propionic acid

propionic acid is a lipid of Fatty Acyls (FA) class. Propionic acid is associated with abnormalities such as Epilepsy, Infection, Tuberculosis, Alkalosis and Ischemia. The involved functions are known as Uptake, Biosynthetic Pathways, Methylation, Protein Overexpression and Biochemical Pathway. Propionic acid often locates in Body tissue, Cytoplasmic matrix, Membrane, Protoplasm and Extracellular. The associated genes with propionic acid are TRIO gene, TRRAP gene, SLC5A8 gene, SLC33A1 gene and Homologous Gene. The related lipids are Fatty Acids, Propionate, butyrate, Valerates and mycocerosic acid.

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Introduction

To understand associated biological information of propionic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with propionic acid?

propionic acid is suspected in Propionic acidemia, Ischemia, Infection, Ulcerative Colitis, Alkalosis, Methylmalonic acidemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with propionic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Sarcoma, Experimental D012513 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Dental Caries D003731 6 associated lipids
Cattle Diseases D002418 24 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Arthritis D001168 41 associated lipids
Abscess D000038 13 associated lipids
Heart Failure D006333 36 associated lipids
Angioedema D000799 6 associated lipids
Coronary Disease D003327 70 associated lipids
Acne Vulgaris D000152 35 associated lipids
Osteolysis D010014 8 associated lipids
Pain, Postoperative D010149 13 associated lipids
Occupational Diseases D009784 42 associated lipids
Asthma D001249 52 associated lipids
Growth Disorders D006130 5 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Acidosis D000138 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Peritonitis D010538 38 associated lipids
Proteinuria D011507 30 associated lipids
Hyperplasia D006965 34 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Hemoglobinopathies D006453 7 associated lipids
Phenylketonurias D010661 7 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Vaginitis D014627 6 associated lipids
Propionic Acidemia D056693 3 associated lipids
Fetal Weight D020567 12 associated lipids
Starvation D013217 47 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with propionic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with propionic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with propionic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with propionic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with propionic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with propionic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with propionic acid

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Per page 10 20 50 100 | Total 6372
Authors Title Published Journal PubMed Link
Busse SC and Jue T Two-dimensional NMR characterization of the deoxymyoglobin heme pocket. 1994 Biochemistry pmid:8086410
LeMagueres P et al. Crystal structure at 1.45 A resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms. 2003 Biochemistry pmid:14674749
Ibrahim M et al. Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. 2010 Biochemistry pmid:20459051
Louie GV et al. Role of phenylalanine-82 in yeast iso-1-cytochrome c and remote conformational changes induced by a serine residue at this position. 1988 Biochemistry pmid:2849996
Zhao D et al. Structure and stability effects of the mutation of glycine 34 to serine in Rhodobacter capsulatus cytochrome c(2). 2000 Biochemistry pmid:10747794
Seibold SA et al. Water chain formation and possible proton pumping routes in Rhodobacter sphaeroides cytochrome c oxidase: a molecular dynamics comparison of the wild type and R481K mutant. 2005 Biochemistry pmid:16060656
