| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Glycosuria | D006029 | 10 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Periodontitis | D010518 | 22 associated lipids |
| Testicular Neoplasms | D013736 | 5 associated lipids |
propionic acid
propionic acid is a lipid of Fatty Acyls (FA) class. Propionic acid is associated with abnormalities such as Epilepsy, Infection, Tuberculosis, Alkalosis and Ischemia. The involved functions are known as Uptake, Biosynthetic Pathways, Methylation, Protein Overexpression and Biochemical Pathway. Propionic acid often locates in Body tissue, Cytoplasmic matrix, Membrane, Protoplasm and Extracellular. The associated genes with propionic acid are TRIO gene, TRRAP gene, SLC5A8 gene, SLC33A1 gene and Homologous Gene. The related lipids are Fatty Acids, Propionate, butyrate, Valerates and mycocerosic acid.
Cross Reference
Introduction
To understand associated biological information of propionic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with propionic acid?
propionic acid is suspected in Propionic acidemia, Ischemia, Infection, Ulcerative Colitis, Alkalosis, Methylmalonic acidemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with propionic acid
PubChem Associated disorders and diseases
What pathways are associated with propionic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with propionic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with propionic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with propionic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with propionic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with propionic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with propionic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Scott DA et al. | Ca2+ storage in Trypanosoma brucei: the influence of cytoplasmic pH and importance of vacuolar acidity. | 1995 | Biochem. J. | pmid:7575411 |
| Smith RM and Osborne-White WS | Synthesis of phosphoenolpyruvate from propionate in sheep liver. | 1971 | Biochem. J. | pmid:4331860 |
| Gaitonde MK | Conversion of [U-14C]threonine into 14C-labelled amino acids in the brain of thiamin-deficient rats. | 1975 | Biochem. J. | pmid:1180921 |
| Biebuyck JF et al. | The effects of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) on glycolysis and biosynthetic processes of the isolated perfused rat liver. | 1972 | Biochem. J. | pmid:4344008 |
| O'Keeffe DT and Anthony C | The two cytochromes c in the facultative methylotroph Pseudomonas am1. | 1980 | Biochem. J. | pmid:6263253 |
| Wilkemeyer MF et al. | Primary structure and activity of mouse methylmalonyl-CoA mutase. | 1990 | Biochem. J. | pmid:1978672 |
| Hancock FE et al. | The 3H-labelling of bilirubin. | 1976 | Biochem. J. | pmid:962882 |
| Arinze IJ and Rowley DL | Gluconeogenesis by isolated guinea-pig liver parenchymal cells. | 1975 | Biochem. J. | pmid:177003 |
| Faulkner A and Turner JM | Microbial metabolism of amino alcohols. Aminoacetone metabolism via 1-aminopropan-2-ol in Pseudomonas sp. N.C.I.B. 8858. | 1974 | Biochem. J. | pmid:4362743 |
| Young OA and Anderson JW | The enzymology of short-chain fatty acyl-coenzyme A synthetase from seeds of Pinus radiata. Kinetic studies and a proposed reaction mechanism. | 1974 | Biochem. J. | pmid:4370933 |
| Young OA and Anderson JW | Properties and substrate specificity of some reactions catalysed by a short-chain fatty acyl-coenzyme A synthetase from seeds of Pinus radiata. | 1974 | Biochem. J. | pmid:4370976 |
| Smith AJ and Lucas C | Propionate resistance in blue-green algae. | 1971 | Biochem. J. | pmid:5003469 |
| Lomax MA et al. | The control of fatty acid metabolism in liver cells from fed and starved sheep. | 1983 | Biochem. J. | pmid:6615480 |
