propionic acid

propionic acid is a lipid of Fatty Acyls (FA) class. Propionic acid is associated with abnormalities such as Epilepsy, Infection, Tuberculosis, Alkalosis and Ischemia. The involved functions are known as Uptake, Biosynthetic Pathways, Methylation, Protein Overexpression and Biochemical Pathway. Propionic acid often locates in Body tissue, Cytoplasmic matrix, Membrane, Protoplasm and Extracellular. The associated genes with propionic acid are TRIO gene, TRRAP gene, SLC5A8 gene, SLC33A1 gene and Homologous Gene. The related lipids are Fatty Acids, Propionate, butyrate, Valerates and mycocerosic acid.

Cross Reference

Introduction

To understand associated biological information of propionic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with propionic acid?

propionic acid is suspected in Propionic acidemia, Ischemia, Infection, Ulcerative Colitis, Alkalosis, Methylmalonic acidemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with propionic acid

MeSH term MeSH ID Detail
Leukemia, Experimental D007942 42 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Galactosemias D005693 5 associated lipids
Erythema D004890 22 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Hyperlipidemias D006949 73 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Cardiomegaly D006332 31 associated lipids
Burkitt Lymphoma D002051 15 associated lipids
Rickets D012279 6 associated lipids
Arthritis, Juvenile D001171 8 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Uveitis D014605 14 associated lipids
Reye Syndrome D012202 14 associated lipids
Poultry Diseases D011201 21 associated lipids
Hyperinsulinism D006946 27 associated lipids
Farmer's Lung D005203 2 associated lipids
Stevens-Johnson Syndrome D013262 3 associated lipids
Blind Loop Syndrome D001765 3 associated lipids
Per page 10 20 50 100 | Total 142

PubChem Associated disorders and diseases

What pathways are associated with propionic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with propionic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with propionic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with propionic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with propionic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with propionic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with propionic acid

