Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
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Authors | Title | Published | Journal | PubMed Link |
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Zong L et al. | Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer. | 2016 | Oxid Med Cell Longev | pmid:26649143 |
Colby JK et al. | Lipoxin Signaling in Murine Lung Host Responses to Cryptococcus neoformans Infection. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26039320 |
Havixbeck JJ et al. | Neutrophil contributions to the induction and regulation of the acute inflammatory response in teleost fish. | 2016 | J. Leukoc. Biol. | pmid:26292979 |
Pazdrak K et al. | Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling. | 2016 | J. Immunol. | pmid:27742828 |
Das UN | Inflammatory bowel disease as a disorder of an imbalance between pro- and anti-inflammatory molecules and deficiency of resolution bioactive lipids. | 2016 | Lipids Health Dis | pmid:26762544 |
Guo Z et al. | Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats. | 2016 | Stroke | pmid:26732571 |
Li L et al. | New development in studies of formyl-peptide receptors: critical roles in host defense. | 2016 | J. Leukoc. Biol. | pmid:26701131 |
Campos-Estrada C et al. | Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin. | 2015 | PLoS Negl Trop Dis | pmid:25978361 |
Wang X et al. | Resolution of inflammation is altered in Alzheimer's disease. | 2015 | Alzheimers Dement | pmid:24530025 |
Zhang C et al. | Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes. | 2015 | PLoS ONE | pmid:25886460 |