| MeSH term | MeSH ID | Detail |
|---|---|---|
| Heart Failure | D006333 | 36 associated lipids |
| Angioedema | D000799 | 6 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Osteolysis | D010014 | 8 associated lipids |
| Pain, Postoperative | D010149 | 13 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Growth Disorders | D006130 | 5 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
propionic acid
propionic acid is a lipid of Fatty Acyls (FA) class. Propionic acid is associated with abnormalities such as Epilepsy, Infection, Tuberculosis, Alkalosis and Ischemia. The involved functions are known as Uptake, Biosynthetic Pathways, Methylation, Protein Overexpression and Biochemical Pathway. Propionic acid often locates in Body tissue, Cytoplasmic matrix, Membrane, Protoplasm and Extracellular. The associated genes with propionic acid are TRIO gene, TRRAP gene, SLC5A8 gene, SLC33A1 gene and Homologous Gene. The related lipids are Fatty Acids, Propionate, butyrate, Valerates and mycocerosic acid.
Cross Reference
Introduction
To understand associated biological information of propionic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with propionic acid?
propionic acid is suspected in Propionic acidemia, Ischemia, Infection, Ulcerative Colitis, Alkalosis, Methylmalonic acidemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with propionic acid
PubChem Associated disorders and diseases
What pathways are associated with propionic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with propionic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with propionic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with propionic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with propionic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with propionic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with propionic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Matsumoto I et al. | Metabolism of branched medium chain length fatty acid. II--beta-oxidation of sodium dipropylacetate in rats. | 1976 | Biomed. Mass Spectrom. | pmid:788806 |
| Millington DS et al. | Application of high resolution fast atom bombardment and constant B/E ratio linked scanning to the identification and analysis of acylcarnitines in metabolic disease. | 1984 | Biomed. Mass Spectrom. | pmid:6743766 |
| Daghestani MH et al. | The role of apitoxin in alleviating propionic acid-induced neurobehavioral impairments in rat pups: The expression pattern of Reelin gene. | 2017 | Biomed. Pharmacother. | pmid:28622594 |
| Tazoe H et al. | Expression of short-chain fatty acid receptor GPR41 in the human colon. | 2009 | Biomed. Res. | pmid:19574715 |
| Kawamata K et al. | Chloride-dependent bicarbonate secretion in the mouse large intestine. | 2006 | Biomed. Res. | pmid:16543661 |
| Cifuentes Y et al. | [Neonatal onset of organic acidemia (propionic) diagnosed by tandem mass spectrometry]. | 2008 | Biomedica | pmid:18645657 |
| Carlier L et al. | NMR resonance assignments of NarE, a putative ADP-ribosylating toxin from Neisseria meningitidis. | 2011 | Biomol NMR Assign | pmid:20737254 |
| Richard JP et al. | Effect of an E461G mutation of beta-galactosidase (Escherichia coli, lac Z) on pL rate profiles and solvent deuterium isotope effects. | 2001 | Bioorg. Chem. | pmid:11437390 |
| Usanov SA et al. | [Molecular organization of the reductase complex in adrenal cortex mitochondria. Study using bifunctional reagents]. | 1986 | Bioorg. Khim. | pmid:3954801 |
| Lash TD et al. | Normal and abnormal heme biosynthesis. Part 7. Synthesis and metabolism of coproporphyrinogen-III analogues with acetate or butyrate side chains on rings C and D. Development of a modified model for the active site of coproporphyrinogen oxidase. | 2011 | Bioorg. Med. Chem. | pmid:21277781 |
| Fracchiolla G et al. | Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity. | 2008 | Bioorg. Med. Chem. | pmid:18835719 |
| Hazeldine ST et al. | Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4. | 2005 | Bioorg. Med. Chem. | pmid:15911307 |
| Innocenti A et al. | Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates. | 2009 | Bioorg. Med. Chem. | pmid:19297172 |
| Bora-Tatar G et al. | Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies. | 2009 | Bioorg. Med. Chem. | pmid:19520580 |
| Bulmer AC et al. | In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin. | 2008 | Bioorg. Med. Chem. | pmid:18304823 |
| Silva PJ and Ramos MJ | A comparative density-functional study of the reaction mechanism of the O2-dependent coproporphyrinogen III oxidase. | 2008 | Bioorg. Med. Chem. | pmid:18226911 |
| Ali Khan SR et al. | Synthesis, characterization and cytotoxicity of new platinum(IV) axial carboxylate complexes: crystal structure of potential antitumor agent [PtIV(trans-1R,2R-diaminocyclohexane)trans(acetate)2Cl2]. | 2000 | Bioorg. Med. Chem. | pmid:10732967 |
