| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Sarcoma, Experimental | D012513 | 13 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Dermatitis, Occupational | D009783 | 12 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
propionic acid
propionic acid is a lipid of Fatty Acyls (FA) class. Propionic acid is associated with abnormalities such as Epilepsy, Infection, Tuberculosis, Alkalosis and Ischemia. The involved functions are known as Uptake, Biosynthetic Pathways, Methylation, Protein Overexpression and Biochemical Pathway. Propionic acid often locates in Body tissue, Cytoplasmic matrix, Membrane, Protoplasm and Extracellular. The associated genes with propionic acid are TRIO gene, TRRAP gene, SLC5A8 gene, SLC33A1 gene and Homologous Gene. The related lipids are Fatty Acids, Propionate, butyrate, Valerates and mycocerosic acid.
Cross Reference
Introduction
To understand associated biological information of propionic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with propionic acid?
propionic acid is suspected in Propionic acidemia, Ischemia, Infection, Ulcerative Colitis, Alkalosis, Methylmalonic acidemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with propionic acid
PubChem Associated disorders and diseases
What pathways are associated with propionic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with propionic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with propionic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with propionic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with propionic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with propionic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with propionic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stankovics J and Ledley FD | Cloning of functional alpha propionyl CoA carboxylase and correction of enzyme deficiency in pccA fibroblasts. | 1993 | Am. J. Hum. Genet. | pmid:8434582 |
| Pirson Y and van Ypersele de Strihou C | Renal side effects of nonsteroidal antiinflammatory drugs: clinical relevance. | 1986 | Am. J. Kidney Dis. | pmid:3538858 |
| Van Hove JL et al. | Cobalamin disorder Cbl-C presenting with late-onset thrombotic microangiopathy. | 2002 | Am. J. Med. Genet. | pmid:12210350 |
| Van Calcar SC et al. | Case reports of successful pregnancy in women with maple syrup urine disease and propionic acidemia. | 1992 | Am. J. Med. Genet. | pmid:1481826 |
| Werlin SL | E. coli sepsis as a presenting sign in neonatal propionic acidemia. | 1993 | Am. J. Med. Genet. | pmid:8357022 |
| Shih VE et al. | Defective lysosomal release of vitamin B12 (cb1F): a hereditary cobalamin metabolic disorder associated with sudden death. | 1989 | Am. J. Med. Genet. | pmid:2596518 |
| Gilmore A et al. | Hyperamylasemia/hyperlipasemia in a child with propionic acidemia. | 2008 | Am. J. Med. Genet. A | pmid:19006211 |
| Morrow G et al. | Propionate metabolism in fetal livers of 15 to 19 weeks' gestation. | 1975 | Am. J. Obstet. Gynecol. | pmid:1115133 |
| ALTER RL et al. | The treatment of mycotic vulvovaginitis with propionate vaginal jelly. | 1947 | Am. J. Obstet. Gynecol. | pmid:20286636 |
| Williams ZR et al. | Late onset optic neuropathy in methylmalonic and propionic acidemia. | 2009 | Am. J. Ophthalmol. | pmid:19243738 |
| Clark DA et al. | Contribution of oxygen-derived free radicals to experimental necrotizing enterocolitis. | 1988 | Am. J. Pathol. | pmid:3348358 |
| Graber ML et al. | Fluorescence identifies an alkaline cell in turtle urinary bladder. | 1986 | Am. J. Physiol. | pmid:3942220 |
| Di Lisa F et al. | Contrasting effects of propionate and propionyl-L-carnitine on energy-linked processes in ischemic hearts. | 1994 | Am. J. Physiol. | pmid:8067396 |
| Bidani A and Heming TA | Kinetic analysis of cytosolic pH regulation in alveolar macrophages: V-ATPase-mediated responses to a weak acid. | 1995 | Am. J. Physiol. | pmid:7631810 |
| Garvey MH and Maude DL | Acid excretion by bicarbonate-free perfused rat kidney. | 1981 | Am. J. Physiol. | pmid:6784580 |
| Harada E and Kato S | Effect of short-chain fatty acids on the secretory response of the ovine exocrine pancreas. | 1983 | Am. J. Physiol. | pmid:6187225 |
| Leffler CW et al. | cAMP production by piglet cerebral vascular smooth muscle cells: pH(o), pH(i), and permissive action of PGI(2). | 1999 | Am. J. Physiol. | pmid:10564143 |
