison of methods for expressing the results on dry weight, wet weight, protein or DNA bases. | 1984 | Prostaglandins | pmid:6390522 |
FitzGerald GA and Oates JA | Selective and nonselective inhibition of thromboxane formation. | 1984 | Clin. Pharmacol. Ther. | pmid:6370554 |
Navran SS et al. | Human platelet activation by bacterial phospholipase C is mediated by phosphatidylinositol hydrolysis but not generation of phosphatidic acid: inhibition by a selective inhibitor of phospholipase C. | 1984 | Thromb. Res. | pmid:6372157 |
Furman BL et al. | Failure of drugs that selectively inhibit thromboxane synthesis to modify endotoxin shock in conscious rats. | 1984 | Br. J. Pharmacol. | pmid:6375795 |
Merola AJ et al. | Prostaglandin response in the exercise conditioned rat. | 1984 | Prostaglandins Leukot Med | pmid:6377328 |
Gross S and Worthington-White DA | The effects of PGF2 alpha, PGI2, and TxB2 on human CFU-C in healthy and leukemic patients. | 1984 | Am. J. Hematol. | pmid:6372442 |
Carter AJ et al. | A comparison of human pulmonary arterial and venous prostacyclin and thromboxane synthesis--effect of a thromboxane synthase inhibitor. | 1984 | Thromb. Haemost. | pmid:6377567 |
Salvetti A et al. | The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients. | 1984 | Br J Clin Pharmacol | pmid:6378233 |
Watanabe J et al. | Effect of vitamin E on platelet aggregation in diabetes mellitus. | 1984 | Tohoku J. Exp. Med. | pmid:6474447 |
Prinz RA et al. | Platelet activation by human pancreatic fluid. | 1984 | J. Surg. Res. | pmid:6482425 |
Wilson L and Huang LS | Temporal response of uterine prostaglandins to estradiol treatment in the ovariectomized-pregnant rat. | 1984 | Prostaglandins | pmid:6484214 |
Walinsky P et al. | Thromboxane A2 in acute myocardial infarction. | 1984 | Am. Heart J. | pmid:6485997 |
Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
D'Angelo A et al. | Increased production of platelet thromboxane B2 in non-insulin-dependent diabetes. Relationship to vascular complications. | 1984 | Eur. J. Clin. Invest. | pmid:6428908 |
Del Maschio A et al. | Inhibition of human platelet cyclo-oxygenase activity by sulfinpyrazone and three of its metabolites. | 1984 | Eur. J. Pharmacol. | pmid:6432556 |
Schenkein HA and Rutherford RB | Effects of serum on C3b-stimulated release of prostaglandins and thromboxane B2 from human monocytes. | 1984 | Immunopharmacology | pmid:6511367 |
Fung WP et al. | Effect of ethanol on gastric secretion of thromboxane B2. | 1984 | Med. J. Malaysia | pmid:6513851 |
Watanabe J et al. | Effect of prostaglandin synthetase inhibitors on platelet aggregation and thromboxane production in diabetes mellitus. | 1984 | Tohoku J. Exp. Med. | pmid:6515648 |
Ninnemann JL and Stockland AE | Participation of prostaglandin E in immunosuppression following thermal injury. | 1984 | J Trauma | pmid:6231383 |
Ditter H and Matthias FR | Changes in thromboxane formation by platelets during and after a continuous endotoxin infusion into rabbits. | 1984 | VASA | pmid:6516562 |
Olanoff LS et al. | Effects of oleic acid on pulmonary capillary leak and thromboxanes. | 1984 | J. Surg. Res. | pmid:6233456 |
Hartung HP et al. | Release of prostaglandin E and thromboxane from macrophages by stimulation with factor H. | 1984 | Clin. Exp. Immunol. | pmid:6234114 |
Uotila P et al. | Prostanoids and hemodynamics in man before and during cardiopulmonary bypass. | 1984 | Prostaglandins | pmid:6335260 |
Riess H et al. | Effects of BM 13.177, a new antiplatelet drug in patients with atherosclerotic disease. | 1984 | Thromb. Res. | pmid:6237460 |
Nichols AB et al. | Effect of heparin bonding on catheter-induced fibrin formation and platelet activation. | 1984 | Circulation | pmid:6237807 |
Sicard GA et al. | Prostaglandin production and platelet reactivity of small-diameter grafts. | 1984 | J. Vasc. Surg. | pmid:6238179 |