Egan RM et al. Mechanism of urocanase as studied by deuterium isotope effects and labeling patterns. 1981 Biochemistry pmid:6110440
Meharenna YT et al. Engineering ascorbate peroxidase activity into cytochrome c peroxidase. 2008 Biochemistry pmid:18771292
Morollo AA et al. Structure of a Michaelis complex analogue: propionate binds in the substrate carboxylate site of alanine racemase. 1999 Biochemistry pmid:10079072
Nagai M et al. Heme structure of hemoglobin M Iwate [alpha 87(F8)His-->Tyr]: a UV and visible resonance Raman study. 2000 Biochemistry pmid:11052661
Santucci R et al. Anion size modulates the structure of the A state of cytochrome c. 2000 Biochemistry pmid:11027143
Yoshimura H et al. Specific hydrogen-bonding networks responsible for selective O2 sensing of the oxygen sensor protein HemAT from Bacillus subtilis. 2006 Biochemistry pmid:16819829
Nakamura S et al. Structure of cytochrome c552 from a moderate thermophilic bacterium, Hydrogenophilus thermoluteolus: comparative study on the thermostability of cytochrome c. 2006 Biochemistry pmid:16681384
Cutler RL et al. Role of arginine-38 in regulation of the cytochrome c oxidation-reduction equilibrium. 1989 Biochemistry pmid:2545252
Peyton DH et al. Proton nuclear magnetic resonance study of the molecular and electronic structure of the heme cavity in Aplysia cyanometmyoglobin. 1989 Biochemistry pmid:2548594
Shokhireva TKh et al. Assignment of heme resonances and determination of the electronic structures of high- and low-spin nitrophorin 2 by 1H and 13C NMR spectroscopy: an explanation of the order of heme methyl resonances in high-spin ferriheme proteins. 2003 Biochemistry pmid:12534280
Hector ML and Fall RR Multiple acyl-coenzyme A carboxylases in Pseudomonas citronellolis. 1976 Biochemistry pmid:8091
Balland V et al. Functional implications of the propionate 7-arginine 220 interaction in the FixLH oxygen sensor from Bradyrhizobium japonicum. 2006 Biochemistry pmid:16475796
Omura S et al. Studies on the biosynthesis of 16-membered macrolide antibiotics using carbon-13 nuclear magnetic resonance spectroscopy. 1977 Biochemistry pmid:18162
Mileni M et al. Probing heme propionate involvement in transmembrane proton transfer coupled to electron transfer in dihemic quinol:fumarate reductase by 13C-labeling and FTIR difference spectroscopy. 2005 Biochemistry pmid:16342962
Barrows TP and Poulos TL Role of electrostatics and salt bridges in stabilizing the compound I radical in ascorbate peroxidase. 2005 Biochemistry pmid:16245922
Behr J et al. Functional properties of the heme propionates in cytochrome c oxidase from Paracoccus denitrificans. Evidence from FTIR difference spectroscopy and site-directed mutagenesis. 2000 Biochemistry pmid:10684616
Delker SL et al. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase . 2010 Biochemistry pmid:21138269
Harada K et al. Structure and ligand binding properties of myoglobins reconstituted with monodepropionated heme: functional role of each heme propionate side chain. 2007 Biochemistry pmid:17636874
Key J and Moffat K Crystal structures of deoxy and CO-bound bjFixLH reveal details of ligand recognition and signaling. 2005 Biochemistry pmid:15779889
Sherman MM and Hutchinson CR Biosynthesis of lasalocid A: biochemical mechanism for assembly of the carbon framework. 1987 Biochemistry pmid:3828316
Zhang H et al. Characterization of the high-spin heme x in the cytochrome b6f complex of oxygenic photosynthesis. 2004 Biochemistry pmid:15610027
Grimshaw CE et al. Use of isotope effects and pH studies to determine the chemical mechanism of Bacillus subtilis L-alanine dehydrogenase. 1981 Biochemistry pmid:6794612
Mendoza MF et al. Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups. 2012 Biochemistry pmid:22989153
Sivuk VF et al. Purification and characteristics of functional properties of soluble nucleoside triphosphatase (apyrase) from bovine brain. 2008 Biochemistry Mosc. pmid:18976223
