| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Graft Occlusion, Vascular | D006083 | 11 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fitscha P et al. | Effects of isradipine on platelet function in hypertension at rest and during exercise. | 1991 | Am. J. Hypertens. | pmid:1827015 |
| Ooi BS et al. | Stimulation of endothelial cell production of vasoconstrictive substances by hypertensive sera. | 1998 | Am. J. Hypertens. | pmid:9524055 |
| Suzuki A et al. | Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats. | 2007 | Am. J. Hypertens. | pmid:17485012 |
| Nawarskas JJ et al. | Effect of aspirin on blood pressure in hypertensive patients taking enalapril or losartan. | 1999 | Am. J. Hypertens. | pmid:10480471 |
| Awad AS et al. | Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats. | 2005 | Am. J. Hypertens. | pmid:15831366 |
| Thakur V et al. | Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs. | 1999 | Am. J. Hypertens. | pmid:10509552 |
| Ganafa AA et al. | Amlodipine attenuates oxidative stress-induced hypertension. | 2004 | Am. J. Hypertens. | pmid:15363814 |
| Macconi D et al. | Defective platelet aggregation in response to platelet-activating factor in uremia associated with low platelet thromboxane A2 generation. | 1992 | Am. J. Kidney Dis. | pmid:1562019 |
| Ingram AJ et al. | Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model. | 1995 | Am. J. Kidney Dis. | pmid:7847360 |
| Barcelli UO et al. | High linoleic acid diets ameliorate diabetic nephropathy in rats. | 1990 | Am. J. Kidney Dis. | pmid:2399916 |
| Gaspari F et al. | Influence of antacid administrations on aspirin absorption in patients with chronic renal failure on maintenance hemodialysis. | 1988 | Am. J. Kidney Dis. | pmid:3354570 |
| Francos GC et al. | Dialysis-induced hypoxemia: membrane dependent and membrane independent causes. | 1985 | Am. J. Kidney Dis. | pmid:3919574 |
| Clive DM et al. | Potassium homeostasis with indomethacin therapy in normal subjects. | 1992 | Am. J. Kidney Dis. | pmid:1739077 |
| Noris M et al. | Renal prostacyclin biosynthesis is reduced in children with hemolytic-uremic syndrome in the context of systemic platelet activation. | 1992 | Am. J. Kidney Dis. | pmid:1496967 |
| Sreedhara R et al. | Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIb-IIIa receptors. | 1996 | Am. J. Kidney Dis. | pmid:8604704 |
| Menè P et al. | Eicosanoid synthesis in peripheral blood monocytes: a marker of disease activity in lupus nephritis. | 1998 | Am. J. Kidney Dis. | pmid:9820447 |
| Cumming AD et al. | Vasoactive hormones in the renal response to systemic sepsis. | 1988 | Am. J. Kidney Dis. | pmid:3276170 |
| Viganò G et al. | Recombinant human erythropoietin to correct uremic bleeding. | 1991 | Am. J. Kidney Dis. | pmid:2063854 |
| Preston FE | Aspirin, prostaglandins, and peripheral gangrene. | 1983 | Am. J. Med. | pmid:6859070 |
| Van Solingen RM et al. | Comparison of the effects of ketoprofen on platelet function in the presence and absence of aspirin. | 2001 | Am. J. Med. | pmid:11566459 |
| Smith MC et al. | Prostacyclin substitution for heparin in long-term hemodialysis. | 1982 | Am. J. Med. | pmid:6753575 |
| Ehrlich HP | Promotion of vascular patency in dermal burns with ibuprofen. | 1984 | Am. J. Med. | pmid:6547810 |
| Barbui T et al. | Aspirin and risk of bleeding in patients with thrombocythemia. | 1987 | Am. J. Med. | pmid:3497579 |
| Magner P | Effects of sulindac on renal prostaglandins and glomerular filtration rate. | 1991 | Am. J. Med. | pmid:1867250 |
| Payno A et al. | Prostanoid production in post-gastrectomy gastritis. Influence of sucralfate. | 1989 | Am. J. Med. | pmid:2735331 |
| Shepherd HA et al. | Effect of sucralfate and cimetidine on rheumatoid patients with active gastroduodenal lesions who are taking nonsteroidal anti-inflammatory drugs. A pilot study. | 1989 | Am. J. Med. | pmid:2735335 |
| Patrono C and Pierucci A | Renal effects of nonsteroidal anti-inflammatory drugs in chronic glomerular disease. | 1986 | Am. J. Med. | pmid:3092667 |
| Halushka PV et al. | Studies on the beneficial effects of aspirin in endotoxic shock. Relationship to inhibition of arachidonic acid metabolism. | 1983 | Am. J. Med. | pmid:6687979 |
