Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Authors Title Published Journal PubMed Link
Kranzhofer R and Ruef J Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism. 2006 Platelets pmid:16702043
Chen GG et al. Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma. 2006 Cancer Lett. pmid:15876485
Zhou Y et al. Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice. 2006 Circ. Res. pmid:16645140
Karkabounas S et al. Anticarcinogenic and antiplatelet effects of carvacrol. 2006 Exp. Oncol. pmid:16837902
Wilder-Smith CH et al. Dose-effect comparisons of the CINOD AZD3582 and naproxen on upper gastrointestinal tract mucosal injury in healthy subjects. 2006 Scand. J. Gastroenterol. pmid:16497612
Brenneis C et al. Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. 2006 FASEB J. pmid:16816110
Baltzer WI et al. Measurement of urinary 11-dehydro-thromboxane B2 excretion in dogs with gastric dilatation-volvulus. 2006 Am. J. Vet. Res. pmid:16426215
Chiu HF et al. Mechanisms involved in the antiplatelet effect of C-phycocyanin. 2006 Br. J. Nutr. pmid:16469164
Rossoni G et al. Nitric oxide and prostacyclin pathways: an integrated mechanism that limits myocardial infarction progression in anaesthetized rats. 2006 Pharmacol. Res. pmid:16488624
Lepäntalo A et al. Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. 2006 Thromb. Haemost. pmid:16493486
Kurosawa S et al. Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy. 2006 J Clin Anesth pmid:16517327
Flipo RM [Are the NSAIDs able to compromising the cardio-preventive efficacy of aspirin?]. 2006 Presse Med pmid:17078596
Dołegowska B et al. Metabolism of eicosanoids and their action on renal function during ischaemia and reperfusion: the effect of alprostadil. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:17011760
Ong TZ et al. Nonsteroidal anti-inflammatory drug use is a significant cause of peptic ulcer disease in a tertiary hospital in Singapore: a prospective study. 2006 J. Clin. Gastroenterol. pmid:17016134
Morchón R et al. High levels of serum thromboxane B2 are generated during human pulmonary dirofilariosis. 2006 Clin. Vaccine Immunol. pmid:17028222
Ibrahim S et al. Transfer of very low density lipoprotein-associated phospholipids to activated human platelets. 2006 J. Lipid Res. pmid:16293890
Cook-Johnson RJ et al. Endothelial cell COX-2 expression and activity in hypoxia. 2006 Biochim. Biophys. Acta pmid:17046322
Faraday N et al. Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population. 2006 Am. J. Cardiol. pmid:16950183
Laleman W et al. A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited. 2006 Eur. J. Clin. Invest. pmid:16620286
Zhao Y et al. Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis. 2006 Ann. Allergy Asthma Immunol. pmid:16802773
Lee KS et al. Antiplatelet activity of [5-(2-methoxy-5-chlorophenyl)furan-2-ylcarbonyl]guanidine (KR-32570), a novel sodium/hydrogen exchanger-1 and its mechanism of action. 2006 Arch. Pharm. Res. pmid:16756082
Peck OM et al. The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide. 2006 Shock pmid:16783195
Frelinger AL et al. Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance. 2006 Circulation pmid:16785341
Cox D et al. Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers. 2006 Stroke pmid:16794200
Munsterhjelm E et al. Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers. 2006 Br J Anaesth pmid:16698862
Nakamura K et al. Effects of atorvastatin and aspirin combined therapy on inflammatory responses in patients undergoing coronary artery bypass grafting. 2006 Cytokine pmid:17300951
Vranic II et al. Adenosine cardioprotection study in clinical setting of paroxysmal supraventricular tachycardia. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16682179
Huntjens DR et al. Correlation between in vitro and in vivo concentration-effect relationships of naproxen in rats and healthy volunteers. 2006 Br. J. Pharmacol. pmid:16682968
Park HS et al. Dietary trans-10, cis-12 and cis-9,trans-11 conjugated linoleic acids induce apoptosis in the colonic mucosa of rats treated with 1,2-dimethylhydrazine. 2006 J Med Food pmid:16579724
Ohmori T et al. Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: involvement of other signaling pathway(s) in cardiovascular events of aspirin-treated patients. 2006 J. Thromb. Haemost. pmid:16706971
Perneby C et al. Dose- and time-dependent antiplatelet effects of aspirin. 2006 Thromb. Haemost. pmid:16601836
Basili S et al. Insulin resistance as a determinant of platelet activation in obese women. 2006 J. Am. Coll. Cardiol. pmid:17174194
Hrushka NH et al. [Effect of thromboxane B2 on morphological features of apoptosis in cultured rat hepatocytes exposed to hepatotropic substances]. 2006 Fiziol Zh pmid:17176837
Niemi TT et al. The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm. 2006 Blood Coagul. Fibrinolysis pmid:16607076
