Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
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Authors | Title | Published | Journal | PubMed Link |
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Levy BD et al. | Lipid mediator class switching during acute inflammation: signals in resolution. | 2001 | Nat. Immunol. | pmid:11429545 |
Wardle N | New vistas in anti-inflammatory therapy. | 2001 | Nephron | pmid:11474222 |
McMahon B et al. | Lipoxins: revelations on resolution. | 2001 | Trends Pharmacol. Sci. | pmid:11478982 |
Goh J et al. | Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo. | 2001 | J. Immunol. | pmid:11509622 |
Qiu FH et al. | Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. | 2001 | FASEB J. | pmid:11687510 |
Goulet JL et al. | Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. | 2001 | J. Immunol. | pmid:11714834 |
Aliberti J et al. | Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. | 2002 | Nat. Immunol. | pmid:11743584 |
Vachier I et al. | Endogenous anti-inflammatory mediators from arachidonate in human neutrophils. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779156 |
Fierro IM et al. | Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4). | 2002 | J. Pharmacol. Exp. Ther. | pmid:11805195 |
Resnati M et al. | The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11818541 |