propionic acid is a lipid of Fatty Acyls (FA) class. Propionic acid is associated with abnormalities such as Epilepsy, Infection, Tuberculosis, Alkalosis and Ischemia. The involved functions are known as Uptake, Biosynthetic Pathways, Methylation, Protein Overexpression and Biochemical Pathway. Propionic acid often locates in Body tissue, Cytoplasmic matrix, Membrane, Protoplasm and Extracellular. The associated genes with propionic acid are TRIO gene, TRRAP gene, SLC5A8 gene, SLC33A1 gene and Homologous Gene. The related lipids are Fatty Acids, Propionate, butyrate, Valerates and mycocerosic acid.
To understand associated biological information of propionic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
propionic acid is suspected in Propionic acidemia, Ischemia, Infection, Ulcerative Colitis, Alkalosis, Methylmalonic acidemia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with propionic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Di Lisa F et al. | Contrasting effects of propionate and propionyl-L-carnitine on energy-linked processes in ischemic hearts. | 1994 | Am. J. Physiol. | pmid:8067396 |
Bidani A and Heming TA | Kinetic analysis of cytosolic pH regulation in alveolar macrophages: V-ATPase-mediated responses to a weak acid. | 1995 | Am. J. Physiol. | pmid:7631810 |
Harada E and Kato S | Effect of short-chain fatty acids on the secretory response of the ovine exocrine pancreas. | 1983 | Am. J. Physiol. | pmid:6187225 |
Petersen KU and Reuss L | Electrophysiological effects of propionate and bicarbonate on gallbladder epithelium. | 1985 | Am. J. Physiol. | pmid:2981476 |
Feldman GM et al. | Propionate induces cell swelling and K+ accumulation in shark rectal gland. | 1989 | Am. J. Physiol. | pmid:2548391 |
Pi-Sunyer FX et al. | Glucagon, insulin, and gluconeogenesis in fasted odd carbon fatty acid-enriched rats. | 1976 | Am. J. Physiol. | pmid:961887 |
Ho AK et al. | Intracellular pH on adrenergic-stimulated cAMP and cGMP production in rat pinealocytes. | 1991 | Am. J. Physiol. | pmid:1656768 |
Szczepańska M and Angielski S | Prevention of maleate-induced tubular dysfunction by acetoacetate. | 1980 | Am. J. Physiol. | pmid:7395994 |
Rojas-GarcÃa PP et al. | Prenatal testosterone excess alters Sertoli and germ cell number and testicular FSH receptor expression in rams. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20858754 |
Cohen DM et al. | Glutamine cycling in isolated working rat heart. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12944323 |
Martini WZ et al. | Quantitative assessment of anaplerosis from propionate in pig heart in vivo. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12388135 |
Jones JG et al. | An integrated (2)H and (13)C NMR study of gluconeogenesis and TCA cycle flux in humans. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11551863 |
King AJ et al. | Hypertension caused by prenatal testosterone excess in female sheep. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17327368 |
Jin ES et al. | Evidence for reverse flux through pyruvate kinase in skeletal muscle. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19190256 |
Wilson KA et al. | Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism. | 2017 | Am. J. Physiol. Endocrinol. Metab. | pmid:28634175 |
Musch MW et al. | SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11254495 |
Aschenbach JR et al. | Bicarbonate-dependent and bicarbonate-independent mechanisms contribute to nondiffusive uptake of acetate in the ruminal epithelium of sheep. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19264953 |
Cremin JD et al. | Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12637251 |
Andriamihaja M et al. | Colon luminal content and epithelial cell morphology are markedly modified in rats fed with a high-protein diet. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20689060 |
Grider JR and Piland BE | The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16973914 |