| Hakim RM and Schafer AI | Hemodialysis-associated platelet activation and thrombocytopenia. | 1985 | Am. J. Med. | pmid:3885730 |
| Maruyama T et al. | Thromboxane-dependent portopulmonary hypertension. | 2005 | Am. J. Med. | pmid:15639216 |
| Di Minno G et al. | Platelet dysfunction in uremia. Multifaceted defect partially corrected by dialysis. | 1985 | Am. J. Med. | pmid:3933340 |
| Hirsh PD et al. | Prostaglandins and ischemic heart disease. | 1981 | Am. J. Med. | pmid:7032286 |
| Fukushima H et al. | Mechanisms underlying early development of pulmonary vascular obstructive disease in Down syndrome: An imbalance in biosynthesis of thromboxane A2 and prostacyclin. | 2010 | Am. J. Med. Genet. A | pmid:20583254 |
| Piccirillo G et al. | High plasma concentrations of cortisol and thromboxane B2 in patients with depression. | 1994 | Am. J. Med. Sci. | pmid:8160715 |
| Oates JC et al. | Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis. | 2011 | Am. J. Med. Sci. | pmid:20924284 |
| Li JX et al. | Delayed thromboxane or tumor necrosis factor-alpha, but not leukotriene inhibition, attenuates prolonged pulmonary hypertension in endotoxemia. | 1995 | Am. J. Med. Sci. | pmid:7668305 |
| Shook LA et al. | Dimethylthiourea reverses sepsis-induced pulmonary hypertension in piglets. | 1990 | Am. J. Med. Sci. | pmid:2115294 |
| White RP et al. | Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus. | 1990 | Am. J. Med. Sci. | pmid:2321665 |
| Benigni A et al. | Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated? | 1985 | Am. J. Nephrol. | pmid:2996352 |
| Abdelwhab S and Elshinnawy S | Pulmonary hypertension in chronic renal failure patients. | 2008 | Am. J. Nephrol. | pmid:18635926 |
| Yang D et al. | Effects of short- and long-term hypercholesterolemia on contrast-induced acute kidney injury. | 2012 | Am. J. Nephrol. | pmid:22189165 |
| Shibasaki T et al. | Mizoribine reduces urinary protein excretion in rats given puromycin aminonucleoside. | 1996 | Am. J. Nephrol. | pmid:8919236 |
| Patrono C and Salvati P | Thromboxane biosynthesis and pharmacologic modulation in progressive glomerulosclerosis. | 1989 | Am. J. Nephrol. | pmid:2646922 |
| Deray G et al. | Effects of ciclosporin on plasma renin activity, catecholamines and prostaglandins in patients with idiopathic uveitis. | 1988 | Am. J. Nephrol. | pmid:3055993 |
| Kraayenbrink AA et al. | Endothelial vasoactive mediators in preeclampsia. | 1993 | Am. J. Obstet. Gynecol. | pmid:8333445 |
| Clark KE et al. | Effect of bisenoic prostaglandins and arachidonic acid on the uterine vasculature of pregnant sheep. | 1982 | Am. J. Obstet. Gynecol. | pmid:7065014 |
| Drake TS et al. | Peritoneal fluid prostanoids in unexplained infertility. | 1983 | Am. J. Obstet. Gynecol. | pmid:6614085 |
| ChavarrÃa ME et al. | Prostacyclin/thromboxane early changes in pregnancies that are complicated by preeclampsia. | 2003 | Am. J. Obstet. Gynecol. | pmid:12712098 |
| Magness RR et al. | Angiotensin II metabolic clearance rate and pressor responses in nonpregnant and pregnant women. | 1994 | Am. J. Obstet. Gynecol. | pmid:8092213 |
| Schiff E et al. | Reduction of thromboxane A2 synthesis in pregnancy by polyunsaturated fatty acid supplements. | 1993 | Am. J. Obstet. Gynecol. | pmid:8420313 |
| Van Assche FA et al. | Increased thromboxane formation in diabetic pregnancy as a possible contributor to preeclampsia. | 1993 | Am. J. Obstet. Gynecol. | pmid:8420355 |
| Paarlberg KM et al. | Vasoactive mediators in pregnancy-induced hypertensive disorders: a longitudinal study. | 1998 | Am. J. Obstet. Gynecol. | pmid:9855596 |
| Wang YP et al. | Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750461 |
| Wang YP et al. | The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal blood. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750462 |
| Myatt L et al. | Endothelin-1-induced vasoconstriction is not mediated by thromboxane release and action in the human fetal-placental circulation. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750466 |
