Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

Cross Reference

Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Authors Title Published Journal PubMed Link
Luzak B et al. Xanthohumol from hop cones (Humulus lupulus L.) prevents ADP-induced platelet reactivity. 2017 Arch. Physiol. Biochem. pmid:27855519
Yu M et al. The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. 2017 Int J Mol Sci pmid:28287417
Jin M et al. Effects of pulmonary static inflation with 50% xenon on oxygen impairment during cardiopulmonary bypass for stanford type A acute aortic dissection: A pilot study. 2017 Medicine (Baltimore) pmid:28272227
Kramkowski K et al. Short-term treatment with nitrate is not sufficient to induce in vivo antithrombotic effects in rats and mice. 2017 Naunyn Schmiedebergs Arch. Pharmacol. pmid:27743016
Obilade OA et al. Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy. 2017 PLoS ONE pmid:28880908
Xie P et al. Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra. 2017 Biomed Res Int pmid:28299338
Kosik-Bogacka DI et al. The inflammatory effect of infection with Hymenolepis diminuta via the increased expression and activity of COX-1 and COX-2 in the rat jejunum and colon. 2016 Exp. Parasitol. pmid:27466058
Pallio G et al. Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis. 2016 Eur. J. Pharmacol. pmid:27450484
Jiang J et al. Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials. 2016 PLoS ONE pmid:26808318
Ferrari D et al. Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation. 2016 Toxicol. Lett. pmid:27793764
Peng LL et al. Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy. 2016 Acta Pharmacol. Sin. pmid:27641736
Maga P et al. 11-dehydro thromboxane B2 levels after percutaneous transluminal angioplasty in patients with peripheral arterial occlusive disease during a one year follow-up period. 2016 J. Physiol. Pharmacol. pmid:27511998
Morel A et al. The increased level of COX-dependent arachidonic acid metabolism in blood platelets from secondary progressive multiple sclerosis patients. 2016 Mol. Cell. Biochem. pmid:27507559
Gonzalez-Paredes FJ et al. Contribution of Cyclooxygenase End Products and Oxidative Stress to Intrahepatic Endothelial Dysfunction in Early Non-Alcoholic Fatty Liver Disease. 2016 PLoS ONE pmid:27227672
Kakouros N et al. Risk Factors for Nonplatelet Thromboxane Generation After Coronary Artery Bypass Graft Surgery. 2016 J Am Heart Assoc pmid:27068626
Becerra AZ et al. Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study. 2016 J. Toxicol. Environ. Health Part A pmid:27029326
Homoródi N et al. The lack of aspirin resistance in patients with coronary artery disease. 2016 J Transl Med pmid:26980433
Wannhoff A et al. Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt. 2016 Aliment. Pharmacol. Ther. pmid:26919285
Santilli F et al. Pentraxin 3 and Platelet Activation in Obese Patients After Gastric Banding. 2016 Circ. J. pmid:26632534
Mayer AM et al. Classical and Alternative Activation of Cyanobacterium Oscillatoria sp. Lipopolysaccharide-Treated Rat Microglia in vitro. 2016 Toxicol. Sci. pmid:26609141
Taneja A et al. Biomarker exposure-response relationships as the basis for rational dose selection: Lessons from a simulation exercise using a selective COX-2 inhibitor. 2016 J Clin Pharmacol pmid:26331692
Siewiera K et al. Long-term untreated streptozotocin-diabetes leads to increased expression and elevated activity of prostaglandin H2 synthase in blood platelets. 2016 Platelets pmid:26325148
Sugita R et al. A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models. 2016 J. Pharmacol. Sci. pmid:26906248
Yan H et al. Seawater Immersion Aggravates Burn Injury Causing Severe Blood Coagulation Dysfunction. 2016 Biomed Res Int pmid:26885523
Zhou Z et al. Mechanisms underlying uridine adenosine tetraphosphate-induced vascular contraction in mouse aorta: Role of thromboxane and purinergic receptors. 2015 Vascul. Pharmacol. pmid:25921923
