Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

Cross Reference

Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

Download all related citations
Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Tanaka H et al. Leukotriene (LT)-receptor antagonist is more effective in asthmatic patients with a low baseline ratio of urinary LTE4 to 2,3-dinor-6-keto-prostaglandin (PG)F1alpha. 1999 Allergy pmid:10380781
Elissalde MH and Beier RC Stimulation and release of prostaglandins and thromboxane from macrophages by cotton dust associated lipopolysaccharides. 1990 Am Ind Hyg Assoc J pmid:2270833
Andersson T et al. Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers. 2012 Am J Cardiovasc Drugs pmid:22631032
Leese PT et al. Valdecoxib does not impair platelet function. 2002 Am J Emerg Med pmid:12098171
Jung TT and Juhn SK Prostaglandins in human cholesteatoma and granulation tissue. 1988 Am J Otol pmid:3177602
Mehta P et al. Plasma concentrations of thromboxane and prostacyclin metabolites in patients with bone tumors. 1985 Am J Pediatr Hematol Oncol pmid:2994511
Natarajan G et al. Chorioamnionitis and ontogeny of circulating prostaglandin and thromboxane in preterm infants. 2008 Am J Perinatol pmid:18726836
Brown HL et al. Plasma and amniotic fluid prostacyclin and thromboxane in mild pregnancy-induced hypertension. 1987 Am J Perinatol pmid:3566883
Satterfield S et al. Biochemical markers of compliance in the Physicians' Health Study. 1990 Sep-Oct Am J Prev Med pmid:2268456
Ingster LM and Feinleib M Salicylate intake and cardiovascular disease: Ingster and Feinleib respond to Hu and Willett. 1998 Am J Public Health pmid:9702172
Cambria RA et al. Thromboxane synthetase inhibition decreases polymorphonuclear leukocyte activation following hindlimb ischemia. 1991 Am Surg pmid:1847027
Montalescot G et al. Early thromboxane release during pacing-induced myocardial ischemia with angiographically normal coronary arteries. 1990 Am. Heart J. pmid:2248190
Hirsh PD et al. Influence of blood sampling site and technique on thromboxane concentrations in patients with ischemic heart disease. 1982 Am. Heart J. pmid:7102506
Smith EF and Lefer AM Stabilization of cardiac lysosomal and cellular membranes in protection of ischemic myocardium due to coronary occlusion:efficacy of the nonsteroidal anti-inflammatory agent, naproxen. 1981 Am. Heart J. pmid:7211667
Nakashima Y et al. Sustained-release nifedipine (nifedipine-L) suppresses plasma thromboxane B2 and 6-keto prostaglandin F1 alpha in both young male smokers and nonsmokers. 1990 Am. Heart J. pmid:2353613
Ikonomidis I et al. Cigarette smoking is associated with increased circulating proinflammatory and procoagulant markers in patients with chronic coronary artery disease: effects of aspirin treatment. 2005 Am. Heart J. pmid:15894964
Kishi Y et al. Inhibition of platelet aggregation by prostacyclin is attenuated after exercise in patients with angina pectoris. 1992 Am. Heart J. pmid:1736562
Tomoda H Development of an experimental model of acute myocardial infarction and the effects of a thromboxane synthetase inhibitor (OKY-046). 1986 Am. Heart J. pmid:3532743
Nitz RE and Martorana PA The activity of molsidomine in experimental models of ischemic cardiac disease. 1985 Am. Heart J. pmid:3919549
Buchanan MR et al. Effect of nafazatrom on platelet function and release: relationship to symptomatic episodes in patients with peripheral vascular disease. 1987 Am. Heart J. pmid:2953219
Walinsky P et al. Thromboxane A2 in acute myocardial infarction. 1984 Am. Heart J. pmid:6485997
Rubenstein MD et al. Platelet activation in clinical coronary artery disease and spasm. 1981 Am. Heart J. pmid:6455912