| Evans CT et al. | [13C]propionate oxidation in wild-type and citrate synthase mutant Escherichia coli: evidence for multiple pathways of propionate utilization. | 1993 | Biochem. J. | pmid:8098211 |
| Brass EP and Beyerinck RA | Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids. | 1988 | Biochem. J. | pmid:3134008 |
| Shepherd M et al. | Purification and kinetic characterization of the magnesium protoporphyrin IX methyltransferase from Synechocystis PCC6803. | 2003 | Biochem. J. | pmid:12489983 |
| Hartshorn RT and Moore GR | A denaturation-induced proton-uptake study of horse ferricytochrome c. | 1989 | Biochem. J. | pmid:2539812 |
| Tonge P et al. | Fourier-transform infra-red studies of the alkaline isomerization of mitochondrial cytochrome c and the ionization of carboxylic acids. | 1989 | Biochem. J. | pmid:2539813 |
| Baird GD et al. | Net hepatic and splanchnic metabolism of lactate, pyruvate and propionate in dairy cows in vivo in relation to lactation and nutrient supply. | 1980 | Biochem. J. | pmid:6989361 |
| Girvan HM et al. | Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3. | 2010 | Biochem. J. | pmid:20180779 |
| Ryan JP and Ryan H | The role of intracellular pH in the regulation of cation exchanges in yeast. | 1972 | Biochem. J. | pmid:4563763 |
| Malaisse WJ et al. | Enzyme-to-enzyme channelling of Krebs cycle metabolic intermediates in Caco-2 cells exposed to [2-13c]propionate. | 1996 | Biochem. J. | pmid:8760374 |
| Srinivas SR et al. | Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). | 2005 | Biochem. J. | pmid:16104846 |
| Black KM et al. | Conserved tryptophan in cytochrome c: importance of the unique side-chain features of the indole moiety. | 2001 | Biochem. J. | pmid:11672447 |
| Hayakawa S et al. | Microbiological degradation of bile acids. Nitrogenous hexahydroindane derivatives formed from cholic acid by Streptomyces rubescens. | 1976 | Biochem. J. | pmid:1016253 |
| Hiltunen JK | Metabolic effects of pent-4-enoate in isolated perfused rat heart. | 1978 | Biochem. J. | pmid:637839 |
| Lomax MA et al. | The effect of fatty acids and starvation on the metabolism of gluconeogenic precursors by isolated sheep liver cells. | 1986 | Biochem. J. | pmid:3827848 |
| Akif M et al. | Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide. | 2011 | Biochem. J. | pmid:21352096 |
| Hiltunen JK et al. | Isolated rat heart mitochondria are able to metabolize pent-4-enoate to tricarboxylic acid-cycle intermediates. | 1980 | Biochem. J. | pmid:7470030 |
| Shepherd M and Hunter CN | Transient kinetics of the reaction catalysed by magnesium protoporphyrin IX methyltransferase. | 2004 | Biochem. J. | pmid:15239672 |
| Giudici TA et al. | Methylmalonic and propionic acidemias: lipid profiles of normal and affected human skin fibroblasts incubated with [1-14C]propionate. | 1986 | Biochem. Med. Metab. Biol. | pmid:2872907 |
| Marsden D et al. | Anabolic effect of human growth hormone: management of inherited disorders of catabolic pathways. | 1994 | Biochem. Med. Metab. Biol. | pmid:7993663 |
| Michalik M and Bryła J | Inhibitory effect of gentamicin on gluconeogenesis from pyruvate, propionate, and lactate in isolated rabbit kidney-cortex tubules. | 1987 | Biochem. Med. Metab. Biol. | pmid:3663396 |
| Dutra JC et al. | Effects of methylmalonate and propionate on uptake of glucose and ketone bodies in vitro by brain of developing rats. | 1991 | Biochem. Med. Metab. Biol. | pmid:2015109 |
| de Mello CF et al. | Effects of methylmalonate and propionate on [3H]glutamate binding, adenylate cyclase activity and lipid synthesis in rat cerebral cortex. | 1997 | Biochem. Mol. Biol. Int. | pmid:9305532 |
