propionic acid is a lipid of Fatty Acyls (FA) class. Propionic acid is associated with abnormalities such as Epilepsy, Infection, Tuberculosis, Alkalosis and Ischemia. The involved functions are known as Uptake, Biosynthetic Pathways, Methylation, Protein Overexpression and Biochemical Pathway. Propionic acid often locates in Body tissue, Cytoplasmic matrix, Membrane, Protoplasm and Extracellular. The associated genes with propionic acid are TRIO gene, TRRAP gene, SLC5A8 gene, SLC33A1 gene and Homologous Gene. The related lipids are Fatty Acids, Propionate, butyrate, Valerates and mycocerosic acid.
To understand associated biological information of propionic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
propionic acid is suspected in Propionic acidemia, Ischemia, Infection, Ulcerative Colitis, Alkalosis, Methylmalonic acidemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with propionic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Kisidayová S et al. | Effects of high- and low-fiber diets on fecal fermentation and fecal microbial populations of captive chimpanzees. | 2009 | Am. J. Primatol. | pmid:19367605 |
Maouyo D et al. | pH heterogeneity at intracellular and extracellular plasma membrane sites in HT29-C1 cell monolayers. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10794671 |
Stewart G et al. | Mouse GPR40 heterologously expressed in Xenopus oocytes is activated by short-, medium-, and long-chain fatty acids. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16267104 |
Spitzer KW et al. | Generation of intracellular pH gradients in single cardiac myocytes with a microperfusion system. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10749735 |
Purmal C et al. | Propionate stimulates pyruvate oxidation in the presence of acetate. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:25320331 |
Carvalho RA et al. | TCA cycle kinetics in the rat heart by analysis of (13)C isotopomers using indirect (1)H. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11514314 |
Nomura N et al. | CaMKII-dependent reactivation of SR Ca(2+) uptake and contractile recovery during intracellular acidosis. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12063291 |
Ragavan M et al. | A comprehensive analysis of myocardial substrate preference emphasizes the need for a synchronized fluxomic/metabolomic research design. | 2017 | Am. J. Physiol. Heart Circ. Physiol. | pmid:28411229 |
Musch MW et al. | SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11254495 |
Aschenbach JR et al. | Bicarbonate-dependent and bicarbonate-independent mechanisms contribute to nondiffusive uptake of acetate in the ruminal epithelium of sheep. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19264953 |
Tyagi S et al. | Mechanism of n-butyrate uptake in the human proximal colonic basolateral membranes. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11897627 |
Cremin JD et al. | Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12637251 |
Hadjiagapiou C et al. | Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11005765 |
Parhar K et al. | Short-chain fatty acid mediated phosphorylation of heat shock protein 25: effects on camptothecin-induced apoptosis. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16469826 |
Andriamihaja M et al. | Colon luminal content and epithelial cell morphology are markedly modified in rats fed with a high-protein diet. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20689060 |
Cuche G et al. | Desensitization of ileal vagal receptors by short-chain fatty acids in pigs. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11292611 |
Grider JR and Piland BE | The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16973914 |
Rojas-GarcÃa PP et al. | Prenatal testosterone excess alters Sertoli and germ cell number and testicular FSH receptor expression in rams. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20858754 |
Cohen DM et al. | Glutamine cycling in isolated working rat heart. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12944323 |
Martini WZ et al. | Quantitative assessment of anaplerosis from propionate in pig heart in vivo. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12388135 |
