Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

Cross Reference

Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

Download all related citations
Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Gross GJ and Moore J Effect of COX-1/COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic acid and acetylcholine. 2004 Pharmacology pmid:15161995
Suzuki N et al. Quantitative liquid chromatography-tandem mass spectrometric analysis of 11-dehydro TXB2 in urine. 2004 Prostaglandins Other Lipid Mediat. pmid:15165035
Sheu JR et al. Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies. 2004 Br. J. Pharmacol. pmid:15289295
Toth B et al. Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock. 2004 J. Appl. Physiol. pmid:15298985
Craft JA et al. Increased platelet-derived microparticles in the coronary circulation of percutaneous transluminal coronary angioplasty patients. 2004 Blood Coagul. Fibrinolysis pmid:15311156
Devi MM and Das UN Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15380818
Ferroni P et al. Platelet activation in type 2 diabetes mellitus. 2004 J. Thromb. Haemost. pmid:15304032
Di Nunno L et al. Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. 2004 J. Med. Chem. pmid:15369392
Zhang L et al. Effects of thiol antioxidant on reduced nicotinamide adenine dinucleotide phosphate oxidase in hypertensive Dahl salt-sensitive rats. 2004 Free Radic. Biol. Med. pmid:15528040
Zhang C et al. Inhibition of inflammation contributes to organ protection of atenolol in sinoaortic-denervated rats. 2004 J. Cardiovasc. Pharmacol. pmid:15071353
Bruno A et al. Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction. 2004 Stroke pmid:14963281
Kwak SH et al. Effects of propofol on endotoxin-induced acute lung injury in rabbit. 2004 J. Korean Med. Sci. pmid:14966342
Scott G et al. Lumiracoxib: pharmacokinetic and pharmacodynamic profile when coadministered with fluconazole in healthy subjects. 2004 J Clin Pharmacol pmid:14747429
Arrebola MM et al. In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesis. 2004 J. Cardiovasc. Pharmacol. pmid:14668571
Freitas CF et al. Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs. 2004 J. Cardiovasc. Pharmacol. pmid:14668575
Park WH et al. Anti-inflammatory effects of a traditional Korean herbal formulation, Silsosangami, consisting of seven medicinal herbs: effect on hemolysis, neutrophil function, and gene expressions of iNOS and COX-2. 2004 Vascul. Pharmacol. pmid:15664882
Vainio M et al. Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders. 2004 Acta Obstet Gynecol Scand pmid:15548142
Tsai CY et al. Proinflammatory cytokines enhance COX-1 gene expression in cultured rat glomerular mesangial cells. 2004 Int. Immunopharmacol. pmid:14975359
Smalling WE et al. Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. 2004 Biol. Neonate pmid:14981352
Ikonomidis I et al. Reduction of daily life ischaemia by aspirin in patients with angina: underlying link between thromboxane A2 and macrophage colony stimulating factor. 2004 Heart pmid:15020512
Dippel DW et al. What is the lowest dose of aspirin for maximum suppression of in vivo thromboxane production after a transient ischemic attack or ischemic stroke? 2004 Cerebrovasc. Dis. pmid:15026612
Kawada N et al. TP receptors regulate renal hemodynamics during angiotensin II slow pressor response. 2004 Am. J. Physiol. Renal Physiol. pmid:15213069
Kawata K et al. The effects of a selective cyclooxygenase-2 inhibitor on small bowel ischemia-reperfusion injury. 2003 Nov-Dec Hepatogastroenterology pmid:14696445
Tuleja E et al. Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy men. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12730088
Leese PT et al. The COX-2 selective inhibitor, valdecoxib, does not impair platelet function in the elderly: results of a randomized controlled trial. 2003 J Clin Pharmacol pmid:12751271
Lang I et al. Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells. 2003 Eur. J. Cell Biol. pmid:12751902
Molina V et al. Synergistic effect of D-003 and aspirin on experimental thrombosis models. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711246
Chavarría ME et al. Prostacyclin/thromboxane early changes in pregnancies that are complicated by preeclampsia. 2003 Am. J. Obstet. Gynecol. pmid:12712098
Dogné JM et al. Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538090
Tanaka S et al. High dose of inhaled fluticasone reduces high levels of urinary leukotriene E4 in the early morning in mild and moderate nocturnal asthma. 2003 Chest pmid:14605047
Pestel S et al. Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. 2003 Biochem. Pharmacol. pmid:12906929
De La Cruz P et al. Effects of clopidogrel and ticlopidine on experimental diabetic ischemic retinopathy in rats. 2003 Naunyn Schmiedebergs Arch. Pharmacol. pmid:12595963