| Maruo S et al. | Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. | 2011 | Bioorg. Med. Chem. | pmid:21903399 |
| Capes A et al. | Quinol derivatives as potential trypanocidal agents. | 2012 | Bioorg. Med. Chem. | pmid:22264753 |
| Zimmermann TJ et al. | Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. | 2009 | Bioorg. Med. Chem. | pmid:19097799 |
| Walsh SP et al. | 3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21514824 |
| Catelani G et al. | Induction of erythroid differentiation of human K562 cells by 3-O-acyl-1,2-O-isopropylidene-D-glucofuranose derivatives. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560743 |
| Pastor L et al. | New antifungals selected by molecular topology. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873584 |
| Yan L et al. | SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17092714 |
| Mokale SN et al. | Synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2-methyl propanoic acid derivatives. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21193309 |
| Sun X et al. | Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21570838 |
| Bolchi C et al. | Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21802946 |
| Leonard K et al. | Non-peptidic alpha(v)beta3 antagonists containing indol-1-yl propionic acids. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15863341 |
| Usui S et al. | Identification of novel PPARalpha ligands by the structural modification of a PPARgamma ligand. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16621530 |
| Yu G et al. | Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20202839 |
| Takano R et al. | Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists. | 2014 | Bioorg. Med. Chem. Lett. | pmid:24835985 |
| Wang Y et al. | The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20005104 |
| Zhou X et al. | (S)-3-(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-(piperazin-1-yl) propanoic acid compounds: synthesis and biological evaluation of dual PPARalpha/gamma agonists. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20299214 |
| Stafford JA et al. | Identification and structure-activity studies of novel ultrashort-acting benzodiazepine receptor agonists. | 2002 | Bioorg. Med. Chem. Lett. | pmid:12372537 |
| Mokale SN et al. | Synthesis and anti-inflammatory activity of some 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20594837 |
| Greenfield A et al. | Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16165356 |
| Lash TD et al. | Metabolism of analogues of coproporphyrinogen-III with modified side chains: implications for binding at the active site of coproporphyrinogen oxidase. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11814818 |
| Cube RV et al. | 3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2). | 2005 | Bioorg. Med. Chem. Lett. | pmid:15837331 |
| Meng Q et al. | Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22429468 |
| Pavar MC et al. | Structure-activity relationship study between Ornithyl-Proline and Lysyl-Proline based tripeptidomimics as angiotensin-converting enzyme inhibitors. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16464585 |
| Kim NJ et al. | Design, synthesis, and structure-activity relationship of carbamate-tethered aryl propanoic acids as novel PPARalpha/gamma dual agonists. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17507225 |
| Yamamoto T et al. | Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17467986 |
| Katoh T et al. | Parallel fluorescent probe synthesis based on the large-scale preparation of BODIPY FL propionic acid. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28174108 |
| Brady SF et al. | Rational design and synthesis of selective BACE-1 inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14741251 |
| McKeown SC et al. | Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17240142 |
| Vianello P et al. | Solid-phase synthesis of a small library of 3-phenylthio-3-nicotinyl propionic acid derivatives acting as antagonists of the integrin alphaVbeta3. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14741263 |
| Gupta K et al. | Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14741265 |
| Nguyen ST et al. | A concise, total synthesis and antibacterial evaluation of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan-3-one. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20805026 |
| Lombardo M et al. | Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects. | 2016 | Bioorg. Med. Chem. Lett. | pmid:27815121 |
| Hoshina Y et al. | 2,3-Diphenylpropionic acids as potent VLA-4 antagonists. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15582442 |