Olszowski T et al. The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages. 2015 Biol Trace Elem Res pmid:25645360
Korbecki J et al. Cyclooxygenase-1 as the main source of proinflammatory factors after sodium orthovanadate treatment. 2015 Biol Trace Elem Res pmid:25398544
Kim TW et al. Evaluation of pharmacokinetic and pharmacodynamic properties of cimicoxib in fasted and fed horses. 2015 N Z Vet J pmid:25075617
Pinto FC et al. Effect of volume replacement during combined experimental hemorrhagic shock and traumatic brain injury in prostanoids, brain pathology and pupil status. 2015 Arq Neuropsiquiatr pmid:26083885
Al-Husseini A et al. Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension. 2015 PLoS ONE pmid:25785937
Mateu A et al. Cross-talk between TLR4 and PPARγ pathways in the arachidonic acid-induced inflammatory response in pancreatic acini. 2015 Int. J. Biochem. Cell Biol. pmid:26510582
Liu TF et al. [Correlation between the level of the urinary 11-dehydrothromboxane B2 and the clinical efficacy of aspirin in patients with type 2 diabetes and coronary artery disease]. 2015 Beijing Da Xue Xue Bao pmid:26679651
Holland B et al. Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses. 2015 J. Vet. Pharmacol. Ther. pmid:25378135
Lüdicke F et al. A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers. 2015 Biomarkers pmid:26616146
Di Minno MN et al. Increased platelet reactivity in Klinefelter men: something new to consider. 2015 Andrology pmid:26216452
Ryu R et al. Ethanol Extract of Persimmon Tree Leaves Improves Blood Circulation and Lipid Metabolism in Rats Fed a High-Fat Diet. 2015 J Med Food pmid:26061228
Larsen SB et al. Determinants of reduced antiplatelet effect of aspirin in patients with stable coronary artery disease. 2015 PLoS ONE pmid:25993271
Isidori AM et al. Mechanisms in endocrinology: The spectrum of haemostatic abnormalities in glucocorticoid excess and defect. 2015 Eur. J. Endocrinol. pmid:25987566
Larsen SB et al. Calprotectin and platelet aggregation in patients with stable coronary artery disease. 2015 PLoS ONE pmid:25970343
Lourenço AL et al. Synthesis and antiplatelet activity of antithrombotic thiourea compounds: biological and structure-activity relationship studies. 2015 Molecules pmid:25903367
Sahota T et al. Model-based prediction of the acute and long-term safety profile of naproxen in rats. 2015 Br. J. Pharmacol. pmid:25884765
Violi F et al. Reply: platelet activation and pneumonia: is soluble p-selectin the right marker? 2015 J. Am. Coll. Cardiol. pmid:25857924
Gurbel PA et al. Platelet activation and pneumonia: is soluble p-selectin the right marker? 2015 J. Am. Coll. Cardiol. pmid:25857923
Violi F et al. Reply: myocardial infarction in patients with pneumonia. 2015 J. Am. Coll. Cardiol. pmid:25857922
Savas G and Kalay N Myocardial infarction in patients with pneumonia. 2015 J. Am. Coll. Cardiol. pmid:25857921
Santos-Gallego CG and Badimon J Reply: platelets interplay between pneumonia and cardiovascular events: establishing a link? 2015 J. Am. Coll. Cardiol. pmid:25857920
Violi F et al. Reply: platelets interplay between pneumonia and cardiovascular events: establishing a link? 2015 J. Am. Coll. Cardiol. pmid:25857919
Khan AR et al. Platelet activation and myocardial infarction in patients with pneumonia: are statins the answer? 2015 J. Am. Coll. Cardiol. pmid:25857918
Gavriilaki E et al. Platelets interplay between pneumonia and cardiovascular events: establishing a link? 2015 J. Am. Coll. Cardiol. pmid:25857917
Véricel E et al. Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. 2015 Thromb. Haemost. pmid:25832443
Khanna V et al. Does the response to aspirin and clopidogrel vary over 6 months in patients with ischemic heart disease? 2015 J. Thromb. Haemost. pmid:25809653