Kondakova AN et al. New structures of the O-specific polysaccharides of Proteus. 3. Polysaccharides containing non-carbohydrate organic acids. 2003 Biochemistry Mosc. pmid:12765528
Morishima I and Iizuka T Nuclear magnetic resonance studies of hemoproteins. IV. Hindered rotation of heme side methyl group as a probe for studying van der Waals contacts in the heme side environments of myoglobin derivatives. 1975 Biochim. Biophys. Acta pmid:1169971
Enser U and Heber U Metabolic regulation by pH gradients. Inhibition of photosynthesis by indirect proton transfer across the chloroplast envelope. 1980 Biochim. Biophys. Acta pmid:6251871
Yount EA and Harris RA Studies on the inhibition of gluconeogenesis by oxalate. 1980 Biochim. Biophys. Acta pmid:6778509
Koutsoupakis C et al. Time-resolved step-scan Fourier transform infrared investigation of heme-copper oxidases: implications for O2 input and H2O/H+ output channels. 2004 Biochim. Biophys. Acta pmid:15100050
Sokolov S et al. Ysp2 mediates death of yeast induced by amiodarone or intracellular acidification. Biochim. Biophys. Acta pmid:16962064
Sorenson MM and De Meis L Effects of anions, pH and magnesium on calcium accumulation and release by sarcoplasmic reticulum vesicles. 1977 Biochim. Biophys. Acta pmid:16250336
Taylor A et al. The effects of propionate on sodium transport by the toad bladder. Evidence for a metabolic mode of action. 1973 Biochim. Biophys. Acta pmid:4198138
Riistama S et al. Interaction between the formyl group of heme a and arginine 54 in cytochrome aa(3) from Paracoccus denitrificans. 2000 Biochim. Biophys. Acta pmid:10611451
Tomaro ML et al. The oxidation of hemins by microsomal heme oxygenase. Structural requirements for the retention of substrate activity. 1984 Biochim. Biophys. Acta pmid:6549143
Wirthensohn G and Guder WG Phosphatidylcholine biosynthesis in rabbit kidney tubule suspensions. Effect of metabolic substrates on precursor incorporation. 1983 Biochim. Biophys. Acta pmid:6860690
Alonso WR and Nelson DA A novel yeast histone deacetylase: partial characterization and development of an activity assay. 1986 Biochim. Biophys. Acta pmid:3513841
Ku EC and Wasvary JM Inhibition of prostaglandin synthase by pirprofen. Studies with sheep seminal vesicle enzyme. 1975 Biochim. Biophys. Acta pmid:804924
Moore GR et al. A spectroscopic investigation of the structure and redox properties of Escherichia coli cytochrome b-562. 1985 Biochim. Biophys. Acta pmid:2986699
Martin JF and Mcdaniel LE Specific inhibition of candicidin biosynthesis by the lipogenic inhibitor cerulenin. 1975 Biochim. Biophys. Acta pmid:811262
Yamamoto Y et al. 1H-NMR study of dynamics and thermodynamics of Cl- binding to ferric hemoglobin of a midge larva (Tokunagayusurika akamusi). 2003 Biochim. Biophys. Acta pmid:14644049
Sundqvist KE et al. Effect of acetate and octanoate on tricarboxylic acid cycle metabolite disposal during propionate oxidation in the perfused rat heart. 1984 Biochim. Biophys. Acta pmid:6487652
Fonteriz RI et al. The role of intracellular acidification in calcium mobilization in human neutrophils. 1991 Biochim. Biophys. Acta pmid:2049405
Wall MJ et al. The effect of short chain fatty acids on transmural electrical potential across rat small intestine in vivo. 1976 Biochim. Biophys. Acta pmid:179592
Yoshikawa S et al. Proton pumping mechanism of bovine heart cytochrome c oxidase. Biochim. Biophys. Acta pmid:16904626
Keller RM and Wüthrich K Assignment of the heme c resonances in the 360 MHz H NMR spectra of cytochrome c. 1978 Biochim. Biophys. Acta pmid:205265
Loureiro SO et al. Propionic and methylmalonic acids increase cAMP levels in slices of cerebral cortex of young rats via adrenergic and glutamatergic mechanisms. 2005 Biochim. Biophys. Acta pmid:15949715
Yu MA et al. Radical formation in cytochrome c oxidase. 2011 Biochim. Biophys. Acta pmid:21718686
