| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Osteitis | D010000 | 10 associated lipids |
| Substance Withdrawal Syndrome | D013375 | 9 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zong L et al. | Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer. | 2016 | Oxid Med Cell Longev | pmid:26649143 |
| Martini AC et al. | Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. | 2016 | J Neuroinflammation | pmid:27059991 |
| Tahan F et al. | Increased Postexercise Lipoxin A4 Levels in Exhaled Breath Condensate in Asthmatic Children With Exercise-Induced Bronchoconstriction. | 2016 | J Investig Allergol Clin Immunol | pmid:27012012 |
| Wu B et al. | Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition. | 2016 | FASEB J. | pmid:26965685 |
| Das UN | Inflammatory bowel disease as a disorder of an imbalance between pro- and anti-inflammatory molecules and deficiency of resolution bioactive lipids. | 2016 | Lipids Health Dis | pmid:26762544 |
| Guo Z et al. | Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats. | 2016 | Stroke | pmid:26732571 |
| Li L et al. | New development in studies of formyl-peptide receptors: critical roles in host defense. | 2016 | J. Leukoc. Biol. | pmid:26701131 |
| Yu D et al. | Inverse Relationship between Serum Lipoxin A4 Level and the Risk of Metabolic Syndrome in a Middle-Aged Chinese Population. | 2015 | PLoS ONE | pmid:26565966 |
| Dakin SG et al. | Inflammation activation and resolution in human tendon disease. | 2015 | Sci Transl Med | pmid:26511510 |
| Prieto P et al. | Activation of autophagy in macrophages by pro-resolving lipid mediators. | 2015 | Autophagy | pmid:26506892 |
| Gao Y et al. | Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease. | 2015 | J. Immunol. | pmid:26324767 |
| Qi W et al. | Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury. | 2015 | Lab. Invest. | pmid:26302186 |
| DoÄŸan B et al. | Lipoxin A4 and Neutrophil/Lymphocyte Ratio: A Possible Indicator in Achieved Systemic Risk Factors for Periodontitis. | 2015 | Med. Sci. Monit. | pmid:26298769 |
| Lehmann C et al. | Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein. | 2015 | FASEB J. | pmid:26289316 |
| Roach KM et al. | Lipoxin A4 Attenuates Constitutive and TGF-β1-Dependent Profibrotic Activity in Human Lung Myofibroblasts. | 2015 | J. Immunol. | pmid:26276873 |
| Sha YH et al. | Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXRα signaling pathway in THP-1 macrophage-derived foam cells. | 2015 | Int J Clin Exp Pathol | pmid:26261553 |
| Yuan ZX and Rapoport SI | Transient postnatal fluoxetine decreases brain concentrations of 20-HETE and 15-epi-LXA4, arachidonic acid metabolites in adult mice. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26234927 |
| Awji EG et al. | Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25137396 |
| Dunn HC et al. | Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. | 2015 | J. Alzheimers Dis. | pmid:25125468 |
| Meng F et al. | Attenuation of lipopolysaccharide-induced lung vascular stiffening by lipoxin reduces lung inflammation. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:24992633 |