Jones JG et al. | An integrated (2)H and (13)C NMR study of gluconeogenesis and TCA cycle flux in humans. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11551863 |
King AJ et al. | Hypertension caused by prenatal testosterone excess in female sheep. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17327368 |
Jin ES et al. | Evidence for reverse flux through pyruvate kinase in skeletal muscle. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19190256 |
Wilson KA et al. | Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism. | 2017 | Am. J. Physiol. Endocrinol. Metab. | pmid:28634175 |
Graber ML et al. | Fluorescence identifies an alkaline cell in turtle urinary bladder. | 1986 | Am. J. Physiol. | pmid:3942220 |
Garvey MH and Maude DL | Acid excretion by bicarbonate-free perfused rat kidney. | 1981 | Am. J. Physiol. | pmid:6784580 |
Leffler CW et al. | cAMP production by piglet cerebral vascular smooth muscle cells: pH(o), pH(i), and permissive action of PGI(2). | 1999 | Am. J. Physiol. | pmid:10564143 |
El-Sharkaway TY and Daniel EE | Ionic mechanisms of intestinal electrical control activity. | 1975 | Am. J. Physiol. | pmid:1200148 |
Conn AR and Steele RD | Transport of alpha-keto analogues of amino acids across blood-brain barrier in rats. | 1982 | Am. J. Physiol. | pmid:6751096 |
Della-Fera MA et al. | Central nervous system injection of dynorphin-(1-13) overrides gastric satiety factors in sheep. | 1990 | Am. J. Physiol. | pmid:1970458 |
Grinstein S et al. | Amiloride-sensitive Na+-H+ exchange in platelets and leukocytes: detection by electronic cell sizing. | 1984 | Am. J. Physiol. | pmid:6089580 |
de Hemptinne A et al. | Influence of organic acids on intracellular pH. | 1983 | Am. J. Physiol. | pmid:6614155 |
Conn AR et al. | Characterization of alpha-keto acid transport across blood-brain barrier in rats. | 1983 | Am. J. Physiol. | pmid:6614164 |
Leclerc J et al. | Metabolism of R-beta-hydroxypentanoate and of beta-ketopentanoate in conscious dogs. | 1995 | Am. J. Physiol. | pmid:7900792 |
Wall SM and Koger LM | NH+4 transport mediated by Na(+)-K(+)-ATPase in rat inner medullary collecting duct. | 1994 | Am. J. Physiol. | pmid:7943362 |
Rowe WA et al. | Propionate activates multiple ion transport mechanisms in the HT29-18-C1 human colon cell line. | 1993 | Am. J. Physiol. | pmid:8214077 |
Graber M et al. | Acetazolamide inhibits acidification by the turtle bladder independent of cell pH. | 1989 | Am. J. Physiol. | pmid:2541630 |
Montrose MH et al. | Separate control of regulatory volume increase and Na+-H+ exchange by cultured renal cells. | 1988 | Am. J. Physiol. | pmid:2839037 |
Harris JB et al. | Lipoate effect on carbohydrate and lipid metabolism and gastric H+ secretion. | 1975 | Am. J. Physiol. | pmid:1090192 |
Ritucci NA et al. | Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive areas of the medulla. | 1998 | Am. J. Physiol. | pmid:9756546 |
Parfenova H and Leffler CW | Effects of hypercapnia on prostanoid and cAMP production by cerebral microvascular cell cultures. | 1996 | Am. J. Physiol. | pmid:8967453 |
Toda N | Mechanical responses of isolated dog cerebral arteries to reduction of external K, Na, and Cl. | 1978 | Am. J. Physiol. | pmid:645879 |
Grinstein S and Furuya W | Characterization of the amiloride-sensitive Na+-H+ antiport of human neutrophils. | 1986 | Am. J. Physiol. | pmid:3953781 |
Szczepańska M and Angielski S | Prevention of maleate-induced tubular dysfunction by acetoacetate. | 1980 | Am. J. Physiol. | pmid:7395994 |
Sellin JH and De Soignie R | Ionic regulation of Na absorption in proximal colon: cation inhibition of electroneutral Na absorption. | 1987 | Am. J. Physiol. | pmid:3812678 |
Forte JG et al. | Substrate dependency for HCl secretion by isolated piglet gastric mucosa. | 1980 | Am. J. Physiol. | pmid:7377308 |
Mariadason JM et al. | Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model. | 1997 | Am. J. Physiol. | pmid:9142899 |
Yamaji Y et al. | Intracellular acidosis activates c-Src. | 1997 | Am. J. Physiol. | pmid:9124524 |
Suarez-Kurtz G and Eastwood AB | Release of sarcoplasmic enzymes from frog skeletal muscle. | 1981 | Am. J. Physiol. | pmid:6792928 |
Hsu P et al. | Mechanisms of hypercapnia-stimulated PG production in piglet cerebral microvascular endothelial cells. | 1995 | Am. J. Physiol. | pmid:7864184 |