Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
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What lipids are associated with Lipoxin A4?
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
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What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| DoÄŸan B et al. | Lipoxin A4 and Neutrophil/Lymphocyte Ratio: A Possible Indicator in Achieved Systemic Risk Factors for Periodontitis. | 2015 | Med. Sci. Monit. | pmid:26298769 |
| Lehmann C et al. | Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein. | 2015 | FASEB J. | pmid:26289316 |
| Roach KM et al. | Lipoxin A4 Attenuates Constitutive and TGF-β1-Dependent Profibrotic Activity in Human Lung Myofibroblasts. | 2015 | J. Immunol. | pmid:26276873 |
| Sha YH et al. | Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXRα signaling pathway in THP-1 macrophage-derived foam cells. | 2015 | Int J Clin Exp Pathol | pmid:26261553 |
| Yuan ZX and Rapoport SI | Transient postnatal fluoxetine decreases brain concentrations of 20-HETE and 15-epi-LXA4, arachidonic acid metabolites in adult mice. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26234927 |
| Herrera BS et al. | LXA4 actions direct fibroblast function and wound closure. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26188508 |
| Fang X et al. | Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4. | 2015 | J. Immunol. | pmid:26116507 |
| Ramirez JL et al. | A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. | 2015 | Nat Commun | pmid:26100162 |
| Awji EG et al. | Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25137396 |
| Dunn HC et al. | Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. | 2015 | J. Alzheimers Dis. | pmid:25125468 |
| Meng F et al. | Attenuation of lipopolysaccharide-induced lung vascular stiffening by lipoxin reduces lung inflammation. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:24992633 |
| Wenceslau CF et al. | Lipoxin A4 mediates aortic contraction via RHOA/RHO kinase, endothelial dysfunction and reactive oxygen species. | 2014 | J. Vasc. Res. | pmid:25612650 |
| Polavarapu S et al. | Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. | 2014 | PLoS ONE | pmid:25536345 |
| Zimring JC | The fat and the skinny on acute lung injury. | 2014 | Blood | pmid:25342661 |
| Martini AC et al. | Neuroprotective effects of lipoxin A4 in central nervous system pathologies. | 2014 | Biomed Res Int | pmid:25276776 |
| Esquivias P et al. | Effect of aspirin treatment on the prevention of esophageal adenocarcinoma in a rat experimental model. | 2014 | Oncol. Rep. | pmid:24737143 |
| Yang F et al. | Regional arterial infusion with lipoxin A4 attenuates experimental severe acute pancreatitis. | 2014 | PLoS ONE | pmid:25265022 |
| Ono E et al. | Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25162465 |
| Ortiz-Muñoz G et al. | Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. | 2014 | Blood | pmid:25143486 |
| Andersson P et al. | Inhibition of neutrophil-dependent cytotoxicity for human endothelial cells by ACE inhibitors. | 2014 | Scand. J. Immunol. | pmid:25124788 |
| Wu R et al. | Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway. | 2014 | Br. J. Pharmacol. | pmid:24923883 |
| Zhou XL et al. | Protective effects of lipoxin A4 in testis injury following testicular torsion and detorsion in rats. | 2014 | Mediators Inflamm. | pmid:24904198 |
| Martin CR et al. | Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. | 2014 | PLoS ONE | pmid:24892762 |
| Tani Y et al. | Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice. | 2014 | FASEB J. | pmid:24891522 |
| Wu H et al. | Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. | 2014 | PLoS ONE | pmid:24671173 |
| Kumar R et al. | Lipoxin Aâ‚„ prevents the progression of de novo and established endometriosis in a mouse model by attenuating prostaglandin Eâ‚‚ production and estrogen signaling. | 2014 | PLoS ONE | pmid:24587003 |