| Larrey D et al. | Effects of erythromycin on hepatic drug-metabolizing enzymes in humans. | 1983 | Biochem. Pharmacol. | pmid:6838653 |
| Wang H et al. | Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen. | 2011 | Biochem. Pharmacol. | pmid:21856293 |
| Larrey D et al. | Formation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats. | 1983 | Biochem. Pharmacol. | pmid:6860368 |
| Otagiri M et al. | Binding of pirprofen to human serum albumin studied by dialysis and spectroscopy techniques. | 1989 | Biochem. Pharmacol. | pmid:2910295 |
| Nambi P et al. | Induction of functional beta-adrenergic receptors in rat aortic smooth muscle cells by sodium butyrate. | 1986 | Biochem. Pharmacol. | pmid:3022740 |
| Krahenbuhl S and Brass EP | Inhibition of hepatic propionyl-CoA synthetase activity by organic acids. Reversal of propionate inhibition of pyruvate metabolism. | 1991 Mar 15-Apr 1 | Biochem. Pharmacol. | pmid:2009071 |
| Muramatsu M et al. | Enhancement of affinity to receptors in the esterified glucocorticoid, hydrocortisone 17-butyrate 21-propionate (HBP), in the rat liver. | 1986 | Biochem. Pharmacol. | pmid:3718538 |
| Sumegi B et al. | Is there tight channelling in the tricarboxylic acid cycle metabolon? | 1991 | Biochem. Soc. Trans. | pmid:1794455 |
| Murphy EJ et al. | Engineering the substrate specificity and reactivity of a heme protein: creation of an ascorbate binding site in cytochrome c peroxidase. | 2008 | Biochemistry | pmid:19061385 |
| Busse SC and Jue T | Two-dimensional NMR characterization of the deoxymyoglobin heme pocket. | 1994 | Biochemistry | pmid:8086410 |
| Sherry AD et al. | Orientation-conserved transfer of symmetric Krebs cycle intermediates in mammalian tissue. | 1994 | Biochemistry | pmid:7910760 |
| LeMagueres P et al. | Crystal structure at 1.45 A resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms. | 2003 | Biochemistry | pmid:14674749 |
| de Vitry C et al. | Biochemical and spectroscopic characterization of the covalent binding of heme to cytochrome b6. | 2004 | Biochemistry | pmid:15049703 |
| Ibrahim M et al. | Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. | 2010 | Biochemistry | pmid:20459051 |
| Ren Y et al. | Mapping the electron transfer interface between cytochrome b5 and cytochrome c. | 2004 | Biochemistry | pmid:15035623 |
| Louie GV et al. | Role of phenylalanine-82 in yeast iso-1-cytochrome c and remote conformational changes induced by a serine residue at this position. | 1988 | Biochemistry | pmid:2849996 |
| Manna SK and Mazumdar S | Role of threonine 101 on the stability of the heme active site of cytochrome P450cam: multiwavelength circular dichroism studies. | 2006 | Biochemistry | pmid:17042489 |
| Seibold SA et al. | Water chain formation and possible proton pumping routes in Rhodobacter sphaeroides cytochrome c oxidase: a molecular dynamics comparison of the wild type and R481K mutant. | 2005 | Biochemistry | pmid:16060656 |
| Haller T et al. | Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli. | 2000 | Biochemistry | pmid:10769117 |
| Meharenna YT et al. | Engineering ascorbate peroxidase activity into cytochrome c peroxidase. | 2008 | Biochemistry | pmid:18771292 |
| Timkovich R et al. | 1H NMR spectroscopy of Paracoccus denitrificans cytochrome c-550. | 1984 | Biochemistry | pmid:6087896 |
| Tran R et al. | Determinants of the heme-CO vibrational modes in the H-NOX family. | 2011 | Biochemistry | pmid:21714509 |
| Nagai M et al. | Heme structure of hemoglobin M Iwate [alpha 87(F8)His-->Tyr]: a UV and visible resonance Raman study. | 2000 | Biochemistry | pmid:11052661 |
| Santucci R et al. | Anion size modulates the structure of the A state of cytochrome c. | 2000 | Biochemistry | pmid:11027143 |