| Leuschen MP et al. | Comparative evaluation of antepartum and postpartum platelet function in smokers and nonsmokers. | 1986 | Am. J. Obstet. Gynecol. | pmid:2947470 |
| Markham SM et al. | The effect of the menstrual cycle and of decompression stress on arachidonic acid-induced platelet aggregation and on intrinsic platelet thromboxane production in women compared with men. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750481 |
| Walsh SW | Preeclampsia: an imbalance in placental prostacyclin and thromboxane production. | 1985 | Am. J. Obstet. Gynecol. | pmid:3923838 |
| Chacho KJ et al. | Peritoneal fluid in patients with and without endometriosis: prostanoids and macrophages and their effect on the spermatozoa penetration assay. | 1986 | Am. J. Obstet. Gynecol. | pmid:2940869 |
| Brown CE et al. | Low-dose aspirin. II. Relationship of angiotensin II pressor responses, circulating eicosanoids, and pregnancy outcome. | 1990 | Am. J. Obstet. Gynecol. | pmid:2256495 |
| Mäkäräinen L and Ylikorkala O | Amniotic fluid 6-keto-prostaglandin F1 alpha and thromboxane B2 during labor. | 1984 | Am. J. Obstet. Gynecol. | pmid:6388335 |
| Hauth JC et al. | Low-dose aspirin therapy to prevent preeclampsia. | 1993 | Am. J. Obstet. Gynecol. | pmid:8475955 |
| Yamaguchi M and Mori N | 6-Keto prostaglandin F1 alpha, thromboxane B2, and 13,14-dihydro-15-keto prostaglandin F concentrations of normotensive and preeclamptic patients during pregnancy, delivery, and the postpartum period. | 1985 | Am. J. Obstet. Gynecol. | pmid:3838119 |
| Keith JC et al. | Beneficial effects of U-63,557A, a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension. | 1987 | Am. J. Obstet. Gynecol. | pmid:3605254 |
| Drake TS et al. | Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F1 alpha in endometriosis. | 1981 | Am. J. Obstet. Gynecol. | pmid:6894667 |
| Ylikorkala O et al. | Maternal prostacyclin, thromboxane, and placental blood flow. | 1983 | Am. J. Obstet. Gynecol. | pmid:6338724 |
| Ylikorkala O and Viinikka L | Prostacyclin, thromboxane, and prostaglandin F2 alpha in maternal plasma during breast-feeding. | 1981 | Am. J. Obstet. Gynecol. | pmid:7011034 |
| Dickinson JE et al. | Placental thromboxane and prostacyclin production in an ovine diabetic model. | 1990 | Am. J. Obstet. Gynecol. | pmid:2147814 |
| Ylikorkala O et al. | Amniotic fluid prostacyclin and thromboxane in normal, preeclamptic, and some other complicated pregnancies. | 1981 | Am. J. Obstet. Gynecol. | pmid:6895277 |
| Fitzgerald DJ et al. | Increased thromboxane biosynthesis in normal pregnancy is mainly derived from platelets. | 1987 | Am. J. Obstet. Gynecol. | pmid:3618681 |
| Nelson DM et al. | Hypoxia limits differentiation and up-regulates expression and activity of prostaglandin H synthase 2 in cultured trophoblast from term human placenta. | 1999 | Am. J. Obstet. Gynecol. | pmid:10203658 |
| Walsh SW et al. | Peroxide induces vasoconstriction in the human placenta by stimulating thromboxane. | 1993 | Am. J. Obstet. Gynecol. | pmid:8238110 |
| Moutquin JM et al. | Do prostacyclin and thromboxane contribute to the "protective effect" of pregnancies with chronic hypertension? A preliminary prospective longitudinal study. | 1997 | Am. J. Obstet. Gynecol. | pmid:9423755 |
| Maher JE et al. | The effect of low-dose aspirin on fetal urine output and amniotic fluid volume. | 1993 | Am. J. Obstet. Gynecol. | pmid:8238144 |
| Owen J et al. | The effect of low-dose aspirin on umbilical artery Doppler measurements. | 1993 | Am. J. Obstet. Gynecol. | pmid:8238148 |
| DuBard MB et al. | Are pill counts valid measures of compliance in clinical obstetric trials? | 1993 | Am. J. Obstet. Gynecol. | pmid:8238182 |
| Glance DG et al. | Prostaglandin production and stimulation by angiotensin II in the isolated perfused human placental cotyledon. | 1985 | Am. J. Obstet. Gynecol. | pmid:3855602 |
| van der Weiden RM et al. | Prostanoid excretion in incipient singleton and twin pregnancies. | 1996 | Am. J. Obstet. Gynecol. | pmid:9065139 |
| Bergman A et al. | The role of prostaglandins in detrusor instability. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750483 |
