| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
Lipoxin A4
Lipoxin a4 is a lipid of Fatty Acyls (FA) class. Lipoxin a4 is associated with abnormalities such as Asthma, Cystic Fibrosis, Pneumonia, Obesity and Septicemia. The involved functions are known as Inflammation, Signal, Signal Transduction, Regulation and Metabolic Inhibition. Lipoxin a4 often locates in Immune system, Blood, soluble, Extracellular and Splenic Tissue. The associated genes with Lipoxin A4 are FPR2 gene, Homologous Gene, SAA1 gene, Trp-Lys-Tyr-Met-Val-Met and Annexin 1. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Lipoxin A4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Lipoxin A4?
Lipoxin A4 is suspected in Asthma, Cystic Fibrosis, Chagas Cardiomyopathy, Pneumonia, Obesity, Septicemia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (7)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Lipoxin A4
PubChem Associated disorders and diseases
What pathways are associated with Lipoxin A4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Lipoxin A4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Lipoxin A4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Lipoxin A4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Lipoxin A4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Lipoxin A4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Lipoxin A4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
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| Alvarez AM et al. | Aspirin-triggered lipoxin prevents antiphospholipid antibody effects on human trophoblast migration and endothelial cell interactions. | 2015 | pmid:25370166 | |
| pmid:23742835 | ||||
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| Hedqvist P et al. | Lipoxin A4 inhibits leukotriene B4-induced inflammation in the hamster cheek pouch. | 1989 | Acta Physiol. Scand. | pmid:2557732 |
| Dahlén SE et al. | Biological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo. | 1987 | Acta Physiol. Scand. | pmid:3630737 |
| Titos E et al. | Aspirin-triggered 15-epi-lipoxin A4 biosynthesis in rat liver cells. | 2002 | Adv. Exp. Med. Biol. | pmid:12664586 |
| Bandeira-Melo C et al. | Inhibition of allergen-induced eosinophil migration by lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4. | 2002 | Adv. Exp. Med. Biol. | pmid:12664587 |
| Filep JG et al. | Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 modulate adhesion molecule expression on human leukocytes in whole blood and inhibit neutrophil-endothelial cell adhesion. | 2002 | Adv. Exp. Med. Biol. | pmid:12664589 |
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| Dahlén SE et al. | Actions of lipoxin A4 and related compounds in smooth muscle preparations and on the microcirculation in vivo. | 1988 | Adv. Exp. Med. Biol. | pmid:3421155 |
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| Serhan CN et al. | Aspirin-triggered 15-epi-lipoxin A4 and stable analogs on lipoxin A4 are potent inhibitors of acute inflammation. Receptors and pathways. | 1999 | Adv. Exp. Med. Biol. | pmid:10086190 |
| Lin KT et al. | Modulation of LTB4 receptor in T-lymphocytes by lipoxin A4 (LXA4) and its role in delayed-type hypersensitivity. | 1999 | Adv. Exp. Med. Biol. | pmid:10086191 |
| Serhan CN et al. | Stereochemistry and biosynthesis of lipoxins. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959121 |
| Serhan CN and Fiore S | Lipoxin recognition sites of human neutrophils. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771345 |
| Wikström E et al. | Lipoxin A4 causes generation of thromboxane A2 in the guinea-pig lung. | 1989 | Agents Actions | pmid:2711953 |
| Dahlén SE et al. | Pharmacodynamics of lipoxin A4 in airway smooth muscle. | 1989 | Agents Actions | pmid:2711954 |
| Kupczyk M et al. | Lipoxin A4 generation is decreased in aspirin-sensitive patients in lysine-aspirin nasal challenge in vivo model. | 2009 | Allergy | pmid:19385948 |
| Soyombo O et al. | Effects of lipoxin A4 on chemotaxis and degranulation of human eosinophils stimulated by platelet-activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1994 | Allergy | pmid:8037356 |
| Wang X et al. | Resolution of inflammation is altered in Alzheimer's disease. | 2015 | Alzheimers Dement | pmid:24530025 |
| Rozsasi A et al. | Cyclooxygenase 2 and lipoxin Aâ‚„ in nasal polyps in cystic fibrosis. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185734 |
| Wu SH et al. | Lipoxin A(4) inhibits transition of epithelial to mesenchymal cells in proximal tubules. | 2010 | Am. J. Nephrol. | pmid:20714129 |
| Maderna P et al. | Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases. | 2002 | Am. J. Pathol. | pmid:12057930 |
| Esper L et al. | Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease. | 2012 | Am. J. Pathol. | pmid:22658486 |
| Wu SH et al. | Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. | 2009 | Am. J. Pathol. | pmid:19095947 |
| Medeiros R et al. | Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. | 2013 | Am. J. Pathol. | pmid:23506847 |
| Ho KJ et al. | Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis. | 2010 | Am. J. Pathol. | pmid:20709806 |
| Leedom AJ et al. | Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury. | 2010 | Am. J. Pathol. | pmid:20008149 |
| Wallace JL | Commonality of defensive roles of COX-2 in the lung and gut. | 2006 | Am. J. Pathol. | pmid:16565482 |
| Bonnans C et al. | Lipoxin A(4) regulates bronchial epithelial cell responses to acid injury. | 2006 | Am. J. Pathol. | pmid:16565483 |
| Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
| Rodgers K et al. | Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells. | 2005 | Am. J. Pathol. | pmid:16127149 |
| Titos E et al. | Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). | 1999 | Am. J. Physiol. | pmid:10564079 |
| Busija DW et al. | Lipoxins A4 and B4 dilate cerebral arterioles of newborn pigs. | 1989 | Am. J. Physiol. | pmid:2916679 |
| Katoh T et al. | Renal hemodynamic actions of lipoxins in rats: a comparative physiological study. | 1992 | Am. J. Physiol. | pmid:1415572 |
| Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
| Simchowitz L et al. | Carrier-mediated transport of lipoxin A4 in human neutrophils. | 1994 | Am. J. Physiol. | pmid:7810593 |