| Zhao Q et al. | LipoxinA4 attenuates myocardial ischemia reperfusion injury via a mechanism related to downregulation of GRP-78 and caspase-12 in rats. | 2014 | Heart Vessels | pmid:24129401 |
| Yao C et al. | Aspirin-triggered lipoxin A4 attenuates lipopolysaccharide induced inflammatory response in primary astrocytes. | 2014 | Int. Immunopharmacol. | pmid:24269179 |
| Ramon S et al. | Lipoxin Aâ‚„ modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism. | 2014 | Eur. J. Immunol. | pmid:24166736 |
| Xu Z et al. | Preeclampsia is associated with a deficiency of lipoxin A4, an endogenous anti-inflammatory mediator. | 2014 | Fertil. Steril. | pmid:24796762 |
| Chen S et al. | Lipoxin A4 regulates expression of the estrogen receptor and inhibits 17β-estradiol induced p38 mitogen-activated protein kinase phosphorylation in human endometriotic stromal cells. | 2014 | Fertil. Steril. | pmid:24835059 |
| Nanhwan MK et al. | Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:25012137 |
| Li C et al. | Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. | 2014 | J. Exp. Med. | pmid:24395886 |
| Ballesteros I et al. | Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPARγ and 5-LO-dependent pathways. | 2014 | J. Leukoc. Biol. | pmid:24338629 |
| Eke Gungor H et al. | Decreased levels of lipoxin A4 and annexin A1 in wheezy infants. | 2014 | Int. Arch. Allergy Immunol. | pmid:24525704 |
| Osuchowski MF | Tender mediation in a ruthless environment: can lipoxins provide lifesaving modifications to fatally deregulated immunoinflammatory responses in sepsis?*. | 2014 | Crit. Care Med. | pmid:24633114 |
| Leo LM et al. | Age-dependent relevance of endogenous 5-lipoxygenase derivatives in anxiety-like behavior in mice. | 2014 | PLoS ONE | pmid:24416334 |
| Hamza B et al. | Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels. | 2014 | Integr Biol (Camb) | pmid:24419464 |
| Ueda T et al. | Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis*. | 2014 | Crit. Care Med. | pmid:24463858 |
| Higgins G et al. | Activation of P2RY11 and ATP release by lipoxin A4 restores the airway surface liquid layer and epithelial repair in cystic fibrosis. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24588705 |
| Zhang D et al. | Glucocorticoids sensitize rat placental inflammatory responses via inhibiting lipoxin A4 biosynthesis. | 2014 | Biol. Reprod. | pmid:24571985 |
| Tateishi N et al. | Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin Aâ‚„ contents in colon, but does not affect severity or prostaglandin Eâ‚‚ content in murine colitis model. | 2014 | Lipids Health Dis | pmid:24507383 |
| Fischer CD et al. | Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production. | 2014 | Antimicrob. Agents Chemother. | pmid:24820086 |
| Ringholz FC et al. | Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis. | 2014 | Eur. Respir. J. | pmid:24696116 |
| Chen XQ et al. | Involvement of K+ channel-dependant pathways in lipoxin A4-induced protective effects on hypoxia/reoxygenation injury of cardiomyocytes. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23602847 |
| Planagumà A et al. | Lack of activity of 15-epi-lipoxin A₄ on FPR2/ALX and CysLT1 receptors in interleukin-8-driven human neutrophil function. | 2013 | Clin. Exp. Immunol. | pmid:23607720 |
| Shryock N et al. | Lipoxin A₄ and 15-epi-lipoxin A₄ protect against experimental cerebral malaria by inhibiting IL-12/IFN-γ in the brain. | 2013 | PLoS ONE | pmid:23613965 |
| Hanson J et al. | Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin Aâ‚„. | 2013 | Biochem. Pharmacol. | pmid:23643932 |
| Medeiros R et al. | Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. | 2013 | Am. J. Pathol. | pmid:23506847 |
| Xu Z et al. | Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4 axis. | 2013 | J. Immunol. | pmid:23677469 |