De Caterina R et al. Inhibition of platelet function during in vivo infusion of isosorbide mononitrates: relationship between plasma drug concentration and hemodynamic effects. 1990 Am. Heart J. pmid:2321506
Lorenzoni R et al. Short-term prevention of thromboembolic complications in patients with atrial fibrillation with aspirin plus clopidogrel: the Clopidogrel-Aspirin Atrial Fibrillation (CLAAF) pilot study. 2004 Am. Heart J. pmid:15215815
Buerke M et al. Aspirin therapy: optimized platelet inhibition with different loading and maintenance doses. 1995 Am. Heart J. pmid:7661062
Mehta J et al. Thromboxane release in coronary artery disease: spontaneous versus pacing-induced angina. 1984 Am. Heart J. pmid:6695662
De Servi S et al. Coronary vasoconstrictor response to cold pressor test in variant angina: lack of relation to intracoronary thromboxane concentrations. 1987 Am. Heart J. pmid:3630891
Cotter G et al. Lack of aspirin effect: aspirin resistance or resistance to taking aspirin? 2004 Am. Heart J. pmid:14760328
Mehta J and Mehta P Prostacyclin and thromboxane A2 production by human cardiac atrial tissues. 1985 Am. Heart J. pmid:3880988
Friedrich T et al. Follow-up of prostaglandin plasma levels after acute myocardial infarction. 1985 Am. Heart J. pmid:3880994
O'Connor KM et al. The effect of thromboxane inhibition on vulnerability to ventricular fibrillation in the acute and chronic feline infarction models. 1989 Am. Heart J. pmid:2929400
Zhu BQ and Parmley WW Modification of experimental and clinical atherosclerosis by dietary fish oil. 1990 Am. Heart J. pmid:2105047
Neri Serneri GG et al. Abnormal cardiocoronary thromboxane A2 production in patients with unstable angina. 1985 Am. Heart J. pmid:3984828
O'Connor KM et al. Effect of thromboxane synthetase inhibition on vulnerability to ventricular arrhythmia following coronary occlusion. 1986 Am. Heart J. pmid:3953390
Roy L et al. Lack of efficacy of nafazatrom, a novel anti-thrombotic compound, in patients with coronary artery disease. 1985 Am. Heart J. pmid:3158183
Austin JC et al. Thromboxane synthetase inhibition reduces ventricular irritability after coronary occlusion and reperfusion. 1988 Am. Heart J. pmid:3344655
Yamada Y et al. Possible mechanism of vascular reocclusion after initially successful thrombolysis with recombinant tissue-type plasminogen activator. 1991 Am. Heart J. pmid:1903579
Arora RR et al. Laser-induced stimulation of thromboxane B2 synthesis in human blood platelets: role of superoxide radicals. 1993 Am. Heart J. pmid:8381256
FitzGerald GA et al. Cigarette smoking and hemostatic function. 1988 Am. Heart J. pmid:3276116
Jouve R et al. Thromboxane B2, 6-keto-PGF1 alpha, PGE2, PGF2 alpha, and PGA1 plasma levels in arteriosclerosis obliterans: relationship to clinical manifestations, risk factors, and arterial pathoanatomy. 1984 Am. Heart J. pmid:6581715
Rebuzzi AG et al. Importance of reperfusion on thromboxane A2 metabolite excretion after thrombolysis. 1992 Am. Heart J. pmid:1539506
Takase B et al. Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. 1994 Am. J. Cardiol. pmid:8198031
Fulton DR et al. Effects of current therapy of Kawasaki disease on eicosanoid metabolism. 1988 Am. J. Cardiol. pmid:2454025
Catella-Lawson F et al. Oral glycoprotein IIb/IIIa antagonism in patients with coronary artery disease. 2001 Am. J. Cardiol. pmid:11472700
Hanet C et al. Myocardial protection by intracoronary nicardipine administration during percutaneous transluminal coronary angioplasty. 1987 Am. J. Cardiol. pmid:2953226
Faraday N et al. Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population. 2006 Am. J. Cardiol. pmid:16950183
Yasu T et al. Effects of aspirin DL-lysine on thrombin generation in unstable angina pectoris. 1993 Am. J. Cardiol. pmid:8480641