Wu F et al. Valsartan decreases platelet activity and arterial thrombotic events in elderly patients with hypertension. 2015 Chin. Med. J. pmid:25591555
Paikin JS et al. Multiple daily doses of acetyl-salicylic acid (ASA) overcome reduced platelet response to once-daily ASA after coronary artery bypass graft surgery: a pilot randomized controlled trial. 2015 J. Thromb. Haemost. pmid:25546465
Voon PT et al. Virgin olive oil, palm olein and coconut oil diets do not raise cell adhesion molecules and thrombogenicity indices in healthy Malaysian adults. 2015 Eur J Clin Nutr pmid:25804278
Bautista-Pérez R et al. Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway. 2015 Am. J. Physiol. Renal Physiol. pmid:25354938
Karamouzis I et al. Enhanced oxidative stress and platelet activation in patients with Cushing's syndrome. 2015 Clin. Endocrinol. (Oxf) pmid:24923553
Willenberg I et al. Determining cyclooxygenase-2 activity in three different test systems utilizing online-solid phase extraction-liquid chromatography-mass spectrometry for parallel quantification of prostaglandin E(2), D(2) and thromboxane B(2). 2015 J Chromatogr A pmid:25777050
Drew RC et al. Healthy older humans exhibit augmented carotid-cardiac baroreflex sensitivity with aspirin during muscle mechanoreflex and metaboreflex activation. 2015 Am. J. Physiol. Heart Circ. Physiol. pmid:26371168
Wang J et al. Prevention of atherosclerosis by Yindan Xinnaotong capsule combined with swimming in rats. 2015 BMC Complement Altern Med pmid:25886942
Hill TL et al. The effect of tramadol and indomethacin coadministration on gastric barrier function in dogs. 2014 May-Jun J. Vet. Intern. Med. pmid:24684670
Yu C et al. Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in rats. 2014 PLoS ONE pmid:25375124
Ross S et al. Association of cyclooxygenase-2 genetic variant with cardiovascular disease. 2014 Eur. Heart J. pmid:24796340
Salazar F et al. Renal effects induced by prolonged mPGES1 inhibition. 2014 Am. J. Physiol. Renal Physiol. pmid:24197070
Kawai VK et al. Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome. 2014 Arthritis Care Res (Hoboken) pmid:24022862
Elsheikh W et al. Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer. 2014 Nitric Oxide pmid:24747869
Suarez-Kurtz G Impact of CYP2C9*3/*3 genotype on the pharmacokinetics and pharmacodynamics of oxicam NSAIDs. 2014 Pharmacogenet. Genomics pmid:25003537
Shan MQ et al. [Comparative study on effects of Rubiae Radix et Rhizoma and carbonized Rubiae Radix et Rhizoma on acute blood stasis rat model]. 2014 Zhongguo Zhong Yao Za Zhi pmid:24946554
Zhou K et al. A CAPE analogue as novel antiplatelet agent efficiently inhibits collagen-induced platelet aggregation. 2014 Pharmazie pmid:25158573
Maurer K et al. Acetylsalicylic acid enhances tachyphylaxis of repetitive capsaicin responses in TRPV1-GFP expressing HEK293 cells. 2014 Neurosci. Lett. pmid:24495935
Shimizu T et al. Up-regulation of Kv7.1 channels in thromboxane A2-induced colonic cancer cell proliferation. 2014 Pflugers Arch. pmid:23995773
DeFilippis AP et al. Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity. 2014 Nutr Metab Cardiovasc Dis pmid:24370448
Togna AR et al. 4-Methylcoumarin derivatives with anti-inflammatory effects in activated microglial cells. 2014 Biol. Pharm. Bull. pmid:24389482
Osmond DA et al. Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension. 2014 Am. J. Physiol. Renal Physiol. pmid:24477682
Cathcart MC et al. Thromboxane synthase expression and correlation with VEGF and angiogenesis in non-small cell lung cancer. 2014 Biochim. Biophys. Acta pmid:24480048
Umar A et al. Effect of Ocimum basilicum L. on cyclo-oxygenase isoforms and prostaglandins involved in thrombosis. 2014 J Ethnopharmacol pmid:24412551
