Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
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Authors | Title | Published | Journal | PubMed Link |
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Maldonado-Pérez D et al. | A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition. | 2011 | FASEB J. | pmid:20959513 |
Zhou M et al. | The protective effects of Lipoxin A4 during the early phase of severe acute pancreatitis in rats. | 2011 | Scand. J. Gastroenterol. | pmid:20950211 |
Khau T et al. | Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. | 2011 | FASEB J. | pmid:20930115 |
Börgeson E et al. | Lipoxin A₄ inhibits porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression. | 2011 | Infect. Immun. | pmid:21263017 |
Kenchegowda S et al. | EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21220563 |
Das UN | Lipoxins as biomarkers of lupus and other inflammatory conditions. | 2011 | Lipids Health Dis | pmid:21569625 |
Pang HY et al. | [Effect of lipoxin A(4) on lipopolysaccharide-induced endothelial hyperpermeability in human umbilical vein endothelial cell]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:21575454 |
He J et al. | Aspirin-triggered lipoxin A4 (15-epi-LXA4) increases the endothelial viability of human corneas storage in Optisol-GS. | 2011 | J Ocul Pharmacol Ther | pmid:21548792 |
Pang H et al. | Effect of lipoxin A4 on lipopolysaccharide-induced endothelial hyperpermeability. | 2011 | ScientificWorldJournal | pmid:21552771 |
Norling LV et al. | Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. | 2011 | J. Immunol. | pmid:21460209 |
Russell R et al. | Lipoxin A4 is a novel estrogen receptor modulator. | 2011 | FASEB J. | pmid:21885654 |
Wang YP et al. | Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells. | 2011 | J Neuroinflammation | pmid:21831303 |
Tang K et al. | Microparticles mediate enzyme transfer from platelets to mast cells: a new pathway for lipoxin A4 biosynthesis. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20801099 |
Das UN | Is lipoxins A4 a better alternative to anti-TNF-alpha antibody to prevent and treat diabetic macular edema and retinopathy? | 2010 | Med. Sci. Monit. | pmid:20802423 |
Wu SH et al. | Lipoxin A(4) inhibits transition of epithelial to mesenchymal cells in proximal tubules. | 2010 | Am. J. Nephrol. | pmid:20714129 |
Chen Y et al. | Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. | 2010 | Mol. Cancer Ther. | pmid:20682645 |
Zhang B et al. | Depletion of regulatory T cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin A4. | 2010 | J. Immunol. | pmid:21068404 |
Spite M and Serhan CN | Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. | 2010 | Circ. Res. | pmid:21071715 |
Ho KJ et al. | Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis. | 2010 | Am. J. Pathol. | pmid:20709806 |
Conte FP et al. | Lipoxin A(4) attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects. | 2010 | Br. J. Pharmacol. | pmid:20860668 |
Yin PL et al. | [Reversed changes of the 15-lipoxygenase product lipoxin Aâ‚„ and the 5-lipoxygenase product leukotriene Câ‚„ in children with asthma]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979801 |
Planagumà A et al. | Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. | 2010 | Mucosal Immunol | pmid:20130564 |
Wang J et al. | Effect of lipoxin A₄ on IL-1β production of monocytes and its possible mechanism in severe preeclampsia. | 2010 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:21181369 |
Leemans J et al. | Prophylactic effects of omega-3 polyunsaturated fatty acids and luteolin on airway hyperresponsiveness and inflammation in cats with experimentally-induced asthma. | 2010 | Vet. J. | pmid:19231257 |
Chen QH et al. | 15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model. | 2010 | Fertil. Steril. | pmid:19268934 |
Krishnamoorthy S et al. | Resolvin D1 binds human phagocytes with evidence for proresolving receptors. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20080636 |
Wu Y et al. | Neuroprotective effect of lipoxin A4 methyl ester in a rat model of permanent focal cerebral ischemia. | 2010 | J. Mol. Neurosci. | pmid:20401639 |
Kure I et al. | Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation. | 2010 | J. Pharmacol. Exp. Ther. | pmid:19846590 |
Leedom AJ et al. | Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury. | 2010 | Am. J. Pathol. | pmid:20008149 |
Bhavsar PK et al. | Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. | 2010 | Respir. Res. | pmid:20529300 |
Chan MM and Moore AR | Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production. | 2010 | J. Immunol. | pmid:20435922 |
Wu SH et al. | Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree. | 2010 | Pediatr. Pulmonol. | pmid:20232472 |
Zhou G et al. | Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. | 2010 | Cardiology | pmid:20234134 |
Maderna P et al. | FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. | 2010 | FASEB J. | pmid:20570963 |
Duffy CD et al. | Synthesis and biological evaluation of pyridine-containing lipoxin A4 analogues. | 2010 | ChemMedChem | pmid:20127785 |
Prieto P et al. | Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways. | 2010 | Cell Death Differ. | pmid:20094061 |
Wu SH et al. | NF-kappaB is involved in inhibition of lipoxin A4 on dermal inflammation and hyperplasia induced by mezerein. | 2010 | Exp. Dermatol. | pmid:20100194 |
Dufton N et al. | Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. | 2010 | J. Immunol. | pmid:20107188 |
Sanchez Y et al. | The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis. | 2010 | J. Biomed. Biotechnol. | pmid:20111744 |
Pamplona FA et al. | Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice. | 2010 | Neurosci. Lett. | pmid:20036315 |
Morris T et al. | Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20421472 |
Simões RL et al. | A synthetic analog of 15-epi-lipoxin A4 inhibits human monocyte apoptosis: involvement of ERK-2 and PI3-kinase. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20004734 |
Marcheselli VL et al. | Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19931440 |
Sun YP et al. | Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs. | 2009 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19853429 |
Sobrado M et al. | Synthesis of lipoxin A4 by 5-lipoxygenase mediates PPARgamma-dependent, neuroprotective effects of rosiglitazone in experimental stroke. | 2009 | J. Neurosci. | pmid:19321784 |
Beck-Speier I et al. | Oxymetazoline inhibits and resolves inflammatory reactions in human neutrophils. | 2009 | J. Pharmacol. Sci. | pmid:19609065 |
Grumbach Y et al. | LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18849442 |
Decker Y et al. | Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19357230 |
Forsman H and Dahlgren C | Lipoxin A(4) metabolites/analogues from two commercial sources have no effects on TNF-alpha-mediated priming or activation through the neutrophil formyl peptide receptors. | 2009 | Scand. J. Immunol. | pmid:19751275 |
Carvalho RR et al. | Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling. | 2009 | Chem. Biol. Interact. | pmid:19026997 |