Willerson JT et al. Potential usefulness of combined thromboxane A2 and serotonin receptor blockade for preventing the conversion from chronic to acute coronary artery disease syndromes. 1990 Am. J. Cardiol. pmid:2146868
McDaniel HG et al. Platelet function abnormalities in response to arachidonic acid in the acute phase of myocardial infarction. 1983 Am. J. Cardiol. pmid:6416046
De Caterina R et al. Inhibition of platelet function by injectable isosorbide dinitrate. 1984 Am. J. Cardiol. pmid:6428211
Eldar M et al. Bradykinin level in the great cardiac vein during balloon angioplasty of the left anterior descending coronary artery. 1992 Am. J. Cardiol. pmid:1466338
Dabaghi SF et al. Effects of low-dose aspirin on in vitro platelet aggregation in the early minutes after ingestion in normal subjects. 1994 Am. J. Cardiol. pmid:7942533
Graziani F et al. Thromboxane production in morbidly obese subjects. 2011 Am. J. Cardiol. pmid:21439532
Théroux P et al. Hemodynamic, platelet and clinical responses to prostacyclin in unstable angina pectoris. 1990 Am. J. Cardiol. pmid:2109927
Feldman M and Cryer B Aspirin absorption rates and platelet inhibition times with 325-mg buffered aspirin tablets (chewed or swallowed intact) and with buffered aspirin solution. 1999 Am. J. Cardiol. pmid:10468077
Willerson JT et al. Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms. 1984 Am. J. Cardiol. pmid:6391133
Hirsh PD et al. Effects of provocation on transcardiac thromboxane in patients with coronary artery disease. 1983 Am. J. Cardiol. pmid:6829431
Walinsky P et al. Beneficial effects of ibuprofen in pacing-induced myocardial ischemia. 1983 Am. J. Cardiol. pmid:6829434
Milani M et al. Effects of fluvastatin and pravastatin on lipid profiles and thromboxane production in type IIa hypercholesterolemia. 1995 Am. J. Cardiol. pmid:7604798
Roy L et al. Increased plasma concentrations of prostacyclin metabolite 6-keto-PGF1 alpha in essential hypertension. Influence of therapy with labetalol. 1983 Am. J. Cardiol. pmid:6823861
Shen H et al. Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study). 2009 Am. J. Cardiol. pmid:19660620
Lam JY et al. Platelet aggregation, coronary artery disease progression and future coronary events. 1994 Am. J. Cardiol. pmid:8109546
Timmermans C et al. Ridogrel in the setting of percutaneous transluminal coronary angioplasty. 1991 Am. J. Cardiol. pmid:1872272
Mason PJ et al. Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular disease. 2005 Am. J. Cardiol. pmid:16275179
Rehr RB et al. Mechanism of nitroglycerin-induced coronary dilatation: lack of relation to intracoronary thromboxane concentrations. 1984 Am. J. Cardiol. pmid:6437206
Wang JP et al. Antiplatelet effect of hsien-ho-t'sao (Agrimonia pilosa). 1985 Am. J. Chin. Med. pmid:3927704
Yan LG et al. Injectable caltrop fruit saponin protects against ischemia-reperfusion injury in rat brain. 2011 Am. J. Chin. Med. pmid:21476209
Wander RC and Patton BD Comparison of three species of fish consumed as part of a Western diet: effects on platelet fatty acids and function, hemostasis, and production of thromboxane. 1991 Am. J. Clin. Nutr. pmid:1858697
Stampfer MJ et al. Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels. 1988 Am. J. Clin. Nutr. pmid:3128100
Salonen JT et al. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status. 1991 Am. J. Clin. Nutr. pmid:1826987
Wan Y et al. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. 2001 Am. J. Clin. Nutr. pmid:11684527
Prakash C et al. Decreased systemic thromboxane A2 biosynthesis in normal human subjects fed a salmon-rich diet. 1994 Am. J. Clin. Nutr. pmid:8074067
Hayes KC et al. Taurine modulates platelet aggregation in cats and humans. 1989 Am. J. Clin. Nutr. pmid:2729158