Sahota T et al. Model-based analysis of thromboxane Bâ‚‚ and prostaglandin Eâ‚‚ as biomarkers in the safety evaluation of naproxen. 2014 Toxicol. Appl. Pharmacol. pmid:24667227
Gonçalves LH et al. Acetylsalicylic acid therapy: influence of metformin use and other variables on urinary 11-dehydrothromboxane B2 levels. 2014 Clin. Chim. Acta pmid:24316050
Jiménez-Romero C et al. Dactyloditerpenol acetate, a new prenylbisabolane-type diterpene from Aplysia dactylomela with significant in vitro anti-neuroinflammatory activity. 2014 Bioorg. Med. Chem. Lett. pmid:24279991
Lee HI et al. Strongly increased exposure of meloxicam in CYP2C9*3/*3 individuals. 2014 Pharmacogenet. Genomics pmid:24322170
Voisin V et al. Protection of Wistar-Furth rats against postischaemic acute renal injury: role for nitric oxide and thromboxane? 2014 Clin. Exp. Pharmacol. Physiol. pmid:25115485
Chou YI et al. Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions. 2014 Biomarkers pmid:25391885
Zhu Y et al. Effects and mechanisms of Fenofibrate on the secretion of vascular endothelial contraction factors in hypertensive rats. 2014 Genet. Mol. Res. pmid:25078582
Tachi M et al. Mass spectrometric determination of prostanoids in rat hypothalamic paraventricular nucleus microdialysates. 2014 Auton Neurosci pmid:24447364
Montserrat-de la Paz S et al. Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages. 2014 J Ethnopharmacol pmid:24239848
Wang Y et al. DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4. 2014 BMC Complement Altern Med pmid:24555740
Fuentes E et al. A novel role of Eruca sativa Mill. (rocket) extract: antiplatelet (NF-κB inhibition) and antithrombotic activities. 2014 Nutrients pmid:25514563
Santos-Gallego CG and Badimon JJ The sum of two evils: pneumonia and myocardial infarction: is platelet activation the missing link? 2014 J. Am. Coll. Cardiol. pmid:25444148
Cangemi R et al. Platelet activation is associated with myocardial infarction in patients with pneumonia. 2014 J. Am. Coll. Cardiol. pmid:25444147
Shinohara M et al. Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. 2014 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:25217660
Hong S et al. Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages. 2014 Chem. Biol. pmid:25200603
Tong B et al. [Atorvastatin inhibits platelet aggregation and activation following carotid balloon injury in cholesterol-fed rabbits]. 2014 Nan Fang Yi Ke Da Xue Xue Bao pmid:25176087
Kaplon-Cieslicka A et al. Younger age, higher body mass index and lower adiponectin concentration predict higher serum thromboxane B2 level in aspirin-treated patients with type 2 diabetes: an observational study. 2014 Cardiovasc Diabetol pmid:25123549
Hayashi G et al. Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. 2014 Hum. Mol. Genet. pmid:25104852
Floyd CN et al. Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects. 2014 Br J Clin Pharmacol pmid:25099258
Zhu SH et al. Protective effect of indomethacin in renal ischemia-reperfusion injury in mice. 2014 J Zhejiang Univ Sci B pmid:25091992
Basili S et al. Aspirin reload before elective percutaneous coronary intervention: impact on serum thromboxane b2 and myocardial reperfusion indexes. 2014 Circ Cardiovasc Interv pmid:25074252
Patrignani P et al. Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action. 2014 J. Thromb. Haemost. pmid:24942808
Mayer AM et al. Vibrio vulnificus MO6-24/O lipopolysaccharide stimulates superoxide anion, thromboxane Bâ‚‚, matrix metalloproteinase-9, cytokine and chemokine release by rat brain microglia in vitro. 2014 Mar Drugs pmid:24675728
van den Elsen LW et al. Dietary fish oil improves endothelial function and lowers blood pressure via suppression of sphingolipid-mediated contractions in spontaneously hypertensive rats. 2014 J. Hypertens. pmid:24569415
Reddoch KM et al. Hemostatic function of apheresis platelets stored at 4°C and 22°C. 2014 Shock pmid:24169210