| El-Sharkaway TY and Daniel EE | Ionic mechanisms of intestinal electrical control activity. | 1975 | Am. J. Physiol. | pmid:1200148 |
| Conn AR and Steele RD | Transport of alpha-keto analogues of amino acids across blood-brain barrier in rats. | 1982 | Am. J. Physiol. | pmid:6751096 |
| Della-Fera MA et al. | Central nervous system injection of dynorphin-(1-13) overrides gastric satiety factors in sheep. | 1990 | Am. J. Physiol. | pmid:1970458 |
| Grinstein S et al. | Amiloride-sensitive Na+-H+ exchange in platelets and leukocytes: detection by electronic cell sizing. | 1984 | Am. J. Physiol. | pmid:6089580 |
| Nutting CW et al. | Vasorelaxant effects of short chain fatty acid salts in rat caudal artery. | 1991 | Am. J. Physiol. | pmid:1877681 |
| de Hemptinne A et al. | Influence of organic acids on intracellular pH. | 1983 | Am. J. Physiol. | pmid:6614155 |
| Conn AR et al. | Characterization of alpha-keto acid transport across blood-brain barrier in rats. | 1983 | Am. J. Physiol. | pmid:6614164 |
| Petersen KU and Reuss L | Electrophysiological effects of propionate and bicarbonate on gallbladder epithelium. | 1985 | Am. J. Physiol. | pmid:2981476 |
| Harada E et al. | Potentiation of carbachol-induced amylase release by propionate in guinea pig and vole pancreatic acini. | 1999 | Am. J. Physiol. | pmid:10484494 |
| Rabinowitz L et al. | Effects of glucagon, insulin, propionate, acetate, and HCO3 on K excretion in sheep. | 1984 | Am. J. Physiol. | pmid:6320683 |
| Leclerc J et al. | Metabolism of R-beta-hydroxypentanoate and of beta-ketopentanoate in conscious dogs. | 1995 | Am. J. Physiol. | pmid:7900792 |
| Wall SM and Koger LM | NH+4 transport mediated by Na(+)-K(+)-ATPase in rat inner medullary collecting duct. | 1994 | Am. J. Physiol. | pmid:7943362 |
| Feldman GM et al. | Propionate induces cell swelling and K+ accumulation in shark rectal gland. | 1989 | Am. J. Physiol. | pmid:2548391 |
| Rowe WA et al. | Propionate activates multiple ion transport mechanisms in the HT29-18-C1 human colon cell line. | 1993 | Am. J. Physiol. | pmid:8214077 |
| Graber M et al. | Acetazolamide inhibits acidification by the turtle bladder independent of cell pH. | 1989 | Am. J. Physiol. | pmid:2541630 |
| Montrose MH et al. | Separate control of regulatory volume increase and Na+-H+ exchange by cultured renal cells. | 1988 | Am. J. Physiol. | pmid:2839037 |
| Harris JB et al. | Lipoate effect on carbohydrate and lipid metabolism and gastric H+ secretion. | 1975 | Am. J. Physiol. | pmid:1090192 |
| Pi-Sunyer FX et al. | Glucagon, insulin, and gluconeogenesis in fasted odd carbon fatty acid-enriched rats. | 1976 | Am. J. Physiol. | pmid:961887 |
| Ritucci NA et al. | Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive areas of the medulla. | 1998 | Am. J. Physiol. | pmid:9756546 |
| Keifer DW | Effect of weak acids on pH regulation and anion transport in barnacle muscle fibers. | 1981 | Am. J. Physiol. | pmid:7304732 |
| Parfenova H and Leffler CW | Effects of hypercapnia on prostanoid and cAMP production by cerebral microvascular cell cultures. | 1996 | Am. J. Physiol. | pmid:8967453 |
| Ho AK et al. | Intracellular pH on adrenergic-stimulated cAMP and cGMP production in rat pinealocytes. | 1991 | Am. J. Physiol. | pmid:1656768 |
| Toda N | Mechanical responses of isolated dog cerebral arteries to reduction of external K, Na, and Cl. | 1978 | Am. J. Physiol. | pmid:645879 |
| Grinstein S and Furuya W | Characterization of the amiloride-sensitive Na+-H+ antiport of human neutrophils. | 1986 | Am. J. Physiol. | pmid:3953781 |
| Szczepańska M and Angielski S | Prevention of maleate-induced tubular dysfunction by acetoacetate. | 1980 | Am. J. Physiol. | pmid:7395994 |
| Sellin JH and De Soignie R | Ionic regulation of Na absorption in proximal colon: cation inhibition of electroneutral Na absorption. | 1987 | Am. J. Physiol. | pmid:3812678 |
| Forte JG et al. | Substrate dependency for HCl secretion by isolated piglet gastric mucosa. | 1980 | Am. J. Physiol. | pmid:7377308 |
| Mariadason JM et al. | Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model. | 1997 | Am. J. Physiol. | pmid:9142899 |
| Yamaji Y et al. | Intracellular acidosis activates c-Src. | 1997 | Am. J. Physiol. | pmid:9124524 |
| Suarez-Kurtz G and Eastwood AB | Release of sarcoplasmic enzymes from frog skeletal muscle. | 1981 | Am. J. Physiol. | pmid:6792928 |