Delgado-Lista J et al. Chronic dietary fat intake modifies the postprandial response of hemostatic markers to a single fatty test meal. 2008 Am. J. Clin. Nutr. pmid:18258620
Craig-Schmidt MC et al. The essential fatty acid deficient chicken as a model for cystic fibrosis. 1986 Am. J. Clin. Nutr. pmid:3466523
Blair IA et al. Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. 1993 Am. J. Clin. Nutr. pmid:8424383
Kwon JS et al. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. 1991 Am. J. Clin. Nutr. pmid:1677525
Qureshi AA et al. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). 1991 Am. J. Clin. Nutr. pmid:2012010
Qureshi AA et al. Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, thromboxane B2, and platelet factor 4 in pigs with inherited hyperlipidemias. 1991 Am. J. Clin. Nutr. pmid:2012015
Blair IA et al. Dietary stearic acid and thromboxane-prostacyclin biosynthesis in normal human subjects. 1994 Am. J. Clin. Nutr. pmid:7977150
McDonald BE et al. Comparison of the effect of canola oil and sunflower oil on plasma lipids and lipoproteins and on in vivo thromboxane A2 and prostacyclin production in healthy young men. 1989 Am. J. Clin. Nutr. pmid:2596428
Freese R and Mutanen M Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. 1997 Am. J. Clin. Nutr. pmid:9280178
Gonzalez-Crussi F et al. Prostaglandins in histiocytosis-X. PG synthesis by histiocytosis-X cells. 1981 Am. J. Clin. Pathol. pmid:6970520
Hyman PE et al. Enhanced urinary immunoreactive thromboxane in neonatal necrotizing enterocolitis. A diagnostic indicator of thrombotic activity. 1987 Am. J. Dis. Child. pmid:2953236
Hammerman C et al. Hypoxic vs septic pulmonary hypertension. Selective role of thromboxane mediation. 1988 Am. J. Dis. Child. pmid:3278589
Singh D et al. Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets. 1981 Am. J. Hematol. pmid:6274189
Zaitsu M et al. Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. 2003 Am. J. Hematol. pmid:12555215
Wu X et al. Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma. 2003 Am. J. Hematol. pmid:12949886
Stuart MJ Effect of endotoxin on arachidonic acid release and thromboxane B2 production by human platelets. 1981 Am. J. Hematol. pmid:7030066
Gross S and Worthington-White DA The effects of PGF2 alpha, PGI2, and TxB2 on human CFU-C in healthy and leukemic patients. 1984 Am. J. Hematol. pmid:6372442
Meyers KM et al. Evaluation of the platelet storage pool deficiency in the feline counterpart of the Chediak-Higashi syndrome. 1981 Am. J. Hematol. pmid:7315839
Horellou MH et al. Familial and constitutional bleeding disorder due to platelet cyclo-oxygenase deficiency. 1983 Am. J. Hematol. pmid:6404162
Carvalho AC et al. Platelet function in acute respiratory failure. 1987 Am. J. Hematol. pmid:2956879
Ryo R et al. Deficiency of P62, a putative collagen receptor, in platelets from a patient with defective collagen-induced platelet aggregation. 1992 Am. J. Hematol. pmid:1311144
Jones CM et al. Arachidonic acid metabolites produced by platelet-depleted human blood monocytes: a possible role in thrombogenesis. 1989 Am. J. Hematol. pmid:2741910
Antonucci R et al. Enhancement of sickle erythrocyte adherence to endothelium by autologous platelets. 1990 Am. J. Hematol. pmid:2109530
Del Principe D et al. Vitamin E consumption by human blood platelets activated by latex particles. 1986 Am. J. Hematol. pmid:3953557
Mezzano D et al. Evidence that platelet buoyant density, but not size, correlates with platelet age in man. 1981 Am. J. Hematol. pmid:7270546
Suarez CR et al. Neonatal and maternal platelets: activation at time of birth. 1988 Am. J. Hematol. pmid:2972197
Smock KJ and Rodgers GM Laboratory evaluation of aspirin responsiveness. 2010 Am. J. Hematol. pmid:20229592