Hess JJ et al. On the effects of propionate and other short-chain fatty acids on sodium transport by the toad bladder. 1975 Biochim. Biophys. Acta pmid:236789
Henly DC and Berry MN Relationship between the stimulation of citric acid cycle oxidation and the stimulation of fatty acid esterification and inhibition of ketogenesis by lactate in isolated rat hepatocytes. 1991 Biochim. Biophys. Acta pmid:1828700
Lancaster CR et al. Recent progress on obtaining theoretical and experimental support for the "E-pathway hypothesis" of coupled transmembrane electron and proton transfer in dihaem-containing quinol:fumarate reductase. 2006 Biochim. Biophys. Acta pmid:16790236
Knight LC and Welch MJ Sites of direct and indirect halogenation of albumin. 1978 Biochim. Biophys. Acta pmid:27226
Wikström M et al. Water-gated mechanism of proton translocation by cytochrome c oxidase. 2003 Biochim. Biophys. Acta pmid:12765763
Pettigrew GW et al. Redox potentials of the photosynthetic bacterial cytochromes c2 and the structural bases for variability. 1978 Biochim. Biophys. Acta pmid:28760
Zheng X et al. Computer simulation of water in cytochrome c oxidase. 2003 Biochim. Biophys. Acta pmid:12615353
Wasternack C et al. Pyrimidine-degrading enzymes. Purification and properties of beta-ureidopropionase of Euglena gracilis. 1979 Biochim. Biophys. Acta pmid:115499
Trewhella J and Wright PE 1H-NMR studies of ferric soybean leghemoglobin: assignment of hyperfine shifted resonances of complexes with cyanide, nicotinate, pyridine and azide. 1980 Biochim. Biophys. Acta pmid:7192162
Keller R et al. Contact-shifted resonances in the 1H NMR spectra of cytochrome b5. Resonance identification and spin density distribution in the heme group. 1976 Biochim. Biophys. Acta pmid:5127
Hayashi S et al. Steady-state kinetics and spectral properties of Corynebacterium sarcosine oxidase. 1983 Biochim. Biophys. Acta pmid:6188492
Rotsaert FA et al. Mutations in cytochrome b that affect kinetics of the electron transfer reactions at center N in the yeast cytochrome bc1 complex. 2008 Biochim. Biophys. Acta pmid:18328328
Adir N et al. Refined structure of c-phycocyanin from the cyanobacterium Synechococcus vulcanus at 1.6 A: insights into the role of solvent molecules in thermal stability and co-factor structure. 2002 Biochim. Biophys. Acta pmid:12460674
HASSALL H and GREENBERG DM The oxidation of 4(5)-imidazolone-5(4)-propionic acid to hydantoin-5-propionic acid by xanthine oxidase. 1963 Biochim. Biophys. Acta pmid:13960896
Peuhkurinen KJ Accumulation and disposal of tricarboxylic acid cycle intermediates during propionate oxidation in the isolated perfused rat heart. 1982 Biochim. Biophys. Acta pmid:7138913
Fiedor L et al. Understanding chlorophylls: central magnesium ion and phytyl as structural determinants. 2008 Biochim. Biophys. Acta pmid:18848915
Fafournoux P et al. Propionate transport in rat liver cells. 1985 Biochim. Biophys. Acta pmid:4016114
Bear CE et al. Intracellular pH influences the resting membrane potential of isolated rat hepatocytes. 1988 Biochim. Biophys. Acta pmid:3179283
Ticku MK and Olsen RW gamma-Aminobutyric acid-stimulated chloride permeability in crayfish muscle. 1977 Biochim. Biophys. Acta pmid:836825
Ziyadeh FN et al. Taurine and cell volume maintenance in the shark rectal gland: cellular fluxes and kinetics. 1988 Biochim. Biophys. Acta pmid:2840958
Xu J and Voth GA Redox-coupled proton pumping in cytochrome c oxidase: further insights from computer simulation. 2008 Biochim. Biophys. Acta pmid:18155154
TOMLINSON N and MACLEOD RA The oxidation of propionic acid by a marine bacterium. 1955 Biochim. Biophys. Acta pmid:13304045
Dwyer LA et al. A 13C-NMR study of the biosynthesis of 3-methylpentacosane in the American cockroach. 1981 Biochim. Biophys. Acta pmid:6894252
