propionic acid is a lipid of Fatty Acyls (FA) class. Propionic acid is associated with abnormalities such as Epilepsy, Infection, Tuberculosis, Alkalosis and Ischemia. The involved functions are known as Uptake, Biosynthetic Pathways, Methylation, Protein Overexpression and Biochemical Pathway. Propionic acid often locates in Body tissue, Cytoplasmic matrix, Membrane, Protoplasm and Extracellular. The associated genes with propionic acid are TRIO gene, TRRAP gene, SLC5A8 gene, SLC33A1 gene and Homologous Gene. The related lipids are Fatty Acids, Propionate, butyrate, Valerates and mycocerosic acid.
To understand associated biological information of propionic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
propionic acid is suspected in Propionic acidemia, Ischemia, Infection, Ulcerative Colitis, Alkalosis, Methylmalonic acidemia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with propionic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Murphy EJ et al. | Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase. | 2008 | Biochemistry | pmid:19061385 |
Busse SC and Jue T | Two-dimensional NMR characterization of the deoxymyoglobin heme pocket. | 1994 | Biochemistry | pmid:8086410 |
Sherry AD et al. | Orientation-conserved transfer of symmetric Krebs cycle intermediates in mammalian tissue. | 1994 | Biochemistry | pmid:7910760 |
LeMagueres P et al. | Crystal structure at 1.45 A resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms. | 2003 | Biochemistry | pmid:14674749 |
de Vitry C et al. | Biochemical and spectroscopic characterization of the covalent binding of heme to cytochrome b6. | 2004 | Biochemistry | pmid:15049703 |
Ibrahim M et al. | Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. | 2010 | Biochemistry | pmid:20459051 |
Rwere F et al. | Resonance Raman interrogation of the consequences of heme rotational disorder in myoglobin and its ligated derivatives. | 2008 | Biochemistry | pmid:18986170 |
Ren Y et al. | Mapping the electron transfer interface between cytochrome b5 and cytochrome c. | 2004 | Biochemistry | pmid:15035623 |
Louie GV et al. | Role of phenylalanine-82 in yeast iso-1-cytochrome c and remote conformational changes induced by a serine residue at this position. | 1988 | Biochemistry | pmid:2849996 |
Manna SK and Mazumdar S | Role of threonine 101 on the stability of the heme active site of cytochrome P450cam: multiwavelength circular dichroism studies. | 2006 | Biochemistry | pmid:17042489 |
Seibold SA et al. | Water chain formation and possible proton pumping routes in Rhodobacter sphaeroides cytochrome c oxidase: a molecular dynamics comparison of the wild type and R481K mutant. | 2005 | Biochemistry | pmid:16060656 |
Haller T et al. | Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli. | 2000 | Biochemistry | pmid:10769117 |
Timkovich R et al. | 1H NMR spectroscopy of Paracoccus denitrificans cytochrome c-550. | 1984 | Biochemistry | pmid:6087896 |
Yang X et al. | Cholesterol metabolism increases the metabolic pool of propionate in Mycobacterium tuberculosis. | 2009 | Biochemistry | pmid:19364125 |
Santucci R et al. | Anion size modulates the structure of the A state of cytochrome c. | 2000 | Biochemistry | pmid:11027143 |
Yoshimura H et al. | Specific hydrogen-bonding networks responsible for selective O2 sensing of the oxygen sensor protein HemAT from Bacillus subtilis. | 2006 | Biochemistry | pmid:16819829 |
Hellwig P et al. | Electrochemical, FTIR, and UV/VIS spectroscopic properties of the ba(3) oxidase from Thermus thermophilus. | 1999 | Biochemistry | pmid:10423243 |
Sakurai M et al. | Glutamate 325 is a general acid-base catalyst in the reaction catalyzed by fructose-2,6-bisphosphatase. | 2000 | Biochemistry | pmid:11123954 |
Mikami S et al. | Effect of the redox-dependent ionization state of the heme propionic acid side chain on the entropic contribution to the redox potential of Pseudomonas aeruginosa cytochrome c551. | 2009 | Biochemistry | pmid:19627115 |
Mauk MR et al. | Electrostatic analysis of the interaction of cytochrome c with native and dimethyl ester heme substituted cytochrome b5. | 1986 | Biochemistry | pmid:3026446 |
Chao YY et al. | 1H NMR and ESR studies of oxidized cytochrome c551 from Pseudomonas aeruginosa. | 1979 | Biochemistry | pmid:33701 |
Peng D et al. | Role of propionates in substrate binding to heme oxygenase from Neisseria meningitidis: a nuclear magnetic resonance study. | 2012 | Biochemistry | pmid:22913621 |
Chen Z et al. | Resonance Raman investigation of the interaction of thromboxane synthase with substrate analogues. | 2003 | Biochemistry | pmid:12614148 |