Zammit M et al. | Aspirin therapy in small-caliber arterial prostheses: long-term experimental observations. | 1984 | J. Vasc. Surg. | pmid:6238183 |
Klaverkamp J and Völkl KP | Maintenance of platelet viability after platelet-labeling with fluorescein isothiocyanate. | 1984 | Haemostasis | pmid:6238881 |
Hänsch GM et al. | Macrophages release arachidonic acid, prostaglandin E2, and thromboxane in response to late complement components. | 1984 | J. Immunol. | pmid:6432907 |
De Lorgeril M et al. | [Platelet function and coronary disease: demonstration of a so-called unstable platelet syndrome]. | 1984 | Arch Mal Coeur Vaiss | pmid:6239599 |
Messmore HL et al. | Molecular markers of platelet activation. | 1984 | Semin. Thromb. Hemost. | pmid:6240115 |
Hornych A et al. | [Changes in plasma prostaglandins in normal subjects in an orthostatic position. Comparison with the response of the renin-aldosterone system]. | 1984 | Presse Med | pmid:6242503 |
Rachmilewitz D and Karmeli F | Effect of nufenoxole on human colonic prostanoid synthesis, Na-K-ATPase and adenylate cyclase activities. | 1984 | Eur. J. Pharmacol. | pmid:6152213 |
De Caterina R et al. | Inhibition of platelet function by injectable isosorbide dinitrate. | 1984 | Am. J. Cardiol. | pmid:6428211 |
Stock JL and Coderre JA | Calcitonin enhances production of prostaglandins by stimulated human monocytes. | 1984 | Prostaglandins | pmid:6087420 |
Triolo G et al. | Circulating immune complexes and platelet thromboxane synthesis in patients with insulin-dependent (type I) diabetes mellitus. | 1984 | Diabetes | pmid:6611280 |
Yui Y et al. | Intravenous infusion of a selective inhibitor of thromboxane A2 synthetase in man: influence on thromboxane B2 and 6-keto-prostaglandin F1 alpha levels and platelet aggregation. | 1984 | Circulation | pmid:6434196 |
Koike K et al. | Platelet secretion defect in patients with the attention deficit disorder and easy bruising. | 1984 | Blood | pmid:6692042 |
Lee EC et al. | Functional responses of tumor cells to phorbol esters: role for prostaglandins. | 1984 | Oncology | pmid:6587276 |
Jackson CA et al. | Near-normal glycaemic control does not correct abnormal platelet reactivity in diabetes mellitus. | 1984 | Clin. Sci. | pmid:6434224 |
Vesterqvist O et al. | Development of a GC-MS method for quantitation of 2,3-dinor-TxB2 and determinations of the daily urinary excretion rates in healthy humans. | 1984 | Thromb. Res. | pmid:6695361 |
Davì G et al. | Platelet function changes in acute myocardial infarction. | 1984 | Adv. Exp. Med. Biol. | pmid:6695571 |
Mehta J et al. | Thromboxane release in coronary artery disease: spontaneous versus pacing-induced angina. | 1984 | Am. Heart J. | pmid:6695662 |
Klotz TA et al. | Urinary excretion of thromboxane B2 in patients with venous thromboembolic disease. | 1984 | Chest | pmid:6697787 |
Maddox Y et al. | A routine source of human peritoneal macrophages. | 1984 | Scand. J. Immunol. | pmid:6701470 |
Girotti MJ et al. | Effects of immunization on cardiopulmonary alterations of gram-negative endotoxemia. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6368499 |
Dembinska-Kieć A et al. | Formation of leukotriene C4-like material by rat brain tissue. | 1984 | Eur. J. Pharmacol. | pmid:6426980 |
Hutton RA et al. | Assessment of platelet function in patients with Raynaud's syndrome. | 1984 | J. Clin. Pathol. | pmid:6229551 |
Ditter H et al. | Comparison of sympathomimetic amines with collagen, calcium ionophor and adenosine diphosphate in their effects on thromboxane formation of human platelet rich plasma. | 1984 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:6083951 |
Stuart MJ et al. | Effects of hyperoxia and hypoxia on vascular prostacyclin formation in vitro. | 1984 | Pediatrics | pmid:6435087 |
Vergani CG et al. | Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease). | 1984 | Eur. J. Clin. Invest. | pmid:6421598 |