Itoh N et al. Cloning and biochemical characterization of Co(2+)-activated bromoperoxidase-esterase (perhydrolase) from Pseudomonas putida IF-3 strain. 2001 Biochim. Biophys. Acta pmid:11342031
WOOD HG and LEAVER FW CO2 turnover in the fermentation of 3,4,5 and 6 carbon compounds by the propionic acid bacteria. Biochim. Biophys. Acta pmid:13115430
Kay WW Genetic control of the metabolism of propionate by Escherichia coli K12. 1972 Biochim. Biophys. Acta pmid:4554901
Hokland BM and Bremer J Metabolism and excretion of carnitine and acylcarnitines in the perfused rat kidney. 1986 Biochim. Biophys. Acta pmid:3697382
Egawa T et al. Critical structural role of R481 in cytochrome c oxidase from Rhodobacter sphaeroides. 2009 Biochim. Biophys. Acta pmid:19463779
Hiltunen JK and Davis EJ The disposition of citric acid cycle intermediates by isolated rat heart mitochondria. 1981 Biochim. Biophys. Acta pmid:7306575
Jørgensen KE and Sheikh MI Characteristics of uptake of short chain fatty acids by luminal membrane vesicles from rabbit kidney. 1986 Biochim. Biophys. Acta pmid:3741867
Brass EP Effect of alpha-ketobutyrate on palmitic acid and pyruvate metabolism in isolated rat hepatocytes. 1986 Biochim. Biophys. Acta pmid:3741887
Richard E et al. Genetic heterogeneity in propionic acidemia patients with alpha-subunit defects. Identification of five novel mutations, one of them causing instability of the protein. 1999 Biochim. Biophys. Acta pmid:10101253
Yoshikawa S et al. Structural studies on bovine heart cytochrome c oxidase. 2012 Biochim. Biophys. Acta pmid:22236806
Emmanuel B The relative contribution of propionate, and long-chain even-numbered fatty acids to the production of long-chain odd-numbered fatty acids in rumen bacteria. 1978 Biochim. Biophys. Acta pmid:564207
Desire B and Saint-Andre S [Accelerating effect of heterocyclic quaternary ammonium salts on neutral ester hydrolysis by acetylcholinesterase and butyrylcholinesterase (author's transl)]. 1981 Biochim. Biophys. Acta pmid:7260096
Gens JS et al. Different ionic conditions prompt NHE2 and NHE3 translocation to the plasma membrane. 2007 Biochim. Biophys. Acta pmid:17303069
Ellfolk N and Perttilä U Heme sulfuric anhydrides as soybean leghemoglobin structure probes. 1978 Biochim. Biophys. Acta pmid:656461
Scaife JR and Tichivangana JZ Short chain acyl-CoA synthetases in ovine rumen epithelium. 1980 Biochim. Biophys. Acta pmid:7407228
Clavero S et al. Functional characterization of PCCA mutations causing propionic acidemia. 2002 Biochim. Biophys. Acta pmid:12385775
Kaila VR et al. The identity of the transient proton loading site of the proton-pumping mechanism of cytochrome c oxidase. 2011 Biochim. Biophys. Acta pmid:20831859
Honig GR et al. Hemoglobin F Lódź (G gamma I 44 Ser replaced by Arg). A newly identified variant from an American infant of Polish descent. 1982 Biochim. Biophys. Acta pmid:6814491
Benavides J et al. Glycine transport in rat brain and liver mitochondria. 1980 Biochim. Biophys. Acta pmid:7388024
Jacobson G et al. Human pituitary thyrotropin. Isolation of alpha and beta subunits by hydrophobic interaction chromatography. 1978 Biochim. Biophys. Acta pmid:708778
Hellwig P et al. Spectroscopic study on the communication between a heme a3 propionate, Asp399 and the binuclear center of cytochrome c oxidase from Paracoccus denitrificans. 2008 Biochim. Biophys. Acta pmid:18078804
Ford SH Amidation of, and (R)-1-amino-2-propanol attachment to, the corrin ring during vitamin B-12 biosynthesis by Clostridium tetanomorphum extracts. 1985 Biochim. Biophys. Acta pmid:4027268
Trotter PJ and Storch J 3-[p-(6-phenyl)-1,3,5-hexatrienyl]phenylpropionic acid (PA-DPH): characterization as a fluorescent membrane probe and binding to fatty acid binding proteins. 1989 Biochim. Biophys. Acta pmid:2742883
Al-Lahham SH et al. Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. 2010 Biochim. Biophys. Acta pmid:20691280