| Yoshimura H et al. | Specific hydrogen-bonding networks responsible for selective O2 sensing of the oxygen sensor protein HemAT from Bacillus subtilis. | 2006 | Biochemistry | pmid:16819829 |
| Hellwig P et al. | Electrochemical, FTIR, and UV/VIS spectroscopic properties of the ba(3) oxidase from Thermus thermophilus. | 1999 | Biochemistry | pmid:10423243 |
| Sakurai M et al. | Glutamate 325 is a general acid-base catalyst in the reaction catalyzed by fructose-2,6-bisphosphatase. | 2000 | Biochemistry | pmid:11123954 |
| Mikami S et al. | Effect of the redox-dependent ionization state of the heme propionic acid side chain on the entropic contribution to the redox potential of Pseudomonas aeruginosa cytochrome c551. | 2009 | Biochemistry | pmid:19627115 |
| Nakamura S et al. | Structure of cytochrome c552 from a moderate thermophilic bacterium, Hydrogenophilus thermoluteolus: comparative study on the thermostability of cytochrome c. | 2006 | Biochemistry | pmid:16681384 |
| Mauk MR et al. | Electrostatic analysis of the interaction of cytochrome c with native and dimethyl ester heme substituted cytochrome b5. | 1986 | Biochemistry | pmid:3026446 |
| Chao YY et al. | 1H NMR and ESR studies of oxidized cytochrome c551 from Pseudomonas aeruginosa. | 1979 | Biochemistry | pmid:33701 |
| Peng D et al. | Role of propionates in substrate binding to heme oxygenase from Neisseria meningitidis: a nuclear magnetic resonance study. | 2012 | Biochemistry | pmid:22913621 |
| Timkovich R and Cork MS | Proton NMR spectroscopy of cytochrome c-554 from Alcaligenes faecalis. | 1984 | Biochemistry | pmid:6324856 |
| Cutler RL et al. | Role of arginine-38 in regulation of the cytochrome c oxidation-reduction equilibrium. | 1989 | Biochemistry | pmid:2545252 |
| Peyton DH et al. | Proton nuclear magnetic resonance study of the molecular and electronic structure of the heme cavity in Aplysia cyanometmyoglobin. | 1989 | Biochemistry | pmid:2548594 |
| Liu GY et al. | Ionic strength dependence of cytochrome c structure and Trp-59 H/D exchange from ultraviolet resonance Raman spectroscopy. | 1989 | Biochemistry | pmid:2548599 |
| Shokhireva TKh et al. | Assignment of heme resonances and determination of the electronic structures of high- and low-spin nitrophorin 2 by 1H and 13C NMR spectroscopy: an explanation of the order of heme methyl resonances in high-spin ferriheme proteins. | 2003 | Biochemistry | pmid:12534280 |
| Balland V et al. | Functional implications of the propionate 7-arginine 220 interaction in the FixLH oxygen sensor from Bradyrhizobium japonicum. | 2006 | Biochemistry | pmid:16475796 |
| Rosenfeld RJ et al. | Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. | 2002 | Biochemistry | pmid:12437348 |
| Omura S et al. | Studies on the biosynthesis of 16-membered macrolide antibiotics using carbon-13 nuclear magnetic resonance spectroscopy. | 1977 | Biochemistry | pmid:18162 |
| Wilson DF and Forman NG | Mitochondrial transmembrane pH and electrical gradients: evaluation of their energy relationships with respiratory rate and adenosine 5'-triphosphate synthesis. | 1982 | Biochemistry | pmid:7074098 |
| Wang J et al. | Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network. | 2006 | Biochemistry | pmid:16388581 |
| Stellwagen E and Babul J | Stabilization of the globular structure of ferricytochrome c by chloride in acidic solvents. | 1975 | Biochemistry | pmid:41 |
| Mileni M et al. | Probing heme propionate involvement in transmembrane proton transfer coupled to electron transfer in dihemic quinol:fumarate reductase by 13C-labeling and FTIR difference spectroscopy. | 2005 | Biochemistry | pmid:16342962 |