Chiang N and Serhan CN New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications. 2006 Compr Ther pmid:17435267
Stergioulas AT and Filippou DK Effects of physical conditioning on lipids and arachidonic acid metabolites in untrained boys: a longitudinal study. 2006 Appl Physiol Nutr Metab pmid:16900233
Fujimoto Y et al. Monochloramine potently inhibits arachidonic acid metabolism in rat platelets. 2006 Biochem. Biophys. Res. Commun. pmid:16615995
Xu S et al. The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice. 2006 Diabetes pmid:16380483
Sánchez M et al. Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. 2006 J. Hypertens. pmid:16331104
Chiang N et al. Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:16293793
Wolfram RM et al. Salivary isoprostanes indicate increased oxidation injury in periodontitis with additional tobacco abuse. 2006 Biofactors pmid:17264390
González-Correa JA et al. Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human blood. 2005 May-Jun Platelets pmid:16011961
Zhao Y et al. [The effect of desloratadine on the TXB2 and leukotrienes levels in the nasal lavage fluid of allergic rhinitis animal model]. 2005 Lin Chuang Er Bi Yan Hou Ke Za Zhi pmid:16075993
Yoshino T et al. Pharmacological profile of celecoxib, a specific cyclooxygenase-2 inhibitor. 2005 Arzneimittelforschung pmid:16080279
Mancini F et al. Time since menopause does not affect plasma viscosity, plasma thromboxane levels and Doppler findings. 2005 Gynecol. Endocrinol. pmid:16019357
Mancini F et al. Effects of hormone replacement therapy on plasma viscosity and Doppler variations in postmenopausal non-smokers and heavy smokers. 2005 Gynecol. Endocrinol. pmid:16019365
Michibayashi T Platelet aggregation and vasoconstriction related to platelet cyclooxygenase and 12-lipoxygenase pathways. 2005 J. Atheroscler. Thromb. pmid:16020916
Svenstrup Poulsen T et al. A critical appraisal of the phenomenon of aspirin resistance. 2005 Cardiology pmid:16020925
Walsh DS et al. Characterization of circulating monocytes expressing HLA-DR or CD71 and related soluble factors for 2 weeks after severe, non-thermal injury. 2005 J. Surg. Res. pmid:16045935
Rodrigue ME et al. Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic rats. 2005 Can. J. Physiol. Pharmacol. pmid:16049546
Esser R et al. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. 2005 Br. J. Pharmacol. pmid:15655513
Myers SI et al. Bile duct ligation induced acute inflammation up-regulates cyclooxygenase-2 content and PGE2 release in guinea pig gallbladder smooth muscle cell cultures. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850713
Nakamura K et al. Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer. 2005 Nutrition pmid:15925286
Coppola A et al. Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype. 2005 Br. J. Haematol. pmid:16173969
Blume C et al. Different effect of cyclosporine A and mycophenolate mofetil on passive Heymann nephritis in the rat. 2005 Nephron Exp. Nephrol. pmid:15855806
Giraudel JM et al. Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats. 2005 Am. J. Vet. Res. pmid:15900953
Song YM et al. Effects of scorpion venom bioactive polypolypeptides on platelet aggregation and thrombosis and plasma 6-keto-PG F1alpha and TXB2 in rabbits and rats. 2005 Toxicon pmid:15975616
Hsiao G et al. Protective mechanisms of inosine in platelet activation and cerebral ischemic damage. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15976325
Montuschi P et al. Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD. 2005 Thorax pmid:16192367
Barbara J et al. Prevention of latex sensitization in guinea pigs by a bacterial and viral filter used in anaesthesia. 2005 Br J Anaesth pmid:15980041
Hsiao G et al. alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation. 2005 J. Agric. Food Chem. pmid:15969494
Wu CC et al. 2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets. 2005 Eur. J. Pharmacol. pmid:16313903
Munsterhjelm E et al. Characterization of inhibition of platelet function by paracetamol and its interaction with diclofenac in vitro. 2005 Acta Anaesthesiol Scand pmid:15954969
Vangroenweghe F et al. Effect of carprofen treatment following experimentally induced Escherichia coli mastitis in primiparous cows. 2005 J. Dairy Sci. pmid:15956299
Wakamoto S et al. Effects of hemoglobin vesicles on resting and agonist-stimulated human platelets in vitro. 2005 Artif Cells Blood Substit Immobil Biotechnol pmid:15960075
Al Kadi H et al. A prospective, longitudinal study of the renin-angiotensin system, prostacyclin and thromboxane in the first trimester of normal human pregnancy: association with birthweight. 2005 Hum. Reprod. pmid:16006463
Beretta C et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. 2005 Pharmacol. Res. pmid:15939622