| Hauth JC et al. | Maternal serum thromboxane B2 reduction versus pregnancy outcome in a low-dose aspirin trial. | 1995 | Am. J. Obstet. Gynecol. | pmid:7645637 |
| Spitz B et al. | Low-dose aspirin. I. Effect on angiotensin II pressor responses and blood prostaglandin concentrations in pregnant women sensitive to angiotensin II. | 1988 | Am. J. Obstet. Gynecol. | pmid:3189434 |
| Miller KW and Keith JC | Erythrocyte morphologic features and serum chemistry studies in ovine pregnancy-induced hypertension treated with thromboxane synthetase inhibitors. | 1988 | Am. J. Obstet. Gynecol. | pmid:3189458 |
| Peaceman AM and Rehnberg KA | The effect of aspirin and indomethacin on prostacyclin and thromboxane production by placental tissue incubated with immunoglobulin G fractions from patients with lupus anticoagulant. | 1995 | Am. J. Obstet. Gynecol. | pmid:7503174 |
| Jouppila P et al. | Ritodrine infusion during late pregnancy: effects on fetal and placental blood flow, prostacyclin, and thromboxane. | 1985 | Am. J. Obstet. Gynecol. | pmid:3885740 |
| Ylikorkala O and Mäkilä UM | Prostacyclin and thromboxane in gynecology and obstetrics. | 1985 | Am. J. Obstet. Gynecol. | pmid:3890549 |
| Capponi A et al. | Indomethacin modifies the fetal hemodynamic response induced by percutaneous umbilical blood sampling. | 1997 | Am. J. Obstet. Gynecol. | pmid:9369815 |
| Wang Y et al. | Placental lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia. | 1992 | Am. J. Obstet. Gynecol. | pmid:1415430 |
| Sørensen JD et al. | Effects of fish oil supplementation in the third trimester of pregnancy on prostacyclin and thromboxane production. | 1993 | Am. J. Obstet. Gynecol. | pmid:8456902 |
| Diss EM et al. | Study of thromboxane and prostacyclin metabolism in an in vitro model of first-trimester human trophoblast. | 1992 | Am. J. Obstet. Gynecol. | pmid:1415390 |
| Romero R et al. | The relationship between spontaneous rupture of membranes, labor, and microbial invasion of the amniotic cavity and amniotic fluid concentrations of prostaglandins and thromboxane B2 in term pregnancy. | 1993 | Am. J. Obstet. Gynecol. | pmid:8317506 |
| Cervar M et al. | Drug actions in preeclampsia: aspirin, but not magnesium chloride or dihydralazine, differentially inhibits cultured human trophoblast release of thromboxane and prostacyclin without affecting angiotensin II, endothelin-1, or leukotriene B4 secretion. | 1997 | Am. J. Obstet. Gynecol. | pmid:9024091 |
| Stonestreet BS et al. | Effects of chronic fetal hyperinsulinemia on plasma arachidonic acid and prostaglandin concentrations. | 1989 | Am. J. Obstet. Gynecol. | pmid:2679106 |
| Aune B et al. | Hormone replacement therapy reduces the reactivity of monocytes and platelets in whole blood--a beneficial effect on atherogenesis and thrombus formation? | 1995 | Am. J. Obstet. Gynecol. | pmid:8610768 |
| Hauth J et al. | Maternal serum thromboxane B2 concentrations do not predict improved outcomes in high-risk pregnancies in a low-dose aspirin trial. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medical Units. | 1998 | Am. J. Obstet. Gynecol. | pmid:9822499 |
| Kurki T et al. | Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin. | 1992 | Am. J. Obstet. Gynecol. | pmid:1733190 |
| Presser SC et al. | Simultaneous measurements of prostacyclin and thromboxane metabolites during the menstrual cycle. | 1991 | Am. J. Obstet. Gynecol. | pmid:1892191 |
| Johnson RD et al. | Aspirin induces increased expression of both prostaglandin H synthase-1 and prostaglandin H synthase-2 in cultured human placental trophoblast. | 1997 | Am. J. Obstet. Gynecol. | pmid:9240586 |
| Thorp JA et al. | Low-dose aspirin inhibits thromboxane, but not prostacyclin, production by human placental arteries. | 1988 | Am. J. Obstet. Gynecol. | pmid:3061295 |
| Kang IS et al. | Dose-related action of gonadotropin-releasing hormone on basal prostanoid production from the human term placenta. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750474 |
| Ylikorkala O et al. | The effect of oral contraceptives on antiaggregatory prostacyclin and proaggregatory thromboxane A2 in humans. | 1982 | Am. J. Obstet. Gynecol. | pmid:7036746 |