| Hsu P et al. | Mechanisms of hypercapnia-stimulated PG production in piglet cerebral microvascular endothelial cells. | 1995 | Am. J. Physiol. | pmid:7864184 |
| Rojas-GarcÃa PP et al. | Prenatal testosterone excess alters Sertoli and germ cell number and testicular FSH receptor expression in rams. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20858754 |
| Cohen DM et al. | Glutamine cycling in isolated working rat heart. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12944323 |
| Martini WZ et al. | Quantitative assessment of anaplerosis from propionate in pig heart in vivo. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12388135 |
| Jones JG et al. | An integrated (2)H and (13)C NMR study of gluconeogenesis and TCA cycle flux in humans. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11551863 |
| King AJ et al. | Hypertension caused by prenatal testosterone excess in female sheep. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17327368 |
| Jin ES et al. | Evidence for reverse flux through pyruvate kinase in skeletal muscle. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19190256 |
| Wilson KA et al. | Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism. | 2017 | Am. J. Physiol. Endocrinol. Metab. | pmid:28634175 |
| Musch MW et al. | SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11254495 |
| Aschenbach JR et al. | Bicarbonate-dependent and bicarbonate-independent mechanisms contribute to nondiffusive uptake of acetate in the ruminal epithelium of sheep. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19264953 |
| Tyagi S et al. | Mechanism of n-butyrate uptake in the human proximal colonic basolateral membranes. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11897627 |
| Cremin JD et al. | Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12637251 |
| Hadjiagapiou C et al. | Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11005765 |
| Parhar K et al. | Short-chain fatty acid mediated phosphorylation of heat shock protein 25: effects on camptothecin-induced apoptosis. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16469826 |
| Andriamihaja M et al. | Colon luminal content and epithelial cell morphology are markedly modified in rats fed with a high-protein diet. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20689060 |
| Cuche G et al. | Desensitization of ileal vagal receptors by short-chain fatty acids in pigs. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11292611 |
| Grider JR and Piland BE | The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16973914 |
| Spitzer KW et al. | Generation of intracellular pH gradients in single cardiac myocytes with a microperfusion system. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10749735 |
| Purmal C et al. | Propionate stimulates pyruvate oxidation in the presence of acetate. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:25320331 |
| Carvalho RA et al. | TCA cycle kinetics in the rat heart by analysis of (13)C isotopomers using indirect (1)H. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11514314 |
| Nomura N et al. | CaMKII-dependent reactivation of SR Ca(2+) uptake and contractile recovery during intracellular acidosis. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12063291 |
| Ragavan M et al. | A comprehensive analysis of myocardial substrate preference emphasizes the need for a synchronized fluxomic/metabolomic research design. | 2017 | Am. J. Physiol. Heart Circ. Physiol. | pmid:28411229 |
| Maouyo D et al. | pH heterogeneity at intracellular and extracellular plasma membrane sites in HT29-C1 cell monolayers. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10794671 |
| Stewart G et al. | Mouse GPR40 heterologously expressed in Xenopus oocytes is activated by short-, medium-, and long-chain fatty acids. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16267104 |
| Kisidayová S et al. | Effects of high- and low-fiber diets on fecal fermentation and fecal microbial populations of captive chimpanzees. | 2009 | Am. J. Primatol. | pmid:19367605 |
| Ushida K et al. | Nutritional significance of the selective ingestion of Albizia zygia gum exudate by wild chimpanzees in Bossou, Guinea. | 2006 | Am. J. Primatol. | pmid:16429414 |