Download all related citations
Per page 10 20 50 100 | Total 6372
Authors Title Published Journal PubMed Link
Hashimoto S and Hayakawa S Microbiological degradation of bile acids. Metabolites formed from 3-(3a alpha-hexahydro-7a beta-methyl-1,5-dioxoindan-4 alpha-yl) propionic acid by Streptomyces rubescens. 1977 Biochem. J. pmid:883963
Ghosh NK et al. Induction of human choriogonadotropin in heLa-cell cultures by aliphatic monocarboxylates and inhibitors of deoxyribonucleic acid synthesis. 1977 Biochem. J. pmid:911320
Scholem RD and Brown GK Metabolism of malonic semialdehyde in man. 1983 Biochem. J. pmid:6418146
Jia Y et al. Kinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilus. 2006 Biochem. J. pmid:16524361
Girvan HM et al. Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3. 2010 Biochem. J. pmid:20180779
Williams DL et al. Metabolic effects of propionate administration to normal and vitamin B12-deficient rats. 1971 Biochem. J. pmid:5116531
Nyhan WL et al. Tiglicaciduria in propionicacidaemia. 1972 Biochem. J. pmid:5073234
Jones A and Turner JM Microbial metabolism of amino alcohols. 1-Aminopropan-2-ol and ethanolamine metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas. 1973 Biochem. J. pmid:4723219
Narumi K et al. Biosynthesis of a mycobacterial lipopolysaccharide. Incorporation of (14C)acyl groups by whole cells in vivo. 1973 Biochem. J. pmid:4725042
Grunnet N and Katz J Effects of ammonia and norvaline on lactate metabolism by hepatocytes from starved rats. The use of 14C-labelled lactate in studies of hepatic gluconeogenesis. 1978 Biochem. J. pmid:687361
Killilea SD et al. Structures and apoprotein linkages of phycoerythrobilin and phycocyanobilin. 1980 Biochem. J. pmid:7396852
Killilea SD and O'Carra P Structure and apoprotein linkages of phycourobilin. 1985 Biochem. J. pmid:3838665
Sumegi B et al. Metabolism of [3-13C]pyruvate and [3-13C]propionate in normal and ischaemic rat heart in vivo: 1H- and 13C-NMR studies. 1995 Biochem. J. pmid:7492338
Koshihara Y et al. Effect of sodium n-butyrate on induction of prostaglandin synthase activity in cloned mastocytoma P-815 2-E-6 cells. 1981 Biochem. J. pmid:6796055
Arinze IJ et al. Effect of methylamalonic acid on gluconeogenesis in isolated rat and guinea-pig hepatocytes. 1979 Biochem. J. pmid:540062
Sugden MC et al. Odd-carbon fatty acid metabolism in hepatocytes from starved rats. 1984 Biochem. Int. pmid:6477599
Prasad R and Höfer M The electrochemical gradient of H+ in Candida albicans and its relevance to the uptake of nutrients. 1987 Biochem. Int. pmid:2839177
Willard HF and Rosenberg LE Inborn errors of cobalamin metabolism: effect of cobalamin supplementation in culture on methylmalonyl CoA mutase activity in normal and mutant human fibroblasts. 1979 Biochem. Genet. pmid:36882
Ruvolo-Takasusuki MC and Collet T Characterization of Nasutitermes globiceps (Isoptera: Termitidae) esterases. 2000 Biochem. Genet. pmid:11301915
Nofer JR et al. Low density lipoproteins inhibit the Na+/H+ antiport in human platelets via activation of p38MAP kinase. 2006 Biochem. Biophys. Res. Commun. pmid:16380078
Riester D et al. Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates. 2004 Biochem. Biophys. Res. Commun. pmid:15485670
Cantenys D et al. Covalent attachment of insulin to the outer surface of liposomes. 1983 Biochem. Biophys. Res. Commun. pmid:6197974
Swaminath G et al. Mutational analysis of G-protein coupled receptor--FFA2. 2011 Biochem. Biophys. Res. Commun. pmid:21216233
Oda Y and Kasai K Photochemical cross-linking of beta-galactoside-binding lectin to polylactosamino-proteoglycan of chick embryonic skin. 1984 Biochem. Biophys. Res. Commun. pmid:6487329
Wächtershäuser A et al. PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. 2000 Biochem. Biophys. Res. Commun. pmid:10833422
Palmeira CM et al. Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids. 2000 Biochem. Biophys. Res. Commun. pmid:10833431
Grinstein S and Furuya W Amiloride-sensitive Na+/H+ exchange in human neutrophils: mechanism of activation by chemotactic factors. 1984 Biochem. Biophys. Res. Commun. pmid:6087813
Finkle TJ and Grover AK Evidence for a Na+/H+ antiport in stomach smooth muscle cells. 1988 Biochem. Biophys. Res. Commun. pmid:2831889
Parsons WH et al. Benzolactams. A new class of converting enzyme inhibitors. 1983 Biochem. Biophys. Res. Commun. pmid:6318742
Ramos-Santana BJ and López-Garriga J Tyrosine B10 triggers a heme propionate hydrogen bonding network loop with glutamine E7 moiety. 2012 Biochem. Biophys. Res. Commun. pmid:22809503
Sha'afi RI and Molski TF Signalling for increased cytoskeletal actin in neutrophils. 1987 Biochem. Biophys. Res. Commun. pmid:3036146
Carini R et al. Evidence for a sodium-dependent calcium influx in isolated rat hepatocytes undergoing ATP depletion. 1994 Biochem. Biophys. Res. Commun. pmid:8037733
Staecker JL et al. Stimulation of DNA synthesis in primary cultures of adult rat hepatocytes by sodium butyrate. 1987 Biochem. Biophys. Res. Commun. pmid:3632683
Sevilla CL et al. Plasminogen activator-anti-human fibrinogen conjugate. 1985 Biochem. Biophys. Res. Commun. pmid:3161501