Uchida M et al. Changes in cerebral microcirculation during and after abdominal aortic cross-clamping in rabbits: the role of thromboxane A2 receptor. 2003 Anesth. Analg. pmid:12598238
Zaitsu M et al. Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. 2003 Am. J. Hematol. pmid:12555215
Kirchheiner J et al. Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. 2003 Br J Clin Pharmacol pmid:12534640
von Aulock S et al. Determination of the eicosanoid response to inflammatory stimuli in whole blood and its pharmacological modulation ex vivo. 2003 J. Immunol. Methods pmid:12799039
Cabrera DM et al. A thromboxane A(2) system in the Atlantic stingray, Dasyatis sabina. 2003 Gen. Comp. Endocrinol. pmid:12568793
Nemr R et al. Effects of nicotine on thromboxane/prostacyclin balance in myocardial ischemia. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591002
Eatman D et al. Influences of prostanoids and nitric oxide on post-suspension hypotension in female Sprague-Dawley rats. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591003
Yregård L et al. Influence of local anaesthetics on inflammatory activity postburn. 2003 Burns pmid:12781610
Ersöz G et al. Effect of sodium selenite treatment on platelet aggregation of streptozotocin-induced diabetic rats. 2003 Thromb. Res. pmid:14698654
Wu X et al. Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma. 2003 Am. J. Hematol. pmid:12949886
Reid G et al. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12835412
Bosetti F et al. Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain. 2003 J. Neurochem. pmid:12694395
Tanaka Y et al. Effects of exercise on platelet and aortic functions in aged rats. 2003 Acta Physiol. Scand. pmid:14510779
Sidhu P et al. Tissue chamber model of acute inflammation in farm animal species. 2003 Res. Vet. Sci. pmid:12507568
Rossoni G et al. Nitric oxide-releasing aspirin inhibits vasoconstriction in perfused tail artery of normotensive and spontaneously hypertensive rats. 2003 Eur. J. Pharmacol. pmid:14512099
Chen L et al. Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12485821
Wolfram R et al. Daily prickly pear consumption improves platelet function. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12878452
Yokoyama Y et al. Role of thromboxane in producing portal hypertension following trauma-hemorrhage. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:14613921
Yu CC and Lai YL Chronic hypoxia attenuates ischemia-reperfusion-induced increase in pulmonary vascular resistance. 2003 Life Sci. pmid:12927588
Zhuang HP et al. [Effect of aspirin combined with perindopril on prostacyclin, thromboxone A2, and norepinephrine in the blood of arteriosclerosis rabbit models and the cardiac function]. 2003 Hunan Yi Ke Da Xue Xue Bao pmid:12934393
Castellani S et al. Thromboxane inhibition improves renal perfusion and excretory function in severe congestive heart failure. 2003 J. Am. Coll. Cardiol. pmid:12849673
Pettus BJ et al. Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. 2003 J. Biol. Chem. pmid:12855693
Shimada N et al. Increased endothelin: nitric oxide ratio is associated with erythropoietin-induced hypertension in hemodialysis patients. 2003 Ren Fail pmid:12911161
Yi H et al. [Protective effect of selective cyclooxygenase-2 inhibitor on alcohol-induced liver injury in rats]. 2003 Zhonghua Gan Zang Bing Za Zhi pmid:14636441
Patrono C Aspirin resistance: definition, mechanisms and clinical read-outs. 2003 J. Thromb. Haemost. pmid:12911581
Villalobos MA et al. Effects of camonagrel, a selective inhibitor of platelet thromboxane synthase, on the platelet-subendothelium interaction. 2003 Pharmacology pmid:12886030
Miceli M et al. Effect of low doses of ethanol on platelet function in long-life abstainers and moderate-wine drinkers. 2003 Life Sci. pmid:12865095
Kankuri E et al. Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro. 2003 Thromb. Res. pmid:14592552
Heller AR et al. Clusterin protects the lung from leukocyte-induced injury. 2003 Shock pmid:12865662
Zhang C et al. Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. 2003 J. Hypertens. pmid:14597858
Wang ZF et al. The role of inflammatory mediators in severe acute pancreatitis and regulation of glucocorticoids. 2003 HBPD INT pmid:14599960
Eder K et al. Conjugated linoleic acids lower the release of eicosanoids and nitric oxide from human aortic endothelial cells. 2003 J. Nutr. pmid:14652352
Li JS et al. [Change in intestinal free radical and prostaglandin metabolism in the aged rats with pneumococcus pneumonia]. 2003 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:14552688
Sánchez-Muniz FJ et al. Platelet aggregation, thromboxane production and thrombogenic ratio in postmenopausal women consuming high oleic acid-sunflower oil or palmolein. 2003 Eur J Nutr pmid:14673602
Lombard JH et al. High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12456391