| Mascaretti OA et al. | Biosynthesis of the macrolide antibiotic chlorothricin. | 1981 | Biochemistry | pmid:7011379 |
| Mimura K et al. | Isolation of stable (alphabeta)4-Tetraprotomer from Na+/K+-ATPase solubilized in the presence of short-chain fatty acids. | 2008 | Biochemistry | pmid:18465843 |
| Baddam S and Bowler BE | Thermodynamics and kinetics of formation of the alkaline state of a Lys 79-->Ala/Lys 73-->His variant of iso-1-cytochrome c. | 2005 | Biochemistry | pmid:16274242 |
| Lee HJ et al. | Properties of Arg481 mutants of the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that neither R481 nor the nearby D-propionate of heme a3 is likely to be the proton loading site of the proton pump. | 2009 | Biochemistry | pmid:19575527 |
| Barrows TP and Poulos TL | Role of electrostatics and salt bridges in stabilizing the compound I radical in ascorbate peroxidase. | 2005 | Biochemistry | pmid:16245922 |
| Frydman RB et al. | Specificity of heme oxygenase: a study with synthetic hemins. | 1981 | Biochemistry | pmid:6895313 |
| Behr J et al. | Functional properties of the heme propionates in cytochrome c oxidase from Paracoccus denitrificans. Evidence from FTIR difference spectroscopy and site-directed mutagenesis. | 2000 | Biochemistry | pmid:10684616 |
| Delker SL et al. | Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase . | 2010 | Biochemistry | pmid:21138269 |
| Brändén G et al. | The protonation state of a heme propionate controls electron transfer in cytochrome c oxidase. | 2005 | Biochemistry | pmid:16060655 |
| Mills DA et al. | An arginine to lysine mutation in the vicinity of the heme propionates affects the redox potentials of the hemes and associated electron and proton transfer in cytochrome c oxidase. | 2005 | Biochemistry | pmid:16060654 |
| Stayton PS et al. | Putidaredoxin competitively inhibits cytochrome b5-cytochrome P-450cam association: a proposed molecular model for a cytochrome P-450cam electron-transfer complex. | 1989 | Biochemistry | pmid:2690937 |
| Harada K et al. | Structure and ligand binding properties of myoglobins reconstituted with monodepropionated heme: functional role of each heme propionate side chain. | 2007 | Biochemistry | pmid:17636874 |
| Andrews H et al. | Expression, mutagenesis, and characterization of recombinant low-potential cytochrome c550 of photosystem II. | 2005 | Biochemistry | pmid:15835898 |
| Zarić SD et al. | Factors determining the orientation of axially coordinated imidazoles in heme proteins. | 2001 | Biochemistry | pmid:11425320 |
| Evans HJ and Wood HG | Purification and properties of pyruvate phosphate dikinase from propionic acid bacteria. | 1971 | Biochemistry | pmid:5544662 |
| Takayama SJ et al. | Control of the redox potential of Pseudomonas aeruginosa cytochrome c551 through the Fe-Met coordination bond strength and pKa of a buried heme propionic acid side chain. | 2005 | Biochemistry | pmid:15807542 |
| Key J and Moffat K | Crystal structures of deoxy and CO-bound bjFixLH reveal details of ligand recognition and signaling. | 2005 | Biochemistry | pmid:15779889 |
| Zhang H et al. | Characterization of the high-spin heme x in the cytochrome b6f complex of oxygenic photosynthesis. | 2004 | Biochemistry | pmid:15610027 |
| Schrimsher JL and Taylor KB | Octopine dehydrogenase from Pecten maximus: steady-state mechanism. | 1984 | Biochemistry | pmid:6722094 |
| Mendoza MF et al. | Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups. | 2012 | Biochemistry | pmid:22989153 |
| Shang L et al. | Biliverdin amides reveal roles for propionate side chains in bilin reductase recognition and in holophytochrome assembly and photoconversion. | 2010 | Biochemistry | pmid:20565135 |