Peyton DH et al. | Proton nuclear magnetic resonance study of the molecular and electronic structure of the heme cavity in Aplysia cyanometmyoglobin. | 1989 | Biochemistry | pmid:2548594 |
Liu GY et al. | Ionic strength dependence of cytochrome c structure and Trp-59 H/D exchange from ultraviolet resonance Raman spectroscopy. | 1989 | Biochemistry | pmid:2548599 |
Omura S et al. | Studies on the biosynthesis of 16-membered macrolide antibiotics using carbon-13 nuclear magnetic resonance spectroscopy. | 1977 | Biochemistry | pmid:18162 |
Wilson DF and Forman NG | Mitochondrial transmembrane pH and electrical gradients: evaluation of their energy relationships with respiratory rate and adenosine 5'-triphosphate synthesis. | 1982 | Biochemistry | pmid:7074098 |
Wang J et al. | Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network. | 2006 | Biochemistry | pmid:16388581 |
Stellwagen E and Babul J | Stabilization of the globular structure of ferricytochrome c by chloride in acidic solvents. | 1975 | Biochemistry | pmid:41 |
Mascaretti OA et al. | Biosynthesis of the macrolide antibiotic chlorothricin. | 1981 | Biochemistry | pmid:7011379 |
Mimura K et al. | Isolation of stable (alphabeta)4-Tetraprotomer from Na+/K+-ATPase solubilized in the presence of short-chain fatty acids. | 2008 | Biochemistry | pmid:18465843 |
Baddam S and Bowler BE | Thermodynamics and kinetics of formation of the alkaline state of a Lys 79-->Ala/Lys 73-->His variant of iso-1-cytochrome c. | 2005 | Biochemistry | pmid:16274242 |
Lee HJ et al. | Properties of Arg481 mutants of the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that neither R481 nor the nearby D-propionate of heme a3 is likely to be the proton loading site of the proton pump. | 2009 | Biochemistry | pmid:19575527 |
Dayem LC et al. | Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. | 2002 | Biochemistry | pmid:11955068 |
Brigé A et al. | The 1.25 A resolution structure of the diheme NapB subunit of soluble nitrate reductase reveals a novel cytochrome c fold with a stacked heme arrangement. | 2002 | Biochemistry | pmid:11939777 |
Behr J et al. | Functional properties of the heme propionates in cytochrome c oxidase from Paracoccus denitrificans. Evidence from FTIR difference spectroscopy and site-directed mutagenesis. | 2000 | Biochemistry | pmid:10684616 |
Horswill AR and Escalante-Semerena JC | Characterization of the propionyl-CoA synthetase (PrpE) enzyme of Salmonella enterica: residue Lys592 is required for propionyl-AMP synthesis. | 2002 | Biochemistry | pmid:11841231 |
Delker SL et al. | Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase . | 2010 | Biochemistry | pmid:21138269 |
Bunik VI et al. | Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. | 2005 | Biochemistry | pmid:16060664 |
Brändén G et al. | The protonation state of a heme propionate controls electron transfer in cytochrome c oxidase. | 2005 | Biochemistry | pmid:16060655 |
Mills DA et al. | An arginine to lysine mutation in the vicinity of the heme propionates affects the redox potentials of the hemes and associated electron and proton transfer in cytochrome c oxidase. | 2005 | Biochemistry | pmid:16060654 |
Raman CS et al. | Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism. | 2001 | Biochemistry | pmid:11695891 |
Stayton PS et al. | Putidaredoxin competitively inhibits cytochrome b5-cytochrome P-450cam association: a proposed molecular model for a cytochrome P-450cam electron-transfer complex. | 1989 | Biochemistry | pmid:2690937 |
Sundaramoorthy M et al. | High-resolution crystal structure of manganese peroxidase: substrate and inhibitor complexes. | 2005 | Biochemistry | pmid:15850380 |
Andrews H et al. | Expression, mutagenesis, and characterization of recombinant low-potential cytochrome c550 of photosystem II. | 2005 | Biochemistry | pmid:15835898 |
Evans HJ and Wood HG | Purification and properties of pyruvate phosphate dikinase from propionic acid bacteria. | 1971 | Biochemistry | pmid:5544662 |
Ahmed AH et al. | Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. | 2009 | Biochemistry | pmid:19284741 |
Schrimsher JL and Taylor KB | Octopine dehydrogenase from Pecten maximus: steady-state mechanism. | 1984 | Biochemistry | pmid:6722094 |
Mendoza MF et al. | Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups. | 2012 | Biochemistry | pmid:22989153 |
Shang L et al. | Biliverdin amides reveal roles for propionate side chains in bilin reductase recognition and in holophytochrome assembly and photoconversion. | 2010 | Biochemistry | pmid:20565135 |