| Ziprin RL et al. | Colonization control of lactose-fermenting Salmonella typhimurium in young broiler chickens by use of dietary lactose. | 1991 | Am. J. Vet. Res. | pmid:1883086 |
| Owens SW et al. | Developmental alterations in the regulation of glucagon and insulin secretion in Holstein calves. | 1986 | Am. J. Vet. Res. | pmid:3513676 |
| De Buysscher EV and Berman DT | Isolation of porcine secretory immunoglobulin A by affinity chromatography and determination of its component chains. | 1975 | Am. J. Vet. Res. | pmid:811140 |
| Brosey BP et al. | Gastrointestinal volatile fatty acid concentrations and pH in cats. | 2000 | Am. J. Vet. Res. | pmid:10772097 |
| Horton GM | Manipulating energy metabolism in sheep exposed to cold. | 1981 | Am. J. Vet. Res. | pmid:7224309 |
| van den Bogaard AE et al. | Rapid presumptive diagnosis of anaerobic infections in animals by gas-liquid chromatography. | 1989 | Am. J. Vet. Res. | pmid:2679251 |
| Mcmanus CM et al. | Effect of short-chain fatty acids on contraction of smooth muscle in the canine colon. | 2002 | Am. J. Vet. Res. | pmid:11843133 |
| Ward GE and Nelson DI | Effects of dietary milk fat (whole milk) and propionic acid on intestinal coliforms and lactobacilli in calves. | 1982 | Am. J. Vet. Res. | pmid:7049020 |
| Nadeau JA et al. | Evaluation of diet as a cause of gastric ulcers in horses. | 2000 | Am. J. Vet. Res. | pmid:10895901 |
| Horton GM and Stockdale PH | Lasalocid and monensin in finishing diets for early weaned lambs with naturally occurring coccidiosis. | 1981 | Am. J. Vet. Res. | pmid:7271008 |
| Bruss ML et al. | Hepatic morphology and effects of intravenous injection of sodium propionate on plasma propionate and glucose in fed and fasted dairy cattle. | 1986 | Am. J. Vet. Res. | pmid:3954216 |
| Gröhn Y et al. | Propionate loading test for liver function during experimental liver necrosis in sheep. | 1985 | Am. J. Vet. Res. | pmid:4014846 |
| Nadeau JA et al. | Effects of hydrochloric, acetic, butyric, and propionic acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses. | 2003 | Am. J. Vet. Res. | pmid:12693528 |
| Mills SW et al. | Evaluation of the effects of short-chain fatty acids and extracellular pH on bovine neutrophil function in vitro. | 2006 | Am. J. Vet. Res. | pmid:17078753 |
| Merritt AM and Smith DA | Osmolarity and volatile fatty acid content of feces from horses with chronic diarrhea. | 1980 | Am. J. Vet. Res. | pmid:7436082 |
| Nagaraja TG et al. | Effect of ionophore antibiotics on experimentally induced lactic acidosis in cattle. | 1985 | Am. J. Vet. Res. | pmid:4083576 |
| Hand WL et al. | Uptake of antibiotics by human alveolar macrophages. | 1984 | Am. Rev. Respir. Dis. | pmid:6732052 |
| He Q et al. | Metabolomic analysis of the response of growing pigs to dietary L-arginine supplementation. | 2009 | Amino Acids | pmid:18989615 |
| Mathioudakis D et al. | Pyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production. | 2011 | Amino Acids | pmid:20839016 |
| Guo GB and Xu CS | Expression profiles of the organic acid metabolism-associated genes during rat liver regeneration. | 2008 | Amino Acids | pmid:18095055 |
| Sanz S et al. | [Ketotic hiperglycinemia: one case of possible propionic acidemia (author's transl)]. | 1978 | An. Esp. Pediatr. | pmid:418714 |
| Casado de FrÃas E et al. | [Treatment of juvenile rheumatoid arthritis (author's transl)]. | 1981 | An. Esp. Pediatr. | pmid:7316291 |
| Gutierrez-Bañuelos H et al. | Zoonotic bacterial populations, gut fermentation characteristics and methane production in feedlot steers during oral nitroethane treatment and after the feeding of an experimental chlorate product. | 2007 | Anaerobe | pmid:17208022 |
| Bonos E et al. | The influence of mannan oligosaccharides, acidifiers and their combination on caecal microflora of Japanese quail (Coturnix japonica). | 2011 | Anaerobe | pmid:21621628 |
| Strompfová V et al. | Enterococcus faecium EK13--an enterocin a-producing strain with probiotic character and its effect in piglets. | 2006 Oct-Dec | Anaerobe | pmid:17071114 |
| Purwani EY et al. | Fermentation RS3 derived from sago and rice starch with Clostridium butyricum BCC B2571 or Eubacterium rectale DSM 17629. | 2012 | Anaerobe | pmid:21979490 |
| Connolly ML et al. | In vitro evaluation of the microbiota modulation abilities of different sized whole oat grain flakes. | 2010 | Anaerobe | pmid:20624475 |