Cifone MG et al. | [Effect of calcium ionophore (A23187) on the production of thromboxane B2 in human polymorphonuclear cells in vitro]. | 1984 | Boll. Soc. Ital. Biol. Sper. | pmid:6422962 |
Ylikorkala O et al. | Peritoneal fluid prostaglandins in endometriosis, tubal disorders, and unexplained infertility. | 1984 | Obstet Gynecol | pmid:6232475 |
Branski D et al. | Prostaglandins in small intestinal mucosa of children with celiac disease. | 1984 | J. Pediatr. Gastroenterol. Nutr. | pmid:6594493 |
Woodcock BE et al. | The platelet defect in acute myeloid leukaemia. | 1984 | J. Clin. Pathol. | pmid:6595273 |
Ogushi F et al. | [In vitro release of arachidonate metabolites by human alveolar macrophages]. | 1984 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:6595434 |
Bommer J et al. | Plastic filing from dialysis tubing induces prostanoid release from macrophages. | 1984 | Kidney Int. | pmid:6595463 |
Brandt R et al. | Effect of propranolol, practolol and atenolol on human platelet thromboxane formation and plasma levels of prostaglandins 6-keto-F1 alpha and E2. | 1984 | Prostaglandins Leukot Med | pmid:6597450 |
Chiba S et al. | Sex and age-related differences in the urinary excretion of TXB2 in normal human subjects: a possible pathophysiological role of TXA2 in the aged kidney. | 1984 | Prostaglandins Leukot Med | pmid:6597456 |
Mahmud I et al. | Thromboxane synthesizing system in rat liver. | 1984 | Prostaglandins Leukot Med | pmid:6597457 |
Morrison AR and Crowley JR | Identification of an unusual cyclooxygenase metabolite of arachidonic acid in rabbit renal medulla. | 1984 | Arch. Biochem. Biophys. | pmid:6437329 |
Stimler NP | Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6440564 |
Wang JP et al. | XC 386: a new antiplatelet agent. | 1984 | Thromb. Res. | pmid:6438827 |
Driss F et al. | Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid. | 1984 | Thromb. Res. | pmid:6098051 |
Fuller RW et al. | Dexamethasone inhibits the production of thromboxane B2 and leukotriene B4 by human alveolar and peritoneal macrophages in culture. | 1984 | Clin. Sci. | pmid:6091982 |
Coker SJ | Further evidence that thromboxane exacerbates arrhythmias: effects of UK38485 during coronary artery occlusion and reperfusion in anaesthetized greyhounds. | 1984 | J. Mol. Cell. Cardiol. | pmid:6433026 |
Codde JP et al. | Validation of the direct radioimmunoassay of prostanoids in serum and kidney. | 1984 | Prostaglandins Leukot Med | pmid:6587406 |
Shaala S et al. | Local effect of thromboxane B2 on the contractility of the human non pregnant uterus. | 1984 | Prostaglandins Leukot Med | pmid:6587408 |
Higgins AJ et al. | Influence of phenylbutazone on eicosanoid levels in equine acute inflammatory exudate. | 1984 | Cornell Vet | pmid:6587959 |
Meydani M et al. | Effects of dietary methionine, methylmercury, and atrazine on ex-vivo synthesis of prostaglandin E1 and thromboxane B2. | 1984 | Prostaglandins Leukot Med | pmid:6588393 |
Branski D et al. | Effect of cimetidine on human gastric and duodenal prostanoid synthesis. | 1984 | Scand. J. Gastroenterol. | pmid:6589742 |
Galli C et al. | Acute effects of ethanol, caffeine, or both on platelet aggregation, thromboxane formation, and plasma-free fatty acids in normal subjects. | 1984 | Drug Nutr Interact | pmid:6510241 |
Lelcuk S et al. | Inhibition of ischemia-induced thromboxane synthesis in man. | 1984 | J Trauma | pmid:6325720 |
Swart SS et al. | Functional significance of the platelet alpha2-adrenoceptor: studies in patients with myeloproliferative disorders. | 1984 | Thromb. Res. | pmid:6326344 |
Gal D et al. | Effect of radiation on prostaglandin production by human bowel in vitro. | 1984 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:6588048 |
Oglesby TD and Gorman RR | The inhibition of arachidonic acid metabolism in human platelets by RHC 80267, a diacylglycerol lipase inhibitor. | 1984 | Biochim. Biophys. Acta | pmid:6424715 |