Al-Waili NS and Boni NS Natural honey lowers plasma prostaglandin concentrations in normal individuals. 2003 J Med Food pmid:12935324
Gu L et al. [Advances in the study on molecular mechanism of diabetic nephropathy treated with Rheum officinale]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15224660
Jones AE et al. Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12639842
De Cristofaro R et al. Lipid and protein oxidation contribute to a prothrombotic state in patients with type 2 diabetes mellitus. 2003 J. Thromb. Haemost. pmid:12871497
Davì G et al. Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration. 2003 Circulation pmid:12810609
Al-Madaney MM et al. Effects of lipid-esterified conjugated linoleic acid isomers on platelet function: evidence for stimulation of platelet phospholipase activity. 2003 Biochim. Biophys. Acta pmid:14729070
Fujii S et al. L-arginine reverses p47phox and gp91phox expression induced by high salt in Dahl rats. 2003 Hypertension pmid:14504257
Bellou A et al. Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. 2003 Shock pmid:12558148
De León EJ et al. A new chloroquinolinyl chalcone derivative as inhibitor of inflammatory and immune response in mice and rats. 2003 J. Pharm. Pharmacol. pmid:14604476
Dong WG et al. Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats. 2003 World J. Gastroenterol. pmid:14606091
De La Cruz JP et al. Differences in the effects of extended-release aspirin and plain-formulated aspirin on prostanoids and nitric oxide in healthy volunteers. 2003 Fundam Clin Pharmacol pmid:12803576
Guyton K et al. Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. 2003 Shock pmid:12813370
Montuschi P et al. Exhaled leukotrienes and prostaglandins in COPD. 2003 Thorax pmid:12832671
Fujimoto Y et al. Effects of endocrine disruptors on arachidonic acid metabolism in rabbit platelets. 2003 Toxicol. Appl. Pharmacol. pmid:12781627
Wolfram RM et al. Narghile (water pipe) smoking influences platelet function and (iso-)eicosanoids. 2003 Life Sci. pmid:14575812
Stephenson AH et al. Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12609822
Beck-Speier I et al. Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. 2003 Prostaglandins Other Lipid Mediat. pmid:14518563
Seebacher F and Franklin CE Prostaglandins are important in thermoregulation of a reptile (Pogona vitticeps). 2003 Proc. Biol. Sci. pmid:12952634
Cipollone F et al. Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina. 2003 Circulation pmid:12515743
Halushka MK et al. Genetic variation in cyclooxygenase 1: effects on response to aspirin. 2003 Clin. Pharmacol. Ther. pmid:12545150
Yokoyama Y et al. Role of thromboxane A2 in early BDL-induced portal hypertension. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12431905
Huang RJ et al. [Effect of tetramethylpyrazine on endothelin, von Willebrand factor and thromboxane A2 during cardiopulmonary bypass in patients of congenital heart disease with pulmonary hypertension]. 2003 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12764908
Li ZG et al. [Progress on study of experimental physico-chemical indexes related with ischemic stroke]. 2003 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12764922
Lei D et al. Antioxidative and antiplatelet effects of aqueous inflorescence Piper betle extract. 2003 J. Agric. Food Chem. pmid:12643677
Park WH et al. The antiplatelet activity of Geiji-Bokryung-Hwan, Korean traditional formulation, is mediated through inhibition of phospholipase C and inhibition of TxB(2) synthetase activity. 2003 Int. Immunopharmacol. pmid:12810354
Tsipas G and Morphake P Beneficial effects of a diet rich in a mixture of n - 6/n - 3 essential fatty acids and of their metabolites on cyclosporine - nephrotoxicity. 2003 J. Nutr. Biochem. pmid:14629893
Hou X et al. Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12626359
Tsuruta LR et al. Characterization of 11-dehydro-thromboxane B2 recombinant antibody obtained by phage display technology. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12628223
Meune C et al. Aspirin alters arterial function in patients with chronic heart failure treated with ACE inhibitors: a dose-mediated deleterious effect. 2003 Eur. J. Heart Fail. pmid:12798824
Sartin JL et al. Estradiol plus progesterone treatment modulates select elements of the proinflammatory cytokine cascade in steers: attenuated nitric oxide and thromboxane B2 production in endotoxemia. 2003 J. Anim. Sci. pmid:12817503
Ojanen R et al. Single dose of acetylsalicylic acid prevents thromboxane release after tourniquet ischemia. 2003 J Trauma pmid:12777914
Nagase T et al. A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12505870
Ji Y et al. Thrombosis and its significance after experimental pulmonary thromboembolism. 2003 Chin. Med. J. pmid:12667387