Klein Gunnewiek JM et al. The influence of acetylsalicylic acid intake by healthy volunteers on duplicate PFA-100 measurements. 2005 Blood Coagul. Fibrinolysis pmid:15970717
Visioli F et al. Virgin Olive Oil Study (VOLOS): vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patients. 2005 Eur J Nutr pmid:15309433
Jin YR et al. Antiplatelet activity of J78 (2-Chloro-3-[2'-bromo, 4'-fluoro-phenyl]-amino-8-hydroxy-1,4-naphthoquinone), an antithrombotic agent, is mediated by thromboxane (TX) A2 receptor blockade with TXA2 synthase inhibition and suppression of cytosolic Ca2+ mobilization. 2005 J. Pharmacol. Exp. Ther. pmid:15328379
Jin YR et al. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. 2005 Basic Clin. Pharmacol. Toxicol. pmid:16128910
Zhu S et al. [Influence of Minkeqing oral liquid on IL-6, IL-8, ET-1, TX-B2 in blood and to observe bronchoalveolar lavage fluid of the rat with inhalating ovalbumin]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16161448
Corazzi T et al. Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). 2005 J. Pharmacol. Exp. Ther. pmid:16144976
Haubelt H et al. Can platelet function tests predict the clinical efficacy of aspirin? 2005 Semin. Thromb. Hemost. pmid:16149017
Ueda T and Hashimoto T [Thromboxane A2 (TXA2), thromboxane B2 (TXB2)]. 2005 Nippon Rinsho pmid:16149442
Francois H et al. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. 2005 Cell Metab. pmid:16154102
Jermany J et al. Lumiracoxib does not affect the ex vivo antiplatelet aggregation activity of low-dose aspirin in healthy subjects. 2005 J Clin Pharmacol pmid:16172182
Persico N et al. Transdermal HRT and Doppler findings in normotensive and hypertensive postmenopausal patients. 2005 Ultrasound Obstet Gynecol pmid:16184506
Perini JA et al. Influence of CYP2C9 genotypes on the pharmacokinetics and pharmacodynamics of piroxicam. 2005 Clin. Pharmacol. Ther. pmid:16198655
Davì G et al. Helicobacter pylori infection causes persistent platelet activation in vivo through enhanced lipid peroxidation. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15472127
Maree AO et al. Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease. 2005 J. Am. Coll. Cardiol. pmid:16198840
Kataoka M et al. A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. 2005 Am. J. Respir. Crit. Care Med. pmid:16192456
Cao D et al. Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils. 2005 Life Sci. pmid:16214179
Léger CL et al. A thromboxane effect of a hydroxytyrosol-rich olive oil wastewater extract in patients with uncomplicated type I diabetes. 2005 Eur J Clin Nutr pmid:15798774
Stichtenoth DO et al. Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers. 2005 Kidney Int. pmid:16221219
Saloheimo P et al. Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage. 2005 Thromb. Res. pmid:15733969
Trebino CE et al. Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages. 2005 J. Biol. Chem. pmid:15722356
Fimognari FL et al. Nocturnal rise of urinary thromboxane B 2 in patients with coronary artery disease. 2005 Thromb. Haemost. pmid:15735822
Mayer AM et al. Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines. 2005 BMC Pharmacol. pmid:15762999
Kalaitzis C et al. Effects of renal denervation of the contralateral kidney on blood pressure and sodium and eicosanoid excretion in the chronic phase of two-kidney, one-clip renovascular hypertension in rats. 2005 Scand. J. Urol. Nephrol. pmid:15764265
García-Saura MF et al. Effects of chronic quercetin treatment in experimental renovascular hypertension. 2005 Mol. Cell. Biochem. pmid:15792364
Awad AS et al. Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats. 2005 Am. J. Hypertens. pmid:15831366
De Candia E et al. Abnormal pH-sensing of platelet Na+/H+ exchanger in patients with cardiac syndrome X. 2005 Int. J. Cardiol. pmid:15837078
Capone ML et al. Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects. 2005 J. Am. Coll. Cardiol. pmid:15837265
Oliveira RL et al. Postmenopausal hormone replacement therapy increases plasmatic thromboxane beta 2. 2005 Int. J. Cardiol. pmid:15771927
Cryer B et al. Double-blind, randomized, parallel, placebo-controlled study of ibuprofen effects on thromboxane B2 concentrations in aspirin-treated healthy adult volunteers. 2005 Clin Ther pmid:15811481
Lappegård KT et al. Differential effect of heparin coating and complement inhibition on artificial surface-induced eicosanoid production. 2005 Ann. Thorac. Surg. pmid:15734405
Yao X et al. [The changes of some vasoactive substances after operation in patients with obstructive sleep apnea-hypopnea syndrome]. 2005 Lin Chuang Er Bi Yan Hou Ke Za Zhi pmid:16398051
Kong XY and Gong PL [Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation]. 2005 Yao Xue Xue Bao pmid:16408809
Gerasimovska-Kitanovska B et al. Decreased nitric oxide in women with essential hypertension in prehypertensive phase. 2005 Croat. Med. J. pmid:16342341