Cathelineau L et al. Effect of propionate and pyruvate on citrulline synthesis and ATP content in rat liver mitochondria. 1979 Biochem. Biophys. Res. Commun. pmid:496983
Rabier D et al. Propionate and succinate effects on acetyl glutamate biosynthesis by rat liver mitochondria. 1979 Biochem. Biophys. Res. Commun. pmid:518644
Hagey LR and Krisans SK Degradation of cholesterol to propionic acid by rat liver peroxisomes. 1982 Biochem. Biophys. Res. Commun. pmid:7138522
Tamai I et al. Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. 1995 Biochem. Biophys. Res. Commun. pmid:7677755
Jennings TM and McDonald MJ Esterification of the propionate groups promotes alpha/beta hemoglobin chain homogeneity of CN-hemin binding. 2002 Biochem. Biophys. Res. Commun. pmid:12054662
Wardell M et al. The atomic structure of human methemalbumin at 1.9 A. 2002 Biochem. Biophys. Res. Commun. pmid:11866438
Stewart PM and Walser M Low dose ethanol prevents propionate induced hyperammonemia. 1981 Biochem. Biophys. Res. Commun. pmid:7295308
Katunuma N et al. Structure-based development of pyridoxal propionate derivatives as specific inhibitors of cathepsin K in vitro and in vivo. 2000 Biochem. Biophys. Res. Commun. pmid:10673380
Nagai J et al. Incorporation of propionate into wax esters by etiolated Euglena. 1971 Biochem. Biophys. Res. Commun. pmid:5542903
Bohle DS et al. Propionic acid side chain hydrogen bonding in the malaria pigment beta-hematin. 2002 Biochem. Biophys. Res. Commun. pmid:12054752
Ishii Y et al. Preparation of EGF labeled liposomes and their uptake by hepatocytes. 1989 Biochem. Biophys. Res. Commun. pmid:2785794
Cannon JB et al. The effect of metalloporphyrins and heme liposomes on delta-aminolevulinate synthase activity in rat liver. 1985 Biochem. Biophys. Res. Commun. pmid:4026834
Nilsson NE et al. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. 2003 Biochem. Biophys. Res. Commun. pmid:12684041
Oizumi J et al. Propionate metabolism by cultured skin fibroblasts from normal individuals and patients with methylmalonicaciduria and propionicacidemia. 1981 Biochem Med pmid:7295302
Fuhrmann H et al. [The evaluation of hormone and metabolite profiles after the infusion of glucose, propionate and butyrate in cattle]. 1989 Berl. Munch. Tierarztl. Wochenschr. pmid:2764872
Havenaar R Intestinal health functions of colonic microbial metabolites: a review. 2011 Benef Microbes pmid:21840809
Roelofsen H et al. The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes. 2010 Benef Microbes pmid:21831781
Bird AR et al. Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics. 2010 Benef Microbes pmid:21831780
Binsl TW et al. Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro. 2010 Benef Microbes pmid:21831778
Mäkivuokko H et al. Synbiotic effects of lactitol and Lactobacillus acidophilus NCFM™ in a semi-continuous colon fermentation model. 2010 Benef Microbes pmid:21840801
Fernando WM et al. Diets supplemented with chickpea or its main oligosaccharide component raffinose modify faecal microbial composition in healthy adults. 2010 Benef Microbes pmid:21831757
Singh S et al. Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation in high-fat-diet fed and streptozotocintreated rats. 2017 Benef Microbes pmid:28008783
Luo J et al. Potential influence of dairy propionibacteria on the growth and acid metabolism of Streptococcus bovis and Megasphaera elsdenii. 2017 Benef Microbes pmid:27824275
Humphries PS et al. ADDP and PS-PPh3: an efficient Mitsunobu protocol for the preparation of pyridine ether PPAR agonists. 2006 Beilstein J Org Chem pmid:17076898
Jervis PJ and Cox LR Tether-directed synthesis of highly substituted oxasilacycles via an intramolecular allylation employing allylsilanes. 2007 Beilstein J Org Chem pmid:17288602
Guazzelli G et al. Synthesis of (-)-Indolizidine 167B based on domino hydroformylation/cyclization reactions. 2008 Beilstein J Org Chem pmid:18197967
Laing DG and Willcox ME An investigation of the mechanisms of odor suppression using physical and dichorhinic mixtures. 1987 Nov-Dec Behav. Brain Res. pmid:3426790
MacFabe DF et al. Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder. 2011 Behav. Brain Res. pmid:20937326
Shultz SR et al. Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism. 2009 Behav. Brain Res. pmid:19154758
Shultz SR et al. Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats. 2015 Behav. Brain Res. pmid:25446754
Foley KA et al. Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: relevance to autism spectrum disorders. 2015 Behav. Brain Res. pmid:25300465
MacFabe DF et al. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. 2007 Behav. Brain Res. pmid:16950524
Ossenkopp KP et al. Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats. 2012 Behav. Brain Res. pmid:22085877
Taegtmeyer H On the inability of ketone bodies to serve as the only energy providing substrate for rat heart at physiological work load. 1983 Jul-Aug Basic Res. Cardiol. pmid:6626122
Kooij V et al. Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium. 2010 Basic Res. Cardiol. pmid:19655190
Yonekura K et al. Inhibition of carnitine synthesis modulates protein contents of the cardiac sarcoplasmic reticulum Ca2+-ATPase and hexokinase type I in rat hearts with myocardial infarction. 2000 Basic Res. Cardiol. pmid:11099160
Neulen A et al. The cardiac troponin C mutation Leu29Gln found in a patient with hypertrophic cardiomyopathy does not alter contractile parameters in skinned murine myocardium. 2009 Basic Res. Cardiol. pmid:19506933
Ishihara K et al. Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19486331
Pathak P et al. The effect of Emblica officinalis diet on lifespan, sexual behavior, and fitness characters in Drosophila melanogaster. 2011 Ayu pmid:22408317
Van Immerseel F et al. The use of organic acids to combat Salmonella in poultry: a mechanistic explanation of the efficacy. 2006 Avian Pathol. pmid:16753609
Van Deun K et al. Short-chain fatty acids and L-lactate as feed additives to control Campylobacter jejuni infections in broilers. 2008 Avian Pathol. pmid:18622853
McHan F and Shotts EB Effect of feeding selected short-chain fatty acids on the in vivo attachment of Salmonella typhimurium in chick ceca. 1992 Jan-Mar Avian Dis. pmid:1567301
Hume ME et al. Effectiveness of dietary propionic acid in controlling Salmonella typhimurium colonization in broiler chicks. 1993 Oct-Dec Avian Dis. pmid:8141732
Lin MY et al. In vitro comparison of the activity of various antifungal drugs against new yeast isolates causing thrush in poultry. 1989 Jul-Sep Avian Dis. pmid:2673187
Nisbet DJ et al. Effect of mixed cecal microflora maintained in continuous culture and of dietary lactose on Salmonella typhimurium colonization in broiler chicks. 1993 Apr-Jun Avian Dis. pmid:8363516
Moorhead PD and Cross RF Prophylaxis of experimental moniliasis in quail. A comparison of ethylenediamine dihydriodide, Benlate, sodium propionate, gentian violet, and nystatin. 1972 May-Jun Avian Dis. pmid:4556823
Matlho G et al. Destruction of Salmonella enteritidis in poultry feed by combination of heat and propionic acid. 1997 Jan-Mar Avian Dis. pmid:9087320
Bieger D et al. Anomalous response to potassium in vascular smooth muscle cells of human saphenous vein. 2006 Auton Autacoid Pharmacol pmid:16371060
Packer EL et al. Rumen fermentation and liveweight gain in beef cattle treated with monensin and grazing lush forage. 2011 Aust. Vet. J. pmid:21864305
Brockman RP and Greer C Effects of somatostatin and glucagon on the utilization of [2-(14)C]propionate in glucose production in vivo in sheep. 1980 Aust. J. Biol. Sci. pmid:6108757
Wastney ME et al. Glucose turnover and hepatocyte glucose production of starved and toxaemic pregnant sheep. 1983 Aust. J. Biol. Sci. pmid:6651639
Celasco G et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. 2004 Arzneimittelforschung pmid:15646372
Tsurumi K et al. Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid. 1st communication: inhibitory effects of rat paw edema. 1986 Arzneimittelforschung pmid:3566840
Tsurumi K et al. Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid. 5th communication: antiplatelet effect of the drug and antiinflammatory effect of its main metabolite. 1986 Arzneimittelforschung pmid:3566843
Süküroglu M et al. Synthesis and analgesic activity of some 4,6-disubstituted-3(2H)-pyridazinone derivatives. 2006 Arzneimittelforschung pmid:16821644
Roll R and Matthiaschk G [Comparative studies on the embryotoxicity of 2-methyl-4-chlorophenoxyacetic acid, mecoprop and dichlorprop in NMRI mice]. 1983 Arzneimittelforschung pmid:6686050
Al-Deeb OA et al. Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-[3-(1-adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl] acetic acids, 2-[3-(1-adamantyl)-4-substituted-5-thioxo-1,2,4-triazolin-1-yl]propionic acids and related derivatives. 2006 Arzneimittelforschung pmid:16478004
Mörsdorf K and Wolf G [On the efficiency of new antiinflammatory agents. A comparative study (author's transl)]. 1977 Arzneimittelforschung pmid:577416
Kawamatsu Y et al. Studies on antihyperlipidemic agents. I. Synthesis and hypolipidemic activities of phenoxyphenyl alkanoic acid derivatives. 1980 Arzneimittelforschung pmid:7387754
Schäd SG et al. Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis. 2007 Arthritis Res. Ther. pmid:17266758
Poli A et al. Synthesis, production, and biotechnological applications of exopolysaccharides and polyhydroxyalkanoates by archaea. 2011 Archaea pmid:22007151
Horz HP and Conrads G The discussion goes on: What is the role of Euryarchaeota in humans? 2010 Archaea pmid:21253553
Hook SE et al. Methanogens: methane producers of the rumen and mitigation strategies. 2010 Archaea pmid:21253540
Kaster AK et al. More than 200 genes required for methane formation from Hâ‚‚ and COâ‚‚ and energy conservation are present in Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus. 2011 Archaea pmid:21559116
Ingram-Smith C and Smith KS AMP-forming acetyl-CoA synthetases in Archaea show unexpected diversity in substrate utilization. 2007 Archaea pmid:17350930
Storbeck S et al. A novel pathway for the biosynthesis of heme in Archaea: genome-based bioinformatic predictions and experimental evidence. 2010 Archaea pmid:21197080